• 대한한의진단학회지
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• 제20권1호
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• pp.15-26
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• 2016

Objectives Syndrome differentiation and treatment (辨證論治) was one of the core theories in Korean medicine and syndrome differentiation (辨證) constitutes a branch of disease diagnosis in Korean medicine. Yoon Gil-Young, one of the modern outstanding scholar of basic medical science in Korean medicine, wrote on basic theories of Korean medicine such as physiology, pathology, formula science, etc. Hereby we will analyze and discuss his works to understand his recognition of historical changes in the syndrome differentiation. Methods We conducted researches into the two works of Yoon Gil-Young's, which are "The Clinical Formula Science of Eastern Medicine (東醫臨床方劑學)" and "The theory of Four-Constitution Medicine (四象體質醫學論)". From Yoon's academic standpoint which connects the basic medical science with the clinical medicine, we analyzed his opinion about the system in the Theory of 'Syndrome Differentiation'. Results According to Yoon's research work on the Theory of 'Syndrome Differentiation', the system of syndrome differentiation, which had its deep root in the theory of Yin and Yang (陰陽) & the theory of abbreviation of the five circuit phases (五運) and the six atomspheric influences (六氣) of the "Huangdi's Internal Classic (黃帝內經)". Conclusions Yoon Gil-Young's theory of differentiation of syndromes and treatment is widespread so much that he studied on the learning field of Traditional Korean Mediciine and ingenious as well. He explain on the main principles of differentiation of syndromes based on "Huang Di Nei Jing" and the system of differentiation of syndromes is composed of Traditional Korean Medical Physiology.

• The Korean Journal of Physiology and Pharmacology
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• 제27권4호
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• pp.365-374
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• 2023

Crohn's disease (CD) is a chronic inflammatory illness of the digestive system with unknown etiology, and its incidence is increasing worldwide. However, there are currently no effective treatments or medications available for individuals with CD. Therefore, novel therapeutic strategies are urgently needed. The bioactive compounds and targets associated with compounds of Qinghua Xiaoyong Formula (QHXYF) were examined using The Traditional Chinese Medicine Systems Pharmacology database, and 5 disease target databases were also used to identify CD-related disease targets. A total of 166 overlapping targets were identified from QHXYF-related and CD-related disease targets and they were found to be enriched in oxidative stress-related pathways and the PI3K/AKT signaling pathway. Molecular docking was then used to predict how the bioactive compounds would bind to the hub targets. It was found that quercetin could be the core bioactive compound and had good binding affinity to the top 5 hub targets. Finally, animal experiments were performed to further validate the findings, and the results revealed that QHXYF or quercetin inhibited 2,4,6-trinitrobenzenesulfonic acid-induced inflammation and oxidative stress processes by inhibiting the PI3K/AKT pathway, thereby improving CD symptoms. These findings suggest that QHXYF and quercetin may be potential novel treatments for CD.

• 대한한의학방제학회지
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• 제32권1호
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• pp.11-28
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• 2024

Objectives : GunRyeong-Tang(GRT) is a traditional herbal prescription that combines Oryeongsan and Sagunja-tang. This study employed network analysis methods on the components of GRT and target genes related to diabetes complications to predict the improvement effects of GRT on diabetes complications. Methods : The collection of active compounds of GRT and related target genes involved the utilization of public databases and the PubChem database. We selected diabetes complication-related genes using GeneCards and confirmed their correlation through comparative analysis with the target genes of GRT. We constructed a network using Cytoscape 3.9.1 and conducted topological analysis. To predict the mechanism, we performed functional enrichment analysis based on Gene Ontology (GO) biological processes and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Results : Through network analysis, 234 active compounds and 1361 related genes were collected from GRT. A total of 9,136 genes related to diabetes complications were collected, and 1,039 target genes overlapping with the components of GRT were identified. The core genes of this network were TP53, INS, AKT1, ALB, and EGFR. In addition, GRT significantly reduced the H9c2 cell size and the expression of myocardial hypertrophy biomarkers (ANP, BNP), which were increased by high glucose (HG). Conclusions : Through this study, we were able to predict the activity and mechanism of action of GRT on diabetes and diabetic complications, and confirmed the potential of GRT as a treatment for diabetes complications through the effect of GRT on improving myocardial hypertrophy for diabetic cardiomyopathy.

