• Journal of the East Asian Society of Dietary Life
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• 제22권2호
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• pp.175-189
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• 2012

The purpose of this study was to investigate the relationship between pack-years of smoking, metabolic biomarkers, and diet quality in male adults. We analyzed data from the combined 2007-2009 Korean National Health and Nutrition Examination Survey (KNHANES). The extent of smoking was quantified in pack-years (py), with 1 py equivalent to 20 cigarettes per day for 1 year. Subjects (n=1,318) were recruited and divided into two groups according to age (30~49 years age group, n=695; ${\geq}50$ years age group, n=623). In ach age group, subjects were divided into three groups according to the extent of smoking, which included non-smokers (30~49 years, n=156; ${\geq}50$ years, n=217), light smoker (30~49 years, n=269; py<16; ${\geq}50$ years, n=189, py<31), and moderate smoker (30~49 years, n=270; $py{\geq}16$; ${\geq}50$ years, n=217, $py{\geq}31$). The Nutrient Adequacy Ratio (NAR) and the number of foods (Dietary Variety Score, DVS) were analyzed by using the data from the 24-recall method. The results showed that moderate smokers were significantly more likely to drink alcohol compared with the other two groups. Triglyceride and cholesterol levels were significantly higher in smoker groups. The non-smoker group consumed significantly higher levels of vitamin C and potassium compared to the smoker groups. In the diet quality, vitamin C NAR of non-smoker group was significantly higher than those of smoker groups. In the ${\geq}50$ age group, the MAR of nonsmoker, light, and moderate smoker groups were 0.81, 0.78, and 0.78 respectively. The smoker group consumed significantly greate sugar and oils compared to the non-smoker group. Py showed a significantly positive relationship with serum triglyceride level, and a negative relationship with MAR after adjusting for potential confounding factors. In conclusion, male moderate smokers take too little vitamin C, partly due to low diet quality. Therefore, a well-planed diet must be used to replace the nutrients lost from excluded food groups in smoker.

• Kidney Research and Clinical Practice
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• 제36권1호
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• pp.48-57
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• 2017

Background: Hepatic steatosis measured with controlled attenuation parameter (CAP) using transient elastography predicts metabolic syndrome in the general population. We investigated whether CAP predicted metabolic syndrome in chronic kidney disease patients. Methods: CAP was measured with transient elastography in 465 predialysis chronic kidney disease patients (mean age, 57.5 years). Results: The median CAP value was 239 (202-274) dB/m. In 195 (41.9%) patients with metabolic syndrome, diabetes mellitus was more prevalent (105 [53.8%] vs. 71 [26.3%], P < 0.001), with significantly increased urine albumin-to-creatinine ratio (184 [38-706] vs. 56 [16-408] mg/g Cr, P = 0.003), high sensitivity C-reactive protein levels (5.4 [1.4-28.2] vs. 1.7 [0.6-9.9] mg/L, P < 0.001), and CAP (248 [210-302] vs. 226 [196-259] dB/m, P < 0.001). In multiple linear regression analysis, CAP was independently related to body mass index (${\beta}=0.742$, P < 0.001), triglyceride levels (${\beta}=2.034$, P < 0.001), estimated glomerular filtration rate (${\beta}=0.316$, P = 0.001), serum albumin (${\beta}=1.386$, P < 0.001), alanine aminotransferase (${\beta}=0.064$, P = 0.029), and total bilirubin (${\beta}=-0.881$, P = 0.009). In multiple logistic regression analysis, increased CAP was independently associated with increased metabolic syndrome risk (per 10 dB/m increase; odds ratio, 1.093; 95% confidence interval, 1.009-1.183; P = 0.029) even after adjusting for multiple confounding factors. Conclusion: Increased CAP measured with transient elastography significantly correlated with and could predict increased metabolic syndrome risk in chronic kidney disease patients.

