• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.1
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• pp.143-151
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• 2010

In Vivo and In vitro antispasmodic effects of Jun-Si-Baek-Chul-San, a Traditional Korean Polyherbal Medicineconsisted of 7 types of herbs were observed in the present study. To clarify the effects of Jun-Si-Baek-Chul-San, on accelerating small intestinal movement induced by the stimulation of cholinergic neurotransmission, we evaluated the effects of Jun-Si-Baek-Chul-San on In vivo carbachol (an acetylcholinergic agent)-accelerated mice small intestinal transit and on In vitro contractions induced by low-frequency electrostimulation, KCl, histamine or acetylcholine using isolated guinea pig ileum. To induce the acceleration of mice small intestinal transit, Carbachol 1 mg/kg was once subcutaneously dosed 15min before last administration of the test drugs. In the present study, Jun-Si-Baek-Chul-San 500, 250 and 125 mg/kg or domperidone 20 mg/kg were orally pretreated on the carbachol-accelerated mice small intestinal transit once a day for 7 days and the small intestinal transit rateof activated charcoal powder were monitored. In vitro assays, Jun-Si-Baek-Chul-San1, 0.1, 0.01 and 0.001 mg/ml or domperidone $2{\times}10^{-5}M$ were treated 10min before ileal contraction was induced by filed stimulation, acetylcholine, KCl and histamine, and the % changes of contractions were observed compared to the treatment of inducer alone. In spontaneous contraction, the % changes of contractions were observed compared to treatment of vehicle alone at 10min after Jun-Si-Baek-Chul-San or domperidone treatment. The efficacy of Jun-Si-Baek-Chul-San was compared to those of domperidone. High concentration, 1 mg/ml of Jun-Si-Baek-Chul-San was found to decrease the spontaneous contraction of the isolated guinea-pig ileum. In addition, Jun-Si-Baek-Chul-San decrease contractions induced by electrostimulation, acetylcholine, histamine and KCl in the isolated guinea-pig ileum. In addition, Jun-Si-Baek-Chul-San effectively inhibited the accelerated small intestinal movement induced by carbachol stimulation of cholinergic neurotransmission in In vivo. Based on the results, although the exact molecular or action mechanism and which herbs or compound in Jun-Si-Baek-Chul-San are responsible for actions, it was concluded that Jun-Si-Baek-Chul-San normalization in the accelerated intestinal motility might be interfere with a variety of muscarinic, adrenergic and histaminic receptor activities or with the mobilization of calcium ions required for smooth muscle contraction non-specificly. Therefore, it is expected that Jun-Si-Baek-Chul-San will be promising as a prescription of clinical treatment of digestive tract disorders such as accelerated the motility of intestine, diarrhea or intestinal painful contractions.

• The Korean Journal of Physiology
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• v.21 no.2
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• pp.241-257
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• 1987

The effects of external $Ca^{2+}$ and $Ca^{2+}-antagonists$ on the spontaneous contractions and electrical activities were investigated in guinea-pig stomach in order to clarify the mechanism for the generation of slow waves. Electrical responses of circular smooth muscle cells were recorded using glass capillary microelectrodes filled with 3 M KCl. All experiments were performed in tris-buffered Tyrode solution which was aerated with 100% $O_2$ and kept at $35^{\circ}C$. The results obtained were as follows: 1) The amplitude of spontaneous contractions was maximal at around 2-4 mM $Ca^{2+}$, whereas their frequency was inversely related with external $Ca^{2+}$ within the range of 0.5 to 16 mM $Ca^{2+}$. 2) Verapamil suppressed the amplitude of spontaneous contraction in a dose-dependent manner, while the frequency of spontaneous contractions was almost not changed over the whole concentration of verapamil $(0.01{\sim}5\;mg/l)$. 3) Manganese increased both the amplitude and the frequency of spontaneous contractions dose-dependently in low $Mn^{2+}$ (below 0.05 mM $Mn^{2+}$), while their amplitude and frequency were decreased in high $Mn^{2+}$ (above 0.1 mM $Mn^{2+}$). 4) The ampltude and maximum rate of rise of slow waves were incrased in high $Ca^{2+}$ solution. In $Ca^{2+}-free$ solution, the spontaneous contractions recorded simultaneously with slow waves ceased and tonic contraction ($Ca^{2+}-free$ contracture) was developed in parallel with membrane depolarization and the disappearance of slow waves. 5) Verapamil (1 mg/1) decreased the amplitude and maximum rate of rise of slow waves and it depolarized the membrane by about 6 mV, whereas the frequency of slow waves was not affected by verapamil. 6) Manganese showed different characteristic effects between low and high $Mn^{2+}$ on the slow waves: In low $Mn^{2+}$ (0.05 mM $Mn^{2+}$), the initial rapid increases and the subsequent gradual decreases in three parameters of slow waves (amplitude, rate of rise, and frequency of slow waves) till a new steady state were observed. However, in high $Mn^{2+}$ (0.5 mM $Mn^{2+}$) slow waves disappeared and membrane was depolarized. From the above results, the following conclusions could be made: 1) $Ca^{2+}$ is necessary for a generation of the slow waves, even though it is small amount. 2) Verapamil suppresses the spontaneous contractions of gastric antral strip by the decreases in amplitude and maximum rate of rise of slow waves, while this drug does not block the $Ca^{2+}-channel$ involved in the generation of slow waves. 3) Manganese has dual actions on the $Ca^{2+}-channels$; the $Ca^{2+}-channel$ involved in the generation of slow waves (or Na-Ca exchange system) or the channel for the generation of spike potentials are stimulated by a low concentration of $Mn^{2+}$, while both the $Ca^{2+}$. Channels are blocked by high concentration of $Mn^{2+}$.

