• Journal of Dairy Science and Biotechnology
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• 제36권3호
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• pp.164-170
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• 2018

본 연구에서는 CPP와 CSO를 사용하여 약 187~282 nm 크기의 균일한 구형의 나노 복합체를 성공적으로 제조하였다. 나노 복합체는 제조 공정 요인인 CPP 농도와 pH 조절을 통해 입자 크기, 다분산 지수, 그리고 표면 전하와 같은 나노 복합체의 물리화학적 특성을 조절할 수 있음을 확인하였다. 또한 CPP/CSO 나노 복합체의 분말화 공정을 통해 분말화 된 나노 복합체의 식품 적용성을 증진시킬 수 있음을 알 수 있었으며, food-grade 물질인 CPP와 CSO를 사용하여 제조한 나노 복합체는 향후 잠재적인 칼슘 전달체로써 식품 산업에 이용될 수 있을 것으로 기대된다.

• Composites Research
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• 제15권3호
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• pp.11-17
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• 2002

본 연구에서는 분산형 강화복합재료에 균열이 발생하면 하중부하능력이 감소와 더불어 재료의 손상을 초래할 수 있어 재료의 완전한 게재물과 균열이 존재한 게재물이 있는 경우를 상정하여 하중부하능력과 탄성 음력분포를 평가한다. 무한체가 전단음력을 받을 때 완전한 게재물과 균열이 내재한 경우에 대하여 3차원 유한요소해석이 수행되어 완전한 게재물의 경우는 게재물의 영역의 음력은 동일하고 게재물의 계면은 다소 불균일하게 나타났다. 그리고 균열이 내재한 경우에는 균열주변에는 음력이 집중되는 경우를 볼수 있을 뿐만아니라 아주 복잡한 분포를 볼수 있었다. 불균질물의 평균응력은 하중부하능력으로 표현이 가능하였고 완전만 게재물과 균열의 경우도 균열손상에 의해 하중부하능력의 차이를 볼 수 있었다. 특히, 균열이 내재한 경우에 에스펙터비(aspect ratio)가 증가할수록 하중부하능력이 증가함을 알 수 있었다.

• 터널과지하공간
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• 제25권4호
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• pp.359-372
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• 2015

암반에는 단층, 절리, 층리 등의 불연속면이 많이 포함되어 있다. 이러한 불연속면은 기하학적 복합성에 의해 복잡한 구조로 나타난다. 이 연구는 스텝으로 배열된 두 전단균열의 끝에서 나타나는 구조 발달을 수치해석적으로 연구하였다. 이 연구에서는 PFC2D(Particle Flow Code) 프로그램을 이용하여 두 전단균열의 끝에서 형성되는 초기균열(incipient fracture)뿐만 아니라 초기균열에서 덧자라는 균열의 성장과정을 살펴보았으며, 균열 발생 시 나타나는 주변응력상태를 관찰하였다. 모든 실험 결과에서는 균열 끝에서 발생한 초기 균열 대부분이 인장균열에 의한 것으로 나타났으며, 균열의 전파각은 초기에 $30{\sim}57^{\circ}$에서 실험이 더 진행되면 저각으로 발달하는 것으로 나타났다.

• 한국대기환경학회:학술대회논문집
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• 한국대기환경학회 2006년도 춘계학술대회 논문집
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• pp.55-56
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• 2006

This thesis describes the use of measured aerosol size distributions and size-resolved hygroscopic growth to examine the physical and chemical properties of several particle classes. The primary objective of this work was to investigate the optical and cloud forming properties of a range of ambient aerosol types measured in a number of different locations. The tool used for most of these analyses is a differential mobility analyzer / tandem differential mobility analyzer (DMA / TDMA) system developed in our research group. To collect the data described in two of the chapters of this thesis, an aircraft-based version of the DMA / TDMA was deployed to Japan and California. The data described in two other chapters were conveniently collected during a period when the aerosol of interest came to us. The unique aspect of this analysis is the use of these data to isolate the size distributions of distinct aerosol types in order to quantify their optical and cloud forming properties. I used collected data during the Asian Aerosol Characterization Experiment (ACE-Asia) to examine the composition and homogeneity of a complex aerosol generated in the deserts and urban regions of China and other Asian countries. An aircraft-based tandem differential mobility analyzer was used for the first time during this campaign to examine the size-resolved hygroscopic properties of particles having diameters between 40 and 586 nm. Asian Dust Above Monterey (ADAM-2003) study was designed both to evaluate the degree to which models can predict the long-range transport of Asian dust, and to examine the physical and optical properties of that aged dust upon reaching the California coast. Aerosol size distributions and hygroscopic growth are measured in College Station, TX to investigate the cloud nucleating and optical properties of a biomass burning aerosol generated from fires on the Yucatan Peninsula. Measured aerosol size distributions and size-resolved hygroscopicity and volatility were used to infer critical supersaturation distributions of the distinct particle types that were observed during this period. The predicted CCN concentrations were used in a cloud model to determine the impact of the different aerosol types on the expected cloud droplet concentration. RH-dependent aerosol extinction coefficients are calculated at a wavelength of 550 nm.

