• Archives of Pharmacal Research
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• v.13 no.2
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• pp.151-160
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• 1990

In order to develop a controlled-release oral drug delivery system (DDS) which sustains the plasma acetaminophen (AAP) concentration for a certain period of time, microporous membrane-coated tablets were prepared and evaluated in vitro. Firstly, highly water-soluble core tablet of AAP were prepared with various formulations by wet granulation and compression technique. Then the core tablets were coated with polyvinychloride (PVC) in which micronized sucrose particles were dispersed. Effect of formula compositions of core tablets and coating suspensions on the pharmaceutical characteristics such as drug release kinetics and membrane stability of the coated tablets was investigated in vitro. AAP was released from the coated tablets as a zero-order rate in a pH-independent manner. This independency of AAP release to pH change from 1.2 to 7.2 is favorable for the controlled oral drug delivery, since it will produce a constant drug release in the stomach and intestine regardless of the pH change in the GI tract. Drug release could be extended upto 10 h according to the coating condition. The release rate could be controlled by changing the formula compositions of the core tablets and coating suspensions, coat weight per each tablet, and especially PVC/sucrose ratio and particle size of the sucrose in the coating suspension. The coated tablets prepared in this study had a fairly good pharmaceutical characteristics in vitro, however, overall evaluation of the coated tablet should await in vivo absorption study in man.

• Journal of Korean Medical classics
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• v.33 no.4
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• pp.67-81
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• 2020

Objectives : This research aims to suggest a automatic data extract method for herbal formula combinations from medical classics' texts. Methods : This research was carried out by using Access of Microsoft Office 365 in Windows 10 of Microsoft. The subject text for extraction was 『Euijongsonik』. Using data sets of herb and dosage terminology, herbal medicinals and their dosages were extracted. Afterwards, using the position value of the character string, the formula combinations were automatically extracted. Results :The PC environment of this research was Intel Core i7-1065G7 CPU 1.30GHz, with 8GB of RAM and a Windows 10 64bit operation system. Out of 6,115 verses, 19,277 herb-dosage combinations were extracted. Conclusions : In this research, it was demonstrated that in the case of classical texts that are available as data, knowledge on herbal medicine could be extracted without human or material resources. This suggests an applicability of classical text knowledge to clinical practice.

• Journal of the Korea Society of Computer and Information
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• v.24 no.1
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• pp.197-206
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• 2019

The purpose of this study is to develop and validate a model for diagnosing core competencies at the higher education level. Based on literature reviews, a potential model for core competencies at university was suggested. A tool for validating the model was composed of 24 items, which were delivered to 226 professors and administrative staffs, 730 students, and 134 graduates & external industrial experts. Five constructs (core competencies) were extracted from the data collected among professors and administrative staff responding to the importance of the items. The results of importance and performance surveys on core competencies with students were respectively 3.28 to 3.66 and 2.68 to 3.28 (4-point Likert scale). Statistical differences between importance level and performance level were found in all the sub-categories of core competencies. Borich priority determination formula and Locus for Focus Model were used for the determination of the priority of needs. Importance survey among graduates and external experts showed that the mean of each items ranged from 2.80 to 3.76 (4-point Likert scale). The overall results of the analyses suggest that the final model is appropriate for measuring the core competencies.

• Communications for Statistical Applications and Methods
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• v.22 no.6
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• pp.665-674
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• 2015

Lack of a general matrix formula hampers implementation of the semi-partial correlation, also known as part correlation, to the higher-order coefficient. This is because the higher-order semi-partial correlation calculation using a recursive formula requires an enormous number of recursive calculations to obtain the correlation coefficients. To resolve this difficulty, we derive a general matrix formula of the semi-partial correlation for fast computation. The semi-partial correlations are then implemented on an R package ppcor along with the partial correlation. Owing to the general matrix formulas, users can readily calculate the coefficients of both partial and semi-partial correlations without computational burden. The package ppcor further provides users with the level of the statistical significance with its test statistic.

• Journal of Korean Association for Spatial Structures
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• v.22 no.1
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• pp.51-57
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• 2022

In this paper, based on the finite element analysis model verified in previous studies, a new model of a buckling restrained brace reinforced with a steel plate was proposed. A design formula was proposed for the new model to dissipate energy without buckling the steel core under load protocol, and the performance of the model satisfying the design formula was evaluated by comparing it with the previous model through the results of hysteresis loop, bi-linear curve, cumulative energy dissipation capacity, and equivalent viscous damping.

