• Environmental Analysis Health and Toxicology
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• 제27권
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• pp.12.1-12.8
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• 2012

Objectives: The aim of this study was to identify the health and environmental risk factors of air contaminants that influence environmental and respiratory diseases in Gyeongju, Pohang and Ulsan in South Korea, with a focus on volatile organic compounds (VOCs). Methods: Samples were collected by instantaneous negative pressure by opening the injection valve in the canister at a fixed height of 1 to 1.5 m. The sample that was condensed in $-150^{\circ}C$ was heated to $180^{\circ}C$ in sample pre-concentration trap using a 6-port switching valve and it was injected to a gas chromatography column. The injection quantity of samples was precisely controlled using an electronic flow controller equipped in the gas chromatography-mass spectrometer. Results: The quantity of the VOC emissions in the industrial area was 1.5 to 2 times higher than that in the non-industrial area. With regards to the aromatic hydrocarbons, toluene was detected at the highest level of 22.01 ppb in Ulsan, and chloroform was the halogenated hydrocarbons with the highest level of 10.19 ppb in Pohang. The emission of toluene was shown to be very important, as it accounted for more than 30% of the total aromatic hydrocarbon concentration. Conclusions: It was considered that benzene in terms of the cancer-causing grade standard, toluene in terms of the emission quantity, and chloroform and styrene in terms of their grades and emission quantities should be selected for priority measurement substances.

• Journal of Power Electronics
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• 제15권2호
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• pp.455-468
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• 2015

A microgrid (MG) with integrated renewable energy resources can benefit both utility companies and customers. As a result, they are attracting a great deal of attention. The control of a MG is very important for the stable operation of a MG. The droop-control method is popular since it avoids circulating currents among the converters without using any critical communication between them. Traditional droop control methods have the drawback of an inherent trade-off between power sharing and voltage and frequency regulation. An adaptive droop control method is proposed, which can operate in both the island mode and the grid-connected mode. It can also ensure smooth switching between these two modes. Furthermore, the voltage and frequency of a MG can be restored by using the proposed droop controller. Meanwhile, the active power can be dispatched appropriately in both operating modes based on the capacity or running cost of the Distributed Generators (DGs). The global information (such as the average voltage and output active power of the MG and so on) required by the proposed droop control method to restore the voltage and frequency deviations can be acquired distributedly based on the Multi Agent System (MAS). Simulation studies in PSCAD demonstrate the effectiveness of the proposed control method.

• Journal of Power Electronics
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• 제15권2호
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• pp.555-566
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• 2015

A TRIAC dimming LED driver that can control the brightness of LED arrays for a wide range of source voltage variations is proposed in this paper. Unlike conventional PWM LED drivers, the proposed LED driver adopts a TRIAC switch, which inherently guarantees zero current switching and has been proven to be quite reliable over its long lifetime. Unlike previous TRIAC type LED drivers, the proposed LED driver is composed of an LC input filter and a variable switched capacitance, which is modulated by the TRIAC turn-on timing. Thus, the LED power regulation and dimming control, which are done by a volume resistor in the same way as the conventional TRIAC dimmers, can be simultaneously performed by the TRIAC control circuit. Because the proposed LED driver has high efficiency and a long lifetime with a high power factor (PF) and low total harmonic distortion (THD) characteristics, it is quite adequate for industrial lighting applications such as streets, factories, parking garages, and emergency stairs. A simple step-down capacitive power supply circuit composed of passive components only is also proposed, which is quite useful for providing DC power from an AC source without a bulky and heavy transformer. A prototype 60 W LED driver was implemented by the proposed design procedure and verified by simulation and experimental results, where the efficiency, PF, and THD are 92%, 0.94, and 6.3%, respectively. The LED power variation is well mitigated to below ${\pm}2%$ for 190 V < $V_s$ < 250 V by using the proposed simple control circuit.

