• Molecules and Cells
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• 제38권2호
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• pp.187-194
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• 2015

Thioredoxin (TRX) is a disulfide reductase present ubiquitously in all taxa and plays an important role as a regulator of cellular redox state. Recently, a redox-independent, chaperone function has also been reported for some thioredoxins. We previously identified nodulin-35, the subunit of soybean uricase, as an interacting target of a cytosolic soybean thioredoxin, GmTRX. Here we report the further characterization of the interaction, which turns out to be independent of the disulfide reductase function and results in the co-localization of GmTRX and nodulin-35 in peroxisomes, suggesting a possible function of GmTRX in peroxisomes. In addition, the chaperone function of GmTRX was demonstrated in in vitro molecular chaperone activity assays including the thermal denaturation assay and malate dehydrogenase aggregation assay. Our results demonstrate that the target of GmTRX is not only confined to the nodulin-35, but many other peroxisomal proteins, including catalase (AtCAT), transthyretin-like protein 1 (AtTTL1), and acyl-coenzyme A oxidase 4 (AtACX4), also interact with the GmTRX. Together with an increased uricase activity of nodulin-35 and reduced ROS accumulation observed in the presence of GmTRX in our results, especially under heat shock and oxidative stress conditions, it appears that GmTRX represents a novel thioredoxin that is co-localized to the peroxisomes, possibly providing functional integrity to peroxisomal proteins.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2009년도 제38회 동계학술대회 초록집
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• pp.124-124
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• 2010

Much interest has been focused on InGaN-based materials and their quantum structures due to their optoelectronics applications such as light emitting diode (LED) and photovoltaic devices, because of its high thermal conductivity, high optical efficiency, and direct wide band gap, in spite of their high density of threading dislocations. Build-in internal field-induced quantum-confined Stark effect in InGaN/GaN quantum well LED structures results in a spatial separation of electrons and holes, which leads to a reduction of radiative recombination rate. Therefore, many growth techniques have been developed by utilizing lateral over-growth mode or by inserting additional layers such as patterned layer and superlattices for reducing threading dislocations and internal fields. In this work, we investigated various characteristics of InGaN multiple quantum wells (MQWs) LED structures grown on selectively wet-etched porous (SWEP) GaN template layer and compared with those grown on non-porous GaN template layer over c-plane sapphire substrates. From the surface morphology measured by atomic force microscope, high resolution X-ray diffraction analysis, low temperature photoluminescence (PL) and PL excitation measurements, good structural and optical properties were observed on both LED structures. However, InGaN MQWs LED structures grown on SWEP GaN template layer show relatively low In composition, thin well width, and blue shift of PL spectra on MQW emission. These results were explained by rough surface of template layer, reduction of residual compressive stress, and less piezoelectric field on MQWs by utilizing SWEP GaN template layer. Better electrical properties were also observed for InGaN MQWs on SWEP GaN template layer, specially at reverse operating condition for I-V measurements.

• 한국문헌정보학회지
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• 제31권3호
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• pp.7-22
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• 1997

이 논문은 한국십진분류법 제4판 철학류에 대한 분석과 평가를 그 목적으로 쓰여졌다. 그 과정에서 개선사항과 아울러 문제점들이 다수 확인되었다. 즉 항목명칭을 합리적으로 변경한 것, 서양인명 표기상의 오류들을 바로 잡은 것, 새로운 항목을 신설한 것 등이 개선사항으로 밝혀졌다. 그런가 하면 전 분야가 균형 있게 전개되지 못한 것 구분의 원칙을 엄격히 준수하지 않은 결과로 항목간의 수평$\cdot$ 수직적 관계가 유기적으로 설정되지 못한 것, 개념의 오용과 사상적 계보에 대한 이해의 혼란에서 파생한 오류 등이 문제점으로 드러났다. 이들 가운데 예의 문제점들은 철학에 대한 충분치 못한 이해에서 비롯된 것으로 볼 수밖에 없다. 이 같은 분석과 평가를 토대로 필자는 다음 개정을 위한 분류위원회구성에 문헌분류전문가 외에 각 주제분야 전문가를 참여시킬 필요가 있다는 결론에 이르렀다. 그렇게 하지 않을 경우 문헌분류법의 근본적 개선은 물론 통용성 제고에도 한계가 불가피할 것이기 때문이다.

