• The Korean Journal of Pain
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• v.13 no.1
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• pp.60-66
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• 2000

Background: For terminal cancer pain management, controlled-release oral morphine (morphine sulfate tablet, MST) is a simple and convenient regimen. Recently, fentanyl transdermal therapeutic system (F-TTS, transdermal fentanyl) has been developed and became one of the alternative ways of providing adequate pain relief. This open prospective study was designed to compare the analgesic efficacy and safety of MST and transdermal fentanyl in the management of terminal cancer pain. Methods: In this open comparative and randomized study, 64 terminal cancer patients received one treatment for 15 days, controlled-release oral morphine (MST group) or fentanyl transdermal therapeutic system (F-TTS group). Daily diaries about the vital sign, visual analogue scale (VAS) for pain, opioids requirement, co-anagesics, adjuvant drugs and adverse effects were completed with 24 patients in MST group, 18 patients in F-TTS group. Results: The majority of patients in both treatment groups were late-stage cancer and their distribution was not different in both groups. Daily opioids requirement was 126.4 mg in MST uced in F-TTS group (P<0.05). The incidence of nausea, vomiting and constipation was lower in F-TTS group (P<0.05). Patients satisfaction was similar, but F-TTS patient group favored continous use of same treatment compared with MST group after the study was finished. Conclusions: Transdermal fentanyl seems to be safe and similar analgesic effect to controlled-release oral morphine for the control of the terminal cancer patients. However, transdermal fentanyl provides a simpler and more convenient especially in respect to constipation, nausea & vomiting. To determine the exact analgesic effect, cost-effectiveness and complications, controlled trials should be followed.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.14 no.11
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• pp.2391-2396
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• 2010

The power-controlled six-port element that can control the local oscillator signal power and receiving RF signal power was designed and implemented in this paper. The direct conversion six-port element configuration was proposed, which provides the constant six-port output power by controlling the six-port input power with various signal strength. The direct conversion six-port element protects the power detector element of six-port receiver from the saturation status and compensates the transmission performance degradation. For implementation of power-controlled six-port element, the power-controlled six-port element including the power controller was analyzed. The implemented power-controlled six-port element shows the power control capability of 36 dB and gain imbalance of about 1.6 dB, phase imbalance of about $4^{\circ}$ in the frequency range of 1.69 GHz. The measured results show the good performance as direct conversion front-end element.

• Herbal Formula Science
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• v.11 no.2
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• pp.111-124
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• 2003

Gamiguibitang(GMGBT) is used in amenorrhea and female infertility caused by ovulation disorder. An attempt was made to evaluate the influences of GMGBT on the serum concentrations of FSH, LH, estradiol(E2) and progesterone, the histological and optical changes of ovary of rats. The results of the study were as follows: 1. Blood FSH level significantly increased in experimental group controlled by four times quantity as compared with control group. 2. Blood LH level increased in experimental group controlled by four times quantity as compared with control group, which showed no efficacy. 3. Blood E2 level increased in experimental group controlled by four times quantity as compared with control group, which showed no efficacy. 4. Blood progesterone level significantly decreased in experimental group controlled by double quantity as compared with control group. 5. In optically observations of ovary, weight of ovary significantly increased in experimental group controlled by double quantity as compared with control group 6. In histological observations of ovary, ovulation significantly increased in experimental group controlled by both double and four times quantity as compared with control group. According to these results, it can be concluded that GMGBT influences the pituitary gland and ovary to increase the ovulation of rats.

• Journal of Oriental Neuropsychiatry
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• v.24 no.3
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• pp.201-210
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• 2013

Objectives : To review the recent trend of randomized controlled clinical trials on insomnia and to provide information for future clinical trials. Methods : A total of 667 pieces of literature were searched using the key words 'insomnia' and 'randomized controlled trial' and using the title 'insomnia' with the topic 'trial or trials', published from 2008 to 2012 through Web of Science. Studies including randomized controlled clinical trials were sorted from the search result and finally 104 pieces of the literature were selected and examined. Results : Besides 104 clinical trials, 14 trials related to CAM (Complementary and Alternative Medicine) were also reviewed. On average, 20 trials were annually conducted and they showed a growing trend. Participants were between 31 and 90 (34.6%), and were observed for less than 30 days (28.8%) in most trials. As intervention methods for clinical trials, non-pharmaceutical methods were used in 59 studies (56.7%), pharmaceutical drug in 43 studies (41.3%) and combinations in 2 studies (1.9%). In 60 studies, only insomnia without any underlying diseases was examined and other 44 studies involved other diseases. As diagnosis assessment tools, Sleep diary and Polysomnography were used. Conclusions : Randomized controlled trials relevant to insomnia were on the increase, but only a small number of clinical trials on Oriental Medicine have been performed. Larger scientific and well-founded randomized controlled trials are required for developing Oriental Medicine and establishing high-quality guideline going forward.

• Transactions of the Korean Society of Automotive Engineers
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• v.25 no.1
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• pp.66-73
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• 2017

In this work, graphene platelets were introduced into wax in an automotive electronic controlled thermostat for the purpose of enhancing its thermal-conductive property and improving response performance. Graphene content ranging from 10 % to 20% was added into and mixed with the wax to investigate the effect of graphene amounts on the performance of an automotive electronic controlled thermostat in terms of response time, hysteresis and melting temperature. The experimental results revealed that graphene in wax contributed to a reduction in the response time and hysteresis of an automotive electronic controlled thermostat. As a consequence, important improvement in thermal sensitivity, full lift, melting temperature and hysteresis were obtained. The thermal response of wax with graphene content of 20 % was improved by 25 %, as compared to that of wax with Cu content of 20 %. Hysteresis of wax with graphene was reduced by $0.6^{\circ}C$ as compared to that of wax with Cu content. The melting temperature of wax is lowered and hysteresis is also improved with increased graphene content of wax in an electronic controlled thermostat. We hope that this study can help further the transition of nano-fluid technology from small-scale research laboratories to industrial application in the automotive sector.

