• Food Science of Animal Resources
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• v.30 no.1
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• pp.66-72
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• 2010

Pediococcus pentosaceus SA131 was isolated from jeotgal, is the bacteriocin producer against bovine mastitis pathogens, Streptococcus uberis E290, Enterococcus gallinarum E362, and Staphylococcus epidermidis ATCC 12228. The medium composition for pediocin SA131 production by P. pentosaceus SA131 was optimized using response surface methodology. Component of medium was studied as carbon source (glucose, fructose, lactose, glycerol, sucrose, maltose, and mannitol), nitrogen source (beef extract, yeast extract, peptone, malt extract, and tryptone), mineral and surfactant ($MgSO_4$, $KH_2PO_4$, $(NH_4)_2SO_4$, $MnSO_4$, NaCl, sodium acetate, and Tween 80). Through one factor-at-a-time experiment, glucose, fructose, yeast extract, malt extract, NaCl, $MgSO_4$, and Tween 80 were determined as the good ingredient. The effects of major factors for pediocin SA131 production were investigated by two-level fractional factorial designs (FFD). By a $2^4$ FFD, fructose, yeast extract, and $MnSO_4$ were found to be the important factors for the bacteriocin production. Subsequently, a $2^3$ central composite design (CCD) was adopted to derive a statistical model for optimizing the composition of the fermentation medium. The estimated optimum composition for the production of pediocin SA131 by P. pentosaceus SA131 was as follows; 0.13% fructose, 1% glucose, 1.8% yeast extract, 2.58% $MnSO_4$, 0.2% NaCl, and 0.2% Tween 80. The pediocin production under optimized medium was increased to 1,000 AU/mL, compared to the 400 AU/mL in MRS medium.

• Journal of Periodontal and Implant Science
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• v.32 no.2
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• pp.325-338
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• 2002

Bone graft using growth factors and guided tissue regeneration have been used for the regeneration of infrabony defects which caused by periodontal disease. Calcium sulfate which is one of the resorbable barrier materials used for guided tissue regeneration. Platelet rich plasma which is a easy method to obtain the growth factors had many common points but, platelet rich plasma was still studying. This study was the comparative study between bone graft using platelet rich plasma and guided tissue regeneration using calcium sulfate barrier material in clinical view. For the study, 28 sites(2 or 3 wall infrabony defects) were treated. 14 infrabony defects were received surgical implantation of BBP-calcium sulfate composite with a calcium sulfate barrier and the others received BBP mixed with platelet rich plasma. Clinical outcome was accessed 3 and 6 months of postsurgery. 1. There was no statistical difference between CS group and PRP group in pocket depth, gingival recession, clinical attachment level, and probing bone level at baseline. 2. There was statistically significant reduction in probing depth, clinical attachment level, and probing bone level at 3 and 6 months postsurgery(p<0.05). 3. In the probing depth and clincial attachment level PPR group had less improvement than CS group, but there was no statistically difference at 3 and 6 months postsurgery. 4. In the recession PPR group had less recession than CS group, but there was no statistically difference at 3 and 6 months postsurgery. 5. In the probing bone level PPR group had less improvement than CS group, but there was no statistically difference at 6 months postsurgery. In conclusion bone graft using platelet rich plasma and guided tissue regeneration using calcium sulfate barrier showed similar clinical improvement for the treatment of 2 or 3 wall infrabony defects.

• Journal of Animal Science and Technology
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• v.53 no.3
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• pp.253-259
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• 2011

The aim of this work was to determine the method and predict the optimum conditions for egg quality stored for 7 days when combination treatments of irradiation and chitosan coating were applied using response surface methodology (RSM). A central composite design was chosen for the RSM in this study and the factors were irradiation dose (0~2 kGy) and concentration of chitosan coating material (0~2%). Performance of the irradiation and chitosan coating were evaluated by analyzing the egg quality and functional property factors. The predicted maximum level of Haugh units and foaming ability calculated by a developed model were 74.19 at 0 kGy of irradiation with coating by 0.96% chitosan solution and 50.83 mm at 2.0 kGy with 1.01%, respectively. The predicted minimum value of foam stability and 2-thiobarbituric acid reactive substances (TBARS) value were 2.97 mm at 0.39 kGy with 0.21% and 0.54 mg malonaldehyde/kg egg yolk at 0 kGy with 0.90% of chitosan solution, respectively. Results clearly showed that gamma irradiation negatively affected the Haugh unit and TBARS but positively affected the foaming capacity. The estimated value from the developed model by RSM was verified by no statistical difference with observed value. Therefore, RSM can be a good tool for optimization and prediction of egg quality when 2 or more treatments are combined. However, one should decide the target quality first to achieve a successful implementation of this technology.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.4 no.4
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• pp.395-404
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• 1994

