• 한국운동역학회지
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• 제16권3호
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• pp.75-83
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• 2006

The purpose of this study was to investigate steady-state force depression following active muscle shortening in human tibialis anterior muscle during voluntary contractions. Subjects (n = 7; age $24{\sim}39$ years; 7 males) performed isometric reference contractions and isometric-shortening-isometric contractions, using maximal voluntary effort. Force depression was assessed by comparing the steady-state isometric torque produced following active muscle shortening with the purely isometric reference torque obtained at the corresponding joint angle. In order to test for effects of the shortening conditions on the steady-state force depression, the speed of shortening were changed systematically in a random order but balanced design. Ankle dorsiflexion torque and joint angle were continuously measured using a dynamometer. During voluntary contractions, muscle activation of the tibialis anterior and the medical gastrocnemius was recorded using surface electromyography. Force depression during voluntary contractions, with a constant level of muscle activation, was 12 %, on average over all subjects. Force depression was independent of the speeds of shortening ($13.8{\pm}2.9%$, $10.3{\pm}2.6%$ for 15 and 45 deg/sec over 15 deg of shortening, respectively). The results of this study suggest that steady-state force depression is a basic property of voluntarily-contracting human skeletal muscle and has functional implication to human movements.

• Journal of Ginseng Research
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• 제17권2호
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• pp.109-113
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• 1993

The effects of ginseng total saponins (GTS) on the action of U-50,488H, a $textsc{k}$-opioid receptor agonist, on the electrically induced twitch responses of mouse vats deferens were studied. U-50,488H ($10^9$~$10^{-5}$M) inhibited the twitch contractions in a dose-dependent manner, which were caused by adenosine 5'-triphosphate (ATP) released from the stimulated sympathetic nerve, and this effect was antagonized by naloxone ($10^6$ M). GTS, which itself induced the inhibition of the twitch contractions, acted additively to U-50,488H, GTS and U-50,488H had no effect on the tension of the unstimulated organs. The contractions elicited by ATP were not affected by U-50,488H, but inhibited by GTS. These results suggest that U-50,488H suppressed the twitch contractions by the inhibition of neurotransmitter release from presynaptic nerve terminals via action on opioid receptor, but G75, by inhibiting the action of the neurotransmitter on the smooth muscle.

• 한국전문물리치료학회지
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• 제1권1호
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• pp.75-82
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• 1994

The purpose of this study is to determine cardiovascular reponses to concentric, eccentric and isometric exercise applied to the knee extensor muscle group. Exercise types studied were concentric, eccentric and isometric. The subjects were sixty healthy male volunteers who had no hypertension or cardiac disease. Heart rate, systolic and diastolic blood pressure were recorded prior to starting exercise. The subjects also performed 10RM on right lower extremity. A N-K table was used for three exercises to right knee extensors. Each exercise was selected randomly and applied to each subject 10 times in a 10 second. After each exercise, heart rate, systolic and diastolic blood pressure were recorded immediately. Findings were as follows concectric contractions had a greater effect on the increase of systolic blood pressure and heart rate than eccentric or isometric contractions. Diastolic blood pressure is influenced only by isometric contractions. Eccentric contractions have less effect on the increase of systolic blood pressure and heart rate than concentric or isometric contractions. We hope that the results of this experiment can be adapted to exercise programs for patients with cardiac disease.

• The Korean Journal of Physiology
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• 제22권2호
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• pp.189-206
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• 1988

