• 한국산학기술학회논문지
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• 제10권2호
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• pp.438-446
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• 2009

본 연구는 급성골수성백혈병의 우선적인 치료방법인 항암화학치료제 투여 후 발생되는 호중구 감소기간을 잘 관리하기 위하여 호중구감소증 정도와 영양상태와의 관련성을 규명한 서술적 조사연구이다. 본 연구는 B시 P대학병원에서 1차 강화항암화학치료까지 받고 회복한 성인환자 54명의 환자의 의무기록지를 열람하여 조사하였다. 연구결과, 항암화학요법 주기내의 호중구감소증이 지속되는 기간은 6일에서 28일(평균 14.78일)이었으며, 호중구감소증이 시작되는 시기는 5일째에서 15일째 사이(평균 9.54일)에 나타났으며, 최저백혈구수의 시기는 평균 18.41일째였으며, 27.8%에서 19일째 가장 적은 백혈구수를 보였다. 항암요법 주기내의 항암화학요법 시작시와 절대호중구수가 가장 낮은 시기의 총단백질량, 체중, 체질량지수와 같은 영양상태 변화는 거의 없었으며, 알부민, 콜레스테롤은 유의하게 감소하였다. 대상자의 일반적인 특성에 따른 호중구감소증은 성별, 나이, 동반질환유무, 체표면적에 따른 차이가 없었다. 호중구감소증과 영양상태간의 상관관계는 없었으나, 급성골수성백혈병 환자의 호중구감소 기간 동안의 영양상태에 대한 정보는 제공해 줄 수 있을 것으로 기대된다.

• Radiation Oncology Journal
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• 제38권2호
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• pp.119-128
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• 2020

Purpose: Colorectal cancer is becoming an increasing concern in the middle-aged population of Iran. This study aimed to compare the preliminary results of short-course and long-course neoadjuvant chemoradiotherapy treatment for rectal cancer patients. Materials and Methods: In this clinical trial we recruited patients with rectal adenocarcinoma located from 5 cm to 15 cm above the anal verge. Patients in group I (short-course) received three-dimensional conformational radiotherapy with a dose of 25 Gy/5 fractions in 1 week plus concurrent XELOX regimen (capecitabine 625 mg/㎡ from day 1-5 twice daily and oxaliplatin 50 mg/㎡ on day 1 once daily). Patients in group II (long-course) received a total dose of 50-50.4 Gy/25-28 fractions for 5 to 5.5 weeks plus capecitabine 825 mg/㎡ twice daily. Both groups underwent consolidation chemotherapy followed by delayed surgery at least 8 weeks after radiotherapy completion. The pathological response was assessed with tumor regression grade. Results: In this preliminary report on complications and pathological response, 66 patients were randomized into two study groups. Mean duration of radiotherapy in the group II (long-course) was 5 ± 1 days (range, 5 to 8 days) and 38 ± 6 days (range, 30 to 58 days). The median follow-up was 18 months. Pathological complete response was achieved in 32.3% and 23.1% of patients in the shortcourse and long-course groups, respectively (p = 0.558). Overall, acute grade 3 or higher treatment-related toxicities occurred in 24.2% and 22.2% of patients in group I and II, respectively (p = 0.551). No acute grade 4 or 5 adverse events were observed in either group except one grade 4 hematologic toxicity that was seen in group II. Within one month of surgery, no significant difference was seen regarding grade ≥3 postoperative complications (p = 0.333). Conclusion: For patients with rectal cancer located at least 5 cm above the anal verge, short-course radiotherapy with concurrent and consolidation chemotherapy and delayed surgery is not different in terms of acute toxicity, postoperative morbidity, complete resection, and pathological response compared to long-course chemoradiotherapy.

• Clinical and Experimental Pediatrics
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• 제57권6호
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• pp.271-277
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• 2014

Purpose: A nationwide outbreak of Mycoplasma pneumoniae pneumonia (MP) refractory to macrolide antibiotics occurred in Korea during 2011. Steroid therapy has been reported to be both efficacious and well tolerated in pediatric patients with refractory MP. We compared clinical features and laboratory characteristics between children with refractory MP requiring steroid treatment and those with macrolide-responsive MP and evaluated the risk factors associated with refractory MP. Methods: We investigated 203 children who were admitted to our institution with MP from June to November 2011. Refractory MP was defined by persistent fever over $38.3^{\circ}C$ with progressive pulmonary consolidation or pleural effusion despite administration of appropriate macrolide antibiotics for 5 days or longer after admission. Steroid therapy was initiated on the fifth day after admission for refractory cases. Results: There were 26 patients with refractory MP requiring steroid therapy. The mean duration of steroid therapy was 5.4 days and most of the patients were afebrile within 24 hours after initiation of steroid therapy. The prevalence of refractory MP was higher in patients with pleural effusion, lobar pneumonia affecting more than 2 lobes, higher levels of serum lactate dehydrogenase, increased oxygen requirements, and longer duration of hospitalization. Atopic sensitization and history of asthma were also associated with refractory MP after adjusting for age and gender. Conclusion: Children with refractory MP had more severe pneumonia. Atopic sensitization and history of asthma may be risk factors for refractory MP requiring steroid therapy in Korean children.

