• Title/Summary/Keyword: complex system products

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Non-Ionic Surfactants Antagonize Toxicity of Potential Phenolic Endocrine-Disrupting Chemicals, Including Triclosan in Caenorhabditis elegans

  • Alfhili, Mohammad A.;Yoon, Dong Suk;Faten, Taki A.;Francis, Jocelyn A.;Cha, Dong Seok;Zhang, Baohong;Pan, Xiaoping;Lee, Myon-Hee
    • Molecules and Cells
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    • v.41 no.12
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    • pp.1052-1060
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    • 2018
  • Triclosan (TCS) is a phenolic antimicrobial chemical used in consumer products and medical devices. Evidence from in vitro and in vivo animal studies has linked TCS to numerous health problems, including allergic, cardiovascular, and neurodegenerative disease. Using Caenorhabditis elegans as a model system, we here show that short-term TCS treatment ($LC_{50}$: ~0.2 mM) significantly induced mortality in a dose-dependent manner. Notably, TCS-induced mortality was dramatically suppressed by co-treatment with non-ionic surfactants (NISs: e.g., Tween 20, Tween 80, NP-40, and Triton X-100), but not with anionic surfactants (e.g., sodium dodecyl sulfate). To identify the range of compounds susceptible to NIS inhibition, other structurally related chemical compounds were also examined. Of the compounds tested, only the toxicity of phenolic compounds (bisphenol A and benzyl 4-hydroxybenzoic acid) was significantly abrogated by NISs. Mechanistic analyses using TCS revealed that NISs appear to interfere with TCS-mediated mortality by micellar solubilization. Once internalized, the TCS-micelle complex is inefficiently exported in worms lacking PMP-3 (encoding an ATP-binding cassette (ABC) transporter) transmembrane protein, resulting in overt toxicity. Since many EDCs and surfactants are extensively used in commercial products, findings from this study provide valuable insights to devise safer pharmaceutical and nutritional preparations.

Characterization and Mechanical Properties of Stainless Steel 316L Fabricated Using Additive Manufacturing Processes (적층식 제조 공정을 활용한 스테인레스 316L 제작기술의 특징과 기계적 속성)

  • Choi, Cheol;Jung, Mihee
    • KEPCO Journal on Electric Power and Energy
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    • v.7 no.1
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    • pp.129-135
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    • 2021
  • Recently, additive manufacturing (AM) technology such as powder bed fusion (PBF) and directed energy deposition (DED) are actively attempted as consumers' needs for parts with complex shapes and expensive materials. In the present work, the effect of processing parameters on the mechanical properties of 316L stainless steel coupons fabricated by PBF and DED AM technology was investigated. Three major mechanical tests, including tension, impact, and fatigue, were performed on coupons extracted from the standard components at angles of 0, 45, 90 degrees for the build layers, and compared with those of investment casting and commercial wrought products. Austenitic 316L stainless steel additively manufactured have been well known to be generally stronger but highly vulnerable to impact and lack in elongation compared to casting and wrought materials. The process-induced pore density has been proved the most critical factor in determining the mechanical properties of AM-built metal parts. Therefore, it was strongly recommended to reduce those lack of fusion defects as much as possible by carefully control the energy density of the laser. For example, under the high energy density conditions, PBF-built parts showed 46% higher tensile strength but more than 75% lower impact strength than the wrought products. However, by optimizing the energy density of the laser of the metal AM system, it has been confirmed that it is possible to manufacture metal parts that can satisfy both strength and ductility, and thus it is expected to be actively applied in the field of electric power section soon.

Analysis of Image Similarity Index of Woven Fabrics and Virtual Fabrics - Application of Textile Design CAD System and Shuttle Loom - (직물과 가상소재의 화상 유사성 분석 연구 - 수직기 및 텍스타일 CAD시스템 활용 -)

