• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.3
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• pp.651-656
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• 2006

Activation of $NF-{\kappa}B$ is known to be a trigger of various cellular disorders including inflammatory and autoimmune diseases such as rheumatoid arthritis. Numerous approaches are ongoing within laboratories to identify potential therapeutic agents which inhibit the $NF-{\kappa}B$ activation. In this study, we have tested the inhibitory effects of five traditional medicines on the activation of $NF-{\kappa}B$ by NIK. Among three medicines which exhibited inhibitory effect on the expression of $NF-{\kappa}B$ repoter plasmid, we investigated further the inhibitory mechanism of Dichroa febrifuga in connection with IKKY activity. Wild type $IKK{\gamma}$ inhibited the $NF-{\kappa}B$ activation by NIK but the C-terminal deletion mutant of IKKY did not show the inhibitory effect, indicating that the C-terminal leucine zipper domain of $NF-{\kappa}B$ is important for the inhibition of $NF-{\kappa}B$ activation. The water extract of Dichroa febrifuga(DFE) also strongly inhibited the $NF-{\kappa}B$ activation by NIK. The inhibitory activity of DFE appeared to be independent of the expression of $IKK{\gamma}$, suggesting that the pathways of inhibition by Dichroa febrifuga and $IKK{\gamma}$ are different. Our results suggest that Dichroa febrifuga can be used as a medicine for inhibition of the $NF-{\kappa}B$ activation in a wide range of cells without relation to the expression of $IKK{\gamma}$.

• Journal of Educational Research in Mathematics
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• v.27 no.4
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• pp.833-855
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• 2017

This study aims to reinvestigate the reason for introducing radian as a new unit to express the size of angles, what is the meaning of radian measures to use arc lengths as angle measures, and why is the domain of trigonometric functions expanded to real numbers for expressing general angles. For this purpose, it was conducted historical, mathematical and applied mathematical analyzes in order to research at multidisciplinary analysis of the radian concept. As a result, the following were revealed. First, radian measure is intrinsic essence in angle measure. The radian is itself, and theoretical absolute unit. The radian makes trigonometric functions as real functions. Second, radians should be aware of invariance through covariance of ratios and proportions in concentric circles. The orthogonality between cosine and sine gives a crucial inevitability to the radian. It should be aware that radian is the simplest standards for measuring the length of arcs by the length of radius. It can find the connection with sexadecimal method using the division strategy. Third, I revealed the necessity by distinction between angle and angle measure. It needs justification for omission of radians and multiplication relationship strategy between arc and radius. The didactical suggestions derived by these can reveal the usefulness and value of the radian concept and can contribute to the substantive teaching of radian measure.

• The Journal of the Korea Contents Association
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• v.12 no.9
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• pp.194-201
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• 2012

The expansion of media is in close connection with the expansion of awareness. The invention of characters enabled mankind to cross over time and space. Machines led to the development of body functions and electricity led to the expansion of space and time. Computers are the extension of the human brain and the advent of the internet led to the expansion of relationships. Even at this moment, media is unremittingly progressing like a spread of a mutant virus, and has resulted in fusion and complex phenomena such as convergence and hybrid media. Transmedia is a compound word formed by the word "Trans" which means traverse, transcend, penetrate or change, and the word "Media" and has the meaning "media which transcends media" which embraces all of modern day media. However, unlike other fusion or complex media, it is different in that it is not a combination of technologies but a combination of technology and emotion. Thus, transmedia should be recognized as a form of media that carries a significant meaning from the user experience aspect as it must simultaneously satisfy both "emotional awareness", which appeals to the human emotion, and "conscious awareness" of mankind, which arises out of the digital technology considered to be important in the smart-era society. This study first examines the concept of transmedia, and then examines the role of user experience design which triggers conscious thinking and strategies for emotional marketing. This study aims to be recognized as a matter for consideration with respect to the development stage for the establishment of a steady communication relationship between developers and designers, as well as communication with users.

• Cartoon and Animation Studies
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• s.41
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• pp.357-378
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• 2015

The recent domestic toy market is filled with the fever of 'Turning Mecard' produced as a character product of units showing in . The toy market of the domestic character licensing industry has shown such rapidly changing trends during the period of broadcasting contents like animation or special films targeting children. Through these contents, the characters are cognized, and also the immersion and loyalty can be increased depending on the progress of the story, on top of marketing effect while the animation is broadcasted. This effect is called gamification meaning that consumers voluntarily participate in the contents after receiving fun. Through the purchase of character products, the immersion and loyalty participate in the animation. Thus, this study analyzed the gamification elements by examining the animation and toy products of currently gaining popularity in the toy market. In the results of the study, the story structure of has the sustainment just like game, which is connected to its character product. Therefore, the users who have watched build up the relationship with each other, and the competition and reward can be done through the game using the character products, which is connected to such high immersion and loyalty.