• Steel and Composite Structures
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• v.48 no.3
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• pp.263-273
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• 2023

This paper investigates dynamic characteristics of a graphene nanoplatelets reinforced composite (GNPRC) sandwich doubly curved shell based on the first-order shear deformation theory (FSDT) and Hamilton's principle. The sandwich doubly curved shell is fabricated from a core made of honeycomb materials sandwiched by composite GNPs reinforced face-sheets. Effective materials properties of composite face-sheets are assumed to vary based on Halpin-Tsai micromechanical models and rule of mixture. Furthermore, the material properties of honeycomb core are estimated using Gibson's formula. The fundamental frequencies of the shell are computed with changes of main geometrical and material properties such as amount and distribution type of graphene nanoplatelets, side length ratio, thickness to length ratio of and side length ratio of honeycomb. The Navier's technique is presented to obtain responses. Accuracy and trueness of the present model and analytical solution is confirmed through comparison of the results with available results in literature. It is concluded that an increase in thickness to length ratio yields a softer core with lower natural frequencies. Furthermore, increase in height to length ratio leads to significant decrease in natural frequencies.

• The Journal of the Convergence on Culture Technology
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• v.6 no.4
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• pp.655-661
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• 2020

In this study, the correlation between concrete core compressive strength and rebound hardness of urban railway underground structures was analyzed. The equations for the range of rebound hardness were derived and compared with the measured concrete core strengths for each range of rebound hardness to confirm the adequacy of the estimated compressive strength. As the result, the linear regression analysis results of the average compressive strength by the Gaussian probability density function (representative compressive strength estimation formula) and the estimation formula by the rebound hardness range were founded to match well within 3% of the experimental concrete core compressive strength test results. Therefore, the stochastic statistical analysis using the rebound hardness measurement results suggested in this study could be help to secure the confidence level of the correlation between the rebound hardness and the concrete compressive strength which are relatively large deviation according to the estimation equations.

• Structural Engineering and Mechanics
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• v.74 no.3
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• pp.395-406
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• 2020

Many prefabricated concrete frame joints have been proposed, and most of them showed good seismic performance. However, there are still some limitations in the proposed fabricated joints. For example, for prefabricated prestressed concrete joints, prefabricated beams and prefabricated columns are assembled as a whole by the pre-stressed steel bar and steel strand in the beams, which brings some troubles to the construction, and the reinforcement in the core area of the joints is complex, and the mechanical mechanism is not clear. Based on the current research results, a new type of fabricated joint of prestressed concrete beams and confined concrete columns is proposed. To study the seismic performance of the joint, the quasi-static test is carried out. The test results show that the nodes exhibit good ductility and energy dissipation. According to the experimental fitting method and the "fixed point pointing" law, the resilience model of this kind of nodes is established, and compared with the experimental results, the two agree well, which can provides a certain reference for elasto-plastic seismic response analysis of this type of structure. Besides, based on the analysis of the factors affecting the shear capacity of the node core area, the formula of shear capacity of the core area of the node is proposed, and the theoretical values of the formula are consistent with the experimental value.

• Nuclear Engineering and Technology
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• v.56 no.6
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• pp.2092-2098
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• 2024

Probabilistic safety assessment (PSA) plays a critical role in ensuring the safe operation of nuclear power plants. In PSA, event trees are developed to identify accident sequences that could lead to core damage. These event trees are then transformed into a core-damage fault tree, wherein the accident sequences are represented by usual and complemented logic gates representing failed and successful operations of safety systems, respectively. The core damage frequency (CDF) is estimated by calculating the minimal cut sets (MCSs) of the core-damage fault tree. Delete-term approximation (DTA) is commonly employed to approximately solve MCSs representing accident sequence logics from noncoherent core-damage fault trees. However, DTA can lead to an overestimation of CDF, particularly when fault trees contain many nonrare events. To address this issue, the present study introduces a new zero-suppressed ternary decision diagram (ZTDD) algorithm that averts the CDF overestimation caused by DTA. This ZTDD algorithm can optionally calculate MCSs with DTA or prime implicants (PIs) without any approximation from the core-damage fault tree. By calculating PIs, accurate CDF can be calculated. The present study provides a comprehensive explanation of the ZTDD structure, formula of the ZTDD algorithm, ZTDD minimization, probability calculation from ZTDD, strength of the ZTDD algorithm, and ZTDD application results. Results reveal that the ZTDD algorithm is a powerful tool that can quickly and accurately calculate CDF and drastically improve the safety of nuclear power plants.

• Steel and Composite Structures
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• v.13 no.5
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• pp.409-421
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• 2012

Recently, as the height of building is getting higher, the applications of CFST column for high-rise buildings have been increased. In structural system of high-rise building, The RC core and exterior concrete-filled tubular (CFST) column-beam pinned connection is one of the structural systems that support lateral load. If this structural system is used, due to the minimal CFST column thickness compared to that of the CFST column width, the local moment occurred by the eccentric distance between the column flange surface from shear bolts joints degrades the shear strength of the CFST column-beam pinned connections. This study performed a finite element analysis to investigate the shear strength under eccentric moment of the CFST column-beam pinned connections. The column's width and thickness were used as variables for the analysis. To guarantee the reliability of the finite element analysis, an actual-size specimens were fabricated and tested. The yield line theory was used to formulate an shear strength formula for the CFT column-beam pinned connection. the shear strength formula was suggested through comparison on the results of FEM analysis, test and yield lime theory, the shear strength formula was suggested.