• 대한본초학회지
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• 제23권1호
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• pp.23-28
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• 2008

Objectives : Socheongryong-Tang(小靑龍湯, SCRT), a herbal remedy, has been widely used to treat respiratory disease such as cough and asthma in Oriental countries. Recent years SCRT was known as anti-allergic agent. However, its therapeutic mechanisms including immunoglobuline such as IgE, IgG1, IgG2a productions are unclear. Methods : We investigated the effects of SCRT on levels of antigen specific total antibody, IgE, IgG1, IgG2a using ELISA method in serum from allergen-induced asthma mice. Results : SCRT decreased level of antigen specific IgE significantly. And SCRT treated mice showed downward tendency of IgG1, a Th1 relative antibody, level. But, SCRT did not affect levels of antigen specific total antibody and IgG2a, a Th1 relative antibody. Conclusions : we demonstrated the strong possibility of SCRT as a complementary or alternative drug to western drug also demonstrated that regulation of Th1/Th2 imbalance may be one of mechanism contributed to treatment for respiratory disease by SCRT.

• 대한본초학회지
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• 제22권1호
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• pp.63-70
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• 2007

Objectives : This experimental study was designed to investigate the effects of Acanthopanax, sessiliflorus SEEM extracts following gamma-ray irradiation on immuno-stimulating and anti-tumor activity in terms of proliferation of tumor cells, thymocytes, splenocytes, and NO production from peritoneal macrophages in mice. Methods: 10AS and 100 AS were the bark powders of Acanthopanax sessiliflorus $S_{EEM}$ stems which were exposed in 10 kGy or 100 kGy of electron beam respectively. Results : Treatment with either 10AS or 100AS increased proliferation rates of thymocytes and splenocytes significantly, and treatment with l0AS also decreased proliferation rates of tumor cells significantly. Treatment with either l0AS or l00AS promoted NO production from peritoneal macrophages significantly. Conclusion : These results suggested that AS has direct inhibition effect of tumor growth and immuno-stimulating activity. In conclusion, we demonstrate that AS could be used to treat cancer patient as complementary or alternative medicine to typical anti-cancer medication.

• Clinical and Experimental Pediatrics
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• 제48권9호
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• pp.929-934
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• 2005

목 적 : 본 연구는 소아, 청소년에게 행해지는 보완대체요법 사용실태에 대한 구체적이고, 다각적인 연구의 필요성이 있었기에 보완대체요법을 접할 기회가 많은 만성질환을 가진 소아, 청소년에서 보완대체요법이 어느 정도 사용되고 있는지, 보완대체요법의 종류에 따른 사용실태를 알아보고, 보완대체요법 사용에 영향을 미치는 인자가 있는지 알아보고자 하였다. 방 법 : 2004년 3월부터 8월까지 관동의대 부속병원 소아과에서 지속적 추적관찰을 해오던 입원 경험이 있는 환아들 중에 만성질환(기관지 천식, 아토피, 간질, 뇌성마비 등)을 앓고 있는 환아(160명)를 대상으로 하였고, 환아와 동행한 보호자에게 설문양식에 따라 면담설문을 실시하였다. 결 과 : 설문 조사에 응답한 만성질환을 앓고 있는 환아는 252명이었고, 그 중 보완대체요법을 시행한 160명(63.5%)을 대상으로 삼았다. 각 질환별 보완대체요법 이용률은 선천성 근병증(100%), 아토피성 피부염(91.1%), 만성 반복성 복통(73.5%), 기관지 천식(72.5%), 만성 설사(50.0%), 뇌성 마비(42.1%), 만성 기관지염(37.5%), 간질(17.1%) 순으로 이용률의 차이를 보였다. 시행한 종류는 식이요법(31.1%), 생약요법(23.4%), 수치요법(16.3%), 마사지(14.2%), 방향요법(8.9%), 침술요법(4.6%), 동종요법(1.3%) 순이었다. 64명(40.0%)이 2가지 이상의 보완대체요법을 동시에 시행하였고, 보완대체요법을 권유받은 경로는 비의사처방에 의한 경우가 133명(83.1%)이었으며, 99명(61.9%)이 보완대체요법의 효과에 대해 긍정적으로 답변했다. 보완대체요법 시행군에 있어서 보완대체요법 사용에 영향을 미치는 인자들 중 부모 연령, 자녀 연령이 통계학적 의의가 있었으며, 부모의 연령이 높을수록 시행경험이 많았고(P=0.001), 자녀의 나이가 어릴수록 보완대체요법을 시행하지 않는 경향을(P=0.002) 보였다. 결 론 : 만성질환을 앓는 환아들은 치료에 있어서 현대의학에 의존하는 반면, 상당수가 보완대체요법을 이용하고 있었으며, 2가지 이상을 동시에 사용하는 경우가 많았고, 그 효과에 대해 긍정적으로 평가하고 있었다. 이와 같은 결과는 국내에서 보완대체요법의 접근성이 용이하고, 긍정적인 측면이 강조되고 있기 때문이므로 무분별한 보완대체요법의 사용을 피하기 위해서는 보완대체요법의 효과와 부작용에 대한 현대의학적인 연구가 더 필요할 것으로 사료된다.