The effects of ouabain on the contractile and electrical activities were investigated in the isolated preparations of guinea-pig taenia coli, and compared with those of vanadate. Spontaneous contractions were recorded with force transducer, and electrical activites were measured by use of suction electrode, or single sucrose-gap technique. The contractions were induced by the electrical stimulation for 5 seconds every 1 minute with alternating current (60 Hz, 3.0 V/cm) through the platinum electrodes located in parallel with the long axis of the preparation. All experiments were performed in tris-buffered Tyrode solution which was aerated with $100%{\;}O_2$ and kept at $35^{\circ}C$. The results obtained were as follows: 1) Responses of spontaneous contractions to ouabain were concentration-dependent; $10^{-7}M$ ouabain caused a rise of basal tone. Above the concentration of $10^{-6}M$ ouabain, an initial increase followed by a decrease in tension was observed. 2) A continuous spike discharge was induced by the administration of $10^{-7}M$ ouabain. Above $10^{-6}M$ ouabain, a transient initial increase followed by a decrease in spike frequency and amplitude was produced, and finally membrane potential was sustained at a certain level without a spike discharge. 3) The characteristic response to $10^{-7}M$ ouabain was not blocked by the pretreatment with $10^{-7}M$ atropine. 4) The electrically induced contractions were completely suppressed at the concentration of $2{\times}10^{-7}M$ ouabain. These contractions were blocked more rapidly in paralled with the increase in ouabain concentration. 5) Effects of vanadate on the spontaneous activities were quite different from those of ouabain; $10^{-6}M$ vanadate increased the amplitude of contractions and $10^{-5}M$ vanadate increased slightly both amplitude and frequency of spontaneous contractions. $10^{-4}M$ vanadate showed irregular phasic contractions superimposed on the increased basal tone. 6) $10^{-5}M$ vanadate depolarized the membrane potential and shortened the interval between the bursts of spike discharge, whereas $10^{-4}M$ vanadate induced continuous spike discharge with membrane depolarization. 7) Vanadate caused a characteristic inhibitory response to the contractions induced by electrical stimulation; An initial rapid inhibition of tension development and then gradual recovery to a certain level. From the above results, the following conclusions could be made: 1) The rise of basal tone at $10^{-7}M$ ouabain is due to continuous spike discharge without a silent period. The continuous spike discharge is likely to be associated with a slight membrane depolarization caused by the blockage of Na pump. 2) The biphasic response induced by above $10^{-6}M$ ouabain seems to occur by the different mechanisms. The initial increase in tension is associated with depolarization along with an increase in spike frquency, whereas the subsequent relaxation occurs through a non-electrical mechanism. 3) The characteristic response to $10^{-7}M$ ouabain is resulted not from the action on intrinsic nerve terminal, but from its direct action on the membrane of smooth muscle cells. 4) The phasic contractions superimposed on the increased basal tone at the concentration of $10^{-4}M$ vanadate is resulted from the continuous spike discharge with membrane depolarization, of which mechanism remains unknown. 5) The inhibitory action of ouabain on the electrically induced contractions suggests that the increasein intracellular Na in some way inhibits the electrically induced $Ca^{2+}$ influx. The mechanism of vanadate action on the induced contractions remains unknown.

• Nonlinear Functional Analysis and Applications
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• 제28권3호
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• pp.703-717
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• 2023

In this paper, we will introduce the notion of 𝜓-type and Jaggi type hybrid contraction in a bipolar metric space and show the existence and uniqueness of fixed point for such type of contractions. In the end, we will provide some corollaries and support our theorems by examples.

• 대한수학회지
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• 제52권5호
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• pp.1003-1021
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• 2015

A matrix completion problem has been exploited amply because of its abundant applications and the analysis of contractions enables us to have insight into structure and space of operators. In this article, we focus on a specific completion problem related to Hankel partial contractions. We provide concrete necessary and sufficient conditions for the existence of completion of Hankel partial contractions for both extremal and non-extremal types with lower dimensional matrices. Moreover, we give a negative answer for the conjecture presented in [8]. For our results, we use several tools such as the Nested Determinants Test (or Choleski's Algorithm), the Moore-Penrose inverse, the Schur product techniques, and a congruence of two positive semi-definite matrices; all these suggest an algorithmic approach to solve the contractive completion problem for general Hankel matrices of size $n{\times}n$ in both types.

• 대한수학회논문집
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• 제27권1호
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• pp.117-128
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• 2012

Using the concept of a g-monotone mapping we prove some common fixed point theorems for g-non-decreasing mappings which satisfy some generalized nonlinear contractions in partially ordered complete quasi b-metric spaces. The new theorems are generalizations of very recent fixed point theorems due to L. Ciric, N. Cakic, M. Rojovic, and J. S. Ume, [Monotone generalized nonlinear contractions in partailly ordered metric spaces, Fixed Point Theory Appl. (2008), article, ID-131294] and R. P. Agarwal, M. A. El-Gebeily, and D. O'Regan [Generalized contractions in partially ordered metric spaces, Appl. Anal. 87 (2008), 1-8].