  • Yoon, Jung-Won;Kim, Jong-Jun
    • Fashion & Textile Research Journal
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    • v.15 no.6
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    • pp.1010-1017
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    • 2013
  • Current global textiles and fashion industries have gradually shifted focus to high value-added, high sensibility, and multi-functional products based on new human-friendliness and sustainable growth technologies. Textile design CAD systems have been developed in conjunction with computer hardware and software sector advances. This study compares the patterns or images of actual woven fabrics and virtual fabrics prepared with a textile design CAD system. In this study, several weave structures (such as fancy yarn weave and patterns) were prepared with a shuttle loom. The woven textile images were taken using a CCD camera. The same weave structure data and yarn data were fed into a textile design CAD system in order to simulate fabric images as similarly as possible. Similarity Index analysis methods allowed for an analysis of the index between the actual fabric specimen and the simulated image of the corresponding fabric. The results showed that repeated small pattern weaves provide superior similarity index values than those of a fancy yarn weave that indicate some irregularities due to fancy yarn attributes. A Complex Wavelet Structural Similarity(CW-SSIM) index resulted in a better index than other methods such as Multi-Scale(MS) SSIM, and Feature Similarity(FS) SSIM, across fabric specimen images. A correlation analysis of the similarity index based on an image analysis and a similarity evaluation by panel members was also implemented.

The Effectiveness of Independent Verification and Validation of Safety-critical Aviation Systems (항공 안전 필수 시스템에 대한 독립적 검증 및 확인의 효과도 분석)

  • Kim, Young-Hoon;Yoo, Beong-Seon;Kang, Ja-Young
    • Journal of Advanced Navigation Technology
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    • v.21 no.2
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    • pp.155-162
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    • 2017
  • In recent years, aviation-related safety-critical systems have been developed in Korea, but these products have not satisfied the specified requirements and thus have not been commercialized or commercialized. Due to increasing complexity of the modern aviation system, traditional verification and validation techniques are not sufficient to identify and reduce latent risks in the system. To overcome this shortcoming, a new method which is called 'Independent verification and validation (IV&V)' is suggested. However, academic researches on the effectiveness of this independent verification and validation have not been conducted domestically, and it is performed very rarely even overseas. Therefore, in this paper, we investigated the application of independent verification and validation of the safety-critical aviation systems performed by advanced aviation organizations, and analyzed various positive effects on projects. As a result of the analysis, IV&V shows that early error detection rate is increased, potential risk is mitigated early, and the complex reworking probability, which appears later in the development life cycle, is reduced, greatly preventing the development schedule and costs from increasing.

Magnetic Levitated Electric Monorail System for Flat Panel Display Glass Delivery Applications (FPD 공정용 Glass 이송 시스템을 위한 자기부상 EMS의 개발)

  • Lee, Ki-Chang;Moon, Ji-Woo;Koo, Dae-Hyun;Lee, Min-Cheol
    • Journal of Institute of Control, Robotics and Systems
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    • v.17 no.6
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    • pp.566-572
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    • 2011
  • In recent semiconductor and FPD (Flat Panel Display) manufacturing processes, high clean-class delivery operation is required more and more for short working time and better product quality. Traditionally SLIM (Single-sided Linear Induction Motor) is widely used in the liner drive applications because of its simplicity in the rail structure. A magnetically levitated (Maglev) unmanned vehicle with SLIM traction, which is powered by a CPS (Contactless Power Supply) can be a high precision delivery solution for this industry. In this paper unmanned FPD-carrying vehicle, which can levitate without contacting the rail structure, is suggested for high clean-class FPD delivery applications. It can be more acceptable for the complex facilities composed with many processes which require longer rails, because of simple rail structure. The test setup consists of a test vehicle and a rounded rail, in which the vehicle can load and unload products at arbitrary position commanded through wireless communications of host computer. The experimental results show that the suggested vehicle and rail have reasonable traction servo and robust electromagnetic suspensions without any contact. The resolution of point servo errors in the SLIM traction system is accomplished under 1mm. The maximum gap error is ${\pm}0.25mm$ with nominal air gap length of 4.0mm in the electromagnetic suspensions. This type of automated delivery vehicle is expected to have significant role in the clean delivery like FPD glass delivery.