• 대한한의학원전학회지
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• 제22권4호
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• pp.15-28
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• 2009

Traditional korean medicine which has long history and many clinical experiments stands out in bold relief because the medicine's point of view has been changed from medical treatment to disease protection and the wellbeing life through health care and complementary alternative medicine has been emerged for the incurable disease. Many traditional korean medical research has been conducted in the fields of preventive medical application, leading material drawing and medical service upgrade through eastern and western medical treatment and the more advanced project are being studied as time goes by. But because we have the hardship of manifesting traditional korean medicine's knowledge into detailed data and information in the field of analytical science and we don't have well arranged research trend data of it, researchers are using much time to survey the preceding research and planners needing more accurate research trend data to protect duplication and raise efficiency. So we have studied the traditional korean medicine's research trend to solve this problems by the method of bibliography applied for the preceding project results. Through the analysis of traditional korean medicine's 370 project reports we came to a conclusion that the R&D investment is concentrated on the university and research institute, the utilization projects are lower than basic and applied research, regional snobbism is excessive than the whole nation's R&D and advanced project has been started since 2006.

• 대한약침학회지
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• 제18권3호
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• pp.32-41
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• 2015

Objectives: Condurango (Gonolobus condurango) extract is used by complementary and alternative medicine (CAM) practitioners as a traditional medicine, including homeopathy, mainly for the treatment of syphilis. Condurango bark extract is also known to reduce tumor volume, but the underlying molecular mechanisms still remain unclear. Methods: Using a cervical cancer cell line (HeLa) as our model, the molecular events behind condurango extract's (CE's) anticancer effect were investigated by using flow cytometry, immunoblotting and reverse transcriptase-polymerase chain reaction (RT-PCR). Other included cell types were prostate cancer cells (PC3), transformed liver cells (WRL-68), and peripheral blood mononuclear cells (PBMCs). Results: Condurango extract (CE) was found to be cytotoxic against target cells, and this was significantly deactivated in the presence of N-acetyl cysteine (NAC), a scavenger of reactive oxygen species (ROS), suggesting that its action could be mediated through ROS generation. CE caused an increase in the HeLa cell population containing deoxyribonucleic acid (DNA) damage at the G zero/Growth 1 (G0/G1) stage. Further, CE increased the tumor necrosis factor alpha ($TNF-{\alpha}$) and the fas receptor (FasR) levels both at the ribonucleic acid (RNA) and the protein levels, indicating that CE might have a cytotoxic mechanism of action. CE also triggered a sharp decrease in the expression of nuclear factor kappa-light-chain-enhancer of activated B cells ($NF-{\kappa}B$) both at the RNA and the protein levels, a possible route to attenuation of B-cell lymphoma 2 (Bcl-2), and caused an opening of the mitochondrial membrane's permeability transition (MPT) pores, thus enhancing caspase activities. Conclusion: Overall, our results suggest possible pathways for CE mediated cytotoxicity in model cancer cells.

• 대한한방내과학회지
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• 제42권3호
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• pp.279-292
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• 2021

Objectives: Analyze papers on the effect of acupuncture on cancer pain from a macroscopic point of view, suggesting global trends and future research directions to promote acupuncture treatment for cancer pain. Methods: By filtering the papers searched for (acupuncture) AND (cancer pain) in the Web of Science database, 351 papers were selected and analyzed by year, field, journal, institution, author, and keyword. Results: Most papers were published in 2020, and research was active in the field of complementary and alternative medicine. Research on the effects of acupuncture in cancer pain has been active in cancer centers and university hospitals, research has been active in various countries. The most frequently mentioned keywords in the titles and abstracts were acupuncture, pain, and quality of life. The latest top 5 keywords were inhibitor-induced arthralgia, acupuncture therapy, risk factors, opioids, and recovery. Conclusions: Acupuncture treatment has the potential to reduce pain and improve quality of life in cancer patients, and it should be actively studied in the future.