• Structural Engineering and Mechanics
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• 제74권6호
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• pp.771-787
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• 2020

The paper provides an inside look into experimental measurements, followed by numerical simulations and their related uncertainties. The goal of the paper is to present findings related to blast loading and the handling of defects that are inherent in experiments. Very often it might seem that experiments are simplified reflections of real-life conditions. In most cases this is true, but there is a good reason for that. The more complex an experiment is, the larger the amount of uncertainties that can be expected. This especially applies when the blast loading of concrete is the subject of research. When simulations fail to reproduce the results of experimental measurements, it does not necessarily mean there is something wrong with the numerical model. The problem could be missing information. Put differently, the numerical simulation may lack information that seemed irrelevant with regard to the experiment. In the presented case, a reference simulation with a proven material model unexpectedly failed to replicate the results of an experiment where concrete slabs were exposed to blast loading. This resulted in a search for possible unknowns. When all of the uncertainties were examined, the missing information turned out to be the orientation of the charge to the concrete slab. Since the experiment was burdened with error, a sensitivity study had to take place so the influence of this factor could be better understood. The findings point to the fact that even the smallest defect during experiments must somehow be taken into account when designing numerical simulations. Otherwise, the simulations are not correlated to the experiments, but merely to some expectations.

• Journal of Pharmaceutical Investigation
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• 제35권1호
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• pp.17-23
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• 2005

Polyethylenimine (PEI) has been used as cationic polymers for efficient gene transfer without the need for endosomolytic agents. Various kinds of PEIs with different molecular weight were tested in order to investigate the effects of the molecular weight of PEI on the transfection efficiency and cell cytotoxicity. The ${\beta}-galactosidase$ expression $(pCMV-{\beta}-gal)$ plasmid was used as a model DNA. Complex formation between PEI and pDNA was assessed by 1% agarose gel electrophoresis method. Particle size and zeta-potential of complexes were determined by electrophoretic light scattering spectrometer. In vitro transfection efficiency was assayed by measuring ${\beta}-galactosidase$ activity. Cell cytotoxicity was determined by MTT assay. Particle sizes of the complexes became smaller on increasing molecular weights of PEI and N/P ratios. Surface potential of complexes was increased as the molecular weight of PEI increased. Transfection efficiency of $pCMV-{\beta}-ga1$ on the HEK 293 cells was greatest with PEI 25 K system but having the lowest cell viability. PEI with high molecular weight showed higher transfection efficiency and cell viability than PEI with low molecular weight.

• 대한기계학회논문집B
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• 제34권7호
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• pp.679-688
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• 2010

본 연구에서는 기존의 역열전달 문제(inverse heat transfer problem)와 같이 역해석(inverse analysis)을 통해 미지의 파라미터를 추정(estimation)하는 개념을 복잡한 연소문제에 도입하였다. 기존의 연구에서는 역해석 기법을 연소문제 자체에 보다는 대부분 연소현상을 동반한 복사열전달과 같은 역열전달 문제에 국한해서 적용하고 있기 때문에, 열전달 문제에 한정되어 사용되고 있는 기존의 역해석을 새로운 공학문제에 확장하여 적용함과 동시에 효율적인 연소기 설계 및 최적화 개념을 제시하는데 본 연구의 의의가 있다고 할 수 있다. 이를 위해 실제적으로 많이 사용하고 있는 축대칭 원통형 연소기 내부로 주입되는 메탄($CH_4$)과 산소($O_2$) 성분의 초기 질량분율 값을 연소기 입구 근방에서 측정한 개스의 온도 데이터를 이용하여 역추정하였다. 이때, 복잡한 확산지배 연소 현상을 효율적으로 역해석하기 위해 최적화 방법 중의 하나인 반발 입자 군집 최적화 방법을 역해석 기법으로 적용하였다.

