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Effect of pitavastatin on erythrocyte membrane fatty acid content in patients with chronic kidney disease: two-arm parallel randomized controlled trial

  • Minna Kim;Seong Eun Kim;Su Mi Lee;Won Suk An
    • Journal of Yeungnam Medical Science
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    • v.41 no.3
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    • pp.188-195
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    • 2024
  • Background: Statins reduce the risk of cardiovascular events in patients with chronic kidney disease (CKD). Although diabetes mellitus (DM) is a reported side effect of statin treatment, some studies have indicated that pitavastatin does not cause DM. The present study investigated the effect of pitavastatin on the fatty acid (FA) content of erythrocyte membranes, which affects the occurrence of DM and cardiovascular diseases. In addition, changes in adiponectin and glycated hemoglobin (HbA1c) levels were evaluated after pitavastatin treatment. Methods: A total of 45 patients were enrolled, 28 of whom completed the study. Over 24 weeks, 16 patients received 2 mg pitavastatin and 12 patients received 10 mg atorvastatin. Dosages were adjusted after 12 weeks if additional lipid control was required. There were 10 and nine patients with DM in the pitavastatin and atorvastatin groups, respectively. Erythrocyte membrane FAs and adiponectin levels were measured using gas chromatography and enzyme-linked immunosorbent assay, respectively. Results: In both groups, saturated FAs, palmitic acid, trans-oleic acid, total cholesterol, and low-density lipoprotein cholesterol levels were significantly lower than those at baseline. The arachidonic acid (AA) content in the erythrocyte membrane increased significantly in the pitavastatin group, but adiponectin levels were unaffected. HbA1c levels decreased in patients treated with pitavastatin. No adverse effects were associated with statin treatment. Conclusion: Pitavastatin treatment in patients with CKD may improve glucose metabolism by altering erythrocyte membrane AA levels. In addition, pitavastatin did not adversely affect glucose control in patients with CKD and DM.

A Study on Development of Off-Line Path Programming for Footwear Buffing Robot

  • Lho, Tae-Jung;Kang, Dong-Joon;Che, Woo-Seung;Kim, Jung-Young;Kim, Min-Sung
    • 제어로봇시스템학회:학술대회논문집
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    • 2004.08a
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    • pp.1469-1473
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    • 2004
  • We suggest how to program off-line robot path along shoes' outsole shape in the footwear buffing process by a 5-axis microscribe system like robot arms. This microscribe system developed consists a 5-axis robot link with a turn table, signal processing circuit, PC and an application software program. It makes a robot path on the shoe's upper through the movement of a microscribe with many joints. To do this, first it reads 5-encoder's pulse values while a robot arm points a shoes' outsole shape from the initial status. This system developed calculates the encoder pulse values for the robot arm's rotation and transmits the angle pulse values to the PC through a circuit. Then, Denavit-Hartenberg's(D-H) direct kinematics is used to make the global coordinate from robot joint one. The determinant is obtained with kinematics equation and D-H variable representation. To drive the kinematics equation, we have to set up the standard coordinates first. The many links and the more complicated structure cause the difficult kinematics problem to solve in the geometrical way. Thus, we can solve the robot's kinematics problems efficiently and systematically by Denavit-Hartenberg's representation. Finally, with the coordinate values calculated above, it can draw a buffing gauge-line on the upper. Also, it can program off-line robot path on the shoes' upper. We are subjected to obtaining shoes' outline points, which are 2 outlines coupled with the points and the normal vector based on the points. These data is supposed to be transformed into .dxf file to be used for data of automatic buffing robot. This system developed is simulated by using spline curves coupled with each point from dxf file in Autocad. As a result of applying this system to the buffing robot in the flexible footwear manufacturing system, it can be used effectively to program the path of a real buffing robot.

