• Title/Summary/Keyword: compositional

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A guideline for the statistical analysis of compositional data in immunology

  • Yoo, Jinkyung;Sun, Zequn;Greenacre, Michael;Ma, Qin;Chung, Dongjun;Kim, Young Min
    • Communications for Statistical Applications and Methods
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    • v.29 no.4
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    • pp.453-469
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    • 2022
  • The study of immune cellular composition has been of great scientific interest in immunology because of the generation of multiple large-scale data. From the statistical point of view, such immune cellular data should be treated as compositional. In compositional data, each element is positive, and all the elements sum to a constant, which can be set to one in general. Standard statistical methods are not directly applicable for the analysis of compositional data because they do not appropriately handle correlations between the compositional elements. In this paper, we review statistical methods for compositional data analysis and illustrate them in the context of immunology. Specifically, we focus on regression analyses using log-ratio transformations and the alternative approach using Dirichlet regression analysis, discuss their theoretical foundations, and illustrate their applications with immune cellular fraction data generated from colorectal cancer patients.

Automatic Extraction Method of Compositional Herb Using Herb List (본초 목록을 이용한 방제의 본초 구성 자동 추출 방법)

  • Kim, Ki-Wook;Kim, Thae-Yul;Lee, Byung-Wook
    • Journal of Korean Medical classics
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    • v.27 no.3
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    • pp.155-166
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    • 2014
  • Objectives : Many keyboarding staff are required for compositional herb data entry from ancient documents. It's the most difficult thing to build DB. So, we have studied to solve this problem. Methods : We have used Windows 7 and Access2013 for automatic extraction compositional herb in the Taipinghuiminhejijufang(太平惠民和劑局方). First of all, we have made synonyms list of herbs and list of herb volumes notation. And than we have analyzied order of arrangements between names of herb and notations of herb volume. Results : We have analyzied a part of prescriptions in the Taipinghuiminhejijufang(太平惠民和劑局方) (519 prescriptions). After 91 seconds, we can complete automatic extraction of compositional herb from 519 prescriptions. Conclusions : If we can analyzie order of arrangements between names of herb and notations of herb volume, we can automatically extract compositional herb of prescription from ancient documents.

Ranking subjects based on paired compositional data with application to age-related hearing loss subtyping

  • Nam, Jin Hyun;Khatiwada, Aastha;Matthews, Lois J.;Schulte, Bradley A.;Dubno, Judy R.;Chung, Dongjun
    • Communications for Statistical Applications and Methods
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    • v.27 no.2
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    • pp.225-239
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    • 2020
  • Analysis approaches for single compositional data are well established; however, effective analysis strategies for paired compositional data remain to be investigated. The current project was motivated by studies of age-related hearing loss (presbyacusis), where subjects are classified into four audiometric phenotypes that need to be ranked within these phenotypes based on their paired compositional data. We address this challenge by formulating this problem as a classification problem and integrating a penalized multinomial logistic regression model with compositional data analysis approaches. We utilize Elastic Net for a penalty function, while considering average, absolute difference, and perturbation operators for compositional data. We applied the proposed approach to the presbyacusis study of 532 subjects with probabilities that each ear of a subject belongs to each of four presbyacusis subtypes. We further investigated the ranking of presbyacusis subjects using the proposed approach based on previous literature. The data analysis results indicate that the proposed approach is effective for ranking subjects based on paired compositional data.

Binary classification on compositional data

  • Joo, Jae Yun;Lee, Seokho
    • Communications for Statistical Applications and Methods
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    • v.28 no.1
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    • pp.89-97
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    • 2021
  • Due to boundedness and sum constraint, compositional data are often transformed by logratio transformation and their transformed data are put into traditional binary classification or discriminant analysis. However, it may be problematic to directly apply traditional multivariate approaches to the transformed data because class distributions are not Gaussian and Bayes decision boundary are not polynomial on the transformed space. In this study, we propose to use flexible classification approaches to transformed data for compositional data classification. Empirical studies using synthetic and real examples demonstrate that flexible approaches outperform traditional multivariate classification or discriminant analysis.

Comparison of Methods for Reducing the Dimension of Compositional Data with Zero Values

  • Song, Taeg-Youn;Choi, Byung-Jin
    • Communications for Statistical Applications and Methods
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    • v.19 no.4
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    • pp.559-569
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    • 2012
  • Compositional data consist of compositions that are non-negative vectors of proportions with the unit-sum constraint. In disciplines such as petrology and archaeometry, it is fundamental to statistically analyze this type of data. Aitchison (1983) introduced a log-contrast principal component analysis that involves logratio transformed data, as a dimension-reduction technique to understand and interpret the structure of compositional data. However, the analysis is not usable when zero values are present in the data. In this paper, we introduce 4 possible methods to reduce the dimension of compositional data with zero values. Two real data sets are analyzed using the methods and the obtained results are compared.

The Compositional Structure without a Mere lmplementation (한갓 구현이 아닌 구성적 구조)

  • Choi, Hoon
    • Korean Journal of Cognitive Science
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    • v.6 no.1
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    • pp.5-30
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    • 1995
  • Fodor and his followers argue that connectionist model does not have compositional structure,or else it is merely an implementation of a classicist model.'Classical constityency'is used importantly to show connectionist model does not have compositional structure.However,in contrast Fodor and his followers,I maintain that it is possible for connectionist model to have compositional structure without attributing classical constituency to cognitive model,and the very classical consitiuency makes the connectionist model nonimplementational.