• 한국구조물진단유지관리공학회 논문집
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• 제23권6호
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• pp.132-140
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• 2019

본 연구는 철근콘크리트 단층 구조물의 구조 부재 위치에 대한 비파괴검사법을 이용한 추정 신뢰도를 알아보기 위해 기둥, 벽체, 보 및 슬래브로 구성된 실험체를 제작하고, 기존 추정식과 비교 과정에서 정확한 분석을 위해 오차율 비교와 모평균 구간 추정을 사용하여 통계적 접근을 통한 신뢰성을 분석하고자 한다. 그 결과, 초음파속도법을 이용하여 압축강도를 추정한 결과와 코어시험 결과를 비교한 전체 평균 오차율은 18.8%, 반발경도법을 이용하여 압축강도를 추정한 결과와 코어시험 결과를 비교한 전체 평균 오차율은 20.1%가 도출되어 현장 적용성을 확인하였다. 그리고 부재별 신뢰성 부분에서 초음파속도법과 반발경도법을 이용하여 신속하고 효율적인 구조물 안전진단을 하기 위해서 각각 벽체 부재와 보 부재를 중심으로 압축강도 추정 시 신뢰도 높은 결과를 도출되는 것을 확인하였다.

• 한국지반환경공학회 논문집
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• 제15권11호
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• pp.21-27
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• 2014

본 연구에서는 37개의 CCRD에 대한 계측자료(46개 지점)를 통해 댐 축조단계에서 얻어지는 계측자료를 이용하여 담수 후 댐의 정부침하량 및 내부침하량 예측기법을 제안하였다. 전체 데이터에 대한 분석 결과, 담수 후 시간경과에 따라 정부침하량이 함께 증가함이 확인되었으며, 댐 코어의 재료를 조립질과 세립질의 2가지 유형으로 구분한 댐 높이와 시공 중 최대 내부침하량의 관계로부터 조립질 재료를 사용 시의 내부침하량이 다소 크게 평가되었다. 또한 내부침하량은 댐 높이에 비례하여 증가하였으며, 댐 코어로서 세립질 재료를 사용하는 경우의 정부침하량이 상대적으로 크게 평가되었다. 본 연구결과는 향후 CCRD의 설계, 시공, 장기적 유지관리를 위한 유용한 도구가 될 것으로 전망된다.

• 한국조리학회지
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• 제7권1호
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• pp.91-105
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• 2001

Chou-cream bread and Red bean paste bread were made by sponge & dough method with the sweet dough formula. The bread quality was studied by the measurements of the temperature variation, the fermentation level of frozen dough in the special condition(dough conditioner of 5$^{\circ}C$, 10$^{\circ}C$, 15$^{\circ}C$, 20$^{\circ}C$ and 30$^{\circ}C$), the product volume and thesensory evaluation with frozen dough thawed, fermented and baked. When thawing temperature was low, the core temperature of frozen dough increased slowly and the time for thawing and fermentationwas long. In thawing and fermentation, the core temperature of Red bean paste dough increased faster than that of Chou-cream dough. When the thawing conditions of dough conditioner(retarder) were 20$^{\circ}C$ and 30$^{\circ}C$, the level of total time decrease for thawing and fermentation was 55 and 86 min in Chou-cream dough and 62 and 90 min in Red bean paste dough respectively in comparison to dough conditioner of 5$^{\circ}C$. In volume of baked products, they showed no significant difference for three weeks of storage, but slight difference for four weeks of storage. The result was that Chou-cream bread was larger than Red bean paste bread in the decrease of volume. In sensory evaluation, the bread quality became low according to the time. When stored for four weeks in the freezer, significant differences were found in Chou-cream vread, but slight difference appeared in Red bean paste bread. The research identified that Red bean paste dough was more effective in manufacturing time than that of Chou-cream dough, when thawing temperature was high, and if frozen dough was thawed in the retarder of lower than 20$^{\circ}C$, the bread quality in terms of volume and sensory evaluation had no significant difference in comparison to the none-freezing Red bean paste bread.

• Journal of Pharmaceutical Investigation
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• 제22권3호
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• pp.205-210
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• 1992

In order to develop a controlled-release oral drug delivery system (DDS) of theophylline (TP), microporous membrane-coated tablets were prepared and evaluated in vitro and in vivo. Rapidly water-soluble core tablets of TP (300 mg) were prepared by wet granulation and compression technique, Then the core tablets were spray-coated with polyvinylchloride (PVC) in which micronized sucrose particles were dispersed. Effect of formula compositions of coating suspensions on the pharmaceutical characteristics such as membrane strength and dissolution was investigated in vitro. The membranes remained unbroken in pH 1.2 buffer at $37^{\circ}C$ at least for 2 hours after the disintergration test. TP was released from the coated-released tablets at a zero-order rate over 8 hours. The release at pH 1.2 and 4.0 was similar in rate but a little more rapid than that at pH 6.8. The coated tablets were administered to three healthy male volunteers and their saliva profiles of TP were compared with those from the commercial sustained release TP tablets such as Slobid and Asconthin. Saliva TP concentrations from the coated tablets were successfully sustained over 48 hours after the dosing and were comparable to those of the commercial sustained-release tablets. The membrane-coating technique is very simple and does not need any sophisticated equipments. In this respect, the membrane-coated tablets may be superior to the commercial sustained-release tablets and this technique is worth adopting by the pharmaceutical industries.