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A Porting Technique of WiFi Device on Android Platform (안드로이드 플랫폼에 WiFi 디바이스 탑재 기법)

  • Jeong, Uyeong;Ju, Youngkwan;Jeon, Joongnam
    • Journal of Convergence Society for SMB
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    • v.2 no.1
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    • pp.51-58
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    • 2012
  • Android platform is a powerful operating system developed on Linux 2.6 Kernel, and provides many features such as comprehensive libraries, a multimedia environment, and powerful interface for phone applications. Since Android is an open operating system, which can be installed in any vendors's equipments. Current smartphones as well as netbooks, navigations, car PCs, tablet PCs, Industrial PCs are used in various fields. It is difficult a lot that to mount to other devices on the Android platform or new devices. In this Paper, The process that data that occurred from a hardware was passed to the highest application and Android platform system for managing hardware devices were analyzed. Building Android & driver compilation environment, How to support the protocol for the use of WiFi in the kernel, How to Mount a WiFi device in the kernel, Device driver registration for the Android platform, WiFi Management Service Daemon (wpa_supplicant) and IP allocation services daemon (dhcpcd) registration, How to create a socket for communication between the daemon (wpa_supplicant) and HAL have been presented. In the experiment using the proposed method, WiFi devices were mounted on the Android platform in the X-86 & ARM family. Understanding the whole process of control flow in Android hierarchy is very important to porting a new device on it. The process included in this paper can help technicians who might encounter the obstacles in their porting works.

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Meta-analysis of Seven Randomized Control Trials to Assess the Efficacy and Toxicity of Combining EGFR-TKI with Chemotherapy for Patients with Advanced NSCLC who Failed First-Line Treatment

  • Xiao, Bing-Kun;Yang, Jian-Yun;Dong, Jun-Xing;Ji, Zhao-Shuai;Si, Hai-Yan;Wang, Wei-Lan;Huang, Rong-Qing
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.7
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    • pp.2915-2921
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    • 2015
  • Background: Some recent clinical trials have been conducted to evaluate a combination of EGFR- TKI with chemotherapy for advanced NSCLC patients as second-line therapy, but the results on the efficacy of such trials are inconsistent. The aim of this meta-analysis was to evaluate the efficacy and safety of combination of EGFR-TKI and chemotherapy for patients with advanced NSCLC who failed first-line treatment. Materials and Methods: We searched relative trials from PubMed, EMBASE, ASCO Abstracts, ESMO Abstracts, Cochrane Library and Clinical Trials.gov. Outcomes analyzed were overall response rate (ORR), progression- free survival (PFS), overall survival (OS) and major toxicity. Results: Seven trails eventually were included in this meta-analysis, covering 1,168 patients. The results showed that the combined regimen arm had a significant higher ORR (RR 1.76 [1.16, 2.66], p=0.007) and longer PFS (HR 0.75 [0.66-0.85], p<0.00001), but failed to show effects on OS (HR 0.88 [0.68-1.15], p=0.36). In terms of subgroup results, continuation of EGFR-TKI in addition to chemotherapy after first-line EGFR-TKI resistance confered no improvement in ORR (RR 0.95 [0.68, 1.33], p=0.75) and PFS (HR 0.89[0.69, 1.15], p=0.38), and OS was even shorter (HR1.52 [1.05-2.21], p=0.03). However, combination therapy with EGFR-TKI and chemotherapy after failure of first-line chemotherapy significantly improved the ORR (RR 2.06 [1.42, 2.99], p=0.0002), PFS (HR 0.71 [0.61, 0.82], p<0.00001) and OS (HR 0.74 [0.62-0.88], p=0.0008), clinical benefit being restricted to combining EGFR-TKI with pemetrexed, but not docetaxel. Grade 3-4 toxicity was found at significantly higher incidence in the combined regimen arm. Conclusions: Continuation of EGFR-TKI in addition to chemotherapy after first-line EGFR-TKI resistance should be avoided. Combination therapy of EGFR-TKI and pemetrexed for advanced NSCLC should be further investigated for prognostic and predictive factors to find the group with the highest benefit of the combination strategy.

