• Molecules and Cells
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• 제43권1호
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• pp.76-85
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• 2020

MARCH5 is a RING finger E3 ligase involved in mitochondrial integrity, cellular protein homeostasis, and the regulation of mitochondrial fusion and fission. To determine the function of MARCH5 during development, we assessed transcript expression in zebrafish embryos. We found that march5 transcripts were of maternal origin and evenly distributed at the 1-cell stage, except for the mid-blastula transition, with expression predominantly in the developing central nervous system at later stages of embryogenesis. Overexpression of march5 impaired convergent extension movement during gastrulation, resulting in reduced patterning along the dorsoventral axis and alterations in the ventral cell types. Overexpression and knockdown of march5 disrupted the organization of the developing telencephalon and diencephalon. Lastly, we found that the transcription of march5 was tightly regulated by the transcriptional regulators CHOP, C/EBPα, Staf, Znf143a, and Znf76. These results demonstrate the essential role of March5 in the development of zebrafish embryos.

• 한국전문물리치료학회지
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• 제31권1호
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• pp.79-88
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• 2024

Background: The abdominal drawing-in maneuver (ADIM), a method of lumbar stabilization training, is an effective neuromuscular intervention for lumbar instability associated with low back pain (LBP). Objects: The purpose of this study was to compare the effect of a 2-week period of the ADIM and tensor fasciae latae-iliotibial band (TFL-ITB) self-stretching on lumbopelvic rotation angle, lumbopelvic rotation movement onset, TFL-ITB length, and pain intensity during active prone hip lateral rotation. Methods: Twenty-two subjects with lumbar extension rotation syndrome accompanying shortened TFL-ITB (16 males and 6 females) were recruited for this study. The subjects were instructed how to perform ADIM training or ADIM training plus TFL-ITB self-stretching program at home for a 2-week period. A 3-dimensional ultrasonic motion analysis system was used to measure the lumbopelvic rotation angle and lumbopelvic rotation movement onset. An independent t-test was used to determine between-group differences for each outcome measure (lumbopelvic rotation angle, lumbopelvic rotation movement onset, TFL-ITB length, and pain intensity). Results: The results showed that ADIM training plus TFL-ITB self-stretching decreased the lumbopelvic rotation angle, delayed the lumbopelvic rotation movement onset, and elongated the TFL-ITB significantly more than did ADIM training alone. Pain intensity was lower in the ADIM training plus TFL-ITB self-stretching group than the ADIM training alone group; however, the difference was not significant. Conclusion: ADIM training plus TFL-ITB self-stretching performed for a 2-week period at home may be an effective treatment for modifying lumbopelvic motion and reducing LBP.

• 대한의용생체공학회:의공학회지
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• 제34권2호
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• pp.55-62
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• 2013

Wrist joints consist of irregularly shaped carpal bones and other complicated structures. Thus, evaluating the motion of a wrist joint is a challenging task. In this study, we used an infrared camera to perform a kinematic analysis of a dart-throwing motion. We measured the difference between the movement of a normal wrist and constrained wrist (wrist with a wrist glove) in the dart-throwing motion with thirty six healthy participants. We measured the ulna flexion - radial extension motion using the attached passive marker and analyzed it using Polygon software and SPSS. The pitch and yaw motions with a glove was bigger than the ones without a glove by 20 and 15 degrees, respectively. On the other hand, the roll motion without a glove was bigger than the one with a glove by 7 degree. Wilcoxon signed rank test (p<0.05) confirmed that there are significant differences between the motion with and without a glove. It was found that the magnitude of the pitch and yaw motion with a constrained wrist joint toward radial extension in dart-throwing motion is smaller than the one with a normal wrist joint. However, a normal wrist joint showed a bigger movement in the roll direction.