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A Study on the Spatial Composition of Hyangdan (향단(香壇)의 건축공간(建築空間) 구성수법(構成手法) 연구(硏究))

  • Ro, Dong-Sung;Hong, Dae-Hyung
    • Journal of architectural history
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    • v.8 no.3 s.20
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    • pp.39-51
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    • 1999
  • The purpose of this study is to establish the theory of the spatial composition that is 'The Structure of Relation' in Korean traditional houses. This study has been focused on the spatial composition of Hyangdan. The form composition is an element defining primitive functions and space and producing aesthetical effects, where 'quality as a substance' is not important but 'quality as a relation' is essential. Quality as a meaningful relationship comes from realization and regulation of visual attributes among form elements. Each form compositional element establishes the hierarchical structure logically with the entire order, In order for the quality of all form compositional elements to be clarified as a meaningful relationship logically, 'compositional concept' which combines a series of form elements into the grammatical dependence to a specific direction, has to be assumed. If the intrinsic relationship among a series of form compositional elements fails to confront with the 'contextual concept' which eventually indicates unique conditions for a place according to the refined compositional concept, the result of form composition never leads to a specific solution

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Compositional and Contextual Factors Related to Area Differentials in Suicide (지역의 자살률 차이와 관련된 구성적 요인과 상황적 요인)

  • Kang, Eunjeong
    • Korean Journal of Health Education and Promotion
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    • v.30 no.1
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    • pp.41-52
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    • 2013
  • Objectives: Rural-urban differences in suicide have been observed in many settings. However, there has been little research addressing what factors can explain these differences. The purpose of this study was to analyze which compositional factors and contextual factors in local areas might be related to local suicide. Methods: The study design was cross-sectional. The data for 251 primary local governments on their age-standardized suicide mortality and their predefined indicators of compositional factors and contextual factors were obtained from Korean Statistical Information Service as of year 2010. Bivariate analysis including one-way ANOVA and chi-square test were used to identify the differences in local features by area type. Seven poisson regression models for each of total, males, and females were used to analyze which compositional and contextual factors were related to suicide. Results: There were differences in suicide between gu and goon in total, male, and female groups. For total, compositional factors including divorce and smoking rate, and contextual factors including financial independency, water and waterwaste coverage, and number of wastewater discharge factories were found to explain the urban-rural differences. Conclusions: This study provided some evidence that contextual factors at the local level as well as compositional factors are useful for predicting local suicide mortality.

A study on the shoulder composition methods of power shoulder jackets and corresponding details (파워숄더 재킷의 어깨 구성 방법과 디테일 대응 분석)

  • Park, Jeongah;Lee, Jeongran
    • The Research Journal of the Costume Culture
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    • v.29 no.3
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    • pp.388-405
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    • 2021
  • This study classifies the compositional methods of power shoulder jackets from 1980 to the present. It analyzes the relevance of jacket details according to how the power shoulder changes and its compositional methods by era. The research subdivides shoulder compositional techniques into seven, based on shoulder variation, sleeve variation, and the body and sleeve combination. The researcher investigates the frequency and trends of composing shoulders and analyzes details pertaining to the silhouette, jacket length, collar shape, and front closure. The most common method of shoulder composition is an angular shoulder variation. The others are a rounded shoulder variation, puffed sleeve, sleeve variation using pattern incision, raglan and kimono sleeves, and a shoulder variation that expanded the angle and width. The frequency differs slightly for each era. The relationship between shoulder compositional methods and details of power shoulder jackets is statistically significant, showing period-related differences. The homogeneity analysis results reveal that the shoulder composition of power shoulder jackets, the times, and details fall into distinct groups. This analysis shows that the silhouette, length, collar, and front closure of the power shoulder jacket differ depending on the power shoulder's compositional methods. Moreover, the shape of the power shoulder jacket is distinctly different. One can use this data to help develop the power shoulder jacket design by reflecting the details of shoulder compositional methods and changing trends over time.

A Study on the Properties of LDPE/LLDPE blends Prepared by Compositional Quenching Process (Compositional Quenching 공정에 의한 LDPE/LLDPE 블렌드의 물성에 관한 연구)

  • Cho, Soo-Min;Lee, Youngchul;Hwang, Seok-Ho;Lee, Sang-Won;Kim, Su-Kyung
    • Applied Chemistry for Engineering
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    • v.7 no.3
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    • pp.504-510
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    • 1996
  • Low-density polyethylene(LDPE)/Linear low-density polyethylene(LLDPE) blends were prepared by the compositional quenching process, a new morphology control method. The blends were characterized in terms of melting and crystallization behavior and mechanical properties. The results were compared with those of mechanically blended and solution blended samples. From DSC experiments, it was found that the melting temperatures and crystallization temperatures of the blends were dependent on the blending methods. In thermal property, LDPE/LLDPE blends prepared by compositional quenching process were similar to the blends prepared by solution blending but different from the blends prepared by mechanical blending. This result is explained to be due to the domain size dispersed in the matrix. The elongation-at-break and tensile strength of the samples blended by compositional quenching showed similar to those of the samples blended by solution blending method but larger than those of samples prepared by mechanical blending. Also, the Young's modulus showed the same trends as elongation-at-break. The tensile strength of the blends prepared by compositional quenching was not as high as the samples prepared by the other two blending methods.

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