• Computers and Concrete
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• 제25권2호
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• pp.95-109
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• 2020

This paper aims to analytically study the effect of loading conditions and confinement type on the mechanical properties of the concrete-steel composite columns under axial compressive loading. The axial loading is applied to the composite columns in the two ways; only on the concrete core, and on the concrete core and steel tube simultaneously, which are called steel tube-confined concrete (STCC) and concrete-filled steel tube (CFST) columns, respectively. In addition, the confinement is investigated in the three types of passive, short-term active and long-term active confinement. Nonlinear finite element 3D models for analyzing these columns are developed using the ABAQUS program, and then these models are verified with respect to the recent experimental results reported by the authors on the STCC and CFST columns experiencing active and passive confinements. Axial and lateral stress-strain curves as well as the failure mode for qualitative verification, and compressive strength for quantitative verification are considered. It is found that there is a good consistency between the finite element analysis results and the experimental ones. In addition, a parametric study is performed to evaluate the effect of axial loading type, prestressing ratio, concrete compressive strength and steel tube diameter-to-wall thickness ratio on the compressive behavior of the composite columns. Finally, the compressive strength results of CFST specimens obtained via the finite element analysis are compared with the values specified by the international codes and standards including EC4, CSA, ACI-318, and AISC, with the results showing that ACI-318 and AISC underestimate the compressive strength of the composite columns, while EC4 and CSA codes present overestimated values.

• 대한조선학회논문집
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• 제53권2호
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• pp.85-91
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• 2016

The most important factor in the structural design of ships and offshore structures operating in arctic region is ice load, which results from ice-structure interaction during the ice collision process. The mechanical properties of ice related to strength and failure, however, show very complicated aspect varying with temperature, volume fraction of brine, grain size, strain rate and etc. So it is nearly impossible to establish a perfect material model of ice satisfying all the mechanical characteristics completely. Therefore, in general, ice collision analysis was carried out by relatively simple material models considering only specific aspects of mechanical characteristics of ice and it would be the most significant cause of inevitable errors in the analysis. Especially, it is well-known that the most distinctive mechanical property of ice is high dependency on strain rate. Ice shows brittle attribute in higher strain rate while it becomes ductile in lower strain rate range. In this study, the simulation method of ice collision to ship hull using the nonlinear dynamic FE analysis was dealt with. To consider the strain rate effects of ice during ice-structural interaction, strain rate dependent constitutive model in which yield stress and hardening behaviors vary with strain rate was adopted. To reduce the huge amount of computing time, the modeling range of ice and ship structure were restricted to the confined region of interest. Under the various scenario of ice-ship hull collision, the structural behavior of hull panels and failure modes of ice were examined by nonlinear FE analysis technique.

• 대한약침학회지
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• 제22권2호
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• pp.90-94
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• 2019