• Clinical and Experimental Pediatrics
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• 제54권3호
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• pp.123-127
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• 2011

Purpose: Kawasaki disease (KD) is the main cause of acquired heart disease in children. In addition to cardiovascular involvement, many complications have been recognized in KD. However, respiratory complications have been rarely reported. We investigated the differences in clinical characteristics, laboratory findings, radiography findings, and echocardiography findings of Mycoplasma pneumoniae infection and other types of pneumonia in KD patients. Methods: Among 358 patients with KD, 54 developed concurrent pneumonia. Among the 54 patients, 12 (22.2%) with high titers of anti-M. pneumoniae antibody (AMA) (>1:640) were grouped in the M. pneumoniae group and 42 were included in the control group. Serum AMA was measured in each patient. Clinical laboratory findings and total duration of fever were analyzed. Results: The duration of fever, serum hemoglobin, white blood cell count, platelet count, erythrocyte sedimentation rate, C-reactive protein level, albumin level, and the incidence of coronary arterial lesions showed no statistical difference in the 2 groups. Neutrophil count was significantly higher in the M. pneumoniae group than in the control group. Among various radiography findings observed in pneumonia, consolidation and pleural effusion were more frequent in the M. pneumoniae group than in the control group. On the other hand, parahilar peribronchial opacification, diffuse interstitial lesion, and normal findings prevailed in the control group. Conclusion: KD patients can have concurrent infections, especially pulmonary symptoms. The cause of KD is likely to be associated with M. pneumoniae infection. Thus, immediate treatment of M. pneumoniae infection in KD patients is very important.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제27권6호
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• pp.570-575
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• 2001

This study evaluated the short-term outcome of treating fractures of the mandible with bioabsorbable plates. Thirty-four fractures of the mandible in 27 patients were treated by open reduction and internal fixation using bioabsorbable plates and 2.4-mm, 2.0-mm, and 1.5-mm pre-tapped screws. The duration of intermaxillary fixation ranged from 0 to 23 days, with a mean of 5.3 days. Patients were evaluated for complications during the follow-up period, which ranged from 2 to 18 months. Five patients(18.5%) experienced complications. These included infection (four patients), and premature occlusal contact(one patient). Except for one case, all complications were minor and adequately managed with incision and drainage, elastic traction, and medication. Delayed infection (osteomyelitis) developed in a symphysis fracture and was treated by saucerization and antibiotics. The fracture line subsequently showed complete consolidation. Bioabsorbable plates can be selectively used for internal fixation in mandibular fractures with the advantage that they do not need to be removed.

• 대한족부족관절학회지
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• 제6권1호
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• pp.73-79
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• 2002

Purpose: To evaluate the effectiveness of callotasis using the external fixator for the treatment of brachymetatarsia. Materials and Methods: Eleven patients(15 cases) who underwent callotasis were available. Follow-up averaged 23 months(15-38 months). Both the patients' postoperative satisfaction and the postoperative radiographic results were retrospectively evaluated. Results: The duration from applying the external fixator to remove averaged 15 weeks (8-21 weeks). We did osteotomy again in two cases because of early consolidation at the osteotomy site during distraction period. All cases were evaluated mild claw toe deformity and motional pain in metatarsophalangeal joint, but all patients satisfied the postoperative results except one complained motional pain and stiffness in metatarsophalangeal joint. The metatarsal shortening averaged 13mm(9-18mm) before operation. The amount of distraction for shortened metatarsals averaged 15mm(5-22mm). We found the 6 cases of narrowing of the metatarsophalangeal joint, 2 cases of subluxation of the metatarsophalangeal joint. Conclusion: We think that callotasis with external fixator is good operative method for the brachymetatarsia.

• 대한치과의사협회지
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• 제37권3호통권358호
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• pp.221-227
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• 1999

The aim of this study was to describe the clinical availability of a variety of facial bone grafts in oral and maxillofacial surgery. Thirty patients with oral and maxillofacial bone defects were treated with mandible, maxilla, and zygoma bone grafts. The ages of the patients ranged from 8 to 64 years, with a mean age of 28.6 years. The follow-up period ranged from 2 to 30 months, with a mean follow-up of 11.7 months. Although postoperative follow-up was of short duration, the recilient sites were favorable to healing and bone consolidation. Healing progressed normally without severe morbidity. The donor site did not present a management problem in any of the patients.Some minor complications developed in 8 patients, of which three were infections and another three were wound dehiscence. There complications were easily managed with incision and drainage, antibiotics and local wound care. We consider that a variety of facial bone grafts can be used for reconsider that a variety of facial bone grafts can be used for reconstruction of small or moderate large bony defects.