• Korean Journal of Agricultural and Forest Meteorology
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• 제21권3호
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• pp.187-195
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• 2019

The needs for precise diagnostics and farm management-decision aids have increased to reduce the risk of climate change and environmental stress. Crop simulation models have been widely used to search optimal solutions for effective cultural practices. However, limited knowledge on physiological responses to environmental variation would make it challenging to apply crop simulation models to a wide range of studies. Advanced research facilities would help investigation of plant response to the environment. In the present study, the sunlit controlled environment chambers, known as Korean SPAR (Soil-Plant-Atmosphere-Research) system, was developed by renovating existing SPAR system. The Korean SPAR system controls and monitors major environmental variables including atmospheric carbon dioxide concentration, temperature and soil moisture. Furthermore, plants are allowed to grow under natural sunlight. Key physiological and physical data such as canopy photosynthesis and respiration, canopy water and nutrient use over the whole growth period are also collected automatically. As a case study, it was shown that the Korean SPAR system would be useful for collection of data needed for understanding the growth and developmental processes of a crop, e.g., soybean. In addition, we have demonstrated that the canopy photosynthetic data of the Korean SPAR indicate the precise representation of physiological responses to environment variation. As a result, physical and physiological data obtained from the Korean SPAR are expected to be useful for development of an advanced crop simulation model minimizing errors and confounding factors that usually occur in field experiments.

• Journal of the Korea Society of Computer and Information
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• 제26권8호
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• pp.197-207
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• 2021

Relationship between bone mineral density (BMD) and type 2 diabetes is still inconsistent. Recently, many epidemiologic data show that fracture risk is increased in type 2 diabetic patients regardless of BMD status. In this study, we used nation-wide data from 2008 to 2011 Korea National Health and Nutrition Examination Survey (KNHANES) to analyze the BMD status in patients with type 2 diabetes compared to non-diabetics. We included subjects aged 50 years or older in men (N=2,959, 2,430 without diabetes, 529 with type 2 diabetes) and postmenopausal women (N=2,902, 2,479 without diabetes, 423 with type 2 diabetes). Subjects with history of medication for osteoporosis or with illness or malignancy affecting bone metabolism were excluded. Data of anthropometric measurements and demographic characteristics were collected by trained examiner. Serum was separated from peripheral venous blood samples obtained after 8 hours of fasting. BMD was measured at lumbar spine and femur using dual-energy X-ray absorptiometry (DXA). There was a significant positive association between lumbar spine BMD and type 2 diabetes after adjusting age, gender, body mass index, monthly house income, education level, physical activity, daily calcium intake and vitamin D concentration by multiple regression analysis in all subjects. In the subgroup analysis by gender, this association was maintained both in male and female after adjusting those confounding factors. However, femur BMD was not different between type 2 diabetic and non-diabetic subjects. In conclusion, lumbar spine BMD was significantly higher in type 2 diabetic patients aged 50 years or more in men and postmenopausal women compared to non-diabetic subjects.

• Clinical and Experimental Reproductive Medicine
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• 제47권4호
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• pp.312-318
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• 2020

Objective: The objective of the study was to compare the effects of long-term and short-term embryo culture to assess whether there is a correlation between culture duration and clinical outcomes. Methods: Embryos were divided into two study groups depending on whether their post-warming culture period was long-term (20-24 hours) or short-term (2-4 hours). Embryo morphology was analyzed with a time-lapse monitoring device to estimate the appropriate timing and parameters for evaluating embryos with high implantation potency in both groups. Propensity score matching was performed to adjust the confounding factors across groups. The grades of embryos and blastocoels, morphokinetic parameters, implantation rate, and ongoing pregnancy rate were compared. Results: No significant differences were observed in the implantation rate or ongoing pregnancy rate between the two groups (long-term culture group vs. short-term culture group: 56.3% vs. 67.9%, p=0.182; 47.3% vs. 53.6%, p=0.513). After warming, there were more expanded and hatching/hatched blastocysts in the long-term culture group than in the short-term culture group, but there was no significant between-group difference in embryo grade. Regarding pregnancy outcomes, the time to complete blastocyst re-expansion after warming is shorter in women who became pregnant than in those who did not in both culture groups (long-term: 2.19±0.63 vs. 4.11±0.81 hours, p=0.003; short-term: 1.17±0.29 vs. 1.94±0.76 hours, p=0.018, respectively). Conclusion: The outcomes of short-term culture and long-term culture were not significantly different in vitrified-warmed blastocyst transfer. Regardless of the post-warming culture time, the degree of blastocyst re-expansion 3-4 hours after warming is an important marker for embryo selection.

