• 국제초고층학회논문집
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• 제7권4호
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• pp.389-396
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• 2018

This paper presents a numerical investigation on the structural response of a multi-story building subjected to spreading multi-compartment fires. A recently proposed simple fire model has been used to simulate two spreading multi-compartment fire scenarios in a 10-story steel-framed office building. By assuming simple temperature rising and distribution profiles in the fire exposed structural components (steel beams, steel column and concrete slabs), finite element simulations using a three-dimensional structural model has been carried out to study the failure behavior of the whole structure in two multi-compartment fire conditions and also in a standard fire condition. The structure survived the standard fire but failed in the multi-compartment fire. Whilst more accurate fire models and heat transfer models are needed to better predict the behaviors of structures in realistic fires, the current study based on very simple models has demonstrated the importance and necessity of considering spreadingmulti-compartment fires in fire resistance design of multi-story buildings.

• 한국임상약학회지
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• 제31권2호
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• pp.125-135
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• 2021

Background: Generally, pharmacokinetics (PK) models could be stratified into two models. The compartment PK model uses the concept of simple compartmentalization to describe complex bodies, and the physiologically based pharmacokinetic (PBPK) model describes the body using multi-compartment networking. Notwithstanding sharing a theoretical background in both models, there was still a lack of knowledge to enhance compatibility in both models. Objective: This study aimed to evaluate the compatibility among PBPK, lumping model and compartment PK model with voriconazole PK case study. Methods: The number of compartments and blood flow on each tissue in the PBPK model were modified using the lumping method, considering physiological similarities. The concentration-time profiles and area under the concentration-time curve (AUC) parameters were simulated at each model, assuming taken voriconazole oral 400 mg single dose. After that, those mentioned PK parameters were compared. Results: The PK profiles and parameters of voriconazole in the three models were similar that proves their compatibility. The AUC of central compartment in the PBPK and lumping model was within a 2-fold range compared to those in the 2- compartment model. The AUC of non-eliminating tissues compartment in the PBPK model was similar to those in the lumping model. Conclusion: Regarding the compatibility of the three PK models, the utilization of the lumping method was confirmed by suggesting its reliable PK parameters with PBPK and compartment PK models. Further case studies are recommended to confirm our findings.

• Toxicological Research
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• 제18권4호
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• pp.311-324
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• 2002

Toxicokinetic studies are intended to provide critical evaluation of drug disposition at toxico-logical doses and help understand the relationship between blood or tissue levels and the time course of toxic events. Relatively high dose levels wed in toxicokinetics, compared to pharmacokinetics, complicates absorption, protein binding, metabolism and elimination processes. In this mini review, frequently wed toxicokinetic models such as linear compartment models, physiological models, and nonlinear kinetic mod-ec are introduced. In addition, optimization of toxicokinetic studies, their role in the drug development process, and prediction oj human toxicokinetics based on animal data by interspecies scaling are briefly discussed.

• 한국안전학회지
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• 제28권6호
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• pp.6-10
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• 2013

A numerical reproducibility of the backdraft phenomena in a compartment was investigated. The prediction performance of two combustion models, the mixture fraction and finite chemistry models, were tested for the backdraft phenomena using the FDS code developed by the NIST. The mixture fraction model could not predict the flame propagation in a fuel-air mixture as well as the backdraft phenomena. However, the finite chemistry model predicted the flame propagation in the mixture inside a tube reasonably. In addition, the finite chemistry model predicted well the backdraft phenomena in a compartment qualitatively. The flame propagation inside the compartment, fuel and oxygen distribution and explosive fire ball behavior were well simulated with the finite chemistry model. It showed that the FDS adopted with the finite chemistry model can be an effective simulation tool for the investigation of backdraft in a compartment.

• 산업기술연구
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• 제10권
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• pp.21-32
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• 1990

Car body resonance often generates severe vibrational and noise problems in vehicle compartment. In this study, vibrational characteristics of 2-D vehicle compartment model is investigated and structural modification is carried out by numerical simulation to shift natural frequencies and to reduce stresses in resonance. To this end, ring models of the compartment are manufactured and analysed by FEA. The results are verified to be in good agreement with those of experimental modal testing. And the results of this study offer efficient strucural modification technique for vibration reduction of real cars.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2013년도 춘계 학술논문 발표대회
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• pp.107-108
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• 2013

In this study, combustibles investigation and fire growth rate experiment were performed for predicting initial fire behavior in buildings. Combustibles investigation was performed for residential buildings, which is most frequently affected by fire in Korea. Spatial characteristics and combustibles properties were separately investigated, and occupied area and layout characteristics of combustibles were identified to produce general layout models. Of the layout models, room was selected for fire test of a single compartment. From this test, fire propagation for each combustible was identified, which was delayed compared to the summed heat release rate of a single combustible.