Objectives: Paclitaxel (PTX) as an anticancer drug used against solid cancers, possesses adverse reactions such as neuropathic pain which has confined its use. PTX-induced neuropathic pain is mediated via activation of oxidative stress. Berberine (BER), an isoquinoline phytochemical found in several plants, exerts strong antioxidant and painkilling properties. In the current study, we aimed to evaluate pain-relieving effect of BER in a mouse model of PTX-induced neuropathic pain. Methods: This study was done using 42 male albino mice that were randomly divided into 6 groups (n = 7) as follow: Sham-operated (not treated with PTX), negative control group (PTX-treated mice receiving normal saline), BER 5, 10, and 20 mg/kg (PTX-treated mice receiving BER) and positive control group (PTX-treated mice receiving imipramine 10 mg/kg). Neuropathic pain was induced by intraperitoneal administration of four doses of PTX (2 mg/kg/day) on days 1, 3, 5 and 7. Then, on day 7, hot plate test was done to assess latency to heat to measure possible anti-neuropathic pain effect of BER. Results: Four doses of PTX 2 mg/kg/day induced neuropathy that was reduced by BER at all time-points (i.e. 0, 30, 60, 90 and 120 min) after injection (P < 0.001 in comparison to control). The statistical analysis of data showed significant differences between groups (P < 0.001 in comparison to negative control), at 30, 60, 90 and 120 min after injection of BER 5, 10 and 20 mg/kg; in other words, 30, 60, 90 and 120 min after BER administration, neuropathic pain was significantly reduced as compared to normal saline-treated mice. Conclusion: Altogether, our results showed that PTX could induce neuropathic pain as reflected by hyperalgesia and BER could alleviate PTX-induced thermal hyperalgesia.

• Advances in concrete construction
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• 제12권5호
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• pp.399-409
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• 2021

The existing method to improve the coordination performance of the inner and outer parts of concrete-encased concrete-filled steel tube (CFST) composite columns by increasing the volume-stirrup ratio causes difficulties in construction due to over-dense stirrups. Thus, this paper proposes an open polygonal composite stirrup with high strength and high ductility CRB600H reinforced rebar, and seventeen specimens were constructed, and their axial compressive performance was tested. The main parameters considered were the volume-stirrup ratio, the steel tube size, the stirrup type and the stirrup strength. The test results indicated: For the specimens restrained by open octagonal composite stirrups, compared with the specimen of 0.5% volume-stirrup ratio, the compressive bearing capacity increased by 14.6%, 15.7% and 21.5% for volume-stirrup ratio of 0.73%, 1.07% and 1.61%, respectively. For the specimens restrained by open composite rectangle stirrups, compared with the specimen of 0.79% volume-stirrup ratio, the compressive bearing capacity increased by 7.5%, 6.1%, and -1.4% for volume-stirrup ratio of 1.12%, 1.58% and 2.24%, respectively. The restraint ability and the bearing capacity of the octagonal composite stirrup are better than other stirrup types. The specimens equipped with open polygonal composite stirrup not only had a higher ductility than those with the traditional closed-loop stirrup, but they also had a higher axial bearing capacity than those with an HPB300 strength grades stirrup. Therefore, the open composite stirrup can be used in practical engineering. A new calculation method was proposed based on the stress-strain models for confined concrete under different restrain conditions, and the predicted value was close to the experimental value.

• 한국구조물진단유지관리공학회 논문집
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• 제28권3호
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• pp.27-36
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• 2024

이 연구의 목적은 생산공정에서 발생할 수 있는 제작오차를 고려한 BIM 절차를 구축하고, 스플라이스 슬리브 공법으로 접합된 프리캐스트 전경량 골재콘크리트 특수전단벽(precast all-lightweight aggregate concrete special shear walls, PLASW)의 휨 연성 모델을 제시하는 데에 있다. 생산현장에서 제작된 PALSW의 콘크리트 피복 두께는 Revit BIM 프로그램으로 모델링된 단면상세보다 평균 1.28배 컸으며, 특히, 후프철근과 내부 크로스타이의 구부림 내면 반지름은 설계 단면상세보다 더 크게 있었다. 결과적으로 띠철근의 제작오차로 인해 코어 콘크리트의 구속비율이 64%에서 54%로 감소하였으며, PALSW의 휨 연성은 약 4.91% 감소하였다. 이 실험결과를 고려하여, 스플라이스 슬리브 공법으로 접합된 PLASW의 BIM 모델링은 띠철근의 구부림 내면 반지름을 보완해야 하며, 구속된 콘크리트의 응력-변형률 관계에서 구속압의 감소를 반영하여 취성도 증가계수는 1.8로 평가될 수 있다.