Ni-graphite composite powders were prepared by reduction of $Ni^{++}$ from ammoniacal nickel sulfate solution on graphite core by hydrogen gas. Effect of reaction factors on the reduction rate and the properties of nickel layer were investigated by SEM, Optical Microscopy, size and chemical analysis. Induction period, a time lag between the injection of hydrogen gas and the start of the reduction, was 20~110 mins and affected by the reaction temperature and stirring speed. The reduction rate of $Ni^{++}$ was $4.5g/{\ell}/min$ at optimum condition and increased with increasing reaction temperature and stirring speed.

• Textile Coloration and Finishing
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• v.21 no.5
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• pp.41-50
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• 2009

Design of experiments (DoE) concept was successfully applied to determine the optimum processing conditions that yield maximum % exhaustion for berberine interaction with synthetic tanning agent pretreated polyamide substrates. The potential of synthetic tanning agent to provide anionic sites on the polyamide for berberine interaction which is cationic in nature was tested to increase the % exhaustion of berberine in this article. Experiments were designed according to Central Composite Rotatable Design (CCRD). The three factors for synthetic tanning agent pretreatment and two factors for berberine interaction each at five different levels, including central and axial points were considered. Experiments were conducted in a laboratory scale infra-red treatment instrument according to CCRD. For each response, second order polynomial models were developed using multiple linear regression analysis incorporating linear, interactions and squared effects of all variables and then optimized. The significance of the mathematical model developed was ascertained using Excel regression (solver) analysis module. Analysis of variance (ANOVA) was performed to check the adequacy and accuracy of the fitted models. The response surfaces and contour maps showing the interaction of process variables were constructed. Applying Monte Carlo simulation, response surface and contour plots, optimum operating conditions were found and at this optimum point, % exhaustion of 81% and 74% respectively for synthetic tanning agent pretreatment and berberine interaction were observed and subsequently the results were experimentally investigated.

• Smart Structures and Systems
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• v.22 no.3
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• pp.335-340
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• 2018

The behavior of concrete slabs in composite beam with C and L shaped angle shear connectors has been studied in this paper. These two types of angle shear connectors' instalment have been commonly utilized. In this study, the finite element (FE) analysis and soft computing method have been used both to present the shear connectors' push out tests and providing data results used later in soft computing method. The current study has been performed to present the aforementioned shear connectors' behavior based on the variable factors aiming the study of diverse factors' effects on C and L shaped angle in shear connectors. ANFIS (Adaptive Neuro Fuzzy Inference System), has been manipulated in providing the effective parameters in shear strength forecasting by providing input-data comprising: height, length, thickness of shear connectors together with concrete strength and the respective slip of shear connectors. ANFIS has been also used to identify the predominant parameters influencing the shear strength forecast in C and L formed angle shear connectors.

• Environmental Engineering Research
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• v.15 no.2
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• pp.63-70
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• 2010

