• Asian Pacific Journal of Cancer Prevention
• /
• 제16권7호
• /
• pp.3009-3014
• /
• 2015

The epidermal growth factor (EGF) may play a pathological role in hepatocellular carcinoma (HCC). However, the conclusions of published reports on the relationship between the EGF $61^*A/G$ polymorphism and HCC risk remain controversial. To derive a more precise estimation we performed a meta-analysis based on 14 studies that together included 2,506 cases and 4,386 controls. PubMed, EMBASE, Web of Knowledge and the Chinese National Knowledge Infrastructure (CNKI) databases were used to retrieve articles up to August 1, 2014. The crude odds ratios (ORs) with 95% confidence intervals (95%CIs) were calculated to evaluate the association. Meta-analysis results showed a significant association between the EGF $61^*A/G$ polymorphism and HCC risk in all four genetic models (allele model: OR=1.25, 95%CI=1.12-1.40; dominant model: OR=1.32, 95%CI=1.14-1.54; recessive model: OR=1.33, 95%CI=1.12-1.58; ho-mozygous model: OR=1.59, 95%CI=1.33-1.90). Moreover, significant associations were observed when stratified by ethnicity, source of controls, etiology and genotype methods. Thus, this meta-analysis suggests that the G-allele of the EGF $61^*A/G$ polymorphism is associated with an increased risk of HCC, especially in Asians and Caucasians, without influence from the source of controls or etiological diversity. Further studies with larger population sizes are needed to confirm these results.

• 전자공학회논문지
• /
• 제49권12호
• /
• pp.226-233
• /
• 2012

본 논문에서는 고속 인터페이스 비트오류율(BER, Bit Error Rate)의 수학적 모델을 기반으로, 간단하고 정확하게 시간마진을 추정할 수 있는 '선형 근사화 추정법(linear approximation method)'을 제안하였다. 기존의 Q-factor를 이용한 추정법과 제안한 선형 근사화 추정법을 이용하여 $10^{-13}$ 이하의 BER을 얻기 위한 시간마진을 추정한 결과는 실측한 값과 비교할 때 약 0.03UI 정도의 작은 오차를 갖는다. 이 중 선형 근사화를 이용한 가속 자가내장측정법(built-in self test)을 내부 BERT(BER Tester)를 포함한 하드웨어로 구현하였다. 3Gbps, 95% 신뢰 수준에서 $10^{-13}$ BER 기준의 시간마진을 직접 측정하는데 소요되는 시간이 약 5.6시간인데 반해, 가속 자가내장측정법은 0.6초 이내에 유사한 정확도로 시간마진을 추정한다. 시간마진 추정치는 시간마진을 내부 BERT로 직접 측정한 값과 0.045UI 이하의 작은 오차를 보였다.

• 대한토목학회논문집
• /
• 제3권3호
• /
• pp.95-106
• /
• 1983

사면(斜面)의 3차원(次元) 파괴(破壞)의 신뢰성(信賴性) 해석(解析)에 안전율(安全率)대신 파괴확률(破壞確率)이 사용(使用)되었다. 강도정수(强度定數)는 정규분포(正規分布)와 베타분포(分布)(beta distribution)로 가정하였고 특별(特別)한 신뢰도(信賴度)와 최우추정법(最尤推定法)에 의하여 구간추정(區間推定)을 하였다. 정규분포(正規分布)와 베타분포(分布)의 의사무작위변수(擬似無作爲變數)는 중심극한정리(中心極限定理)와 Rejection방법(方法)에 따라 일양분포변환방법(一樣分布變換方法)을 사용(使用)하여 발생(發生)시켰고 몬테칼로방법 (Monte-Carlo Method)에 의한 파괴확률(破壞確率)은 다음과 같이 정의(定義)된다. $$P_f$$=M/N M: 파괴회수(破壞回數) N: 시행회수(施行回數) 본(本) 연구(硏究)의 결론(結論)은 강도정수(强度定數)를 정규분포(正規分布)로 가정한 경우에는 주어진 파괴표면(破壞表面)에 대하여 어떤 해석방법(解析方法)과 차원(次元)에 대해서도 안전율(安全率)과 파괴확률(破壞確率)과의 관계는 일정(一定)하였으나 베타분포(分布)로 가정 한 경우에는 일정(一定)한 관계가 나타나지 않았다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권11호
• /
• pp.6681-6686
• /
• 2013