• Korean Journal of Acupuncture
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• 제27권2호
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• pp.79-94
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• 2010

Objectives : Many researchers in western societies raised questions on methodological limitations of randomized controlled trial (RCT) for studying Complementary and Alternative Medicine (CAM), and they have tried to find alternatives to RCT. Some of them recently have interest in health service research as one of the alternatives. Discussing the significance of health services research in CAM studies will be helpful to guide the researchers in Korea who are also interested in developing an appropriate research methodology for traditional Korean medicine. Methods : Previous studies on methodological issues of studying CAM and health service researches published in western societies until 2009 were searched mainly from Pubmed. The definition, main research domains, and research methods of health service research and the significance of it for researches on CAM were summarized. Results & Conclusions : Health service researches are important in two aspects. First, health service researches evaluate the actual practice of CAM, including the individualized diagnosis as well as treatment and interaction between practitioners and patients. Second, when evaluating the outcomes, they put an emphasis on subjective evaluation by patients as well as objective evaluation by doctors. Thus, it can reflect the treatment goals of CAM which is improving the overall quality of life and the physical and psychological health. Therefore, health services researches such as descriptive studies, qualitative studies, outcomes studies including economic evaluation, and whole systemic research should be more utilized in order for studying traditional Korean medicine.

• Journal of Acupuncture Research
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• 제37권1호
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• pp.13-18
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• 2020

This review examined recently published (July 2014 to June 2017), randomized controlled trials (RCTs) which investigated the safety and effectiveness of combined Korean medicine/complementary alternative medicine (CAM) and Western medicine, to indicate the direction for integrative medical practice. The Korean Medicine Convergence Research Information Center evidence-based medicine database (KMCRIC EBM DB) was used to retrieve relevant RCTs indexed in the last 3 years. Study design, country, sample size, disease/condition with the Korean Standard Classification of Diseases code, interventions, direction of outcomes, and adverse events were extracted and summarized. A total of 93 RCTs were included in this review. Acupuncture/moxibustion was the most commonly used intervention (n = 47; 51%), and 19% (n = 18) of the studies treated musculoskeletal disorders, followed by circulatory disorders (n = 16; 17%), and mental and behavioral disorders (n = 9; 10%). Integrative treatment was reported as more effective than monotherapy in approximately 83% of these studies. Adverse events were poorly reported in most studies. This review suggests that integrative treatments are feasible, effective, and safe for various diseases/conditions, based on the evidence from recently published RCTs. Future studies on integrative healthcare are warranted.

• 대한한방내과학회지
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• 제29권4호
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• pp.1061-1074
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• 2008

Objectives : Recently, the number of cancer patients who use complementary and alternative medicine (CAM), including oriental medicine, are increasing. Also, evidence for efficacy and safety of cancer CAM is reported continuously. This study was designed to evaluate the quality of the published papers for clinical studies about oriental medical cancer treatment in Korea. Methods : We searched for clinical research papers on the websites of the Korean oriental medical society and subsidiary academies, Korean traditional knowledge portal. Koreanstudies information service system (KISS), etc. We used the reference words 'cancer', 'malignant tumor', 'leukemia', 'lymphoma', 'multiple myeloma', 'melanoma', etc, We then chose studies that had been presented between 1991 and 2008 and analyzed them by publication year, design, cancer type, intervention, subject and journal. Results : There were 86 clinical research papers that were published between 1991 and 2008. The number of clinical studies has increased in a time-dependent manner. Case reports and case series studies account for 78% of total clinical research. Studies of lung cancer account for 17%. Studies of cancer-related symptoms of cancer patients account for 38%. Studies of Hang-Am-Dan account for 33%. Studies published in the journal of the Korean Society of Oriental Internal Medicine account for 35%. Conclusion : The clinical research papers about oriental medicine are increasing over time, but most of the studies are retrospective case reports or case series. Well-designed and prospective clinical trials would be recommended to provide more reliable evidence.

• Food Science and Biotechnology
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• 제14권4호
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• pp.509-513
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• 2005

The purpose of this study was to develop a new preparation process of ginseng extract using high concentrations of ginsenoside $Rg_3$, a special component in red ginseng. From when the ginseng saponin glycosides transformed into the prosapogenins chemically, they were analyzed using the HPLC method. The ginseng and ginseng extract were processed with several treatment conditions of an edible brewing vinegar. The results indicated that ginsenoside $Rg_3$ quantities increased over 4% at the pH 2-4 level of vinegar treatment. This occurred at temperatures above $R90^{\circ}C$, but not occurred at other pH and temperature condition. In addition, the ginseng and ginseng extract were processed with the twice-brewed vinegar (about 14% acidity). This produced about 1.5 times more ginsenoside $Rg_3$ than those processed with regular amounts of brewing vinegar (about 7% acidity) and persimmon vinegar (about 3% acidity). Though the white ginseng extract was processed with the brewing vinegar over four hr, there was no change for ginsenoside $Rg_3$. However, the VG8-7 was the highest amount of ginsenoside $Rg_3$ (4.71%) in the white ginseng extract, which was processed with the twice-brewed vinegar for nine hr. These results indicate that ginseng treated with vinegar had 10 times the quantity of ginsenoside $Rg_3$, compared to the amount of ginsenoside $Rg_3$ in the generally commercial red ginseng, while ginsenoside $Rg_3$ was not found in raw and white ginseng.