• Advances in Traditional Medicine
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• 제10권3호
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• pp.141-149
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• 2010

A concern of safety issue for traditional herbal medicine is the possibility of some herbs containing heavy metals responsible for several cases of metal poisoning. In our previous study, the physiological levels of heavy metals, such as Cd, Cu, Hg and Pb, were examined to evaluate a potential risk in patients taking herbal medicine. In this study, the levels of 12 heavy metals, including non-metallic element, Se, were analyzed in hair and compared to the results from the previous study. In the previous study, the levels of Cd, Cu, Hg and Pb in hair showed a significantly lower odds ratio than 1. In this study, however, all metals did not show any significant odds ratio higher or lower than 1 even if 5 of 12 metals showed lower odds ratio than 1. In addition, the levels of metal concentrations, especially for Cu, Fe, Pb and Zn, exceeding the WHO reference values were observed in hair. However, any evidence for metal accumulation in hair caused by taking herbal medicines for long duration was not observed in analysis of multiple regression and odds ratio from case-control study. This result would show another possibility for a role of herbs as a non-enzymatic chelator inhibiting the gastrointestinal absorption of heavy metals.

• Ocean and Polar Research
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• 제43권3호
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• pp.141-148
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• 2021

Microplastic contamination in waterbodies is a growing source of concern for researchers and other stakeholders. We investigated oxidative stress and toxicity in goldfish (Carassius auratus) in response to exposure to 1-㎛ diameter micro-polystyrene (MP) at concentrations of 0, 10, 100, and 1000 beads/mL (MP 0, MP 10, MP 100, and MP 1000 groups) for 7 d (at day 0, 1, 3, 5, and 7). We analyzed the survival rates; superoxide dismutase (SOD) and catalase (CAT) mRNA expression levels in the liver; SOD and CAT activity in the plasma; caspase-3 mRNA expression in the liver; and the levels of hydrogen peroxide (H₂O₂) in plasma. Terminal transferase dUTP nick end labeling (TUNEL) assays were also conducted to determine apoptosis levels in the liver. All fish in the MP 1000 group died by day 7 and the MP 100 group had a lower survival rate than the MP 10 and MP 0 groups. The mRNA expression as well as SOD, CAT, and caspase-3 activity levels were increased significantly with increases in MP concentration and exposure time. Finally, according to the TUNEL assay, more apoptosis was observed in the MP 1000 group at day 5 than in other groups. In summary, MP concentrations above 100 beads/mL caused death and oxidative stress to goldfish. We conclude that MP can cause oxidative stress and apoptosis in goldfish, which leads to death.

• 한국식품위생안전성학회지
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• 제23권3호
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• pp.239-247
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• 2008