• 한국산업융합학회 논문집
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• 제4권4호
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• pp.379-386
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• 2001

The lower toughness or brittle materials for mechanical test lead to the additional requirement that applied displacements be controlled with high resolution. Biaxial tension and shear tester using stepper motor with harmonic driver is shown. The device had to be high resolution so that the crack initiation process of slow extension and steady growth could be examined, Grip plates were connected to a linear bearing and actuator. The actuators consisted of stepper motors with harmonic driver connected to pre-loaded ball screw and nut assemblies. The encoders and motor controllers were connected to a personal computer so that arbitrary displacements histories could he prescribed in normal and tangential directions. The linear bearings were used to react loads perpendicular to their axes while allowing low friction, parallel movement of the attached grips. Load cells measured the reactions normal and tangential. the loads measured the reactions were recorded by the computer.

• 디지털융복합연구
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• 제17권3호
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• pp.463-471
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• 2019

본 연구는 무릎 근력의 불균형이 백 스쿼트 시 인체 움직임의 제한 요인으로 작용하는지를 확인하는 것에 목적이 있다. 백 스쿼트 유경험자로 최근 2년간 부상이 없는 서울시 소재 S대학교 학생 8명을 연구 대상자로 선정하였다. Cybex 770으로 무릎관절의 등속성 근력을 측정한 후, 동측 주작용근과 대항근의 근력 불균형 정도와 좌 우 같은 근 군의 결손율에 따라 그룹을 나눈 후, 개인별 몸무게의 25%, 50%, 100%, 125%의 중량과 같은 바벨을 백 스쿼트로 들게 하였다. 무릎 굽힘 각도, 신체중심의 수직 변위, V-COP의 측정 구간 내 평균 위치로부터 매 순간 V-COP 까지의 거리 합 변인들에 대한 집단별 차이를 검증하기 위해 독립표본 T 검정을 실시하였다. 125%BW 조건에서 무릎관절 근력의 동측 불균형은 쭈그려 앉는 자세의 제한 요인으로, 좌 우측 폄 근력의 불균형은 평형성 유지의 제한 요인으로 작용하였다. 근력의 불균형이 인체 움직임의 제한 요인으로 작용할 수 있음을 확인하였으므로, 차후 임상에서는 근력 불균형에 대한 검사법과 함께 교정 및 재활 운동 방법 또한 발전시켜 나갈 필요가 있다.

• 디지털융복합연구
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• 제13권7호
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• pp.373-380
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• 2015

본 연구는 테니스 한손과 양손 백핸드 스트로크 동작에서 하지관절 움직임의 차이를 확인하여 유형별 특성을 밝히는데 그 목적이 있으며 그 결과는 다음과 같다. 볼의 속도를 결정하는 중요한 요인인 라켓헤드의 합성 속도는 양손 백핸드 스트로크 동작이 한손보다 빠른 속도를 나타냈다. 양손 백핸드 스트로크는 하체의 움직임을 최소화시키고 몸통 회전을 통한 스트로크를 하는 반면 한손 백핸드 스트로크는 몸통을 이용한 스트로크를 하기 보다는 공을 쫓아가듯이 스트로크 하는 것으로 나타났다. 슬관절의 신전모멘트는 한손 백핸드 스트로크가 큰 것으로 나타났지만, 내번모멘트와 회내모멘트 그리고 굴곡모멘트는 양손 스트로크에서 크게 나타났다. 고관절의 경우 신전, 내번, 회내 모멘트가 양손 백핸드 스트로크가 한손 보다 모두 큰 것으로 나타났는데 특히 내번모멘트의 경우 큰 차이를 나타난 반면, 외번모멘트는 한손 백핸드 스트로크가 큰 것으로 나타났다.