• 한국재료학회지
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• 제22권5호
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• pp.243-248
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• 2012

ZrN nanoparticles were prepared by an exothermic reduction of $ZrCl_4$ with $NaN_3$ in the presence of NaCl flux in a nitrogen atmosphere. Using a solid-state combustion approach, we have demonstrated that the zirconium nitride nanoparticles synthesis process can be completed in only several minutes compared with a few hours for previous synthesis approaches. The chemistry of the combustion process is not complex and is based on a metathesis reaction between $ZrCl_4$ and $NaN_3$. Because of the low melting and boiling points of the raw materials it was possible to synthesize the ZrN phase at low combustion temperatures. It was shown that the combustion temperature and the size of the particles can be readily controlled by tuning the concentration of the NaCl flux. The results show that an increase in the NaCl concentration (from 2 to 13 M) results in a temperature decrease from 1280 to $750^{\circ}C$. ZrN nanoparticles have a high surface area (50-70 $m^2/g$), narrow pore size distribution, and nano-particle size between 10 and 30 nm. The activation energy, which can be extracted from the experimental combustion temperature data, is: E = 20 kcal/mol. The method reported here is self-sustaining, rapid, and can be scaled up for a large scale production of a transition metal nitride nanoparticle system (TiN, TaN, HfN, etc.) with suitable halide salts and alkali metal azide.

• 폴리머
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• 제28권6호
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• pp.502-508
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• 2004

암을 치료하기 위한 양이온성 리포솜은 화학치료요법의 분야에서 발전되어 왔다. 양이온성 리포솜은 음이온성의 세포 표면에 정전기적 상호작용에 의해 결합이 된다. 본 연구의 목적은 음이온성 세포와 이온결합을 할 수 있는 양이온성 리포솜을 제조하는 것이다. 양이온성 리포솜은 지질인 1,2-디스테로일-sn-글리콜-3-포스포에탄올아민 (DSPE)과 양이온성 고분자인 폴리에틸렌이민 (PEI)을 그라프트 중합으로 합성된 물질로부터 제조하였다. 리포솜 표면의 이온 특성은 제타 포텐셜을 측정하여 확인하였다. 소 혈청 수용액에서 리포솜의 혈장 단백질 흡착 특성은 입자 크기와 탁도 변화를 측정하여 확인하였다. 완충 용액 속에서 리포솜 안정성을 예측하기 위하여 입자 크기를 7일 동안 상온에서 측정하였다. 양이온성 리포솜은 소 혈청 수용액에서 많은 양의 혈장 단백질이 흡착되었다. 이는 혈장 단백은 음전하를 가지고 있어서 양이온성 리포솜의 표면과 잘 붙기 때문이다. 양이온성 폴리에틸렌이민을 이용한 리포솜의 표면 변형은 소 혈청 수용액 내에서 단백질 흡착을 강화시킨다는 것을 예상하게 한다. 또한, 제조된 리포솜의 완충 용액 내에서 7일 동안 안정한 상태임을 관찰하였다.

• 한국전기전자재료학회논문지
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• 제29권2호
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• pp.101-105
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• 2016

The basic characteristics of glass are highly fragile and brittle consequences the ultimate purpose of glass manufacturing is to make a transparent glass with complex shape. In order to solve this problem, mechanical properties of glass can be increased by crystallization of its amorphous glass. However, glass-ceramics has become opaque through crystallization process due to the distracted interface of glass by precipitated particles. This study has been investigated thermal processing conditions of LAS transparent glass-ceramic by using DTA (differential thermal analysis), in order to control size of precipitated particle and then fabricate transparent glass-ceramic. DTA indicated that crystallization peak area was declined with increased nucleation temperature. Subsequently, we have been established optimum temperature for crystallization depending on the nucleation temperature. The transmission and thermal expansion were measured after crystallization, and the size of precipitated particle was identified in range of 20~100 nm by FE-SEM. In addition, by setting the optimized crystallization condition, with high transmission and low thermal expansion glass was synthesized through this experiment.