• Molecules and Cells
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• 제39권7호
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• pp.550-556
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• 2016

During meiosis, exchange of DNA segments occurs between paired homologous chromosomes in order to produce recombinant chromosomes, helping to increase genetic diversity within a species. This genetic exchange process is tightly controlled by the eukaryotic RecA homologs Rad51 and Dmc1, which are involved in strand exchange of meiotic recombination, with Rad51 participating specifically in mitotic recombination. Meiotic recombination requires an interaction between homologous chromosomes to repair programmed double-strand breaks (DSBs). In this study, we investigated the budding yeast meiosis-specific proteins Hop2 and Sae3, which function in the Dmc1-dependent pathway. This pathway mediates the homology searching and strand invasion processes. Mek1 kinase participates in switching meiotic recombination from sister bias to homolog bias after DSB formation. In the absence of Hop2 and Sae3, DSBs were produced normally, but showed defects in the DSB-to-single-end invasion transition mediated by Dmc1 and auxiliary factors, and mutant strains failed to complete proper chromosome segregation. However, in the absence of Mek1 kinase activity, Rad51-dependent recombination progressed via sister bias in the $hop2{\Delta}$ or $sae3{\Delta}$ mutants, even in the presence of Dmc1. Thus, Hop2 and Sae3 actively modulate Dmc1-dependent recombination, effectively progressing homolog bias, a process requiring Mek1 kinase activation.

• 한양메디칼리뷰
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• 제33권1호
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• pp.10-16
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• 2013

Follicular helper T cells (Tfh) play a significant role in providing T cell help to B cells during the germinal center reaction, where somatic hypermutation, affinity maturation, isotype class switching, and the differentiation of memory B cells and long-lived plasma cells occur. Antigen-specific T cells with IL-6 and IL-21 upregulate CXCR5, which is required for the migration of T cells into B cell follicles, where these T cells mature into Tfh. The surface markers including PD-1, ICOS, and CD40L play a significant role in providing T cell help to B cells. The upregulation of transcription factor Bcl-6 induces the expression of CXCR5, which is an important factor for Tfh differentiation, by inhibiting the expression of other lineage-specific transcription factors such as T-bet, GATA3, and RORγt. Surprisingly, recent evidence suggests that CD4 T cells already committed to Th1, Th2, and Th17 cells obtain flexibility in their differentiation programs by downregulating T-bet, GATA3, and RORγt, upregulating Bcl-6 and thus convert into Tfh. Limiting the numbers of Tfh within germinal centers is important in the regulation of the autoantibody production that is central to autoimmune diseases. Recently, it was revealed that the germinal center reaction and the size of the Tfh population are also regulated by thymus-derived follicular regulatory T cells (Tfr) expressing CXCR5 and Foxp3. Dysregulation of Tfh appears to be a pathogenic cause of autoimmune disease suggesting that tight regulation of Tfh and germinal center reaction by Tfr is essential for maintaining immune tolerance. Therefore, the balance between Tfh and Tfr appears to be a critical peripheral tolerance mechanism that can inhibit autoimmune disorders.

• Progress in Superconductivity
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• 제4권1호
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• pp.1-9
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• 2002

Transferring single flux quanta across a Josephson junction at an exactly determined rate has made highly precise voltage measurements possible. Making use of self-shunted Nb-based SINIS junctions, programmable fast-switching DC voltage standards with output voltages of up to 10 V were produced. This development is now extended from fundamental DC measurements to the precise determination of AC voltages with arbitrary waveforms. Integrated RSFQ circuits will help to replace expensive semiconductor devices for frequency control and signal coding. Easy-to-handle AC and inexpensive quantum voltmeters of fundamental accuracy would be of interest to industry. In analogy to the development in the flux regime, metallic nanocircuits comprising small-area tunnel junctions and providing the coherent transport of single electrons might play an important role in quantum current metrology. By precise counting of single charges these circuits allow prototypes of quantum standards for electric current and capacitance to be realised. Replacing single electron devices by single Cooper pair circuits, the charge transfer rates and thus the quantum currents could be significantly increased. Recently, the principles of the gate-controlled transfer of individual Cooper pairs in superconducting A1 devices in different electromagnetic environments were demonstrated. The characteristics of these quantum coherent circuits can be improved by replacing the small aluminum tunnel Junctions by niobium junctions. Due to the higher value of the superconducting energy gap ($\Delta_{Nb}$ ＝ $7\Delta_{Al}$), the characteristic energy and the frequency scales for Nb devices are substantially extended as compared to A1 devices. Although the fabrication of small Nb junctions presents a real challenge, the Nb-based metrological devices will be faster and more accurate in operation. Moreover, the Nb-based Cooper pair electrometer could be coupled to an Nb single Cooper pair qubit which can be beneficial for both, the stability of the qubit and its readout with a large signal-to-noise ratio..