• 한국화재소방학회논문지
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• 제15권2호
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• pp.46-52
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• 2001

To evaluate the usability of compartment fire models for predicting sprinkler response time, fire experiment was conducted and measured sprinkler response time. The experimental data was compared with zone model "FASTLite"and field model "FDS"and field Model "SMARTFIRE" A Compartment fire conducted in a 2.4 m by 3.6 m by 2.4 m ISO 9705 room and measured H.R.R was approximately 100.3 kW. In test, Sprinkler activation temperature used is $72^{\circ}c$ and responded at 198s. The output of FASTLite, SMARTFIRE and, FDS for this fire scenario were 209s, 183s, and 192s, respectively. As a results, prediction using FDS model approached to that of test very closely and other models showed good approximated results also.

• Environmental Engineering Research
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• 제25권3호
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• pp.400-408
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• 2020

Hydrodynamic study of Activated Sludge Process (ASP) is important to optimize the reactor performance and detect anomalies in the system. Residence time distribution (RTD) study has been performed using LiCl as tracer on a pilot scale aeration tank (AT) and ASP, treating the pulp and paper mill effluent. The hydraulic performance and treatment efficiency of the AT and ASP at different operating parameters like residence time, recycle rate was investigated. Flow anomalies were identified and based on the experimental data empirical models was suggested to interpret the hydrodynamics of the reactors using compartment modelling technique. The analysis of the RTD curves and the compartment models indicated increase in back-mixing ratio as the mean hydraulic retention time (MHRT) of the tank was increased. Bypassing stream was observed at lower MHRT. The fraction of dead zone in the tank increased by approximate 20-25% with increase in recycle rate. The fraction of the stagnant zone was found well below 5% for all performed experiments, which was under experimental error. The substrate removal of 91% for Chemical oxygen demand and 96% for Biochemical oxygen demand were observed for the ASP working at a hydraulic mean residence time 39 h MRT with a 20% recycling of activated sludge.

• 디지털융복합연구
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• 제16권7호
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• pp.259-265
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• 2018

수학모형의 한 유형인 구획모형은 전염병의 확산처럼 순차적인 이벤트나 프로세스로 구성된 동적 시스템의 변화를 분석하는 데 폭넓게 활용되어 왔다. 구획모형은 상자와 화살표로 표현되는 구획과 구획 간 관계로 구성된다. 이러한 원리는 stock과 flow로 구성되는 시스템다이내믹스(SD)의 모델링 원리와 비슷하다. 두 모형 모두 미분방정식을 이용하여 구조화된다. 이와 같은 두 모형 간 변환 가능성을 이용하여 국내 MERS 전염의 특징을 분석한 최근 연구의 SEIR 참조모형을 SD 관점에서 해석 변환한다. 변환된 SEIR 모형(Model 2)은 참조모형(Model 1)의 재현 결과와 비교하여 동일한 시뮬레이션 결과를 나타내었다. 본 연구는 전염병 구획모형의 구축에 도식과 미분방정식을 이용한 SD 방법론의 활용에 대한 인사이트를 제공하며, 변환된 SD 모형은 다른 전염병을 위한 참조모형으로 활용 가능하다.

• 약학회지
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• 제38권6호
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• pp.733-741
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• 1994

To detect anxiolytic activity from Sanguisorbae Radix we used various animal models of fear or anxiety that are sensitive to known anxiolytic drugs. While diazepam showed significant anxiolytic activities in all five animal models empolyed in this study, $5-HT_3$ antagonist ondansetron and ethylacetate fraction of Sanguisorbae Radix did show anti-anxiety effects in social interaction and two compartment exploration tests. Ethylacetate fraction of Sanguisorbae Radix and 5-HT related drugs like ondansetron and buspirone, however, seem to have merit over diazepam in terms of not causing drowsiness. Among ten subfractions obtained from ethylacetate fraction of Sanguisorbae Radix by silica gel chromatography, subfraction I showed higher anxiolytic activities than subfraction DEF in two animal models, social interaction and two compartment exploration tests. There is growing evidence for the role of 5-HT in the control of anxiety. We hope that new compound(s) will be found from the active fractions of Sanguisorbae Radix as a potential anxiolytic agent in the future.