Implementation of the AMBA AXI4 Bus interface for effective data transaction and optimized hardware design (효율적인 데이터 전송과 하드웨어 최적화를 위한 AMBA AXI4 BUS Interface 구현)

  • Kim, Hyeon-Wook;Kim, Geun-Jun;Jo, Gi-Ppeum;Kang, Bong-Soon
    • Journal of the Institute of Convergence Signal Processing
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    • v.15 no.2
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    • pp.70-75
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    • 2014
  • Recently, the demand for high-integrated, low-powered, and high-powered SoC design has been increasing due to the multi-functionality and the miniaturization of digital devices and the high capacity of service informations. With the rapid evolution of the system, the required hardware performances have become diversified, the FPGA system has been increasingly adopted for the rapid verification, and SoC system using the FPGA and the ARM core for control has been growingly chosen. While the AXI bus is used in these kinds of systems in various ways, it is traditionally designed with AXI slave structure. In slave structure, there are problems with the CPU resources because CPU is continually involved in the data transfer and can't be used in other jobs, and with the decreased transmission efficiency because the time not used of AXI bus beomes longer. In this paper, an efficient AXI master interface is proposed to solve this problem. The simulation results show that the proposed system achieves reductions in the consumption clock by an average of 51.99% and in the slice by 31% and that the maximum operating frequency is increased to 107.84MHz by about 140%.

Molecular Genetic Analysis of Microdeletions in Y Chromosome from Korean Male Infertility Patients (한국인 남성 불임환자에서 Y염색체내 미세결실의 분자유전학적 분석)

  • Yoon, Hyun-Soo;Lee, Jeong-Hen;Seo, Ju-Tae;Kim, Hae-Jung;Lee, Dong-Ryul;Jeon, Jong-Sik;Cho, Jung-Hyun;Kim, Moon-Kyoo;Lee, Moo-Sang;Roh, Sung-Il
    • Clinical and Experimental Reproductive Medicine
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    • v.23 no.3
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    • pp.367-377
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    • 1996
  • Genes on the long arm of Y chromosome, particularly interval 6, are believed to playa critical role in human spermatogenesis. The objective of this study was to validate a sequenced-tagged site(STS)-mapping strategy for the detection of Yq microdeletion and to use this method to determine the proportion of men with Yq microdeletions in idiopathic, obstructive, nonobstructive azoospermia, severe OATS and in normal males. We analyzed three STS markers mapped to interval 6 within long arm of the Y chromosome from 106 nonobstructive, 30 obstructive azoospermia, 15 severe OATS patients, and normal 42 males in Korean men. By PCR, we tested leukocyte DNA, for the presences of STS markers(DAZ, sY129 and sY134) and SRY gene as internal control. And PCR results were confirmed by Southern hybridization, and were investigated by SSCP analysis for DAZ gene mutation. None of 42 normal males and 30 obstructive azoospermia had microdeletions, Of the 15 severe OATS typed with DAZ, sY129 and sY134, 3(20.0%) patients failed to amplify 1 or more STS markers, and of the 106 nonobstructive azoospermia typed with DAZ, sY129 and sY134, 12(11.3%) patients failed to amplify 1 or more STS markers. From these results, high prevalence(12.4%) of Yq deletion(DAZ, sY129, sY134) in men with nonobstructive idopathic azoospermia and severe OATS were observed in Korean infertility patients. To avoid the infertile offspring by assisted reproductive technique using ICSI or ROSI, genetic diagnosis will be needed in IVF-ET program.

