• Archives of Pharmacal Research
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• v.26 no.2
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• pp.168-172
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• 2003

Radiation synovectomy is one of the most useful methods for treating patients with refractory synovitis because of its convenience, long-term effects, repeatability and the avoidance of surgery. In this study, we investigated the toxicity, stability and biodistribution of a rhenium-188 ($^{188}$Re)-tin colloid to evaluate its suitability as a synovectomy agent. Twenty four hours after injecting the $^{188}$Re-tin colloids (74 KBq/0.1 mL) into the tail vein of ICR mice, most of the $^{188}$Retin colloidal particles was found in the lungs. In addition, there were no particle size changes at either room temperature or at $37^{\circ}C$ after injecting the $^{188}$Re-tin colloids in human plasma and synovial fluid. In vitro stability tests showed that the $^{188}$Re-tin colloid remained in a colloidal form without a critical size variation over a 2-day period. We investigated the leakage of $^{188}$Retin colloids from the intraarticular injection site with gamma counting in New Zealand white rabbits. The $^{188}$Re-tin colloids (55.5 MBq/0.15 mL) were injected at the cavum articular and the mean retention percentage of the $^{188}$Re-tin colloid was 98.7% for 1 day at the injection site, which suggests that there was neither change in the particle size nor leakage at the injection sites. In the biodistribution study with the SD rats, the liver showed the highest radioactivity (0.0427% ID/organ) except for the injected knees (99.49%). In the SD rats, mild toxicities including the skin or a synovium inflammation were observed as a result of a radioactivity of 15 mCi/kg at the intraarticular injection site. However, there was no systemic toxicity. In the Ovalbumin (OVA)-induced arthritic rabbits, the $^{188}$Re-tin colloid improved the macroscopic, the histological score and reduced the knee joint diameter when compared to the arthritic control. In conclusion, a $^{188}$Re-tin-colloid is considered as a strong candidate for radiation synovectomy with a superior efficacy and safety.

• Journal of Korean Society of Forest Science
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• v.108 no.4
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• pp.513-521
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• 2019

With rapid climate change and increasing global warming, the distribution of evergreen broad-leaved trees (EBLTs) is gradually expanding to the inland regions of Korea. The aim of the present study was to analyze the survival rate of 148 EBLT plantations measuring 180 ha and to determine the optimal plantation size that would help in coping with climate change in the warm, temperate climate zone of the Korean peninsula. For enhancing the reliability of our estimated survival model, we selected a set of 11 control variables that may have also influenced the survival rates of the EBLTs in the 148 plantations. The results of partial correlation analysis showed that the survival rate of 67.0±26.9 of the EBLTs in the initial plantation year was primarily correlated with plantation type by the crown closure of the upper story of the forest, wind exposure, and precipitation. For predicting the probability of survival by quantification theory, 148 plots were surveyed and analyzed with 11 environmental site factors. Survival rate was in the order of plantation type by the crown closure of upper story of the forest, wind exposure, total cumulative precipitation for two weeks prior to planting, and slope stiffness in the descending order of score range in the estimated survival model for the EBLTs with the fact that survival rate increased with shade rate of upper story to some extent.

• The Korean Journal of Zoology
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• v.8 no.1
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• pp.1-7
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• 1965

The short-necked clam is distributed widely in Korean tidal flats and it is a much an important bivalve quantitatively as to control the production of the tidal flat. The shell of this clam tends to show remarkable morphological variations depending on the habitat. Under a seemingly favorable condition for the growth , the color pattern of shell of the clam is clear and obvious and having less weight and elongated shape, the ratios of shell length to both height and width are small . On the contrary , when the environment appears to be an unfavorable one, the shell is found to be heavy and stunted with smudgy color pattern. If this correlation between could be a basis for the judgement in suitability of growth environment for the clam. In the Ikawazu Bay, Japan, it is revealed that the elongated shell is produced from the coast outside of the Bay (1) , the stunted from the esturay (2) and the intermediate from the floodgate area (3) and the middle of the Bay (4). Followings are the results obtained from the morphological investigation of the claim in this Bay. 1. Relationship between the shell length and the largest shell rib length is linear and between the shell length and the shell width is also linear but with a critical point at the shell length of 17-20 mm. The ratio between the width and the largest rib length at a given shell length increases with the order of 1, 3, 4, and 2. 2. A gradual decreases of the ratio of the shell length to the largest rib length is observed when the former is less than 17-18 mm, and this ratio increases with the shell of longer. Also there is a different range of this ratio in each different location ; the greatest range in 2, the smallest in 1 and 4 being in between. 3. A similar biometric finding is apparent with the ratio between the length and width of the shell and the order in value is 2, 4, 1 and 3. 4. The ratios between the length and the largest rib length of elongated and stunted shell are 0.84-0.86 and 0.89-0.92, respectively , and those between the length and width are 0.40-0.51 and 0.49-0.58, respectively. 5. Generally , the elongated short necked clam shells are products of the tidal flat of good circulation of sea water with high salinity and smaller fluctuations of salinity and temperature within a day. The stunted shells are produced for tidal flats of opposite of above conditions.

