• Journal of the Institute of Electronics Engineers of Korea TC
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• v.46 no.3
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• pp.1-8
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• 2009

DS-CDMA system has very low bandwidth efficiency, hence it is difficult to maintain high spreading gain for high speed data transmission. Offset stacked spreading CDMA(OSS-CDMA) is a transmission scheme where spreading codes with chip offsets are overlapped, then transmitted. This kind of system requires a code set that guarantees orthogonality between codes in the set of any cjip offset. An orthogonal complementary code set has a property that the crosscorrelation function between codes in the group is zero for all shifts, hence it can be used for an OSS-CDMA system. In an OCC-OSS CDMA system each user is assigned an orthogonal complementary code group. User data bit is spread by the given codes and overlapped, and the code sequences are transmitted with multicarrier. However, the offset stacked spread sequences are multilevel, and the number of symbol levels is increases as the spreading efficiency is increased. When the OSS sequence is transmitted with MPSK mapping, the signal constellation becomes dense, and the system is easily affected by channel impairments. In this paper, we propose a level clipping scheme on OSS sequence before MPSK modulated. Simulations have been carried out to investigate the BER performance of the OCC-OSS CDMA system in AWGN environment. The results show that proposed scheme outperform the scheme without level clipping.

• Journal of Microbiology and Biotechnology
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• v.14 no.1
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• pp.81-89
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• 2004

Tumor necrosis factor-$\alpha$ (TNF-$\alpha$) and lymphotoxin-$\alpha$ (LT-$\alpha$, TNF-$\beta$) can initiate and perpetuate human diseases such as multiple sclerosis (MS), rheumatoid arthritis (RA), and insulin-dependent diabetes mellitus (IDDM). TNFs can be blocked by the use of soluble TNF receptors. However, since monomeric soluble receptors generally exhibit low affinity or function as agonists, the use of monomeric soluble receptors has been limited in the case of cytokines such as TNF-$\alpha$, TNF-$\alpha$, interleukin (IL)-1, IL-4, IL-6, and IL-13, which have adapted to a multi component receptor system. For these reasons, very high-affinity inhibitors were created for the purpose of a TNFs antagonist to bind the TNFR and trigger cellular signal by using the multistep polymerase chain reaction method. First, recombinant simple TNFR-Ig fusion proteins were constructed from the cDNA sequences encoding the extracellular domain of the human p55 TNFR (CD120a) and the human p75 TNFR (CD120b), which were linked to hinge and constant regions of human $IgG_1$ heavy chain, respectively using complementary primers (CP) encoding the complementary sequences. Then, concatameric TNFR-Ig fusion proteins were constructed using recombinant PCR and a complementary primer base of recombinant simple TNFR-Ig fusion proteins. For high level expression of recombinant fusion proteins, Chinese hamster ovary (CHO) cells were used with a retroviral expression system. The transfected cells produced the simple concatameric TNFR-Ig fusion proteins capable of binding TNF and inactivating it. These soluble versions of simple concantameric TNFR-Ig fusion proteins gave rise to multiple forms such as simple dimers and concatameric homodimers. Simple TNFR-1g fusion proteins were shown to have much more reduced TNF inhibitory activity than concatameric TNFR-Ig fusion proteins. Concatameric TNFR-Ig fusion proteins showed higher affinity than simple TNFR-Ig fusion proteins in a receptor inhibitor binding assay (RIBA). Additionally, concatameric TNFR-Ig fusion proteins were shown to have a progressive effect as a TNF inhibitor compared to the simple TNFR-Ig fusion proteins and conventional TNFR-Fc in cytotoxicity assays, and showed the same results for collagen induced arthritis (CIA) in mice in vivo.

• Journal of Broadcast Engineering
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• v.13 no.1
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• pp.174-184
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• 2008

Complementary color filter array (CCFA) is widely used in consumer-level digital video cameras, since it not only has high sensitivity and good signal-to-noise ratio in low-light condition but also is compatible with the interlaced scanning used in broadcast systems. However, the full-color images obtained from CCFA suffer from the color artifacts such as false color and zipper effects. These artifacts can be removed with edge-adaptive demosaicking (ECD) approaches which are generally used in rrimary color filter array (PCFA). Unfortunately, the unique array pattern of CCFA makes it difficult that CCFA adopts ECD approaches. Therefore, to apply ECD approaches suitable for CCFA to demosaicking is one of the major issues to reconstruct the full-color images. In this paper, we propose a new ECD algorithm for CCFA. To estimate an edge direction precisely and enhance the quality of the reconstructed image, a function of spatial variances is used as a weight, and new color conversion matrices are presented for considering various edge directions. Experimental results indicate that the proposed algorithm outperforms the conventional method with respect to both objective and subjective criteria.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.13 no.3
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• pp.263-268
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• 2002

DFDM is a good candidate for beyond-3G high-speed wireless communication application because of the robustness to the intersymbol interference and multipath fading. However. an OFDM signal has a serious problem of the high PAPR, which results in the significant nonlinear distortion when it passes through a nonlinear high power amplifier. We propose a new PAPR reduction method using pre-emphasis and clipping. Via the proposed method, the OFDM output signal can have a low PAPR and BER improvement. Then. de-emphasis process is requisite in OFDM receiver. PAPR is reduced to about 5.7 ㏈ at the CCDF= 10$\^$-3/ when the subcarrier number is 16, QPSK modulation is used. pre-emphasis change point Is 3/9 of the peak amplitude of the IFFT output and clipping level is 11 in the IFFT output amplitude. The required SNR at BER=10$\^$-3/ the proposed system is improved by 2 dB than that of the original OFDM system.