• 유변학
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• 제11권2호
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• pp.82-90
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• 1999

전기유변 유체(electorheological fluid)는 전기장이 가해지면 아주 짧은 시간에 유변 물성이 급격히 변하며 그 응답이 반복적으로 수행될 수 있는 유체이다. 전기유변 유체는 전기장의 세기에 따라 면찰 응력(shear stress)과 점도의 크기를 조절할 수 있고, 짧은 응답시간은 빠른 제어를 요하는 분야에 효과적으로 이용될 수 있지만, 낮은 항복 응력, 조업 온도 범위의 제한성, 전력 소비에 의한 열적 불안정성, 그 외에도 응집, 침전 등의 단점이 있다. 특히, 이 유체가 갖는 항복 응력의 크기와 그 성질은 실제 장치에 응용하는데 중요한 특성이다. 이러한 문제점을 해결하기 위해 면찰 유동(shear flow)이 아닌 압착 유동(squeezing flow)을 고려하게 되었고, 이 유동 하에서의 전기유변 유체의 거동을 이해하기 위해 본 연구에서는 전기유변 유체의 압착 유동에 대한 동적 수치모사를 수행하였다. 고립된 사슬 구조에 대한 수치모사를 통하여 사슬의 위치와 압착 속도를 변화 시키면서 이에 따른 수력학적 힘과 정전기적 힘의 효과를 예측하였으며, 이를 토대로 많은 사슬을 포함한 현탁액 모델에 대한 수치모사를 수행하였다. 그 결과 실험에서 관찰할 수 있는 수직 응력의 증가와 초기 항복 응력의 존재를 확인하였고, 수직 응력의 효과적인 제어는 수력학적 힘과 정전기적 힘 간의 최적화된 조건에서 얻어질 수 있음을 예측하였다. 이러한 수치모사의 개발을 통해 압착 유동을 이용한 전기유변 유체의 응용에 대한 이론적인 토대를 마련하였고, 향후 보다 깊은 이해를 위한 기반을 구축할 수 있었다.

• 지질공학
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• 제19권3호
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• pp.351-363
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• 2009

경상분지 내 구미노두와 다사노두 지역에서 신동층군의 사암층을 대상으로 절리 연구가 집중적으로 이루어졌다. 사암-이암 시퀀스의 양 지역 노두에서 똑같이 두 조의 직교 절리가 사암층에 전형적으로 발달하고 있다. 여러 가지 절리 자료들을 양 지역의 동일한 두께의 층에서 비교하여보면 상당히 유사한데 이는 절리 조들이 동일한 응력장에서 신장 변형 작용으로 균질하게 생성되었음을 이야기 한다. 대부분의 절리들은 퇴적물이 매몰되어 고화되는 과정에서 수압단열작용에 의해 생성된 것으로 생각되며, 사암층의 층 경계에 수직이고 층 경계에 이르러 중지한다. 두 조의 직교하는 절리들은 단열 격자차단 양상으로 해석되는 상호 접경하는 관계로 볼 때 ${\sigma}_1$은 수직으로 고정된 상태에서 ${\sigma}_2$ 와 ${\sigma}_3$의 빠른 교환에 의해 거의 동시에 생성된 것으로 판단된다. 사암층에서의 절리조들은 인접한 절리 간에 평행한 배향을 가지며 규칙적인 간격을 가지고 절리면은 평탄하다. 절리간격은 층 두께에 비례하고 간격분포는 대부분의 층에서 대수-정규분포 내지 정규 분포를 나타낸다. 그러나 다중층에서는 간격의 분포범위가 크고 불규칙한 형태를 보여준다. 연구지역에서 두 조의 절리들은 최빈값/평균값의 비가 1 내외로 포화상태를, 또 다른 척도인 변동계수(Cv)도 1이하의 낮은 값으로 포화를 지시한다. 절리의 개구는 모든 사암충의 절리에서 균질하기보다는 절리의 길이가 증가함에 따라 증가하는 경향을 갖는다.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2006년도 추계학술대회
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• pp.65-74
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• 2006