• Microbiology and Biotechnology Letters
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• v.48 no.4
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• pp.556-563
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• 2020

The purpose of this study was to verify the antioxidant and whitening effects of fermented Ambrosia trifida L. extract (ATFE) and to verify its usefulness as a cosmetic material. The antioxidant effects were measured by assessing the electron-donating capacity and 2,2-azino-bis(3-ethyl-benthiazoline-6-sulfonic acid) (ABTS) radical scavenging ability of these extracts. ATFE was shown to have an electron-donation capacity of 68.4% at a concentration of 1000 ㎍/ml. While its ABTS+ radical scavenging ability was shown to be 58.7% at the same concentration. The ATFE tyrosinase inhibitory effect, which is related to skin-whitening, was shown to be 32.35% at a concentration of 1000 ㎍/ml and a cell viability assay using melanoma cells showed a 14.8% reduction in cell viability at a concentration of 100 ㎍/ml. Surviving cells were then used in western blot analyses to evaluate the protein inhibitory effects of ATFE at 25, 50, 100 ㎍/ml where β-actin was used as a positive control. The whitening effects of these extracts were also evaluated by western blot and show that the expression of microphthalmia-associated transcription factors, Tyrosinase-related proteins (TRP)-1, TRP-2 and Tyrosinase were all inhibited, 51.14%, 55.4%, 38.6%, 83.77% respectively, at 100 ㎍/ml ATFE. The efficacy of the whitening effects was verified and the suitability of ATFE as a cosmetic material was assured.

• Journal of Life Science
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• v.31 no.8
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• pp.761-770
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• 2021

In this study, the optimal medium composition for enhancing protease production was established by the Bacillus strain isolated from Makgeolli, a traditional fermented food, using the response surface methodology. B. amyloliquefaciens SRCM115785 was selected as the protease producer by productivity analysis and identified by 16S rRNA gene sequencing. Plackett-Burman design (PBD) was introduced to analyze the effect of each component on protease production among the 11 selected medium components. As a result, glucose, yeast extract, and beef extract were finally selected as factors for enhancing protease production. Central composite design (CCD) analysis was designed as a method to determine the optimal concentration of each component for protease production and the concentration of each medium composition for maximum protease production was predicted to glucose 6.75 g/l, yeast extract 12.42 g/l and beef extract 17.48 g/l. The suitability of the experimental model was proved using ANOVA analysis and as a result of quantitative analysis to prove this, the amount of increase was 230.47% compared to the LB medium used as a control. Through this study, the optimization of medium composition for enhancing protease production was established, and based on this, it is expected that it can be efficient use of protease as an industrial enzyme.

• Journal of the Korea Convergence Society
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• v.13 no.4
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• pp.433-439
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• 2022

The purpose of the study was to determine the suitability of the research model on the intentions of university students to watch mega sports events for people with disabilities to which the theory of planned behavior was applied, and to examine the influence relationship between variables. Based on the items of sub-variables derived from the previous research, the questionnaire was optimally constructed through expert meetings, validity, and reliability verification. For data analysis, Cronbach's 𝛼 and exploratory factor analysis were performed using SPSS 21.0, and structural equation model analysis (SEM) and confirmatory factor analysis (CFA) were performed using AMOS 18.0. The results were as follows; first, as a result of verification of the research model of intentions of university students to watch mega sports events with people with disabilities to which the theory of planned behavior was applied, the evaluation indices of CFI, NFI, and IFI met the acceptance criteria, indicating that this research model was well suited. Second, as a result of examining the influence relationship of the research model on the intentions of university students to watch mega sports event for people with disabilities, it was found that the behavioral beliefs and normative beliefs of university students had a significantly positive (+) influence to intentions. However, it was found that there was a significantly negative (-) influence on the control beliefs to intentions.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.54 no.6
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• pp.880-889
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• 2021

The home meal replacement (HMR) market has attracted significant attention due to COVID-19 pandemic and products that utilize the combination of different processed ingredients are now being developed. In this study, Broughton's ribbed ark Scapharca broughtonii was soaked in seasoned soy sauce with the incorporation of mustard leaf Brassica juncea (M-BRA), which is known to have a unique texture as well as excellent functional properties such as antioxidation, to develop a regional specialty product. The optimal conditions for manufacturing M-BRA from the seasoned soy sauce (the sauce to be added [X₁] and the soaking time [X₂]), were examined using response surface methodology (RSM) to analyze the significance of the salinity (Y₁), amino-N content (Y₂), and overall acceptance (Y₃). The coefficient of determination (R²) between X₁-X₂ and Y₁-Y₃ were close to 1, thereby confirming the suitability of the RSM model. The optimal conditions were seasoned soy sauce addition of 140% and soaking time of 156 min. The M-BRA manufactured under these conditions exhibited superior overall acceptance compared to seasoned commercial soy sauce, which was used as a control. We expect that the market for M-BRA manufactured by combining marine and agricultural materials will expand owing to superior overall acceptance compared with commercial products.

