• Geomechanics and Engineering
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• v.11 no.2
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• pp.253-267
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• 2016

The stability of surrounding rock will be poor when the tunnel is excavated through nearly horizontal stratum. In this paper, the instability mechanism of local nearly horizontal stratum in super-large section and deep buried tunnel is revealed by the analysis of the macro failure and micro fracture. A structural model is proposed to explain the mechanics of surrounding rock collapse under the action of stress redistribution and shed light on the macroscopic analytical approach of the stability of surrounding rock. Then, some highly effective formulas applied in the tunnel engineering are developed according to the theory of mixed-mode micro fracture. And well-documented field case is made to demonstrate the effectiveness and accuracy of the proposed analytical methods of mixed-mode fracture. Meanwhile, in order to make the more accurate judgment about yield failure of rock mass, a series of comprehensive failure criteria are formed. In addition, the relationship between the nonlinear failure criterion and $K_I$ and $K_{II}$ of micro fracture is established to make the surrounding rock failure criterion more comprehensive and accurate. Further, the influence of the parameters related to the tension-shear mixed-mode fracture and compression-shear mixed-mode fracture on the propagation of rock crack is analyzed. Results show that ${\sigma}_3$ changes linearly with the change of ${\sigma}_1$. And the change rate is related to ${\beta}$, angle between the cracks and ${\sigma}_1$. The proposed simple analytical approach is economical and efficient, and suitable for the analysis of local nearly horizontal stratum in super-large section and deep buried tunnel.

• Korean Circulation Journal
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• v.54 no.7
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• pp.363-381
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• 2024

With global aging, the number of patients with heart failure has increased markedly. Heart failure is a complex condition intricately associated with aging, organ damage, frailty, and cognitive decline, resulting in a poor prognosis. The relationship among frailty, sarcopenia, cachexia, malnutrition, and heart failure has recently received considerable attention. Although these conditions are distinct, they often exhibit a remarkably close relationship. Overlapping diagnostic criteria have been observed in the recently proposed guidelines and position statements, suggesting that several of these conditions may coexist in patients with heart failure. Therefore, a comprehensive understanding of these conditions is essential, and interventions must not only target these conditions individually, but also provide comprehensive management strategies. This review article provides an overview of the epidemiology, diagnostic methods, overlap, and prognosis of frailty, sarcopenia, cachexia, and malnutrition in patients with heart failure, incorporating insights from the FRAGILEHF study data. Additionally, based on existing literature, this article discusses the impact of these conditions on the effectiveness of guideline-directed medical therapy for patients with heart failure. While recognizing these conditions early and promptly implementing interventions may be advantageous, further data, particularly from well-powered, large-scale, randomized controlled trials, are necessary to refine personalized treatment strategies for patients with heart failure.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.38 no.10
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• pp.1179-1184
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• 2014

Reliability allocation is generally used during the early stage of system development to apportion the system reliability target to its individual modules. This paper presents a comprehensive method for performing the reliability allocation of KTX door systems. Nine criteria for reliability allocation include failure criticality, operating time, risk, complexity, failure rate, maintenance, manufacturing technology, working condition, and reliability cost. For satisfying the system reliability target, the allocated $B_{10}$ lives of four modules are provided.

• Magazine of the Korea Concrete Institute
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• v.8 no.3
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• pp.209-218
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• 1996

The purpose of the present study is to explore the effects of local reinforced type and to suggest reliable failure mechanism and the design criteria on the anchorage zones of the precast prestressed concrete bridges. To accomplish these objectives, a comprehensive experimental and analytical study has been conducted. From this study, the cracking and ultimate load capacities for spirally reinforced anchorage zone are found to be larger than those for orthogonal reinforced anchorage zone. This indicate the effectiveness of spiral reinforcement in controlling the cracking. And realistic failure mechanism and design criteria of prestressed anchorage zones based on the present study are suggested.

• Korean Journal of Clinical Pharmacy
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• v.24 no.2
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• pp.115-125
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• 2014

Purpose: The purpose of the present study was to assess the incidence of the potentially inappropriate medication (PIM) use in Korean elderly patients with heart failure, and to evaluate factors that influence PIM use. Method: Korean National Health Insurance claims database between January 2009 and December 2009 was used. Using 2012 updated Beers criteria, PIM use in heart failure patients aged 65 years or older was examined. Result: The incidence of PIM use in elderly heart failure patients was higher than in overall elderly patients. Among the 12,759 elderly patients with heart failure, 46.2% of study subjects were prescribed PIM(s) at least once. The number of PIM per 10 medications that patients received per patient was 1.53. The most commonly used PIMs in elderly heart failure patients were benzodiazepines (30.9%), non-steroidal anti-inflammatory drugs (NSAIDs) including COX-2 inhibitors (16.3%), digoxin (9.9%), and spironolactone (9.0%). Women (odds ratio, 1.20; 95% CI, 1.17-1.24), medical aid (odds ratio, 1.11; 95% CI, 1.08-1.13), and long-term facilities (odds ratio, 2.69; 95% CI, 2.44-2.96) were revealed to be important factors associated with PIM use. In addition, patient's age also seems to influence PIM use. Conclusion: Elderly heart failure patients are at a greater risk for adverse drug events attributed by inappropriate medication use. Efforts to increase awareness of PIM use in elderly heart failure patients are needed. In addition, various comprehensive strategies and policies to identify and prevent PIM use should be established nationwide.