• 한국산학기술학회논문지
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• 제22권6호
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• pp.60-66
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• 2021

광물자원의 개발 적합성을 가늠하기 위하여 굴착 장비로 지반 굴착을 통하여 코어를 채취한다. 코어를 채취하기 위해서는 시추장비의 가장 앞부분에 굴착을 위한 비트를 설치하여 직접지반을 굴착한다. 굴착을 진행 중에 드릴 비트는 지반과 직적접인 마찰로 인하여 국부에 응력을 받게 된다. 또한 마찰로 인하여 드릴 비트의 파손이 발생할 수 있기 때문에 지반의 조건에 따라 적합한 비트의 사용이 요구된다. 따라서 본 논문에서는 시추장비에 일반적으로 사용되는 세립비트를 기준으로 현재 개발 되어있는 비트의 모델을 이용하여 각각 이종재료와 동종재료의 보강재를 삽입한 새로운 비트 모델의 형상 및 재질을 비교·분석하였다. 그리고 세립비트의 형상을 각각의 형태로 모델링하여 절삭에 필요한 경도 및 항절력을 이론적 수식을 이용하여 계산하여 적합성을 확인하였다. 또한 기존의 모델과 새로운 형태의 설계모델을 Amsys Program을 이용하여 FEM해석을 실시하여 응력과 변형률을 계산한 결과, 응력이 1.92E+7Pa, 변형율 9.6E-5m/m인 응력과 변형율이 최소화된 새로운 모델을 설계하였고 그에 따른 세립비트 형상 및 구조의 최적화 설계를 진행하였다.

• International Journal of Computer Science & Network Security
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• 제22권11호
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• pp.255-259
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• 2022

The new social reality emerging amid the global rise of communication links and integration processes acutely emphasizes the problems of communication in large and small social systems. The method of their communication becomes one of the keys to ensuring global security. It has become the mission of humanitarian education to prepare the younger generations for life in a changing world with no image of the future and increasing uncertainty. In psychological and pedagogical research, there is a growing scientific interest in the problems of interaction of the individual with the social environment. The mental trace of a person's practice in society shapes the experience of social interaction, which constitutes simultaneously the source, tool, and condition for the emergence and development of personality. The study outlines the methodological foundations for the study of individual experiences of social interaction. A hypothesis about the productivity of the functional matrix method is tested. Materials for the training of specialists in the humanities include interdisciplinary approaches to the study and transformation of the experience of social interaction and systematic methodology for the study of complex objects. Fundamental to the study is the systematic-dialectical method, and the matrix method is employed as the instrumental-technological method. The paper presents the results of a multidisciplinary overview of scientific literature concerning the essential characteristics and functions of social interaction and the respective experience. The overview points to the fragmented nature of scientific understanding of the elements of experience outside its integrity and systemic properties. Based on the formula "personality interacts with the social environment", the study presents an algorithm for the application of a systematic methodology for the study of complex objects, which made it possible to identify the system parameters of experience at three levels of cognition and develop the reference structural and functional matrices for the didactic system of its pedagogical enrichment.

• 한국산학기술학회논문지
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• 제18권10호
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• pp.717-724
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• 2017

콘크리트 매립형 궤도를 운행하는 트램의 주행 안전성을 향상시키기 위해 핵심 구성품인 대차를 개발하고 제작하여 시험 차체와 조립한 후, 단거리 급곡선 급경사 궤도를 건설하고 시험운행을 실시하였다. 대차의 급곡선 주행 중 차륜 플랜지와 매립형 궤도의 간섭을 검토할 수 있는 산식을 제시하였고, 산식 결과에 따라 궤도를 설계하였다. 간략화된 계산식을 도출하여 곡선에서 탈선계수와 윤중감소율을 추정하였다. 단거리 급경사 급곡선 매립형 궤도에서 대차와 차체가 주행할 때에 차체의 가속도를 계측하였고, 영상 시스템을 통해 차륜과 궤도의 인터페이스 상태를 점검하였다. 계산 추정 결과에 따르면 차륜의 탈선계수와 윤중감소율은 안전기준 이하였는데, 실제 주행 시험 중에도 탈선은 발생하지 않았고, 가속도 계측 결과도 주행 안전기준을 만족하였다. 또한, 차륜과 궤도의 간섭은 발생하지 않았고, 영상 모니터링 결과도 차륜의 올라타기 등 탈선조짐은 발견되지 않았으며, 중앙의 피니언과 랙이 원활히 접촉하면서 양호한 주행안전성을 보여주고 있었다. 외부 소음 계측을 통해서 소음 기준을 만족하고 있음을 확인하였다.