Background: Fatal adverse events (FAEs) have been reported with sorafenib, a vascular endothelial growth factor receptor kinase inhibitor (VEGFR TKI). We here performed an up-to-date and detailed meta-analysis to determine the overall risk of FAEs associated with sorafenib. Methods: Databases, including PubMed, Embase and Web of Science, and abstracts presented at the American Society of Clinical Oncology annual meetings were searched to identify relevant studies. Eligible studies included randomized controlled trials evaluating sorafenib effects in patients with all malignancies. Summary incidence rates, relative risks (RRs), and 95% confidence intervals (CIs) were calculated for FAEs. In addition, subgroup analyses were performed according to tumor type and therapy regimen. Results: 13 trials recruiting 5,546 patients were included in our analysis. The overall incidence of FAEs with sorafenib was 1.99% (95%CI, 0.98-4.02%). Patients treated with sorafenib had a significantly increased risk of FAEs compared with patients treated with control medication, with an RR of 1.77 (95%CI 1.25-2.52, P=0.001). Risk varied with tumour type, but appeared independent of therapy regimen. A significantly increased risk of FAEs was observed in patients with lung cancer (RR 2.26; 95% CI 1.03-4.99; P= 0.043) and renal cancer (RR 1.84; 95% CI 1.15-2.94; P= 0.011). The most common causes of FAEs were hemorrhage (8.6%) and thrombus or embolism (4.9%). Conclusions: It is important for health care practitioners to be aware of the risks of FAEs associated with sorafenib, especially in patients with renal and lung cancer.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권11호
• /
• pp.6703-6707
• /
• 2013

Background: Numerous epidemiological studies have been conducted to evaluate the association between variants of the DNA repair gene XRCC3 and cancer risk. Here we focused on one XRCC3 polymorphism and development of cervical cancer, performing a meta-analysis. Methods: The pooled association between the XRCC3 Thr241Met polymorphism and cervical cancer risk was assessed by odds ratios (ORs) and their 95% confidence intervals (95%CIs). Results: A total of 5 case-control studies met the inclusion criteria. The pooled ORs for the total included studies showed no association among homozygotes TT vs. CC: OR=1.93, 95%CI=0.68-5.49, P=0.22; dominant model TT+TC vs. CC: OR=1.37, 95%CI=0.90-2.06, P=0.14; and recessive model TT vs. TC+CC: OR=1.76, 95%CI=0.68-4.55, P=0.25, but might be a slight risk factor for cervical cancer in heterozygote contrast TT vs. CT: OR= 1.33, 95%CI=1.04-1.71, P=0.02. In subgroup analysis, significant associations were found for Asians under all genetic models. Conclusions: Our meta-analysis suggested the XRCC3 Thr241Met polymorphism might not act as a cervical cancer risk factor overall. However, in subgroup analysis, a significant association was found in Asians under all genetic models. The association should be studied with a larger, stratified population, especially for Asians.

• Radiation Oncology Journal
• /
• 제32권4호
• /
• pp.247-255
• /
• 2014

Purpose: To determine whether neoadjuvant androgen deprivation therapy (NADT) improves clinical outcomes in patients with prostate cancer treated with definitive radiotherapy. Materials and Methods: We retrospectively reviewed medical records of 201 patients with prostate cancer treated with radiotherapy between January 1991 and December 2008. Of these, 156 patients with more than 3 years of follow-up were the subjects of this study. The median duration of follow-up was 91.2 months. NADT was given in 103 patients (66%) with median duration of 3.3 months (range, 1.0 to 7.7 months). Radiation dose was escalated gradually from 64 Gy to 81 Gy using intensity-modulated radiotherapy technique. Results: Biochemical relapse-free survival (BCRFS) and overall survival (OS) of all patients were 72.6% and 90.7% at 5 years, respectively. BCRFS and OS of NADT group were 79.5% and 89.8% at 5 years and those of radiotherapy alone group were 58.8% and 92.3% at 5 years, respectively. Risk group (p = 0.010) and radiation dose ${\geq}70Gy$ (p = 0.017) affected BCRFS independently. NADT was a significant prognostic factor in univariate analysis, but not in multivariate analysis (p = 0.073). Radiation dose ${\geq}70Gy$ was only an independent factor for OS (p = 0.007; hazard ratio, 0.261; 95% confidence interval, 0.071-0.963). Conclusion: NADT prior to definitive radiotherapy did not result in significant benefit in terms of BCRFS and OS. NADT should not be performed routinely in the era of dose-escalated radiotherapy.

• 한국지하수토양환경학회지:지하수토양환경
• /
• 제7권3호
• /
• pp.45-59
• /
• 2002

본 연구의 목적은 국가 지하수 관측망 자료를 활용하여 우리나라 지하수위 변동 곡선의 유형을 구분하고, 각 유형별 함양률을 평가하여 지하수 함양률의 공간적 변동성을 규명하는 데 있다. 전국 지하수의 수위 변동 곡선을 구분하기 위하여 요인 분석 방법을 사용했으며 그 결과 총 5 개의 유형으로 구분하였다. 유형별 함양률은 95.44%의 신뢰도 수준에서 6.2 %(유형 I), 4.1 %(유형 II), 9.2 %(유형 III), 5.8 %(유형 IV), 15.3 %(유형 V)로 추정되었으며 한 유형에서도 관측 지점별로 약 6 %의 변화폭을 보였다. 지하수위 변동 곡선법을 이용하여 유역별로 지하수 함양률을 평가한 결과 한강과 금강 유역에서는 각각 강수량 대비 10.0 %, 8.3 %의 함양률을 보였고, 낙동강 및 영산강·섬진강 유역에서는 각각 6.1 %, 6.6 %의 함양률을 보였으며 기저유출법에 의해서 유역별로 함양률을 추정한 연구의 결과와 유사하게 나타났다 따라서 본 연구를 통하여 지하수 함양률이 수위 변동 곡선의 유형별 혹은 유역별로 변동성을 가짐을 규명할 수 있었다.