• 한국지반공학회논문집
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• 제18권2호
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• pp.161-170
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• 2002

본 논문은 최적화기법을 이용하여 현장에서 수행된 피에조콘 소산시험의 초기 경향으로부터 평형간극수압과 지반의 강성지수$(=G/s_u)$를 역해석하는 기법에 관하여 기술하였다. 피에조콘 관입으로 인해 콘 주변에 발생된 초기 과잉간극 수압의 크기 및 분포, 그리고 연속된 간극수압 소산과정은 Randolph & Wroth(1979)가 제안한 해석적 해를 이용하여 지반의 강성지수의 함수로 표현되었다. 제안된 기법에서는 주어진 강성지수에 대해 정규화 된 이론 소산곡선과 평형간극수압으로 정규화 된 피에조콘 관측 소산곡선이 가장 일치하도록 하는 평형간극수압과 지반의 강성지수가 최적화기법을 이용하여 결정되었다. 제안된 기법을 압밀이 진행중인 지반에서 관측된 피에조콘 소산시험 결과(Tanaka & Sakagami, 1989) 해석에 적용하였고 역해석된 평형간극수압과 현장에서 관측된 평형간극수압의 크기를 비교하였다. 또한 제안된 기법으로 얻어진 지반의 강성지수와 평형간극수압을 바탕으로 수평압밀계수를 추정하였으며 일차원 압밀실험 결과와 비교하였다. 그 결과 제안된 기법이 지반에 잔류하는 평형간극수압의 크기를 매우 정확하게 예측함을 알 수 있었고 역해석 된 강성지수를 이용한 압밀계수의 추정이 타당함을 알 수 있었다. 또한 얻어진 강성지수의 변형 률수준에 관한 검토결과 피에조콘 해석을 위한 강성지수는 중간 또는 대변형 상태의 변형상태에 해당하는 값을 사용하는 것이 타당할 것으로 판단되었다.

• 한국수산과학회지
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• 제24권1호
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• pp.9-20
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• 1991

광양만에 분포하는 미고결 퇴적충의 물성특성을 Core 시료를 채취하여 분석하였다 퇴적상태의 특성을 지시하는 퇴적층의 공극율이 퇴적깊이에 따라 일정한 변화를 나타내지 않으며, 이는 자체하중에 의한 자연적 압밀이 매우 미세한 것을 나타내고 있다. 조석에 의한 해수면 변동이 퇴적층 거동에 미치는 영향을 수치해석적으로 분석한 결과, 퇴적층에 형성되는 공극수압이 이토층의 낮은 투수계수에 기인하여 해수면 변동에 따른 표층 수압변화보다 느리게 진행되고 있다. 따라서, 최소 해수면시점에 발생되는 공극수압이 해수압에 의한 역학적 응력보다 커서 퇴적층의 유효응력이 인장력으로 반전되며 일정깊이에서의 현장유효응력도 인장력상태(quick sand condition)인 것으로 나타난다. 이러한 현상은 퇴적물조직의 재구성이 내부적으로 발생될 수 있는 가능성을 제시해 주고 있다. 모래질이토층(sandy mud layer)이 이토층내에 존재할 경우에도 이토층과의 경계부분에서 인장력강태의 현장유효응력(quick sand condition)이 발생한다. 이는 퇴적물 재구성작용에 의해 모래질 입자가 표층에서 하부층으로 하강될 수 있는 역학적 이론근거를 제시해 주고 있으며, 본 연구결과에 의하면 모래질 입자들이 약 40cm 깊이에 하강될 때까지 quick sand condition이 형성된다.

• Radiation Oncology Journal
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• 제33권4호
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• pp.310-319
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• 2015

Purpose: Follicular lymphoma (FL) is an indolent non-Hodgkin's lymphoma that is highly sensitive to radiotherapy (RT). However, the effectiveness of RT has not been well established. We reviewed our experiences to assess the role of RT for FL and analyze treatment results. Materials and Methods: Retrospective analysis was done on 29 patients who received first RT between January 2003 and August 2013. Of 23 early stage (stage I, II) patients, 16 received RT alone, four received chemotherapy followed by RT, two received RT postoperatively, and one received salvage RT for relapse after resection. Six advanced-stage (stage III, IV) patients received RT after chemotherapy: two received consolidation RT, three received salvage RT for residual lesions, and one received RT for progressive sites. Median RT dose was 30.6 Gy (range, 21.6 to 48.6 Gy). Median follow-up duration was 62 months (range, 6 to 141 months). Results: All patients showed complete response in the radiation field. Eight outfield relapses were reported. Seven patients received salvage treatment (three chemotherapy, four RT). Four patients showed excellent responses, especially to RT. Estimated 5-year and 10-year relapse-free survivals were 72% and 60%. In the RT-alone group, 5-year relapse-free survival was 74.5%. All advanced-stage patients were disease-free with 100% 5-year overall survival. Disease-specific death was noted in only one patient; four others died of other unrelated causes. No significant toxicity was reported. Conclusion: RT resulted in excellent treatment outcomes for all FL stages when used as a primary treatment modality for early stage or salvage-treatment modality for advanced-stage disease.