• Journal of applied mathematics & informatics
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• 제38권5_6호
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• pp.507-518
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• 2020

In this article, we establish some fixed point results in G-metric spaces using the modified JS-G-contractions and we provide some suitable examples to support the results. Also, we give an application to solve an integral equation.

• The Korean Journal of Physiology and Pharmacology
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• 제20권1호
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• pp.69-74
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• 2016

The present study was undertaken to investigate the influence of cardamonin on vascular smooth muscle contractility and to determine the mechanism(s) involved. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Cardamonin significantly relaxed fluoride-, phenylephrine-, and phorbol ester-induced vascular contractions, suggesting that it has an anti-hypertensive effect on agonist-induced vascular contraction regardless of endothelial nitric oxide synthesis. Furthermore, cardamonin significantly inhibited the fluoride-induced increase in pMYPT1 level and phenylephrine-induced increase in pERK1/2 level, suggesting inhibition of Rho-kinase and MEK activity and subsequent phosphorylation of MYPT1 and ERK1/2. This study provides evidence that the relaxing effect of cardamonin on agonist-induced vascular contraction regardless of endothelial function involves inhibition of Rho-kinase and MEK activity.

• 약학회지
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• 제41권5호
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• pp.666-671
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• 1997

We studied effects of genistein and tyrphostin, inhibitors of tyrosine kinase, on contractions induced by high $K^+$ and norepinephrine in rat aorta. Genistein $(10^{-6}{\sim}10^{-4}M)$ and tyrphostin ($(10^{-5}{\sim}10^{-4}M)$) inhibited high $K^+$ and norepinephrine-induced sustained contractions, respectively in a concentration-dependent manner. High $K^+$ and norepinephrine caused an increase in $^{45}Ca^{2+}$ uptake while $10^{-4}M$ genistein and tyrphostin inhibited the $K^+$ and norepinephrine-increased $^{45}Ca^{2+}$ uptake, respectively. These results show that inhibitor of tyrosine kinase blocks the voltage-and receptor-operated $Ca^{2+}$ channels in rat aorta, respectively.

• Archives of Pharmacal Research
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• 제17권3호
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• pp.150-153
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• 1994

Ethanolic extract of Daucus carota (DC) at the dose of 10-100 mg/kg caused a dose-dependent fall in systolic and diastolic arterial blood pressure in nomotensive anesthetized rats. These effects were not blocked by atropine (1 mg/kg) and pretratment with DC did not alter the pressor response to norepinephrine indicating that cardiovascular effects of DC are independent of cholinergic or adrenergic recptors involvement. In spontaneously beating guinea-pig paired atria, DC induced a concentration-dependent (03-5 mg/ml) decrease in force and rate of atrial contractions. In rabbit thoracic aorta, DC caused inhibition of $K^+$-induced contractions at similar concentrations. These results suggest that the extract may exhibit $Ca^{2+}$ channel blocking-like direct relaxant action on cardiac and smooth muscle preperations and this action may be responsible for its hypotensive effect observed in the in vivo studies.

• Archives of Pharmacal Research
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• 제21권4호
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• pp.370-373
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• 1998

Ten substituted phenacyl derivatives of 4-hydroxypiperidine were synthesized and studied for their effects on the mean arterial blood pressure (MABP) in normotensive anaesthetized rats and smooth muscles contractions of isolated rabbit jejunum. Two derivatives caused fall in blood pressure at the dose of 10-20 mg/kg and one rise in blood pressure at the dose of 20 mg/kg. Two compounds exhibited biphasic response (hypotensive followed by hypertensive) and one gave triphasic response at 10 mg/kg dose. Rest of four derivatives were found devoid of any effect on mean arterial blood pressure up to the dose of 30 mg/kg. All the derivatives except two caused relaxant effect on the spontaneous contraction of rabbit jejunum at the dose range of 0.1 -2 mg/kg.

• Biomaterials and Biomechanics in Bioengineering
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• 제2권3호
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• pp.173-183
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• 2015

In obstetrics, cardiotocography is a procedure to record the fetal heartbeat and the uterine contractions usually during the last trimester of pregnancy. It helps to monitor patterns associated with the fetal activity and to detect the pathologies. In this paper, random forest classifier is used to classify normal, suspicious and pathological patterns based on the features extracted from the cardiotocograms. The results showed that random forest classifier can detect these classes successfully with overall classification accuracy of 93.6%. Moreover, important features are identified to reduce the feature space. It is found that using seven important features, similar classification accuracy can be achieved by random forest classifier (93.3%).

• Nonlinear Functional Analysis and Applications
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• 제26권1호
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• pp.13-33
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• 2021

The aim of this paper is to establish common fixed point theorems under generalized (ψ - ϕ)-weak contractions in the setting of complete S-metric spaces and we support our result by some examples. Also an application of our results, we obtain some fixed point theorems of integral type. Our results extend Theorem 2.1 and 2.2 of Doric [5], Theorem 2.1 of Dutta and Choudhury [6], and many other several results from the existing literature.

• East Asian mathematical journal
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• 제25권4호
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• pp.415-423
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• 2009

In this paper, we consider the hybrid monotone projection algorithm for asymptotically quasi-pseudocontractive mappings. A strong convergence theorem is established in the framework of Hilbert spaces. Our results mainly improve the corresponding results announced by [H. Zhou, Demiclosedness principle with applications for asymptotically pseudo-contractions in Hilbert spaces, Nonlinear Anal. 70 (2009) 3140-3145] and also include Kim and Xu [T.H. Kim, H.K. Xu, Strong convergence of modified Mann iterations for asymptotically nonexpansive mappings and semigroups, Nonlinear Anal. 64 (2006) 1140-1152; Convergence of the modified Mann's iteration method for asymptotically strict pseudo-contractions, Nonlinear Anal. 68 (2008) 2828-2836] as special cases.

• Nonlinear Functional Analysis and Applications
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• 제29권1호
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• pp.209-224
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• 2024

The goal of this study is to instigate various new and novel optimum proximity point theorems using the notion of implicit relation type ℶ-proximal contraction for non-self mappings. An illustrated example is used to demonstrate the validity of the obtained results. Furthermore, some uniqueness results for proximal contractions are also furnished with partial order and graph. Various well-known discoveries in the present state-of-the-art are enhanced, extended, unified, and generalized by our findings. As an application, we generate some fixed point results fulfilling a modified contraction and a graph contraction, using the profundity of the established results.

• Asian-Australasian Journal of Animal Sciences
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• 제2권3호
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• pp.167-168
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• 1989