• Journal of the Korean Society for information Management
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• v.24 no.4
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• pp.285-303
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• 2007

This study aims to explore a new technique making complementary linkage between controlled vocabularies and uncontrolled vocabularies for analyzing a research domain. Co-word analysis can be largely divided into two based on the types of vocabulary used: controlled and uncontrolled. In the case of using controlled vocabulary, data sparseness and indexer effect are inherent drawbacks. On the other case, word selection by the author's perspective and word ambiguity. To complement each other, we suggest a descriptor profiling that represents descriptors(controlled vocabulary) as the co-occurrence with words from the text(uncontrolled vocabulary). Applying the profiling to the domain of information science implies that this method can complement each other by reducing the inherent shortcoming of the controlled and uncontrolled vocabulary.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.12
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• pp.2326-2332
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• 2016

In this paper, the proposed small size PLL works stable with the discrete loop filter which is controlled by voltage controlled oscillator's output signal. A switch controlled loop filter is introduced into the proposed PLL instead of a conventional $2^{nd}$-order loop filter. Those three switches are controlled by the very high frequency output signal of voltage controlled oscillator. The switches are also controlled by UP/DN signals and 'on/off' depending the presence of UP/DN signals. A negative feedback functioned capacitor with a switch does make it possible to integrate the PLL into a single chip. The proposed PLL works stably even though a total of small 180pF capacitor used in the discrete loop filter. The proposed PLL has been designed with a 1.8V supply voltage, 0.18um multi - metal and multi - poly layer CMOS process and proved by Hspice simulation.

• Earthquakes and Structures
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• v.6 no.6
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• pp.647-664
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• 2014

A reduction of the response of irregular structures subjected to earthquake excitation by control devices equipped by suitable control algorithm is proposed in this paper. The control algorithm, which is used, is the pole placement one. A requirement of successful application of pole placement algorithm is a definition-selection of suitable poles (eigen-values) of controlled irregular structures. Based on these poles, the required action is calculated and applied to the irregular structure by means of control devices. The selection of poles of controlled irregular structure, is a critical issue for the success of the algorithm. The calculation of suitable poles of controlled irregular structure is proposed herein by the following procedure: a fictitious symmetrical structure is considered from the irregular structure, adding vertical elements, such as columns or shear walls, at any location where is necessary. Then, the eigen-values of symmetrical structure are calculated, and are forced to be the poles of irregular controlled structure. Based on these poles and additional damping, the new poles of the controlled irregular structure are calculated. By pole placement algorithm, the feedback matrix is obtained. Using this feedback matrix, control forces are calculated at any time during the earthquake, and are applied to the irregular structure by the control devices. This procedure results in making the controlled irregular structure to behave like a symmetrical one. This control strategy can be applied to one storey or to multi-storey irregular buildings. Furthermore, the numerical results were shown that with small amount of control force, a sufficient reduction of the response of irregular buildings is achieved.

• Journal of Korea Multimedia Society
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• v.9 no.2
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• pp.244-254
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• 2006

This paper presents an efficient hybrid technique to compact the trie indexing the huge forward table small enough to be stored into cache for speeding up IP lookup. It combines two techniques, an encoding scheme called bit-map and a controlled-prefix expanding scheme to replace slow memory search with few fast-memory accesses and computations. For compaction, the bit-map represents each index and child pointer with one bit respectively. For example, when one node denotes n bits, the bit-map gives a high compression rate by consumes $2^{n-1}$ bits for $2^n$ index and child link pointers branched out of the node. The controlled-prefix expanding scheme determines the number of address bits represented by all root node of each trie's level. At this time, controlled-prefix scheme use a dynamic programming technique to get a smallest trie memory size with given number of trie's level. This paper proposes standard that can choose suitable trie structure depending on memory size of system and the required IP lookup speed presenting optimal memory size and the lookup speed according to trie level number.

• Archives of Pharmacal Research
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• v.13 no.2
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• pp.151-160
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• 1990

In order to develop a controlled-release oral drug delivery system (DDS) which sustains the plasma acetaminophen (AAP) concentration for a certain period of time, microporous membrane-coated tablets were prepared and evaluated in vitro. Firstly, highly water-soluble core tablet of AAP were prepared with various formulations by wet granulation and compression technique. Then the core tablets were coated with polyvinychloride (PVC) in which micronized sucrose particles were dispersed. Effect of formula compositions of core tablets and coating suspensions on the pharmaceutical characteristics such as drug release kinetics and membrane stability of the coated tablets was investigated in vitro. AAP was released from the coated tablets as a zero-order rate in a pH-independent manner. This independency of AAP release to pH change from 1.2 to 7.2 is favorable for the controlled oral drug delivery, since it will produce a constant drug release in the stomach and intestine regardless of the pH change in the GI tract. Drug release could be extended upto 10 h according to the coating condition. The release rate could be controlled by changing the formula compositions of the core tablets and coating suspensions, coat weight per each tablet, and especially PVC/sucrose ratio and particle size of the sucrose in the coating suspension. The coated tablets prepared in this study had a fairly good pharmaceutical characteristics in vitro, however, overall evaluation of the coated tablet should await in vivo absorption study in man.