The Representation Methodology for the Ship Model based on Product Model (제품모델을 기호로 한 선박모델의 표현방법론)

  • W.S. Kang;S.W. Suh;D.W. Shin;K.O. Lee;K.Y. Lee
    • Journal of the Society of Naval Architects of Korea
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    • v.29 no.4
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    • pp.45-57
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    • 1992
  • In this paper, the trends for the standardization of the product model was surveyed, and the product model can be used as concrete means to realize the communication of information between the CAD/CAM softwares, which are used for the design and manufacturing of the complex products such as ships. We have proposed the newly developed methodology for the representation and definition of the ship model on a basis of the product model. And also we have studied the product modeling technology for the aspect of an application, and the object-oriented system technology have been surveyed for the system implementation issues. We would like to verify the consistency and correctness of our proposed representation methodology by using the prototype application model, which is applied to design work of ship compartmentation model. For this purpose we have developed the "OO_COMDEF"(which means the Object-Oriented System for the Compartmentation Definition of ship) program that is applied to the compartmentation model which can be considered as a submodel of the general ship models. The results of research work have been proved that the representation methodology for the ship model based on the product model is an efficient and appropriate scheme for the ship model definitions. Consequently, this methodology can be proposed as a fundamental framework for the development of the shipbuilding CAD/CAM system.

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A Study on the Treatment of Combustible Wastes and the Resource Recovery by Pyrolysis (熱分解에 의한 可燃性 廢棄物의 처리 및 資源回收에 관한 연구)

  • Kim, Sam-Cwan;Zong, Moon-Shik
    • Journal of Environmental Health Sciences
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    • v.13 no.1
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    • pp.17-33
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    • 1987
  • As a result of technical advances and industrialization, the characteristics of domestic and industrial wastes are becoming more complex. Accordingly, improved treatment and disposal systems are being continuously sought to take account of complex characteristics and to comply with economic restrictions. In this study, an application of pyrolysis to the treatment of industrial wastes, including waste scrap rubber, waste raw material used in making the slipper bottom and waste PVC pipe, and the effectiveness of pyrolysis in resource recovery from these wastes were investigated. Batches of wastes were pyrolysed by external heating to a temperature of 400-800$\circ$C in a 32 mm diameter x 0.9 m long silica tube to produce combustible gases, oils and chars. Before the start of pyrolysis runs, the entire system was purged with nitrogen gas to exclude the air. The temperature inside the retort was controlled by the thermocouple in the gas stream, and referred to as the pyrolysis temperature. Under these conditions three products were separately collected and further analyzed. The results were summarized as follows. 1. More gases and less chars were produced with higher pyrolyzing temperature and with higher rates of heating, but the yields of oils tended downwards at temperatures above 700$\circ$C. Accordingly, operating conditions of pyrolysis should be varied with desired material. 2. Calorific values and sulfur contents of produced oils were sufficient and suitable for fuel use. Chars from waste rubber had high heating values with low sulfur contents, but calorific values of chars from waste PVC and waste slipper were as low as 3, 065-4, 273 kcal/kg and 942-2, 545 kcal/kg, respectively. Therefore, char from these wastes are inappropriate for fuel. 3. Soluble contents of Pb, Cd, Cu and Zn in chars from waste rubber and waste slipper were below the Specific Hazardous Waste Treatment Standards. However soluble contents of Pb and Cd in chars from waste PVC were one or two times and five or seven times exceedingly the Specific Hazardous Waste Treatment Standards, respectively. 4. Post high heating is desirable for treatment method of waste PVC which generates toxic hydrogen chloride. 5. The proportions of hydrogen, methane and ethane in produced gases were in the range of 3.99-35.61% V/V, 18.22-32.50% V/V and 5.17-5.87% V/V, respectively. 6. Pyrolysis is a useful disposal method in case of waste slipper, which was hardly combustible, and thus investigations of this kind of materials are required for effective management of industrial waste. 7. Based upon the possible market development for products, overall pyroly economics to take account of treatment values of noncombustible or hazardous materials should be evaluated.