• 한국지반환경공학회 논문집
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• 제15권1호
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• pp.53-62
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• 2014

기존 국내 병설터널의 이격거리는 지반조건에 따라 터널직경(D)의 2~5D 정도를 확보하는 것이 일반화되어 왔으나, 최근 들어 대규모 절취에 따른 환경훼손 및 용지매입의 제약, 선형의 연속성 유지 등의 문제를 수반하게 되면서 터널 중심간격이 1D 이하인 근접 병설터널의 현장 적용성이 확대되고 있다. 특히, 터널 필라폭이 감소할 경우 필라(Pillar)의 안전성이 터널의 거동에 영향을 미치게 되므로, 이에 대한 다양한 연구의 필요성이 대두되고 있다. 그러나 현재까지의 연구는 주로 필라의 거동특성이나 설계 영향 인자들에 대한 분석에 국한되었으며, 실무에 적용 가능하고 정량적인 데이터는 제시하지 못하고 있는 실정이다. 이에 본 연구에서는 현장 시공조건을 최대한 반영할 수 있는 안정성 평가기법 및 설계 지표를 제시하기 위해 현장조건으로 터널 간 근접도가 가장 높은 갱구부 구간의 지형 및 지층특성을 반영하고, 암반 및 완전풍화 상태의 다층지반조건 상태를 모사하였으며, 지반 강도별 필라폭 변화에 따른 수치 해석적 분석을 통해 필라의 안전성이 터널 전체 안정성에 미치는 영향 정도를 평가하였다. 또한, 지표침하비 및 간섭체적비, 평균강도/응력비 등에 대한 종합적 분석 결과와 Hoek & Brown(1980) 파괴기준을 토대로 실무에 적용이 가능한 근접 병설터널 필라의 안전율 평가식과 지반 강도별 최소 필라폭을 제시하였다.

• 지질공학
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• 제19권3호
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• pp.351-363
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• 2009

경상분지 내 구미노두와 다사노두 지역에서 신동층군의 사암층을 대상으로 절리 연구가 집중적으로 이루어졌다. 사암-이암 시퀀스의 양 지역 노두에서 똑같이 두 조의 직교 절리가 사암층에 전형적으로 발달하고 있다. 여러 가지 절리 자료들을 양 지역의 동일한 두께의 층에서 비교하여보면 상당히 유사한데 이는 절리 조들이 동일한 응력장에서 신장 변형 작용으로 균질하게 생성되었음을 이야기 한다. 대부분의 절리들은 퇴적물이 매몰되어 고화되는 과정에서 수압단열작용에 의해 생성된 것으로 생각되며, 사암층의 층 경계에 수직이고 층 경계에 이르러 중지한다. 두 조의 직교하는 절리들은 단열 격자차단 양상으로 해석되는 상호 접경하는 관계로 볼 때 ${\sigma}_1$은 수직으로 고정된 상태에서 ${\sigma}_2$ 와 ${\sigma}_3$의 빠른 교환에 의해 거의 동시에 생성된 것으로 판단된다. 사암층에서의 절리조들은 인접한 절리 간에 평행한 배향을 가지며 규칙적인 간격을 가지고 절리면은 평탄하다. 절리간격은 층 두께에 비례하고 간격분포는 대부분의 층에서 대수-정규분포 내지 정규 분포를 나타낸다. 그러나 다중층에서는 간격의 분포범위가 크고 불규칙한 형태를 보여준다. 연구지역에서 두 조의 절리들은 최빈값/평균값의 비가 1 내외로 포화상태를, 또 다른 척도인 변동계수(Cv)도 1이하의 낮은 값으로 포화를 지시한다. 절리의 개구는 모든 사암충의 절리에서 균질하기보다는 절리의 길이가 증가함에 따라 증가하는 경향을 갖는다.