벼 재배 농업인들에게 기술지원을 하고, 소비자들에게 우리 쌀의 안전성을 널리 알리고자, '05-'07년 "탑라이스 생산단지" 및 인근 관행재배 지역에서 토양 및 쌀 시료를 채취하여 중금속을 분석한 결과 다음과 같았다. 탑라이스 생산단지 및 인근 관행재배 논토양 중 비소(As) 함량은 1.33 mg/kg으로 토양환경보전법상 우려기준(4 mg/kg)과 대책기준(10 mg/kg)의 1/5-1/11 이하로 매우 낮은 수준이었다. 백미 중 비소(As) 함량은 중국의 잔류허용기준 0.15 mg/kg의 1/4 이하로 매우 안전하였다. 논토양 중 카드뮴(Cd) 함량은 0.06 mg/kg으로 우려기준(1.5 mg/kg)과 대책기준(4 mg/kg)의 1/25-1/67 이하로 매우 낮은 수준이었다. 백미 중 카드뮴(Cd) 함량은 우리나라 잔류허용기준 0.2 mg/kg의 1/5 이하로 매우 안전하였다. 논토양 중 구리(Cu) 함량은 4.57 mg/kg으로 우려기준(50 mg/kg)과 대책기준(125 mg/kg)의 1/11-1/27 이하로 매우 낮은 수준이었다. 백미 중 구리(Cd) 함량은 우리나라 먹는물 기준 1 mg/kg의 1/4 이하로 매우 안전하였다. 논토양 중 납(Pb) 함량은 4.68 mg/kg으로 우려기준(100 mg/kg)과 대책기준(300 mg/kg)의 1/21-1/64 이하로 매우 낮은 수준이었다. 백미 중 납(Pb) 함량은 우리나라 잔류허용기준 0.2 mg/kg의 1/9 이하로 매우 안전하였다. 논토양 중 수은(Hg) 함량은 0.03 mg/kg으로 우려기준(4 mg/kg)과 대책기준(10 mg/kg)의 1/131-1/328 이하로 매우 낮은 수준이었다. 백미 중 수은(Hg) 함량은 평균 0.0022 mg/kg으로 나타났고, 중국 0.02 mg/kg 및 대만 0.05 mg/kg의 1/9-1/23 이하로 매우 적었다. 탑라이스의 중금속 함량과 2005년 국민건강영양조사 제3기 결과보고서의 일일 식품 섭취량 자료를 토대로 우리나라 국민의 중금속 섭취량을 PTWI와 비교하여 안전성을 평가한 결과, 탑라이스(백미) 섭취를 통한 우리나라 국민의 중금속의 주간 섭취량은 체중 kg당 $As\;0.892{\mu}g,\;Cd\;1.035{\mu}g,\;Cu\;6.712{\mu}g,\;Pb\;1.161{\mu}g$, 그리고 Hg 0.054 ${\mu}g$으로 이는 각각 중금속의 PTWI의 약 As 5.9%, Cd 14.79%, Cu 0.19%, Pb 4.65% 및 Hg 1.07%에 불과하였다. 한편, 현미를 통한 중금속 섭취량은 각 중금속들의 PTWI 대비 1% 이내로 안전하였다. 결론적으로 "탑라이스" 생산단지를 포함한 인근의 관행재배지역 토양은 중금속에 오염되지 않았으며, 여기에서 생산된 우리 쌀은 매우 안전하였다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제6권10호
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• pp.2708-2730
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• 2012

The growing concern for the protection of personal information has made it critical to implement effective technologies for privacy and data management. By observing the limitations of existing approaches, we found that there is an urgent need for a flexible, privacy-aware system that is able to meet the privacy preservation needs at both the role levels and the personal levels. We proposed a conceptual system that considered these two requirements: a graph-based, access control model to safeguard patient privacy. We present a case study of the healthcare field in this paper. While our model was tested in the field of healthcare, it is generic and can be adapted to use in other fields. The proof-of-concept demos were also provided with the aim of valuating the efficacy of our system. In the end, based on the hospital scenarios, we present the experimental results to demonstrate the performance of our system, and we also compared those results to existing privacy-aware systems. As a result, we ensured a high quality of medical care service by preserving patient privacy.

• 대한간호학회지
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• 제34권6호
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• pp.1057-1068
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• 2004

Purpose: This study was conducted to identify the differences of health patterns; health-related characteristics, health behaviors, health problems, and self-care levels of elderly, living alone in an urban area according to age roup. Method: The study design was a descriptive survey and the subjects were 1,800 elderly consisting of 937 young old, 704 middle old, and 159 old old. Data was collected from May to July 2003 using the structured questionnaire and analyzed by descriptive statistics, $\chi$$^2$-test, Fisher's exact probability test, ANOVA and Scheffe test using SPSS/PC. Result: The health related characteristics which involved body mass index, mental status, use of assistant devices, perceived health, concern of health, and social support were different among the groups and more aggravated by aging. Health behaviors and health problems were also significantly aggravated in the old old group. The self-care levels measured by ADL, physical activity, and self-care ability scores were also significantly decreased in the old old group. Conclusion: For the level of health status, health behaviors and self-care ability were significantly decreased by aging, health care services for the elderly should be planned considering the difference in the health pattern by age group.

• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.6895-6898
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• 2015

Background: We aimed to explore whether levels of patient-centredness, job satisfaction and psychological distress varied between oncology nurses and doctors. Materials and Methods: In a cross-sectional study using self-administered questionnaires, a total of 24 nurses and 43 doctors were assessed for patient-centredness, psychological distress, and job satisfaction using the Patient-Practitioner Orientation Scale, Hospital Anxiety and Depression Scale, and Job Satisfaction Scale. Data were analysed using descriptive statistics, independent samples t-test and MANCOVA, with p<0.05 considered significant. Results: Overall response rate was 95.6% (43/45) for physicians and 85.7% (24/28) for nurses. Even after adjusting for known covariates, our principal finding was that doctors reported greater psychological distress compared to nurses (p=0.009). Doctors also reported lower job satisfaction compared to nurses (p = 0.017), despite higher levels of patient-centredness found in nurses (p=0.001). Findings may be explained in part by differences in job characteristics and demands. Conclusions: Mental health is an important concern not just in cancer patients but among healthcare professionals in oncology.