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$Hg^{2+}$-induced Aquation of trans-[Co(3,2,3-tet)$X_2]^+$ (3,2,3-tet = 4,7-diazadecane-1,10-diamine, $X_2\;=\;Cl_2,\;(NO_2)Cl,\;Br_2,\;(NO_2)Br,\;and\;(NO_3)_2)$ Complexes in Aqueous Solution (수용액에서 $Hg^{2+}$에 의한 trans-[Co(3,2,3-tet)X$_2]^+$ (3,2,3-tet = 4,7-diazadecane-1,10-diamine, $X_2\;=\;Cl_2,\;(NO_2)Cl,\;Br_2,\;(NO_2)Br,\;(NO_3)_2)$ 착물의 아쿠아 반응)

  • Doo Cheon Yoon;Chang Eon Oh;Myung Ki Doh
    • Journal of the Korean Chemical Society
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    • v.37 no.11
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    • pp.951-960
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    • 1993
  • $Hg^{2+}$-induced aquation trans-[Co(3,2,3-tet)$X_2]^+$(3,2,3-tet = 4,7-diazadecane-1,10-diamine, $X_2\;=\;Cl_2,\;(NO_2)Cl,\;Br_2,\;(NO_2)Br,\;(NO_3)_2)$ complexes was investigated in aqueous solution. The products and the reaction mechanism were confirmed by chromatography, UV/Vis. spectrum, and circular dichroism (CD) spectrum. From the results, $Hg^{2+}$-induced aquation of 3,2,3-tet system has been produced cis-${\beta}$ complex via trans complex. The kinetic studies on $Hg^{2+}$-induced aquation of trans-[Co(3,2,3-tet)$Cl_2]^+$ complex and trans-[Co(3,2,3-tet)$(NO_2)Cl]^+$ complex were also carried out to study the reaction mechanism. The results show that trans-[Co(3,2,3-tet)$Cl_2]^+$ complex undergoes the D(dissociative)-mechanism and trans-[Co(3,2,3-tet)$(NO_2)Cl]^+$ complex $I_d$(interchange dissociavite)-mechanism. In order to confirm steric course for the reaction mechanism, $Hg^{2+}$-induced aquation on trans-[Co(R,R-3,2,3-tet)$Cl_2]^+$ complex to which chiral R,R-3,2,3-tet was coordinated instead of the racemic(R,R:S,S) 3,2,3-tet was used has been examined by CD spectrum. From the results, the final complex was confirmed to be ${\Delta}-cis-{\beta}$-[Co(R,R-3,2,3-tet)$(OH_2)_2]^{3+}$ complex indicating the chirality was retained through whole process.

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A study for promoting tourism craftwork of Kangwondo (강원도 관광공예품 육성방안에 관한 연구)

  • Lee, Mi-Suk
    • Korean Business Review
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    • v.21 no.1
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    • pp.73-90
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    • 2008
  • Kangwondo has been focused on tourism resource cultivation using beautiful scenery, because it was difficult to develop large scaled industrial complex by reason of human geography. In addition, after the implementation of local autonomy system, Kangwondo has been promoting various programs for local development using tourism resource which is the more dominate than any other province. This study will present the right way of tourism craftwork development which represents the regional emotion and character as a part of tourism and local policy of Kangwondo. I have recognized the problems of the craftwork such as design, products and companies, and tried to find related agency, support policy and its promoting programs to solve them.

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The Microcosm study for evaluating biobarrier application on sequential degradation of TCE products by Gasoline-Degradaing Mixed Culture

  • Lee, Jae-Sun;Lee, Si-Jin;Lee, Young-Kee;Chang, Soon-Woong
    • 한국생물공학회:학술대회논문집
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    • 2003.10a
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    • pp.440-444
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    • 2003
  • A new approach for ground water treatment combines a permeable Fe(0) barrier to breakdown higher chlorinated solvents like PCE and TCE with a down gradient aerobic biological treatment system to biotransform less chlorinated solvents, such as DCE and vinyl chloride (VC). The expected bacterial performance down gradient of an Fe(0) barrier was evaluated through laboratory batch experiments with a toluene-degrading mixed culture that cometabolically transforms cis-1,2-DCE and VC. The amount of cis-1,2-DCE (initially at 2,000 ppb) and VC (initially at 2,000 ppb) transformed was controlled by the initial toluene(20,000 ppb) concentration. VC was removed much more effectively than Cis-1,2-DCE, and a higher toluene concentration in comparison to the co-substrate concentrations was needed for complete co-substrate removal. Overall, the coupling of an Fe(0) barrier and subsequent biodegradation appears feasible for remediation of complex mixtures of chlorinated solvents and petroleum hydrocarbons in groundwater.

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