• YAKHAK HOEJI
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• v.16 no.3
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• pp.113-120
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• 1972

The last decade of this centry is now the accepted birth date of that sub-discipline of pharmacy that is now called 'biopharmceutics'. Wagner defines biopharmaceutics 'as the study of the influence of fomulation on the therapeutic activity of a drug product.' More specifically, he states that biopharmaceutics encompasses the study of the relationship between the nature and intensity of the biological effects observed in animals or man and the following factors: 1. The nature of the form of the drug (ester, salt, complex, etc). 2. The physical state, particle size, and surface area. 3. Presence or absence of adjuvants with the drug. 4. The type of dosage form in which the drug is administered. 5. The pharmaceutical process (es) used to make the dosage form. The philosophy inherent in this definition has revolutionized our thinking with respect to product development, quality control, and to the practice of pharmacy itself. Althoughthe the emphasis herein will be on quality control, the interrelationship between this and the other areas of pharmacy will be evident. The principles of quality control dictate that a wide variety of techniques be used to evaluate the quality of a dosage form. Since quality must be built into a dosage form, the pharmaceutical scientist begins the process at the research stage, continues it during the production stage, and ends it by applying the tests and procedures established by parmacopeial commissions. These stages are usually separate and distinct and, because of this, product quality has become synonymous with compliance with pharmacopeial specifications.

• 한국생물공학회:학술대회논문집
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• 2000.04a
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• pp.516-519
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• 2000

Generally pancreas consist of lipid, water and protein, digestion enzyme complex (pro-tease, lipase, amylase). The sample used in this work was frozen dry and treated by a semi-batch flow type. In order to develop a supercritical fluid extraction process to rem-ove lipid from the pancreas, experiments were conducted at various operating conditions(pressure range $1500{\sim}2800psi$, temperature range $25{\sim}40^{cdot}C$, particle size$(0.25{\sim}1.0mm$, flow rate $20{\sim}80m{\ell}/min)$. Also cholesterol in the pancreas was removed. The highest extraction efficiency was 2500psi, $35^{\cdot}C$, 0.25mm of pancreas size. The enzyme activity of the pancreas produced from this work showed high value compared with imported pancreas.

• The Transactions of the Korean Institute of Power Electronics
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• v.11 no.5
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• pp.471-479
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• 2006

Automatic transfer equipments of manufacturing and process line trend toward big size as LCD glass is big size, heavy weight. The conventional stocker uses rotational motor and mechanical power converter device as travel axis of stocker crane and then frequent maintenances by complex structure and mechanical friction are required. Also it has problem to minimize the particle generation. To solve these problems, this paper verified the performance of permanent magnet(PM) excited transverse flux linear motor(TFLM) that is big power density per unit volume applied for travel axis of 7 generation stocker that is being big size, high power, long distance by the experiment based on proposed control algorithm, controller and power converter device.

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2003.10a
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• pp.24-29
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• 2003

Deep sea water has cold temperature, abundant nutrients and minerals, and good water quality that is pathogen-free and stable. Compared with surface water, deep sea water contains more nutrition salt, such as nitrogen and phosphor. Moreover, if has the good balance of minerals. Because of the ability of the spray drying process to produce a free-flowing power considering of spherical particles with a well-defined size distribution and the rapid drying times for heat-sensitive material, spray drying is attractive for a wide range of applications spray drying is a unique unit operation in which powders are produced from a liquid feed in a single processing step. Key component of the process are atomizer, spray chamber. Design of spray chamber should be based on the atomizer type, the production rate, and the particle size required. Because of the complex processes taking place during spray drying, traditional design method are based on pilot-plant tests and empirical scale-up rules. Modern technique such as CFD have a role to play in design and troubleshooting.

• Proceedings of the Korean Society For Composite Materials Conference
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• 2001.10a
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• pp.87-90
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• 2001

In particle or short-fiber reinforced composites, cracking of the reinforcements is a significant damage mode because the broken reinforcements lose load carrying capacity. This paper deals with elastic stress distributions and load carrying capacity of intact and cracked ellipsoidal inhomogeneities. Three dimensional finite element analysis has been carried out on intact and broken ellipsoidal inhomogeneities in an infinite body under pure shear. For the intact inhomogeneity, as well known as Eshelby(1957) solution, the stress distribution is uniform in the inhomogeneity and non-uniform in the surrounding matrix. On the other hand, for the broken inhomogeneity, the stress in the region near crack surface is considerably released and the stress distribution becomes more complex. The average stress in the inhomogeneity represents its load carrying capacity, and the difference of average stresses between the intact and broken inhomogeneities indicates the loss of load carrying capacity due to cracking damage. The load carrying capacity of the broken inhomogeneity is expressed in terms of the average stress of the intact inhomogeneity and some coefficients. It is found that the broken inhomogeneity with higher aspect ratio still maintains higher load carrying capacity.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.39 no.3
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• pp.253-260
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• 2015

Particle contamination in a cleanroom is very complex with a complicated process and several pieces of spreading equipment. Detailed information on the locations of the contamination sources and the path of the contamination is needed for economical and efficient control of the contaminant particles in such a cleanroom. An allocation method was developed to quantitatively predict the contamination generated from the pollution sources. In this paper, we propose a zoning method to accelerate the computation time for estimating the contributions. Our results showed that we can quantitatively estimate the amount of contamination generated from pollution sources.