• Convergence Security Journal
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• v.22 no.5
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• pp.49-59
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• 2022

Cyber security in the automobile sector is a key factor in the life cycle of automobiles, and cyber security evaluation standards are being strengthened worldwide. In addition, not only manufacturers who design and produce automobiles, but also due to the nature of automobiles consisting of complex components and various parts, the safety of cybersecurity can be secured only when the implementation level of the cybersecurity management system of companies participating in the entire supply chain is evaluated and managed. In this study, I analyzed the requirements of ISO/SAE 21434 and TISAX, which are representative standards for evaluating automotive cybersecurity. Through a survey conducted on domestic/overseas company security officers and related experts, suitability and feasibility were reviewed according to priorities and industries, so 6 areas and 45 evaluation criteria were derived and presented as final evaluation items. This study is meaningful as a study in that it presented a model that allows companies participating in the automotive supply chain to evaluate the current cybersecurity management level of the company by first applying ISO/SAE 21434 and TISAX overall control processes before uniformly introducing them.

• Nuclear Engineering and Technology
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• v.55 no.10
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• pp.3913-3923
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• 2023

Todays, medium energy resolution detectors are preferably used in radioisotope identification devices(RID) in nuclear and radioactive material categorization. However, there is still a need to develop or enhance « automated identifiers » for the useful RID algorithms. To decide whether any material is SNM or NORM, a key parameter is the better energy resolution of the detector. Although masking, shielding and gain shift/stabilization and other affecting parameters on site are also important for successful operations, the suitability of the RID algorithm is also a critical point to enhance the identification reliability while extracting the features from the spectral analysis. In this study, a RID algorithm based on Bayesian statistical method has been modified for medium energy resolution detectors and applied to the uranium gamma-ray spectra taken by a LaBr3:Ce detector. The present Bayesian RID algorithm covers up to 2000 keV energy range. It uses the peak centroids, the peak areas from the measured gamma-ray spectra. The extraction features are derived from the peak-based Bayesian classifiers to estimate a posterior probability for each isotope in the ANSI library. The program operations were tested under a MATLAB platform. The present peak based Bayesian RID algorithm was validated by using single isotopes(²⁴¹Am, ⁵⁷Co, ¹³⁷Cs, ⁵⁴Mn, ⁶⁰Co), and then applied to five standard nuclear materials(0.32-4.51% at.²³⁵U), as well as natural U- and Th-ores. The ID performance of the RID algorithm was quantified in terms of F-score for each isotope. The posterior probability is calculated to be 54.5-74.4% for ²³⁸U and 4.7-10.5% for ²³⁵U in EC-NRM171 uranium materials. For the case of the more complex gamma-ray spectra from CRMs, the total scoring (ST) method was preferred for its ID performance evaluation. It was shown that the present peak based Bayesian RID algorithm can be applied to identify ²³⁵U and ²³⁸U isotopes in LEU or natural U-Th samples if a medium energy resolution detector is was in the measurements.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2020.08a
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• pp.55-55
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• 2020

This study investigated the growth and chlorophyll fluorescence reactions of three Ardisia genus grown under various indoor light intensity conditions with the aim of evaluating their suitability as indoor plants. Young seedlings of A. crispa (Thunb.) A.DC., A. pusilla DC., and A. japonica (Thunb.) Blume were used in the experiment. The plants were cultivated indoors for 10 weeks under different light intensities: 10, 50, 100, and 200 PPFD (μmol·m^-2·s^-1), and their growth was compared with that of plants cultivated in a greenhouse during the same period (mean value 236.8±20.4 PPFD at noon). Also, chlorophyll fluorescence analysis was investigated with a portable PAM fluorometer. The indoor plants were maintained at 12/12 h photoperiod, temperature at 25±1℃, and humidity at 55±3%. Irrigation frequency (once every three days) was the same for the indoors and the greenhouse. The results of growth in three Ardisia plants showed that almost all parameters except leaf number and chlorophyll content had similar levels regardless of light intensity. A. crispa and A. pusilla plants grown in 200 PPFD were investigated to have low chlorophyll contents. Meanwhile, chlorophyll fluorescence parameters differed based on light levels. In A. crispa, the Fv/Fm (0.77), DIo/RC (0.47) and Fm/Fo (4.77) parameters tended to be poor at 200 PPFD compared to those at other light intensities. Similarly, the DIo/RC, Fm/Fo, and Pi_Abs parameters of A. pusilla plant (200 PPFD) are 0.45, 4.48 and 2.42, respectively, which can be considered stress. The analysis of fluorescence in A. japonica showed that all parameters except ETo/RC had similar levels regardless of light intensity. The ETo/RC parameter was 0.49 and 0.72 in the control plants and plants 200 PPFD, respectively, which was lower than those in plants at other light intensities. Therefore, it seems that the relatively high light intensity acted as a stressor for Ardisia plants.