• Spatial Information Research
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• v.20 no.3
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• pp.15-25
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• 2012

In order to resolve transportation system focused on vehicles which have led to all sorts of problems such as traffic congestion, air pollution and so on, Korea recently have tended to center around Transit Oriented Development(TOD) which is capable of initiating public traffic demands. It is imperative to develop objective evaluation method which is able to measure pedestrian environment and amenity in order to facilitate green transit. The purpose of this paper is to present evaluation indices and measurement framework of pedestrian environment by analyzing effect on TOD major planning factors such as diversity, density, design, and supply etc. For this, we applied evaluation index with regard to TOD planning factors, investigating connection to pedestrian and employed AHP (Analytic Hierarchy Process) so as to quantify the result of measurement in Jongro 3ga and Hangangjin station. As a result, we presented relationship between travel patterns of pedestrian and each TOD planning factor. More importantly, the proposed framework is expected to make the best of the visualization as well as evaluation method for the pedestrian accessibility, convenience of public transportation, and the mixed land-use patterns in subway area and transit center.

• Journal of Oral Medicine and Pain
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• v.43 no.2
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• pp.27-33
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• 2018

Purpose: Many researchers have established a connection between sleep disturbances and the symptoms of temporomandibular disorder (TMD) in adults, but there are a few studies targeted at adolescents with TMD. The aim of this study was to analyze the sleep pattern of adolescents with TMD and to determine the effect of poor sleep quality on their clinical symptoms. Methods: The subjects were composed of 47 adolescents with TMD. The sleep pattern and preliminary information of patients were measured by self-reported questionnaires; Pittsburgh Sleep Quality Index (PSQI) and Questionnaire for TMD analysis. TMD pain was scored using the Numerical Rating Scale. The Kruskal-Wallis test, Mann-Whitney U test, Fisher's exact test and logistic regression were used for statistical analysis. Results: The poor sleeping group had statistically more females (25.00% males, 75.00% females) than the good sleeping group. As compared with that of good sleepers, sleep quality of poor sleepers was significantly worse in the items of subjective sleep quality, sleep latency, sleep duration, sleep disturbances, daytime dysfunction and global PSQI score. The sleep time of adolescents was much longer during vacation ($7.20{\pm}1.38hours$) than during school days ($6.10{\pm}1.26hours$). Poor sleep of patients was associated with the pain in the ear or in front of the ear, in the face, jaw, throat or temple and in neck or back. Adolescents with pain in those areas had significantly higher proportion of poor sleepers than adolescents with no pain in those areas. Conclusions: The high ratio of girls in poor sleeping group could reflect the greater prevalence of TMD in women than in men. Pain in peri-temporomandibular joint areas, neck or back could negatively influence sleep quality of adolescents with TMD.

• Journal of the Korean Institute of Landscape Architecture
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• v.24 no.2
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• pp.86-98
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• 1996

This study is intended to revaluate old tree, five of the shot of the Natural Monument and 66 shot trees under protection in the city at present. The study covers distribution, management of usage, investigation and research into various matters relating to the situation of old trees in Pusan. Because 60% of the old trees selected for protection is on private land, citizens have difficulty gaining access to them. Also space for growth is impinged on by various urban facilities. Some trees have problems of growth because the land is covered with cement and asphalt. As regards space for old trees, many places have been destroyed due to the lack of protection fences and the failure to establish a guidance board. Only 40% of the space has been set aside for rest. In these places the establishment of rest areas, benches and handy chairs is needed. And there are 20 holy places where people observe religious ceremonies. As for space security necessary for old trees according to trunk width, the minimum trunk width and availale area needed are more than 1:1.5, but less than 30% have the necessary space. The growth of many old trees is threatended because of the small apace for growth. The prescription of the boundary space is divided between inside and outside. This indicates the domain nature and space rank of the old tree. It can be classified into five forms for research purposes. The elements for prescription of critical space outside are connected with the security of space, and the elements relating to inside space portray the conditions for sensitive growth according to the institution and the ground conditions. The open and closed nature of old tree space has some connection with the relationship between usage and the intimacy of the user. Most of the spaces for old trees can't be used or are difficult to gain access to, so it is necessary to secure enough space for them. The 18 places, despite having easy access, are near farmland, hills or forest. So the intimacy factor is low, and the security of space of the old trees is not generally sufficient. Henceforth, it will be necessary to have security of area for old trees as well as maintenance control to protect them. Also the space should be used as a communal and recreation are in the city. It is the time to construct a landscaped area which people can easily approach, a place with a secure entrance where they can play, rest and converse.