• Journal of the Korean Mathematical Society
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• v.21 no.1
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• pp.1-7
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• 1984

• Journal of the Korean Mathematical Society
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• v.14 no.1
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• pp.127-133
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• 1977

• Journal of the Korean Mathematical Society
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• v.14 no.1
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• pp.99-103
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• 1977

• The Transactions of The Korean Institute of Electrical Engineers
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• v.57 no.3
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• pp.527-535
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• 2008

Many signal processing techniques have been described in the literature for estimating amplitude, frequency and duration variables of the surface EMG signal detected during constant voluntary contractions. They have been used in different application areas for the non-invasive assessment of muscle function. The main purpose of our research is to compare the most frequently used algorithms for information extraction from surface EMG signals under varying conditions in terms of the different window lengths, muscle contraction levels, muscles and subjects. In particular we focus on the issue of estimating the slope and intercept to resolve an linear regression line with utilizing real SEMG signals which represents voluntary contractions during thirty seconds.

• Journal of Mechanical Science and Technology
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• v.14 no.3
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• pp.338-349
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• 2000

Neck muscle forces and spinal loads at the C4/5 level were estimated that result from isometric voluntary ramp efforts gradually developing to maximums in flexion, extension, left lateral bending and right lateral bending. Electromyographic (EMG) activities, a three-dimensional anatomic data of the neck and a hybrid model, EMG-assisted optimization (EMGAO) model, were used. The model computed the cervical loads at 25%,50%,75%, and 100% of peak moments. The highest model-predicted C4/5 joint compressive forces occurred during flexion; $361\;({\pm}164)\;N,\;811\;({\pm}288)\;N,\;1207\;({\pm}491)\;N\;and\;1674\;({\pm}319)\;N$ in 25%, 50%, 75% and 100% of peak moment respectively. Variations in load distribution among the agonistic muscles and co-contractions of antagonistic muscles were estimated during ramp efforts. Results suggest that higher C4/5 joint loads than previously reported are possible during isometric, voluntary muscle contractions. These higher physiological loads at C4/5 level must be considered possible during orthopedic reconstruction at this level.

• Journal of the Korean Mathematical Society
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• v.40 no.6
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• pp.933-942
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• 2003

It is shown that if a paranormal contraction T has no nontrivial invariant subspace, then it is a proper contraction. Moreover, the nonnegative operator Q = T/sup 2*/T/sup 2/ - 2T/sup */T ＋ I also is a proper contraction. If a quasihyponormal contraction has no nontrivial invariant subspace then, in addition, its defect operator D is a proper contraction and its itself-commutator is a trace-class strict contraction. Furthermore, if one of Q or D is compact, then so is the other, and Q and D are strict ontraction.

• Journal of applied mathematics & informatics
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• v.33 no.1_2
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• pp.13-31
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• 2015

In this paper, we introduce a general iterative algorithm for finding a common element of the common fixed point set of an infinite family of ${\lambda}_i$-strict pseudo-contractions and the solution set of a general system of variational inclusions for two inverse strongly accretive operators in q-uniformly smooth Banach spaces. Then, we analyze the strong convergence of the iterative sequence generated by the proposed iterative algorithm under mild conditions.

• Journal of the Korean Society of Safety
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• v.10 no.4
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• pp.103-108
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• 1995

This study was performed to investigate a relationship between a biomechanical analysis of compressive force at L5/S1 and electromyographic analysis of erector spinae muscle during lifting task. In the experiment, isometric contractions at 25, 50, 75, 100%MVC for short duration and sustained isometric contractions at 50%MVC were performed. For muscle recruitment patten and compressive force analysis, rectified EMG amplitudes analysis and computerized biomechanical analysis were used. To achieve data, angles of neck, shoulder, elbow, wrist, hip, knee, ankle and length of body segments were measured. Results shows that trends of initial EMG rectified amplitude were similar to those of biomechanical calculation value and for sustained isometric contraction at 50%MVC EMG rectified amplitude of erector spinae muscle after 40seconds was increased up to level of 75%MVC. Based on the results of this study, biomechanical analysis should be supplemented considering muscle fatigue, and it is also suggested that work-rest cycle critera and the evaluation of back-pain injuries should include muscle fatigue.