• The Journal of Korean Physical Therapy
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• 제34권6호
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• pp.317-320
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• 2022

Purpose: This study aimed: to confirm the balance ability of patients with spinal cord injury in the sitting state through a functional reach test using an elastic aid; and to propose a balance improvement plan. Methods: The study evaluated seven patients with spinal cord injury who could maintain a sitting posture through minimum assistance. A functional reach test was performed before and after wearing an elastic aid while sitting on a chair, and the effects before and after use of the elastic aid were compared and analyzed through a motion analyzer. Results: In the functional reach test, the forward movement distance of the hand was 97.45 mm before wearing the elastic aid, but significantly increased to 131 mm after wearing the aid (p<0.05). Corresponding forward movement distances for the shoulder were 81.26 mm and 113 mm (p<0.05 for the increase). There was no statistically significant change in lateral functional arm extension. Conclusion: It was confirmed, through a functional reach test, that trunk stability in patients with spinal cord injury increased with use of an elastic aid. In future, more efficient rehabilitation treatment programs will be possible if trunk stability in patients with spinal cord injury is improved by using elastic aids, and if various exercise treatments are also included in the rehabilitation programs.

• The Journal of Korean Physical Therapy
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• 제33권3호
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• pp.162-167
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• 2021

Purpose: A hyperextended knee is described as knee pain associated with an impaired knee extensor mechanism. Additionally, a hyperextended knee may involve reduced position sense of the knee joint that decreases the individual's ability to control end-range knee extension movement. The purpose of this study was to investigate the effects of visual biofeedback information for plantar pressure distribution on knee joint angle and lower extremity muscle activities in participants with hyperextended knees. Methods: Twenty-three participants with hyperextended knees were recruited for the study. Surface electromyography signals were recorded for the biceps femoris, rectus femoris, gastrocnemius, and tibialis anterior muscle activities. The plantar pressure distribution was displayed and measured using a pressure distribution measuring plate. Knee joint angle kinematic parameters were recorded using a motion analysis system. The visual biofeedback condition was the point at which the difference between the forefoot and backfoot plantar foot pressure on the monitor was minimized. The Wilcoxon signed-rank test was used to determine the significance between the visual biofeedback condition and the preferred condition. Results: The knee joint angle was significantly decreased in the visual biofeedback condition compared to that in the preferred condition (p<0.05). The rectus femoris and gastrocnemius muscle activities were significantly different between the visual biofeedback and preferred conditions (p<0.05). Conclusion: The results of this study showed that visual biofeedback of information about plantar pressure distribution is effective for correcting hyperextended knees.

• 한국응용과학기술학회지
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• 제37권4호
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• pp.839-847
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• 2020

본 연구는 외발 착지 시 신체적 특성 요인들인 발목 유연성, 성별, Q-angle이 발목 관절 상해 요인들에 미치는 영향을 분석하는데 목적이 있었다. 이를 위해 오른발을 주발로 사용하고 체육을 전공하는 20대 남성 16명(나이: 20.19±1.78 years, 체중: 69.54±10.12 kg, 신장: 173.22±4.43 cm), 여성 16명(나이: 21.05±1.53 years, 체중: 61.75±6.97 kg, 신장: 159.34±4.56 cm)을 연구대상자로 선정하였다. 외발 착지 시 신체적 특성 요인들이 발목 관절 상해에 미치는 영향을 확인하기 위하여 첫째, 발목 상해 경험에 따른 하지 관절 움직임과 관절 모멘트의 독립 t-test를 실시하였다(α = .05). 둘째, t-test를 통하여 유의한 차이를 나타낸 변인을 종속변인으로 설정하고 발목 유연성, 성별의 차이, Q-angle을 독립변인으로 지정하여 선형다중회귀분석(Multiple Linear Regression)을 사용하였다(α = .05). 본 연구결과 발목 관절 상해를 경험한 그룹은 상해를 경험하지 않은 그룹과는 다르게 발목 관절의 내전, 무릎 관절의 내측 회전을 통한 착지 전략과 기술을 사용하는 것으로 나타났다. 또한 이러한 움직임은 발목 관절의 신전 모멘트를 증가시키고, 엉덩 관절의 신전 모멘트는 감소시키는 것으로 확인되었다. 특히 발목의 배측굴곡 유연성은 발목과 무릎의 착지전략에 영향을 미치며, 성별의 차이는 발목의 신전 모멘트에 영향을 미치는 것을 알 수 있었다. 따라서 외발 착지 시 신체적 특성 요인들이 발목 관절 상해에 영향을 미치는 요인들임을 확인 할 수 있었다.