• Lingua Humanitatis
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• v.1 no.2
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• pp.123-139
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• 2001

In the history of linguistics in the world the scholars in India could be regarded as the representative linguists, who had provided the cornerstone of the academic development at linguistics. Without looking into the contents of Indian linguistic theories devised and developed in the past it would be almost impossible to account for the origin of descriptive linguistics and historical linguistics. These linguistics trends became full-fledged in 19 and 20 century and are still accepted by a lot of researchers in order to analyze newly revealed languages and train students only coming up the toddling level of linguistic studies. In this paper I will show how far the influence of Indian linguistics has colored the flow of linguistic growth historically. Especially through the analysis of Panini grammar I will prove the intimate relationship between the Indian linguistic theory and the generative grammar - it is the most active theory at present. The methods that Panini applied to constitute the rules like sutra include lots of information, that also could be discovered at the rules postulated in the generative grammar. One of the common features found at both linguistic theories is the simplicity of rule representation. At the generative grammar a rule has to be established without any redundancy. When certain number of sounds like p, b, m show the same phonological. change relevant to lips (labial in linguistic term) different rules need not to be given for each sound separately. It is better to find a way of putting the sounds together in a rule with grouping the 3 sounds with the shared phonetic feature 'labial'. In Panini grammar the form of a rule was decided based on the simplicity, too. For example, sutra 6.1.77 shows the phonological connection between the vowels i, u r 1 and the semi-vowels y, v, r, 1. However, it does not require to postulate 4 individual rules respectively. Instead a rule in which the vowels and the semi-vowels are involved is suggested, and linguistically the rule make it clear that the more simpler the rules will be the better they can reflect the efficiency of human language acquisition. Although the systems introduced at Panini grammar have some sense of distance from the language education itself we cannot deny the fact that the grammar formulates the a turning point of linguistic development. It is essential for us to think over the grammar from the view point of the modem linguistic theories to understand their root and trunk more thoroughly. It will also help us to predict in which way linguistic tendency will proceed to in future.

• Lingua Humanitatis
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• v.1 no.2
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• pp.47-63
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• 2001

"A Variation of Love" is a characteristic Kim Soo-Young poem, in that it embodies the poet′s innovative use of language and proceeds speedily, like many of his other poems. Above all, the poem reveals the core of Kim′s poetical spirit, his speculation about love. The poem is difficult to understand because it broadly uses run-on lines and even run-on stanzas, a technique that many readers are unfamiliar with. The semiological approach of this paper will bring new light on the poem by restructuring the relationship between signs, that is, by taking apart the sign system of the original text and reconstructing its sentence structure. If we rearrange the poem from its original six stanzas and fifty-one lines to four stanzas and twenty-three lines, we will discover a close connection between stanzas 1 and 2, and between stanzas 3 and 4. Of the many keywords of the poem, we may establish the dominant word as "love," into which every poetic word converges and from which each word emanates. Another important keyword is "fatigue of the city" in stanza 4. Similarly negative aspects of the city may be found in the line "the same may be said of Bombay, of New York, of Seoul" in stanza 3, as well as in the words "desire" in combination with "the lamplights of Seoul like leftovers in the pig sty" in stanza 1. The persona of the poem tries to overcome the "fatigue of the city" by "love," but the way he realizes love is, somewhat peculiarly, through stillness and silence. The persona aligns "the stones of the peach and the apricot and the dried persimmon" with the his faith in love. He calls the stones "beautiful hardness" presumably because that hardness (the stillness and silence) may blossom into beauty. In the earlier stanzas, the persona′s quest for love results in an awareness that love is omnipresent, but the persona determines "not to shout it out loud." The reason for this determination is found in stanza 4. Those who experience the "fatigue of the city" will be able to realize it by themselves. This seemingly defeatist conclusion by no means suggest pessimism, for the persona holds the conviction that "there will come a day when [one] will rave for love." This conviction rescues the poem from the dismal mood suggested by the "fatigue of the city." At all events, it is important to note that the "fatigue of the city" should not be considered apart from "love." Yet, strangely enough, the poem embodies a severe critique of the city, and further investigation is necessary in order to clarify why this critique appears in the form of "love." But this will be the treated in another paper.

• Journal of Gifted/Talented Education
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• v.22 no.2
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• pp.265-290
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• 2012

This study try to analyze the effect that personal and social factors affects the interactions among science gifted students. For this, I analyze the interacting role of science gifted students in social co-construction and scientific model constructing class for phase change and rising-sinking time of moon and categorize according to type. I analyze aspects of interaction and association of each elements in the students after I understand character type self conception friendship a parents-children relationship relation with teachers derived from advanced research through questionnaire and depth interview. After analyzing, I find the following-close friendship form or not and usual school class participation appear important factors that have strong connection with the aspect of the interactions. Also, character type, self conception and relation of parents affect the interactions relatively lower. Through this study, We identify two things. Firstly, We must consider individual's inside factors for making animatedly the interaction among the students. Secondly, We get considering factors that devise the strategies for making the interaction animatedly.