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Effects of Cnidium of ficinale(CO) extracts through administrated by means of oral and herbal acupuncture method at GB2l acupoint on focal ischemic brain injury induced by MCAO in rats (천궁(川芎)의 구강투여(口腔投與) 및 약침시술(藥鍼施術)이 흰쥐 MCAO로 유발된 국소뇌허혈(局所腦虛血)에 대(對)한 콜린성 신경보호효과(神經保護效果) 연구(硏究))

  • Kim, Kyung-Sun;Youn, Dae-Hwan;Hong, Seok;Na, Chang-Su
    • Korean Journal of Acupuncture
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    • v.22 no.3
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    • pp.137-156
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    • 2005
  • Objectives : Cnidium officinale(CO) has been used for medication for stroke in the Oriental Medicine. So this study was planned to investigate the effects of CO on the focal ischemia-induced by Middle Cerebral Artery Occlusion(MCAO) in rats Materials and methods : The focal ischemia was induced by MCAO. CO extracts through oral administration and herbal acupuncture at GB2l was carried out during 3 weeks after focal ischemia-induced. Eight-arm radial maze was used for the behavioral task. For the neuroprotective effect of CO, we investigated AchE, ChAT, and NGF-expression by immnohistochemical method. Results : The error rate in the eight-arm radial maze task was significantly decreased in normal group compared to control group on 1-6days, OA-CO1(CO oral administration, 0.8g/kg) group on 1-6days, OA-CO2(CO oral administration, 1.6g/kg) group on 1-3,5,6days, HA-CO1(CO herbal acupuncture, 0.016g/kg) group on 2,3,6days, HA-CO2(CO herbal acupuncture, 0.008g/kg) group on 1-3,5,6days. The rate of correct choice was significantly increased in OA-CO1, HA-CO2. The density of neurons in the hippocampal CA1 was the most increased in OA-CO1, HA-CO1, HA-CO2. The density of ChAT in the hippocampal CA1 was increased in OA-CO1, HA-CO2. The density of ChAT in the hippocampal CA1 was significantly increased in OA-CO1, HA-CO2. The density of NGE in the hippocampal CAI was significantly increased in OA-CO1, OA-CO2, HA-CO2. Conclusions : These results suggest that CO oral administration with 0.8g/kg and CO herbal acupuncture with 0.008g/kg might be used as a regulator of cell death of cholinergic system induced by stroke.

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A Study of Dance Movement Training on the Wellness of young Women (율동적 동작 훈련이 젊은 여성의 Wellness에 미치는 영향)

  • ;Lou Heber
    • Journal of Korean Academy of Nursing
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    • v.25 no.3
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    • pp.538-548
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    • 1995
  • Exercises are achievement oriented, the process is frequently perceived as hard and difficult Participants drop out from exercise programs in the middle of the training period. Dance movement, which is the deliberate and systematic use of movement, is enjoyable during the movement and provides opportunities for persons to express them-selves. Regular long term dance movement may in-duce a training effect with a decreased drop out rate. Dance movement could be one way to attain wellness, however, there have been few studies to evaluate both physiological and psychological aspects of dance movement. This study focused on evaluating the effects of dance movement training on body weight, resting blood pressure and heart rate, limb circumference and strength, stress response and subjective feelings. This quasi-experimental study was designed as a nonequivalent control group pre test -post test study. Ten healthy fe-male subjects, aged between 19 and 31 years volunteered for an eight week dance movement program. Ten healthy female subjects, between 19 and 21 years of age paticipated as controls. None of the subjects had performed regular physical activity for six months prior to the study. Dance movement was created with reference to Heber's movement guide. The Dance movement program consisted of approximately 30 minutes of dance, three days per week, for eight weeks. During each 30 minute work out, there were approximately 5 minutes of warm-up dancing, 20 minutes of conditioning dance and 5 minutes of cool-down dancing. The intensity for the conditioning phase was at between 60% and 65% of age-adjusted maximum heart rates. Body weight, resting blood pressure and heart rate, circumference of mid upper arm, mid thigh and mid calf, muscle strength of upper and lower limb, physical and psychological response to stress were measured prior to, and following the experimental treatment. Body weight was measured by digital weight scale(Kyung In Corp., Korea). Resting systolic and diastolic blood pressure were measured by sphygmomanometer, Resting heart rate was measured for one minute in a relaxed sitting position using the radial artery. Circumference of mid upper arm, mid thigh and mid calf was determined by tape measure. Muscle strength of the upper extremities was measured by a grip dynamometer (Takei Corp. No.1857, Japan) and that of the extremities was measured by the length of time the leg could be held at 45° Physical and psychological responses to stress were measured using the Symptoms of Stress (SOS)Scale. Paticipants in the dance movement were interviewed by the facilitator following the eight weeks, and their thematic responses about the dance movement were recorded. Following the eight week dance movement train-ing, body weight decreased significantly, circumference of mid thigh and mid calf increased. The length of time leg - raising could be held tended to increase following the dance movement training. Resting systolic and resting heart rate showed a tendency to decrease. Total mean score of stress response tended to de-crease, and mean score of habitual patterns, do-pression, anxiety / fear, anger and cognitive disorganization decreased remarkably following the eight week dance movement. Thematic responses about the dance movement were positive following the training.

