• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.21 no.7
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• pp.609-614
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• 2011

The ship working environment of combat service support boat is much inferior to the ground working environment. For this reason, the crew of a combat service support boat suffer from an occupational disease such as hardness of hearing. Owing to its small size and low status, the improvement of its working and residential environment was occasionally ignored and its indoor noise was not fully investigated. In this study, for improving its residential environment indoor, the indoor noise of its shipboard compartments was analysed. These studies define the indoor noise level of combat service support boat is very high and some of indoor noise is exceeded the criteria for ship noise. Compared with marine police vessels, the indoor noise levels of marine police vessels are higher than the level of combat service support boat.

• Molecules and Cells
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• v.21 no.1
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• pp.76-81
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• 2006

Tubulin is synthesized in the cell body and must be delivered to the axon to support axonal growth. However, the exact form in which these proteins, in particular tubulin, move within the axon remains contentious. According to the "polymer transport model", tubulin is transported in the form of microtubules. In an alternative hypothesis, the "short oligomer transport model", tubulin is added to existing, stationary microtubules along the axon. In this study, we measured the translocation of microtubule plus ends in soma segments, the middle of axonal shafts and the growth cone areas, by expressing GFP-EB3 in cultured Xenopus embryonic spinal neurons. We found that none of the microtubules in the three compartments were transported rapidly as would be expected from the polymer transport model. These results suggest that microtubules are stationary in most segments of the axon, thus supporting the model according to which tubulin is transported in nonpolymeric form in rapidly growing Xenopus neurons.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2019.11a
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• pp.96-97
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• 2019

According to building law, there are only regulations on the fire prevention compartments that can perform the function of partial smoke compartment, but the building law management of the smoke compartment for effective smoke diffusion prevention and control is not possible. The lack of control on the smoke compartment such as leakage rate on the penetrating part, and the lack of leakage rate in the design of smoke control of fire safety law resulted in the absence of fundamental safety technology. Therefore, this study seeks to find solutions to domestic problems after reviewing relevant domestic laws and regulations.

• Advances in aircraft and spacecraft science
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• v.3 no.1
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• pp.77-93
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• 2016

In this paper, a zero-dimensional mathematical formulation for rapid and explosive decompression analyses of pressurized aircraft is developed. Air flows between two compartments and between the damaged compartment and external ambient are modeled by assuming an adiabatic, reversible transformation. Both supercritical and subcritical decompressions are considered, and the attention focuses on intercompartment venting systems. In particular, passive and active vents are addressed, and mathematical models of both swinging and translational blowout panels are provided. A numerical procedure based on an explicit Euler integration scheme is also discussed for multi-compartment aircraft analysis. Various numerical solutions are presented, which highlight the importance of considering the opening dynamics of blowout panels. The comparisons with the results from the literature demonstrate the validity of the proposed methodology, which can be also applied, with no lack of accuracy, to the decompression analysis of spacecraft.

• BMB Reports
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• v.54 no.10
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• pp.489-496
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• 2021

Chromatin has highly organized structures in the nucleus, and these higher-order structures are proposed to regulate gene activities and cellular processes. Sequencing-based techniques, such as Hi-C, and fluorescent in situ hybridization (FISH) have revealed a spatial segregation of active and inactive compartments of chromatin, as well as the non-random positioning of chromosomes in the nucleus, respectively. However, regardless of their efficiency in capturing target genomic sites, these techniques are limited to fixed cells. Since chromatin has dynamic structures, live cell imaging techniques are highlighted for their ability to detect conformational changes in chromatin at a specific time point, or to track various arrangements of chromatin through long-term imaging. Given that the imaging approaches to study live cells are dramatically advanced, we recapitulate methods that are widely used to visualize the dynamics of higher-order chromatin structures.

• Journal of Korean Foot and Ankle Society
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• v.25 no.1
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• pp.46-49
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• 2021

Acute compartment syndrome occurs when pressure increases within closed compartments due to injuries causing soft tissue damage. Delayed treatment can lead to undesirable consequences. This paper reports a three-year-old patient in whom a fasciotomy was performed successfully despite the potential side effects. Fasciotomy may be considered when the diagnosis and clinical symptoms of delayed compartment syndrome are clear. This study determined that the three-year-old patient would undergo a relatively smooth recovery compared to elderly patients of advanced age. Because the dorsalis pedis artery pulse was palpable, an emergency surgical treatment was performed to restore the damaged tissues and prevent further necrosis. The patient has shown a satisfactory recovery.