• 한국환경보건학회지
• /
• 제32권5호
• /
• pp.424-430
• /
• 2006

Since 1985, the Gangwon Institute of Health and Environment(GIHE) and Ministry of Environment have collected rivers and streams water quality data in an ambient surface water monitering program. This study was prepared to propose an achievement of water quality of rivers subject to management by area according to an created level while establishing a water quality level applicable to the Gangwon area. As a result of evaluating correlativity on the BOD-based water quality data, BOD versus TP, and TP versus SS demonstrated significance at a confidence level of 95%. Evaluating correlativity on $10{\sim}90$ percentile values of analyzed data, a coefficient of determination, $r^{2}$ of BOD versus TP, and TP versus SS were 0.625, 0.286 respectively. Grading the results by evaluation method, the representative values of TP were 0.030 mg/l for I level, 0.100 mg/l for II level, 0.200 mg/l for Ill level, 0.300 mg/l for IV level, and 0.350 mg/l for V level, and those of SS were indicated 4.0 mg/l for I level, 15.0 mg/l for II level, 30.0 mg/l for III level, 45.0 mg/l for IV level, and 60.0 mg/l for V level. As for the limiting factor allowing the water quality standard exceeded, BOD posted 61% as the factor was found in 11 places, TP 28%, and SS 33%.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권7호
• /
• pp.3179-3185
• /
• 2012

Background: Most of the epidemiology studies on the effects of sun exposure and prostate cancer were conducted among the temperate countries of North America and Europe. Little is known about the influence on Asian populations. The purpose of current study was to evaluate any association of sun exposure with risk of prostate cancer in Chinese, Malays and Indians who reside in the tropics. Methods: The Singapore Prostate Cancer Study is a hospital-based case-control study of 240 prostate cancer incident cases and 268 controls conducted in Singapore between April 2007 and May 2009. Detailed information on outdoor activities in the sun, skin colour, sun sensitivity and other possible risk factors were collected in personal interviews. Cases were further classified by Gleason scores and TNM staging. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression analysis, adjusted for age, ethnicity, education, family history of any cancers, BMI and skin colour. Results: We found that prostate cancer risk was increased in subjects with black/dark-brown eyes (OR 5.88, 95%CI 3.17-10.9), darker skin colour e.g. tan/dark brown/black (OR 7.62, 95%CI 3.41-17.0), frequent sunburn in lifetime (OR 4.30, 95%CI 1.7-11.2) and increased general sun exposure in adulthood per week (OR 2.03, 95%CI 1.09-3.81). The increased risk was consistent for high grade tumours and advanced stage prostate cancers. Conclusion: The findings from this study suggest that excessive sun exposure is a risk factor for prostate cancer in Asians.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권15호
• /
• pp.6387-6390
• /
• 2014

Background: The prognostic significance of the circulating absolute monocyte count (AMC) in patients with locally advanced hepatocellular carcinoma (HCC) is uncertain. This study was designed to assess the association of circulating AMC with survival outcomes in patients diagnosed with locally advanced or metastatic HCC receiving systemic chemotherapy. Materials and Methods: Between January 1, 2005 and December 30, 2012, locally advanced or metastatic HCC patients who had Child-Pugh stage A or B disease and received systemic chemotherapy were retrospectively enrolled. Patient features including gender, age, extrahepatic metastasis, Child-Pugh stage, serum alpha-fetoprotein(AFP) level and AMC were collected to investigate their prognostic impact on overall survival(OS). Results: A total of 216 patients were eligible for the study. The optimal cut-off value of AMC for OS analysis was $0.38{\times}10^9/L$. Median OS was 5.84 months in low-AMC group (95% confidence interval [CI], 5.23 to 6.45), and 5.21 months in high-AMC group (95% CI, 4.37 to 6.04; p=0.003). In COX multivariate analysis, elevated AMC remained as an independent prognostic factor for worse OS (HR, 1.578; 95% CI, 1.120 to 2.223, p=0.009). Conclusions: Our results indiicate that circulating AMC is confirmed to be an independent prognostic factor for OS in patients with locally advanced or metastatic HCC receiving systemic chemotherapy.