• Pediatric Infection and Vaccine
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• 제28권3호
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• pp.149-159
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• 2021

Purpose: Antibiotic exposure during pregnancy may affect the fetus and newborn in many ways. This study investigated the impact of prenatal antibiotic exposure duration on neonatal outcomes in very preterm (VP) or very low birth weight (VLBW) infants. Methods: From September 2015 to December 2020, preterm infants with gestational age less than 32 weeks or with a BW less than 1,500 g who were admitted to the neonatal intensive care unit, and their mothers were enrolled. Prenatal antibiotic exposure was defined as antibiotics received by mothers before delivery, and the patients were categorized into the non-antibiotic group, short-duration (SD; ≤7 days) group, or long-duration (LD; >7 days) groups. Results: A total of 93 of 145 infants were exposed to prenatal antibiotics, among which 35 (37.6%) were in the SD group and 58 (62.4%) were in the LD group. Infants in the LD group had a significantly higher birth weight-for-gestational-age (BW/GA) Z-score than those in the non-antibiotic group, even after the adjustment for confounding factors (beta, 0.258; standard error, 0.149; P<0.001). Multivariate logistic regression analysis showed that prolonged prenatal antibiotic exposure was independently associated with death (adjusted odds ratio [aOR], 8.926; 95% confidence interval [CI], 1.482-53.775) and composite outcomes of death, necrotizing enterocolitis (NEC), and late-onset sepsis (LOS) (aOR, 2.375; 95% CI, 1.027-5.492). Conclusions: Prolonged prenatal antibiotic exposure could increase the BW/GA Z-score and the risk of death and composite outcomes of death, NEC, and LOS in VP or VLBW infants.

• Korean Journal of Clinical Laboratory Science
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• 제54권3호
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• pp.192-200
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• 2022

The association between heavy metals in the blood and obesity has been examined in many studies. However, inconsistencies have been observed in the results from these studies. The present study was conducted using data from 119,181 participants of the Korea National Health and Nutrition Examination Survey (KNHANES) for 11 years in 2005 and between 2008 and 2017. The subjects with missing heavy metal blood tests, health interview data, and health examination data were excluded from the study. The study population comprised 1,844 individuals (972 men, 872 women) who were eligible for inclusion. It was found that obesity and abdominal obesity were associated with an increase in both blood mercury (P<0.001) and alanine aminotransferase (ALT) (P<0.001). After adjusting the confounding factors, those with concurrent high levels of ALT and the highest tertile of mercury showed an increased risk of obesity (odds ratio 4.46, 95%, confidence interval 2.23~8.90, P<0.001) as well as abdominal obesity (odds ratio 5.36, 95%, confidence interval 2.57~11.17, P<0.001). The interrelationship of mercury and ALT with the parameters of body mass index (P for interaction=0.009) and waist circumference (P for interaction=0.012), respectively, have been observed to be significant, suggesting that the reciprocal relationship could contribute to obesity and abdominal obesity.

• Journal of Nutrition and Health
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• 제55권5호
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• pp.558-571
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• 2022