• Journal of the Institute of Convergence Signal Processing
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• v.5 no.1
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• pp.66-72
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• 2004

PID control has been well used for several decades. For PID algorithms, some tuning methods are used for selecting PID parameters and with these selected parameters, PID control system is designed. But in some cases various kinds of performance indices are used instead of well-known tuning rules, and so variable type of performance index must be tested so that the designed control system meets the some specifications. For 2 DOF PID controller design this paper presents a linear combinational type of performance indices constituting of index for robust performance, which is obtained by h infinity norm of a weighted complementary sensitivity function, including other time domain indices such as error, energy and changing rate of control input. By numerical methods, the optimal 2 DOF PID parameters are obtained. Therefore various types of 2 degree of freedom PID controllers such as I-PD controller are used so that this two degree of freedom PID controllers may give more desirable output characteristics. Simulations are done with MATLAB m file and mdl files.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.15 no.4
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• pp.379-386
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• 2004

OFDM(orthogonal frequency division multiplexing) communications system is very attractive for the high data rate transmissionin the frequency selective fading channel. Since OFDM has high PAPR(peak-to-average power ratio), OFDM signal may be distorted by the nonlinear HPA(high power amplifier). In this paper, we propose an improved dummy sequence scheme for reducing the PAPR in OFDM communication system. This method inserts each different dummy sequence at the predefined sub-carriers fur PAPR reduction. After IFFT, the OFDM data signal with the lowest PAPR is selected to transmit. The complementary sequence is used as dummy sequence. So, it can cut down the computation time and quantity because it dose not require the peak value optimization for finding the phase rotation factor and the transmission of the side information about the rotation factor unlike the PTS method.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.11 no.2
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• pp.322-329
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• 2007

A single pixel photon counting type image sensor which is applicable for medical diagnosis with digitally obtained image and industrial purpose has been designed with $0.18{\mu}m$ triple-well CMOS process. The designed single pixel for readout chip is able to be operated by single supply voltage to simplify digital X-ray image sensor module and a preamplifier which is consist of folded cascode CMOS operational amplifier has been designed to enlarge signal voltage(${\Delta}Vs$), the output voltage of preamplifier. And an externally tunable threshold voltage generator circuit which generates threshold voltage in the readout chip has been newly proposed against the conventional external threshold voltage supply. In addition, A dark current compensation circuit for reducing dark current noise from photo diode is proposed and 15bit LFSR(Linear Feedback Shift Resister) Counter which is able to have high counting frequency and small layout area is designed.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.11 no.2
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• pp.330-336
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• 2007

A single pixel photon counting type image sensor which is applicable for medical diagnosis with digitally obtained image and industrial purpose has tern designed with $0.18{\mu}m$ triple-well CMOS process. The designed single pixel for readout chip is able to be operated by single supply voltage to simplify digital X-ray image sensor module and a preamplifier which is consist of folded cascode CMOS operational amplifier has been designed to enlarge signal voltage(${\Delta}Vs$), the output voltage of preamplifier. And an externally tunable threshold voltage generator circuit which generates threshold voltage in the readout chip has been newly proposed against the conventional external threshold voltage supply. In addition, A dark current compensation circuit for reducing dark current noise from photo diode is proposed and 15bit LFSR(Linear Feedback Shift Resister) Counter which is able to have high counting frequency and small layout area is designed.

• Journal of the Korean Society of Radiology
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• v.15 no.4
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• pp.565-573
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• 2021

The spatial distribution of electromagnetic fields in the human body can be adjusted by using high dielectric materials. This method has a complementary compared to other methods. However, it can be used as a powerful dielectric shimming tool in certain applications. It can be manufactured in a geometrically free shape and a pad manufactured according to the purpose can be applied without any change of the system. Especially in ultrahigh magnetic field (UHF) MRI, the clinical high dielectric pad used to increase the intensity of the transmit (B1+) and receive (B1-) fields, which has low sensitivity due to the high operating frequency, has great potential. In addition, there are few studies applied to UHF MRI. Therefore, in this study, a high dielectric material pad made of calcium titanate suspension was developed in the laboratory. And the signal increase of clinically useful images was confirmed in various protocols of UHF 7T MRI.

• The Korean Journal of Physiology and Pharmacology
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• v.27 no.1
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• pp.1-8
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• 2023

Hypothyroidism alone can lead to myocardial fibrosis and result in heart failure, but traditional hormone replacement therapy does not improve the fibrotic situation. Hydrogen sulfide (H₂S), a new gas signaling molecule, possesses anti-inflammatory, antioxidant, and anti-fibrotic capabilities. Whether H₂S could improve hypothyroidism-induced myocardial fibrosis are not yet studied. In our study, H₂S could decrease collagen deposition in the myocardial tissue of rats caused by hypothyroidism. Furthermore, in hypothyroidism-induced rats, we found that H₂S could enhance cystathionine-gamma-lyase (CSE), not cystathionine β-synthase (CBS), protein expressions. Finally, we noticed that H₂S could elevate autophagy levels and inhibit the transforming growth factor-β1 (TGF-β1) signal transduction pathway. In conclusion, our experiments not only suggest that H₂S could alleviate hypothyroidism-induced myocardial fibrosis by activating autophagy and suppressing TGF-β1/SMAD family member 2 (Smad 2) signal transduction pathway, but also show that it can be used as a complementary treatment to conventional hormone therapy.