• 한국지역사회생활과학회지
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• 제25권4호
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• pp.629-636
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• 2014

Polybrominated diphenyl ethers (PBDEs) as flame-retardant additives have been used in a wide array of products, including building materials, electronics, furnishings, motor vehicles, airplanes, plastics, polyurethane foams, and textiles. They are structurally similar to PCBs and other polyhalogenated compounds. PBDEs are found in a variety of foods, and 95% of all human exposure to POPs comes from food. The major food sources are fish/seafood and dairy products. A number of studies have reported high levels of PBDEs in animals, increasing the public's concern over PBDE levels in animals. This study evaluates the relationship between the level of PBDEs according to piglet diseases. Salmonella spp. and Streptococcus are bacterial diseases. Porcine respiratory reproductive syndrome (PRRS) is a viral disease. The concentration of PBDEs in the piglet liver from viral diseases was higher than that from bacterial diseases. BDE-47 and BDE-99 were detected in most samples. More PBDEs were detected in the piglet liver from PRRS of North American type than from that of European type.

• ALGAE
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• 제29권1호
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• pp.15-25
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• 2014

The number of species of non-native and invasive marine algae is growing, with concomitant public concern about native ecosystems and coastlines. Gelidium vagum, recently introduced from northeast Asia to Europe and North America, commonly occurs from the intertidal to subtidal zones in Korea, China, and Japan. To investigate the level of genetic diversity of native populations, we analyzed mitochondrial cox1 and cob from 108 specimens of G. vagum from Korea, China, eastern Russia, including from the Netherlands and USA. The haplotype network of individual and cox1 + cob datasets revealed no genetic structure in local populations, suggesting genetic flow between Korean populations. Our results corroborate a typical pattern of genetic diversity for introduced species, with low levels in introduced populations and high levels in native populations. All haplotypes were shared between the Netherlands and USA, but not between Korea and the Netherlands / USA except cox1. Additional sampling will identify donor populations in native northeast Asian waters. This is the first report of the utility of the mitochondrial coding cob sequences in red algae.

• 한국실내디자인학회논문집
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• 제13권4호
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• pp.196-203
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• 2004

In The Lighting design is important to acknowledge appearance space. Development of artificial light makes a extension to life space in the Modern life. With the rapid development of efficient light sources, have lighting design acquired the tools that allow artificial lighting to be produced with adequate illuminance levels. However, by the task of defining the objectives and methods behind discipline, of deciding on the criteria by which the artificial lighting that is now provide many available data to be anpaied. The main concern is which illuminace levels and types of lighting will ensure optimum visual performance, high productive and safety at design which are affordable. This study is support to standard design process with material reflection rate, installing the lighting fixture, task illuminance level and automatic arithmetic calculation during the lighting design. Lighting Design database can check and support other final lighting level. A quantitative light that is primarily oriented toward providing a recommended illuminance level, the criterion of develop a concept that goes beyond the requirements that would ensure productivity and safety to meet the needs of the architecture and interior space. illuminance level is compose to space task and space code according to KS A 3011. To be able to design the visual effect of an environment the central reference quantity has to provided the Database.

• Nuclear Engineering and Technology
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• 제52권8호
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• pp.1764-1770
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• 2020

The present work was mainly concerned with studying the operation of RC-phase shift oscillator based on MOSFET type 2N6660 under the influence of different temperature levels ranging from room temperature (25 ℃) up-to135 ℃ and gamma-irradiation up-to 3.5 kGy. In this concern, both the static (I-V) characteristic curves of MOSFET devices and the output signal of the proposed oscillator were recorded under ascending levels of both temperature and gamma-irradiation. From which, it is clearly shown that the drain current was decreased from 0.22 A, measured at 25 ℃, down to 0.163 A, at 135 ℃. On the other hand, its value was increased up-to 0.49 A, whenever the device was exposed to gamma-rays dose of 3.5 kGy. Considering RC-phase shift oscillator, the oscillation frequency and output pk-pk voltage were decreased whenever MOSFET device exposed to gamma radiation by ratio 54.9 and 91%, respectively. While, whenever MOSFET device exposed to temperature the previously mentioned parameters were shown to be decreased by ratio 2.07 and 46.2%.