• Wind and Structures
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• v.28 no.2
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• pp.89-97
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• 2019

The non-linear equations governing wind-induced internal pressures for a two-compartment building with background leakage are linearized based on some reasonable assumptions. The explicit admittance functions for both building compartments are derived, and the equivalent damping coefficients of the coupling internal pressure system are iteratively obtained. The RMS values of the internal pressure coefficients calculated from the non-linear equations and linearized equations are compared. Results indicate that the linearized equations generally have good calculation precision when the porosity ratio is less than 20%. Parameters are analyzed on the explicit admittance functions. Results show that the peaks of the internal pressure in the compartment without an external opening (Compartment 2) are higher than that in the compartment with an external opening (Compartment 1) at lower Helmholtz frequency. By contrast, the resonance peak of the internal pressure in compartment 2 is lower than that in compartment 1 at higher Helmholtz frequencies.

• Journal of Yeungnam Medical Science
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• v.36 no.1
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• pp.8-15
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• 2019

Connective tissue diseases (CTDs) can affect all compartments of the lungs, including airways, alveoli, interstitium, vessels, and pleura. CTD-associated lung diseases (CTD-LDs) may present as diffuse lung disease or as focal lesions, and there is significant heterogeneity between the individual CTDs in their clinical and pathological manifestations. CTD-LDs may presage the clinical diagnosis a primary CTD, or it may develop in the context of an established CTD diagnosis. CTD-LDs reveal acute, chronic or mixed pattern of lung and pleural manifestations. Histopathological findings of diverse morphological changes can be present in CTD-LDs airway lesions (chronic bronchitis/bronchiolitis, follicular bronchiolitis, etc.), interstitial lung diseases (nonspecific interstitial pneumonia/fibrosis, usual interstitial pneumonia, lymphocytic interstitial pneumonia, diffuse alveolar damage, and organizing pneumonia), pleural changes (acute fibrinous or chronic fibrous pleuritis), and vascular changes (vasculitis, capillaritis, pulmonary hemorrhage, etc.). CTD patients can be exposed to various infectious diseases when taking immunosuppressive drugs. Histopathological patterns of CTD-LDs are generally nonspecific, and other diseases that can cause similar lesions in the lungs must be considered before the diagnosis of CTD-LDs. A multidisciplinary team involving pathologists, clinicians, and radiologists can adequately make a proper diagnosis of CTD-LDs.

• Journal of Yeungnam Medical Science
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• v.38 no.3
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• pp.183-193
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• 2021

Since its discovery in 1780, lactate has long been misunderstood as a waste by-product of anaerobic glycolysis with multiple deleterious effects. Owing to the lactate shuttle concept introduced in the early 1980s, a paradigm shift began to occur. Increasing evidence indicates that lactate is a coordinator of whole-body metabolism. Lactate is not only a readily accessible fuel that is shuttled throughout the body but also a metabolic buffer that bridges glycolysis and oxidative phosphorylation between cells and intracellular compartments. Lactate also acts as a multifunctional signaling molecule through receptors expressed in various cells and tissues, resulting in diverse biological consequences including decreased lipolysis, immune regulation, anti-inflammation, wound healing, and enhanced exercise performance in association with the gut microbiome. Furthermore, lactate contributes to epigenetic gene regulation by lactylating lysine residues of histones, accounting for its key role in immune modulation and maintenance of homeostasis.

• BMB Reports
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• v.55 no.12
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• pp.577-586
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• 2022

Stress granules (SGs) are stress-induced subcellular compartments, which carry out a particular function to cope with stress. These granules protect cells from stress-related damage and cell death through dynamic sequestration of numerous ribonucleoproteins (RNPs) and signaling proteins, thereby promoting cell survival under both physiological and pathological condition. During tumorigenesis, cancer cells are repeatedly exposed to diverse stress stimuli from the tumor microenvironment, and the dynamics of SGs is often modulated due to the alteration of gene expression patterns in cancer cells, leading to tumor progression as well as resistance to anticancer treatment. In this mini review, we provide a brief discussion about our current understanding of the fundamental roles of SGs during physiological stress and the effect of dysregulated SGs on cancer cell fitness and cancer therapy.