• Animal cells and systems
• /
• v.5 no.3
• /
• pp.247-251
• /
• 2001

Differentiating HiB5 cells, a rat hippocampal cell line, expressed neuregulins and showed constitutive activation of a neuregulin receptor, ErbB2, suggesting development of a neuregulin autocrine loop. RT-PCR analyses indicated that HiB5 cells produced SMDF and NDF, but not GGF, during the differentiation. None of neuregulin isoforms were detected in proliferating HiB5 cells. The neuregulins in HiBS cells, at least in part, are the $\beta$-isoforms of which the most of neuronal neuregulin isoforms are. The expression of SMDF and NDF was enhanced by PDGF and bFGF that promote cell survival and differentiation, suggesting a close relationship between the synthesis of neuregulins and the differentiation process. HiB5 cells have ErbB2 and ErbB4, but not ErbB3 receptors. Constitutive tyrosine phosphorylation of ErbB2 was detected in HiB5 cells that had not been exposed to exogenous GGF.

• Structural Engineering and Mechanics
• /
• v.33 no.4
• /
• pp.391-406
• /
• 2009

Viscoelastic materials store as well as dissipate energy to the thermal domain under deformation. Two efficient modelling techniques reported in literature use coupled (thermo-mechanical) ATF (Augmenting Thermodynamic Fields) displacements and ADF (Anelastic Displacement Fields) displacements, to represent the constitutive relationship in time domain by using certain viscoelastic parameters. Viscoelastic parameters are first extracted from the storage modulus and loss factor normally reported in hand books with the help of Genetic Algorithm and then constitutive relationships are used to obtain the equations of motion of the continuum after discretizing it with finite beam elements. The equations of motion are solved to get the frequency response function and modal damping ratio. The process may be applied to study the dynamic behaviour of composite beams and rotors comprising of several viscoelastic layers. Dynamic behaviour of a composite beam, formed by concentric layers of steel and aluminium is studied as an example.

• Structural Engineering and Mechanics
• /
• v.47 no.1
• /
• pp.27-44
• /
• 2013

A finite element computational procedure for the accurate analysis of quasistatic thermorheological complex structures response is developed. The geometrical nonlinearity, arising from large displacements and rotations (but small strains), is accounted for by the total Lagrangian description of motion. The Schapery's nonlinear single-integral viscoelastic constitutive model is modified for a time-stress-temperature-dependent behavior. The nonlinear thermo-viscoelastic constitutive equations are incrementalized leading to a recursive relationship and thereby the resulting finite element equations necessitate data storage from the previous time step only, and not the entire deformation history. The Newton-Raphson iterative scheme is employed to obtain a converged solution for the non-linear finite element equations. The developed numerical model is verified with the previously published works and a good agreement with them is found. The applicability of the developed model is demonstrated by analyzing two examples with different thermal/mechanical loading histories.

• Journal of the Korean Geosynthetics Society
• /
• v.12 no.4
• /
• pp.87-98
• /
• 2013

This study was performed a series of the isotropic compression-expansion tests and the drained triaxial tests with various the relative densities 40%, 60%, 80% and 95% for bottom ash. Using the tests results the characteristic of the parameters of Lade's single hardening constitutive model were investigated. The soil parameters Kur and n representing elastic behavior are not much affected by the change of the relative density. The other parameters such as failure criterion(m, ${\eta}_1$), hardening function(c, p) and plastic potential(${\psi}_2$, ${\mu}$) are in a positive linear relationship with the relative density. Since the soil parameters h and ${\alpha}$ representing yield function do not change much to the change of relative density and also closely related to failure criterion, they can be replaced by failure criterion ${\eta}_1$. We also observed that predicted values from the Lade's single hardening constitutive model were well consistent with the observed data.

• Journal of the Korean Geotechnical Society
• /
• v.15 no.6
• /
• pp.121-130
• /
• 1999

The objective of this study is to perform finite element analyses(FEA) using the anisotropic hardening constitutive model on the basis of the total stress concept. An anisotropic hardening model was then developed to solve the problem and its mathematical formulations and experimental verifications were also described. In a companion paper, the constitutive equation will be formulated for accurate and efficient solutions of FEA, and coded into a nonlinear analysis program, and finally a field problem will be analyzed. The proposed model includes the failure criterion of a von Mises type and the anisotropic hardening rule based on the generalized isotropic hardening description, which can model the nonlinearity and the anisotropy of the stress-strain relationship. As a result this study could verty the experimental results for UU triaxial tests, CU triaxial tests for overconsolidated samples, and anisotropic loading tests with the rotation of principal stress axes for $K_0$consolidated samples.

• Journal of the Korean Geosynthetics Society
• /
• v.10 no.4
• /
• pp.29-36
• /
• 2011

In this study, a series of the isotropic compression-expansion tests and the drained triaxial tests were performed on Pocheon granite soil with various the dry densities of $16.67kN/m^3$, $17.26kN/m^3$ and $17.65kN/m^3$. Using the tests results the characteristic of the parameters of Lade's single hardening constitutive model were investigated. The soil parameters such as kur and n related to elastic behavior, m and ${\eta}_1$ related to failure criterion, c and p related to hardening function and ${\psi}_2$ and ${\mu}$ related to plastic potential show in a positive linear relationship with the dry density. Since the soil parameters h and representing yield function do not change much to relative density and also are closely related to failure criterion, they can be replaced by failure criterion. We also observed that predicted values from the Lade's single hardening constitutive model were well consistent with the observed data.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.31 no.1C
• /
• pp.11-17
• /
• 2011