Modem drug discovery requires rapid pharmacokinetic evaluation of chemically diverse compounds for early candidate selection. This demands the development of analytical methods that offer high-throughput of samples. Naturally, liquid chromatography / tandem mass spectrometry (LC-MS/MS) is choice of the analytical method because of its superior sensitivity and selectivity. As a result of the short analysis time(typically 3-5min) by LC-MS/MS, sample preparation has become the rate- determining step in the whole analytical cycle. Consequently tremendous efforts are being made to speed up and automate this step. In a typical automated 96-well SPE(solid-phase extraction) procedure, plasma samples are transferred to the 96-well SPE plate, internal standard and aqueous buffer solutions are added and then vacuum is applied using the robotic liquid handling system. It takes only 20-90 min to process 96 samples by automated SPE and the analyst is physically occupied for only approximately 10 min. Recently, the ultra-high flow rate liquid chromatography (turbulent-flow chromatography)has sparked a huge interest for rapid and direct quantitation of drugs in plasma. There is no sample preparation except for sample aliquotting, internal standard addition and centrifugation. This type of analysis is achieved by using a small diameter column with a large particle size(30-5O ${\mu}$m) and a high flow rate, typically between 3-5 ml/min. Silica-based monolithic HPLC columns contain a novel chromatographic support in which the traditional particulate packing has been replaced with a single, continuous network (monolith) of pcrous silica. The main advantage of such a network is decreased backpressure due to macropores (2 ${\mu}$m) throughout the network. This allows high flow rates, and hence fast analyses that are unattainable with traditional particulate columns. The reduction of particle diameter in HPLC results in increased column efficiency. use of small particles (<2 urn), however, requires p.essu.es beyond the traditional 6,000 psi of conventional pumping devices. Instrumental development in recent years has resulted in pumping devices capable of handling the requirements of columns packed with small particles. The staggered parallel HPLC system consists of four fully independent binary HPLC pumps, a modified auto sampler, and a series of switching and selector valves all controlled by a single computer program. The system improves sample throughput without sacrificing chromatographic separation or data quality. Sample throughput can be increased nearly four-fold without requiring significant changes in current analytical procedures. The process of Bioanalytical Method Validation is required by the FDA to assess and verify the performance of a chronlatographic method prior to its application in sample analysis. The validation should address the selectivity, linearity, accuracy, precision and stability of the method. This presentation will provide all overview of the work required to accomplish a full validation and show how a chromatographic method is suitable for toxirokinetic sample analysis. A liquid chromatography/tandem mass spectrometry (LC-MS/MS) method developed to quantitate drug levels in dog plasma will be used as an example of tile process.

• 한국철도학회논문집
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• 제19권5호
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• pp.617-628
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• 2016

본 논문은 철도차량의 추진용 유입식 변압기 및 AC/DC 컨버터를 대체하기 위한 지능형 변압기의 구조를 제안한다. 제안된 지능형 변압기는 반도체 스위칭 소자 및 고주파 변압기를 사용한 양방향 전력 변환 컨버터의 형태로써, 기존 변압기에 비해 경량화 되고, 역률 제어 등의 능동적인 제어 성능으로 인해 단상 계통 전원의 효율적인 활용을 가능하게 한다. 제안하는 지능형 변압기는 60Hz 교류 고전압을 직류 고전압으로 변환하기 위한 정류단으로 Neutral point clamped type 의 H-bridge 컨버터를 여러 개 직렬 연결해 구성했다. 직류로 변환된 입력단 전력은 고주파 변압기와 Neutral point clamped type H-bridge 컨버터 2개로 구성된 Dual-Active-Bridge 컨버터를 이용해 출력측에 필요한 저전압을 공급할 수 있도록 했다. 또한, 본 논문에서는 다수의 컨버터 모듈 내부 직류단 전압을 균형제어하며, 단상 교류 전원에서 직류 출력 전원간의 양방향 전력 제어를 가능하게 하는 제어 알고리즘을 제안한다. 제안한 지능형 변압기의 구조 및 제어 시스템은 75kVA 급 3.3kVrms 입력, 750VDC 출력의 지능형 변압기를 설계 및 회로 시뮬레이션 결과를 통해 검증했다.