In this study, the response surface method and experimental design were applied as an alternative to conventional methods for the optimization of coagulation tests. A central composite design, with 4 axial points, 4 factorial points and 5 replicates at the center point were used to build a model for predicting and optimizing the coagulation process. Mathematical model equations were derived by computer simulation programming with a least squares method using the Minitab 15 software. In these equations, the removal efficiencies of turbidity and total organic carbon (TOC) were expressed as second-order functions of two factors, such as alum dose and coagulation pH. Statistical checks (ANOVA table, $R^2$ and $R^2_{adj}$ value, model lack of fit test, and p value) indicated that the model was adequate for representing the experimental data. The p values showed that the quadratic effects of alum dose and coagulation pH were highly significant. In other words, these two factors had an important impact on the turbidity and TOC of treated water. To gain a better understanding of the two variables for optimal coagulation performance, the model was presented as both 3-D response surface and 2-D contour graphs. As a compromise for the simultaneously removal of maximum amounts of 92.5% turbidity and 39.5% TOC, the optimum conditions were found with 44 mg/L alum at pH 7.6. The predicted response from the model showed close agreement with the experimental data ($R^2$ values of 90.63% and 91.43% for turbidity removal and TOC removal, respectively), which demonstrates the effectiveness of this approach in achieving good predictions, while minimizing the number of experiments required.

• Journal of the Korean Solar Energy Society
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• v.32 no.5
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• pp.68-74
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• 2012

Investigation of the effective soil thermal conductivity($k$) is the first step in designing the ground loop heat exchanger(borehole) of a geothermal heat pump system. Another important factor is the borehole thermal resistance($R_b$). Thermal response tests offer a good method to determine the ground thermal properties for the total heat transport in the ground. The first step is measured for initial soil temperature. This is done by supplying a only pump power into a borehole heat exchanger. They need to supply into water unload heat power more than 30 minutes. In this study, the initial soil temperature was found to analysis $14.1{\sim}16.0^{\circ}C$,the ratio was 68.7% represented. In this case of $k$, was 2.1~3.0 $W/m{\cdot}k$, $R_b$ was 0.11~0.20 $m{\cdot}K/W$. In this work, it is also shown that the distribution of a soil thermal conductivity and borehole thermal resistance were on the influence of initial soil temperature. And soil thermal conductivity was related with factors of equation by linear least square method, borehole thermal resistance was on the influence of composite factors.

• Structural Engineering and Mechanics
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• v.22 no.6
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• pp.665-683
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• 2006

The strength behaviors of Fiber Reinforced Plastics (FRP) Composites can be greatly influenced by the properties of constitutive materials, the laminate structures, and load conditions etc, accompanied by many uncertainty factors. So the reliability study on FRP is an important subject of research. Many achievements have been made in reliability studies based on the probability theory, but little has been done on the roles played by fuzzy variables. In this paper, a fuzzy reliability model for FRP laminates is established first, in which the loads are considered as random variables and the strengths as fuzzy variables. Then a numerical model is developed to assess the fuzzy reliability. The Monte Carlo simulation method is utilized to compute the reliability of laminas under the maximum stress criterion. In the second part of this paper, a generalized fuzzy reliability model (GFRM) is proposed. By virtue of the fact that there may exist a series of states between the failure state and the function state, a fuzzy assumption for the structure state together with the probabilistic assumption for strength parameters is adopted to construct the GFRM of composite materials. By defining a generalized limit state function, the problem is converted to the conventional reliability formula that enables the first-order reliability method (FORM) applicable in calculating the reliability index. Several examples are worked out to show the validity of the models and the efficiency of the methods proposed in this paper. The parameter sensitivity analysis shows that some of the mean values of the strength parameters have great influence on the laminated composites' reliability. The differences resulting from the application of different failure criteria and different fuzzy assumptions are also discussed. It is concluded that the GFRM is feasible to use, and can provide an effective and synthetic method to evaluate the reliability of a system with different types of uncertainty factors.

• Journal of Korean Society of Steel Construction
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• v.18 no.5
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• pp.535-542
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• 2006

In this study, the effects of cross beams on the lateral distribution of live loads in composite rolled H-beam girder bridges, were investigated through three-dimensional finite element analysis. The parameters considered in this study were the inertial moment ratio between the main girder and the cross beam, the presence of the cross beam, and the number of cross beams. The live load lateral distribution factors were investigated through finite element analysis and the customary grid method. The results show that there was no difference between the bridge models with and without a cross beam. The cross beam of the beam and frame types also showed almost the same live load lateral distribution factors. However, the finite element analysis showed that the concrete slab deck plays a major role in the lateral distribution of a live load, and consequently, the effect of the cross beam is not so insignificant that it can be neglected.