• Geomechanics and Engineering
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• v.15 no.1
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• pp.621-630
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• 2018

In the note a comprehensive and optimal passive-active mode for describing the limit failure of circular shallow tunnel with settlement is put forward to predict the catastrophic stability during the geotechnical construction. Since the surrounding soil mass around tunnel roof is not homogeneous, with tools of variation calculus, several different curve functions which depict several failure shapes in different soil layers are obtained using virtual work formulae. By making reference to the simple-form of Power-law failure criteria based on numerous experiments, a numerical procedure with consideration of combination of upper bound theorem and stochastic medium theory is applied to the optimal analysis of shallow-buried tunnel failure. With help of functional catastrophe theory, this work presented a more accurate and optimal failure profile compared with previous work. Lastly the note discusses different effects of parameters in new yield rule and soil mechanical coefficients on failure mechanisms. The scope of failure block becomes smaller with increase of the parameter A and the range of failure soil mass tends to decrease with decrease of unit weight of the soil and tunnel radius, which verifies the geomechanics and practical case in engineering.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.23 no.6
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• pp.501-510
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• 2020

Purpose: To develop a probability-based differential diagnosis for pediatric acute liver failure (PALF) based on age and socioeconomic status of the country of origin. Methods: Comprehensive literature search using PubMed, EMBASE, and SCOPUS databases was performed. Children 0-22 years of age who met PALF registry criteria were included. Articles included >10 children, and could not be a case report, review article, or editorial. No language filter was utilized, but an English abstract was required. Etiology of PALF, age of child, and country of origin was extracted from included articles. Results: 32 full text articles were reviewed in detail; 2,982 children were included. The top diagnosis of PALF in developed countries was acetaminophen toxicity (9.24%; 95% CredI 7.99-10.6), whereas in developing countries it was Hepatitis A (28.9%; 95% CredI 26.3-31.7). In developed countries, the leading diagnosis of PALF in children aged <1 year was metabolic disorder (17.2%; 95% CredI 10.3-25.5), whereas in developing countries it was unspecified infection (39.3%; CredI 27.6-51.8). In developed countries, the leading diagnosis in children aged >1 year was Non-A-B-C Hepatitis (8.18%; CredI 5.28-11.7), whereas in developing countries it was Hepatitis A (32.4%; CredI 28.6-36.3). Conclusion: The leading causes of PALF in children aged 0-22 years differ depending on the age and developmental status of their country of origin, suggesting that these factors must be considered in the evaluation of children with PALF.

• Journal of Welding and Joining
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• v.32 no.1
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• pp.79-86
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• 2014

The purpose of this study is to determine the proper fillet weld size for the stiffeners on hull bottom plate of crude oil tanker. To achieve it, the effective notch stress and hot spot stress of the fillet weld with leg length specified in the rule were evaluated by using comprehensive FE analyses. Based on the results, the fatigue damages at each location of weld were calculated. Meanwhile the transitional behavior of initial welding distortion in the hull bottom plate under the design conditions was investigated by using a non-linear FEA. Welding distortion and residual stress introduced during fabrication process were considered as initial imperfections. According to FE analysis results, if the fillet leg length satisfies the design criteria of the classification society, the concern on the root failure at the fillet welds in the bottom hull plate during the design life can be negligible. In addition, considering the transitional behavior of the distortion during the service life, the fillet leg length should be minimized.

• The Journal of Advanced Prosthodontics
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• v.14 no.3
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• pp.182-202
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• 2022

PURPOSE. The aim of this study is to summarize various biomechanical aspects in evaluating the long-term stability of dental implants based on finite element method (FEM). MATERIALS AND METHODS. A comprehensive search was performed among published studies over the last 20 years in three databases; PubMed, Scopus, and Google Scholar. The studies are arranged in a comparative table based on their publication date. Also, the variety of modeling is shown in the form of graphs and tables. Various aspects of the studies conducted were discussed here. RESULTS. By reviewing the titles and abstracts, 9 main categories were extracted and discussed as follows: implant materials, the focus of the study on bone or implant as well as the interface area, type of loading, element shape, parts of the model, boundary conditions, failure criteria, statistical analysis, and experimental tests performed to validate the results. It was found that most of the studied articles contain a model of the jaw bone (cortical and cancellous bone). The material properties were generally derived from the literature. Approximately 43% of the studies attempted to examine the implant and surrounding bone simultaneously. Almost 42% of the studies performed experimental tests to validate the modeling. CONCLUSION. Based on the results of the studies reviewed, there is no "optimal" design guideline, but more reliable design of implant is possible. This review study can be a starting point for more detailed investigations of dental implant longevity.

• Structural Engineering and Mechanics
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• v.58 no.5
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• pp.757-781
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• 2016

The results of diagnostics and analysis of an industrial hall located on the premises of a thermal power plant severely damaged by fire are presented in the paper. The comprehensive failure-related diagnostics, non-destructive and destructive tests of steel and concrete materials, geodetic surveying of selected structural members, numerical modelling, static analysis and reliability assessment were focused on two basic goals: The determination of the current technical condition of the load bearing structure and the assessment of its post fire resistance as well as assessing the degree of damage and subsequent design of reconstruction measures and arrangements which would enable the safe and reliable use of the building. The current mechanical properties of the steel material obtained from the tests and measured geometric characteristics of the structural members with imperfections were employed in finite element models to study the post-fire behaviour of the structure. In order to compare the behaviour of the numerically modelled steel roof truss, subjected to the effects of fire, with the real post-fire response of the damaged structure theoretically obtained resistance, critical temperature and the time at which the structure no longer meets the required reliability criteria under its given loading are compared with real values. A very good agreement between the simulated results and real characteristics of the structure after the fire was observed.