Purpose: The purpose of this study was to analyze the dietary intake of Korean adults with atopic dermatitis (AD) to determine whether the risk of developing AD was related to their diet. Methods: Among the participants in the 7th National Health and Nutrition Survey (2016 to 2018), 10,571 adults aged 19-64 were divided into AD (AD group, n = 366) and control groups (non-AD group, n = 10,205) to compare and analyze their nutrient intake status and Korean Healthy Eating Index (KHEI) score. Depending on the prevalence of AD, the nutrient intake, nutrient intake per 1,000 kcal, acceptable macronutrient distribution range, and KHEI score were tested for significance by correcting for age, sex, body mass index, education, marriage, occupation, residence area, physical activity, and energy intake variables that were derived for confounding factors. Results: The acceptable macronutrient distribution range for protein was lower in the AD group than in the non-AD group. Comparing the nutrient intake per 1,000 kcal, the intakes of protein, phosphorus, iron, and potassium of the AD group were significantly lower than those of the non-AD group. In the KHEI, the scores of total vegetables, vegetables excluding kimchi and pickles, meat, fish, eggs, and legumes of the AD group were significantly lower than those of the non-AD group. In addition, as these food intake scores increased, the risk of AD significantly decreased. Conclusion: In conclusion, adult AD patients had low intakes of vegetables, meat, fish, eggs, and legumes, and it was confirmed that high intakes of these foods may be associated with low AD risk. Therefore, we suggest that an adequate intake of vegetables and foods containing protein would be necessary for the management and treatment of AD in adults.

• Journal of Korean society of Dental Hygiene
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• 제23권5호
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• pp.343-350
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• 2023

Objectives: Water constitutes a majority of the human body and is essential for health. In addition, water intake can prevent dental caries by improving salivary lubrication and self-cleaning. This study aimed to determine the relationship between the amount of daily water intake and the symptoms of oral disease in Korean adolescents. Methods: We used data from the Korea Youth Risk Behavior Web-based Survey (KYRBS), conducted in Korea in 2021, and identified the relationship between daily water intake and oral disease symptoms in Korean adolescents. KYRBS is a nationwide cross-sectional survey conducted by the Korea Disease Control and Prevention Agency (KDCA), and a total of 54,848 participants were included in this study. Results: After adjusting for confounding factors, logistic regression analysis showed that tooth pain was more often experienced by those who drank less than two cups of water per day (odds ratio [OR]: 1.14; 95% confidence interval [CI]: 1.01-1.30) than those who drank five or more cups of water per day. Conclusions: A low daily water intake is associated with tooth pain, a symptom of dental caries. The results of our study suggest that increasing water intake may reduce dental caries. Therefore, adequate water intake may help prevent dental caries.

• Journal of Nutrition and Health
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• 제50권4호
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• pp.336-349
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• 2017

Purpose: The purposes of this study were to describe changes in weight, waist circumference (WC), and prevalence of obesity over 8 years as well as investigate demographic and dietary factors associated with weight gain in Korean adults. Methods: The Korean Genome and Epidemiology Study is an ongoing community-based longitudinal study, which was started in 2001~2002 and repeated every 2 years. Height, weight, and WC were measured, and demographic data and food intake information using the food frequency questionnaire were collected from 10,038 adults aged 40~69 years at baseline. Among those individuals, 3,506 healthy individuals without chronic diseases completed the 4th follow-up survey in 2009~2010. Results: Mean weight decreased by 0.35 kg and 0.65 kg in men and women, respectively, whereas mean WC increased by 1.71 cm and 1.85 cm during the 8-year period. Prevalence of obesity based on body mass index (BMI) decreased from 34.5% to 33.5% in men and from 38.0% to 36.7% in women, whereas abdominal obesity increased from 14.8% to 22.2% in men and from 28.8% to 35.4% in women. Weight change was associated with age and smoking status in men, and residence area, age, education, income, and alcohol drinking in women. Approximately 57.5% maintained their BMI over 8 years (<${\pm}1kg/m^2$, stable weight group), 19.5% showed a BMI increase of ${\geq}1kg/m^2$ (weight gain group), and 23.0% showed a BMI decrease of more than $1kg/m^2$ (weight loss group). There was no significant difference in energy intake calculated as the percentage of estimated energy requirements among the three weight change groups. Intakes of coffee mix and milk were significantly higher in the weight gain group than in the weight loss group in men after controlling for confounding factors. Conclusion: Our results show that higher consumption of coffee mix and milk was associated with weight gain in Korean healthy men.