• Journal of Korean Society of Water and Wastewater
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• v.28 no.3
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• pp.277-286
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• 2014

Water discolouration and increased turbidity in the local water service distribution network occurred from hydraulic incidents such as drastic changes of flow and pressure at large consumer. Hydraulic incidents impose extra shear stresses on sediment layers in the network, leading to particle resuspension. Therefore, real time measuring instruments were installed for monitoring the variation of water flow, pressure, turbidity and particulates on a hydrant in front of the inlet point of large apartment complex. In this study, it is attempted to establish a more stable water supply plan and to reduce complaints from customers about water quality in a district metering area. To reduce red or black water, the water flow monitoring and control systems are desperately needed in the point of the larger consumers.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.27 no.11
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• pp.1637-1644
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• 2003

Stereoscopic particle image velocimetry is a measurement technique to acquire three dimensional velocity field by two cameras. With a laser sheet illumination, the third velocity component can be deduced from out-of$.$plane velocity components using a stereoscopic matching method. Most industrial fluid flows are three dimensional turbulent flows, so it is necessary to use the stereoscopic PIV measurement method. However the existing stereoscopic PIV system seems hard to use since it is very expensive and complex. In this study we have developed a Miniature Stereo-PIV(MSPIV) system based on the concept of the Miniature PIV system which we have already developed. In this paper, we address the design and some primitive experimental results of the Miniature Stereo-PIV system. The Miniature Stereo-PIV system features relatively modest performances, but is considerably smaller, cheaper and easy to handle. The proposed Miniature Stereo-PIV system uses two one-chip-only CMOS cameras with digital output. Only two other chips are needed, one for a buffer memory and one for an interfacing logic that controls the system. Images are transferred to a personal computer (PC) via its standard parallel port. No extra hardware is required (in particular, no frame grabber board is needed).

• Asian Journal of Atmospheric Environment
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• v.9 no.1
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• pp.91-99
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• 2015

The Multi-wavelength Raman LIDAR (MRL) system was developed to enable a better understanding of the complex properties of aerosols in the atmosphere. In this study, the microphysical, optical, and radiative properties of mixed aerosols were retrieved using the discrete aerosol observation products from the MRL. The dust mixing ratio, which is the proportion of dust particles to the total mixed, was derived using the particle depolarization ratio. It was employed in the retrieval of backscattering and extinction coefficient profiles for dust and non-dust particles. The vertical profiles of aerosol optical properties were then used as input parameters in the inversion algorithm for the retrieval of microphysical parameters including the effective radius, refractive index, and the single scattering albedo (SSA). Those products were successfully applied to an analysis of radiative flux using a radiative transfer model. The relationship between the MRL derived extinction and aerosol radiative forcing (ARF) in short-wavelength was assessed over Gwangju, Korea. The results clearly demonstrate that the MRL-derived extinction profiles are a good surrogate for use in the estimation of optical, microphysical, and radiative properties of aerosols. It is considered that the analytical results shown in this study can be used to provide a better understanding of air quality and the variation of local radiative effects due to aerosols.

• Structural Engineering and Mechanics
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• v.4 no.3
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• pp.227-242
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• 1996

An important class of problems in the field of geotechnical engineering may be analyzed with the aid of a simple integro-differential equation. Behavior of "rigid" piles(say concrete piles), "deformable" piles(say gravel piles), pile groups, pile-raft foundations, heavily reinforced earth, flow within circular silos and down drag on cylindrical structures (for example the crusher unit of a mineral processing complex) are the type of situations that can be handled by this type of equation. The equation under consideration has the form; $$\frac{{\partial}w(r,\;z)}{{\partial}z}+f(z){\int}^z_0g({\xi})(\frac{{\partial}^2w(r,\;{\xi})}{{\partial}r^2}+\frac{1}{r}\frac{{\partial}w(r,\;{\xi})}{{\partial}r})d{\xi}+h(r,\;z)=0$$ where w(r, z) is the vertical displacement of a soil particle expressed as a function of the polar cylindrical space coordinates (r, z) and the symbols f, g and h represent soil properties and the loading conditions. The merit of the analysis is its simplicity (both in concept and in application) and the ease with which it can be expressed in a computer code. In the present paper the analysis is applied to investigate the behavior of a single rigid pile to bedrock. The emphasis, however, is placed on developing the equation, the numerical techique used in its evaluation and validation of the technique, hereafter called the ID technique, against a formal program, CRISP, which uses the FEM.