• Journal of applied mathematics & informatics
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• 제27권3_4호
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• pp.763-771
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• 2009

T.H. Kim, H.K. Xu, [Convergence of the modified Mann's iteration method for asymptotically strict pseudo-contractions, Nonlinear Anal.(2007),doi:l0.l016/j.na.2007.02.029.] proved the strong convergence for asymptotically strict pseudo-contractions by the classical CQ iterative method. In this paper, we apply the monotone CQ iterative method to modify the classical CQ iterative method of T.H. Kim, H.K. Xu, and to obtain the strong convergence theorems for asymptotically strict pseudo-contractions. In the proved process of this paper, Cauchy sequences method is used, so we complete the proof without using the demi-closedness principle, Opial's condition or others about weak topological technologies. In addition, we use a ingenious technology to avoid defining that F(T) is bounded. On the other hand, we relax the restriction on the control sequence of iterative scheme.

• The Korean Journal of Physiology and Pharmacology
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• 제3권6호
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• pp.587-595
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• 1999

This study was designed to investigate effects of calcium antagonists on endothelial and neuronal dysfunction of right coronary artery (RCA) induced by ischemia- reperfusion in anesthetized, open-chest pigs. After reperfusion, pigs were sacrificed and the RCA was rapidly dissected for in vitro experiments. Experimental groups were divided into 4 groups: control (C-RCA), ischemia-reperfusion only (I-RCA), verapamil infusion (VI-RCA) and nifedipine infusion (NI-RCA) group, respectively. The ischemia did not affect hemodynamics, mean arterial pressure, heart rate, LVdP/dtmax, and decreased RCA flow. Arterial pressure and heart rate during ischemia-reperfusion were decreased in VI-RCA and NI-RCA, and RCA flow during reperfusion was increased in NI-RCA. 5-Hydroxytryptamine (5-HT) produced concentration-dependent contractions in C-RCA. The 5-HT-induced contractions were potentiated in I-RCA and VI-RCA, but not in NI-RCA. Endothelium-dependent relaxation by calcium ionophore A23187 was inhibited in I-RCA and VI-RCA, and recovered in NI-RCA. Cyclic GMP contents were decreased in I-RCA group alone. Electrical field stimulation in C-RCA produced transient and frequency-dependent contractions and at 50 Hz caused biphasic contractions. The transient contractions were not affected by pretreatment with phentolamine and atropine, but the biphasic contraction was altered by the pretreatment. Both contractions were inhibited in I-RCA, and were partially recovered in VI-RCA and NI-RCA. Ischemia-reperfusion of RCA in pigs causes endothelial and neuronal dysfunctions, and calcium antagonists partially prevent both.

• The Korean Journal of Physiology and Pharmacology
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• 제13권3호
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• pp.201-207
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• 2009

Our previous study demonstrated that flavone inhibits vascular contractions by decreasing the phosphorylation levelof the myosin phosphatase target subunit (MYPT1). In the present study, we hypothesized that flavone attenuates vascular contractions through the inhibition of the RhoA/Rho kinase pathway. Rat aortic rings were denuded of endothelium, mounted in organ baths, and contracted with either 30 nM U46619 (a thromboxane A2 analogue) or 8.0 mM NaF 30 min after pretreatment with either flavone (100 or 300 $({\mu}M$) or vehicle. We determined the phosphorylation level of the myosin light chain ($MLC_{20}$), the myosin phophatase targeting subunit 1 (MYPT1) and the protein kinase C-potentiated inhibitory protein for heterotrimeric myosin light chain phophatase of 17-kDa (CPI17) by means of Western blot analysis. Flavone inhibited, not only vascular contractions induced by these contractors, but also the levels of $MLC_{20}$ phosphorylation. Furthermore, flavone inhibited the activation of RhoA which had been induced by either U46619 or NaF. Incubation with flavone attenuated U46619 or NaF-induced phosphorylation of $MYPT1^{Thr855}$ and $CPI17^{Thr38}$, the downstream effectors of Rho-kinase. In regards to the $Ca^{2+}$-free solution, flavone inhibited the phosphorylation of $MYPT1^{Thr855}$ and $CPI17^{Thr38}$, as well as vascular contractions induced by U 46619. These results indicate that flavone attenuates vascular contractions, at least in part, through the inhibition of the RhoA/Rho-kinase pathway.