This study was performed a series of the isotropic compression-expansion tests and the drained triaxial tests with various the relative densities 25%, 50%, 80% and 100% for Baekma river sand. Using the tests results the characteristic of the parameters of Lade's single hardening constitutive model were investigated. The soil parameters Kur and n representing elastic behavior are not much affected by the change of the relative density. The other parameters such as failure criterion (m, ${\eta}_1$), hardening function (C, p) and plastic potential (${\Psi}_2$, ${\mu}$) are in a positive linear relationship with the relative density. Since the soil parameters h and $\alpha$ representing yield function do not change much to the change of relative density and also closely related to failure criterion, they can be replaced by failure criterion ${\eta}_1$. We also observed that predicted values from the Lade's single hardening constitutive model were well consistent with the observed data.

• Steel and Composite Structures
• /
• v.10 no.4
• /
• pp.317-329
• /
• 2010

According to the results of 9 circular concrete filled steel tube (CFT) push-out tests, a new theoretical model for average bond stress versus free end slip curve is proposed. The relationship between verage bond stress and free end slip is obtained considering some varying influential parameters such as slenderness ratio and diameter-to-thickness ratio. Based on measured steel tube strain and relative slip at different longitudinal positions, the distribution of bond stress and relative slip along the length of steel tube is obtained. An equation for predicting the varying bond-slip relationship along longitudinal length and a position function reflecting the variation are proposed. The presented method can be used in the application of finite element method to analyze the behavior of CFT structures.

• Steel and Composite Structures
• /
• v.46 no.4
• /
• pp.451-469
• /
• 2023

The use of precast hollow-core slabs (PCHCS) in civil construction has been increasing due to the speed of execution and reduction in the weight of flooring systems. However, in the literature there are no studies that present a finite element model (FEM) to predict the load-slip relationship behavior of pushout tests, considering headed stud shear connector and PCHCS placed at the upper flange of the downstand steel profile. Thus, the present paper aims to develop a FEM, which is based on tests to fill this gap. For this task, geometrical non-linear analyses are carried out in the ABAQUS software. The FEM is calibrated by sensitivity analyses, considering different types of analysis, the friction coefficient at the steel-concrete interface, as well as the constitutive model of the headed stud shear connector. Subsequently, a parametric study is performed to assess the influence of the number of connector lines, type of filling and height of the PCHCS. The results are compared with analytical models that predict the headed stud resistance. In total, 158 finite element models are processed. It was concluded that the dynamic implicit analysis (quasi-static) showed better convergence of the equilibrium trajectory when compared to the static analysis, such as arc-length method. The friction coefficient value of 0.5 was indicated to predict the load-slip relationship behavior of all models investigated. The headed stud shear connector rupture was verified for the constitutive model capable of representing the fracture in the stress-strain relationship. Regarding the number of connector lines, there was an average increase of 108% in the resistance of the structure for models with two lines of connectors compared to the use of only one. The type of filling of the hollow core slab that presented the best results was the partial filling. Finally, the greater the height of the PCHCS, the greater the resistance of the headed stud.

• Radiation Oncology Journal
• /
• v.24 no.2
• /
• pp.128-137
• /
• 2006

Purpose: We investigated whether a relationship exists between tumor control dose 50 ($TCD_{50}$) or tumor growth delay (TGD) and radiation induced apoptosis (RIA) in syngeneic murine tumors. Also we investigated the biological markers that can predict radiosensitivity in murine tumor system through analysis of relationship between $TCD_{50}$, TGD, RIA and constitutive expression levels of the genetic products regulating RIA. Materials and Methods: Syngeneic murine tumors such as ovarian adenocarcinoma, mammary carcinoma, squamous cell carcinoma, fibrosarcoma, hepatocarcinoma were used In this study. C3H/HeJ mice were bred and maintained in our specific pathogen free mouse colony and were $8{\sim}12$ weeks old when used for the experiments. The tumors, growing in the right hind legs of mice, were analyzed for $TCD_{50}$, TGD, and RIA at 8 mm in diameter. The tumors were also analyzed for the constitutive expression levels of $p53,\;p21^{WAF1/CIP1},\;BAX,\;Bcl-2,\;Bcl-X_L,\;Bcl-X_S$, and p34. Correlation analysis was peformed whether the level of RIA were correlated with $TCD_{50}$ or TGD, and the constitutive expression levels of genetic products regulating RIA were correlated with $TCD_{50}$, TGD, RIA. Results: The level of RIA showed a significant positive correlation (R=0.922, p=0.026) with TGD, and showed a trend to correlation (R=-0.848), marginally significant correlation with $TCD_{50}$ (p=0.070). It indicates that tumors that respond to radiation with high percentage of apoptosis were more radiosensitive. The constitutive expression levels of $p21^{WAF1/CIP1}$ and 34 showed a significant correlation either with $TCD_{50}$ (R=0.893, p=0.041 and R=0.904, p=0.035) or with TGD (R=-0.922, p=0.026 and R=-0.890 p=0.043). The tumors with high constitutive expression levels of $p21^{WAF1/CIP1}$ or p34 were less radiosensitive than those with low expression. Conclusion: Radiosensitivity may be predicted with the level of RIA in murine tumors. The constitutive expression levels of $p21^{WAF1/CIP1}$ or p34 can be used as biological markers which predict the radiosensitivity.