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Effects of task-oriented activities on hand functions in patients with hand injuries (과제 지향적 활동이 수부손상환자의 손 기능에 미치는 효과)

  • Noh, Dong-Hee;Han, Seung-Hyup;Jo, Eun-Ju;Ahn, Sung-Ho;Kim, Hun-Ju;Kam, Kyung-Yoon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.16 no.2
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    • pp.1153-1163
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    • 2015
  • The purpose of this study is to investigate the effects of task-oriented activities on hand functions in patients with hand injuries. From December 2011 to October 2012, sixteen patients with hand injuries at C Hospital in Changwon, Gyeongsangnam-do, Korea were randomly divided into two groups. One group was subjected to task-oriented activity and the other to general exercise. Two groups performed each activity once a day, three times a week, for four weeks. The group with the task-oriented activities was provided with the tasks according to subject-preference based on the result of Canadian Occupational Performance Measure (COPM). To verify the effect of intervention, the following hand function measures were used: grip strength, pinch strength, and the range of opposition and abduction, Purdue pegboard test and Disabilities of the Arm, Shoulder and Hand (DASH). Both groups showed significant increase in all of the hand function measures after 4-week activities(p<.05). The task-oriented activity group was significantly different from the control group in powers for tip pinch, lateral pinch and three-jaw chuck pinch, Purdue pegboard test and DASH(p<.05) except in grip strength and the range of opposition and abduction suggesting better improvement in hand functions. This study shows that task-oriented activities improve the hand functions more effectively in patients with hand injuries.

The Effects of Task oriented Training on Motor and Cognitive Function in Alzheimer's Dementia Rat (과제지향훈련이 알츠하이머성 치매 흰쥐의 운동 및 인지기능에 미치는 영향)

  • Lim, Gun-Hong;Lee, Hong gyun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.20 no.7
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    • pp.119-126
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    • 2019
  • This study was conducted to investigate the effects of task oriented training on motor and cognitive function recovery in rats with induced Alzheimer's dementia. Thirty Sprague-Dawley rats were randomly assigned to a control group (n=15) and an experimental group (n=15). Training was given three times a week, for 20 minutes a session for 4 weeks. The cognitive and motor functions of the rats were evaluated by an eight arm radial maze test and ladder rung walk test. The eight arm radial maze test showed significant differences between groups according to the time of day 14 and 28 (p<.001). The difference in measured values according to the timing of the two groups was significant (p<.001). Additionally, there was a significant difference between the time and the group interaction (p<.001). The ladder rung walk test showed significant differences between groups according to the time of day 14 and 28 (p<.001). The difference in the measured values according to the timing of the two groups was significant (p<.001), and there was a significant difference between the time and the group interaction (p<.001). As a result, task oriented training for Alzheimer's dementia rats was found to have a positive effect on recovery of motor and cognitive function.