• Analytical Science and Technology
• /
• v.35 no.2
• /
• pp.60-68
• /
• 2022

In this study, we developed and validated a sensitive analytical method to quantify baphicacanthin A in mouse plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The standard calibration curves for baphicacanthin A ranged from 0.5 to 200 ng/mL and were linear, with an r² of 0.985. The inter- and intra-day accuracy and precision and the stability fell within the acceptance criteria. Besides, we investigated the pharmacokinetics of baphicacanthin A following its intravenous (5 mg/kg) and oral administration (30 mg/kg). Intravenously injected baphicacanthin A showed biphasic elimination kinetics with high clearance and volume of distribution values. Furthermore, baphicacanthin A showed a rapid absorption but low aqueous solubility (182.51±0.20 mg/mL), resulting in low plasma concentrations and low oral bioavailability (2.49 %). Thus, we successfully documented the pharmacokinetic properties of baphicacanthin A using this newly developed sensitive LC-MS/MS quantification method, which could be used in future lead optimization and biopharmaceutic studies.

• Journal of Preventive Medicine and Public Health
• /
• v.28 no.3 s.51
• /
• pp.588-608
• /
• 1995

This study was intended to enhance the level of hospital personnel management through analysing job satisfaction of hospital employees in terms of structural, personal and environmental variables. The sample of this study consist of a total of 790 persons including doctors, residents, interns, pharmacists, nurses, medical engineers, office workers and manual workers who have worked for general hospitals with 200 beds, 300 beds and 800 beds respectively. The Likert's 5 scales were used for the measurement of satisfaction. The results can be summarized as follows: 1. Structural Variables The level of satisfaction on the job itself was generally low, 2.8 in Likert's 5 scales, with the order of role ambiguity(3.87), routinization(2.6), work overload (2.45) and autonomy(2.37). Hospital employees are aware of their responsibility and they regarded their work as heavy one. The compensatory satisfaction degree was 2.5 which was also low: There were in the order stability(3.1), distributive justice(2.57), pay(2.3) and promotion(1.9). Usually hospital employees showed high degree of stability, while, their satisfaction on promotion possibility is quite low due to specially differentiated structures of hospitals. The degree of satisfaction on the internal conditions of organizational culture was relatively higher as 2.92: They were co-worker's support(3.69), supervisory support(3.15), role conflict(2.64) and welfare(2.17) in order. The satisfaction on welfare as an economic condition was the lowest. 2. Personal Variables The level of satisfaction on personal variables was 3.27 which seemed to be quite high: Contribution to the hospital(3.38), attitude on job performance(3.28) and pride as a member of the hospital(3.07). They seem to believe that their work has been helpful to the performance of hospitals. 3. Environmental Variables The degree of satisfaction on these variables was 3.07 on the average which was derived from environmental factors such as family-role conflict and community support related to hospital employees' environment. The order of satisfaction for each variable is community support(3.2) and family-role conflict(2.94). They turned out to be fairly satisfied with their job in community and yet, they wanted more spare time to spend with their family.

• Korean Journal of Environmental Agriculture
• /
• v.39 no.1
• /
• pp.65-74
• /
• 2020

BACKGROUND: Soil carbon sequestration has been investigated for a long time because of its potential to mitigate the greenhouse effect. No- or reduced tillage, crop rotations, or cover crops have been investigated and practiced to sequester carbon in soils but the roles of soil biota, particularly microorganisms, have been mostly ignored although they affect the amount and stability of soil organic matters. METHODS AND RESULTS: In this study we analyzed the organic matter and microbial community in organically cultivated corn field soils where no-tillage (NT) or conventional tillage (CT) had been practiced for about three years. The amounts of organic matter and recalcitrant carbon pool were 18.3 g/kg dry soil and 4.1 g C/kg dry soil, respectively in NT soils, while they were 12.4 and 2.5, respectively in CT soils. The amounts of RNA and DNA, and the copy numbers of bacterial 16S rRNA genes and fungal ITS sequences were higher in NT soils than in CT soils. No-tillage treatment increased the diversities of soil bacterial and fungal communities and clearly shifted the bacterial and fungal community structures. In NT soils the relative abundances of bacterial phyla known as copiotrophs, Betaproteobacteria and Bacteroidetes, increased while those known as oligotrophs, Acidobacteria and Verrucomicrobia, decreased compared to CT soils. The relative abundance of a fungal phylum, Glomeromycota, whose members are known as arbuscular mycorrhizal fungi, was about two time higher in NT soils than in CT soils, suggesting that the higher amount of organic matter in NT soils is related to its abundance. CONCLUSION: This study shows that no-tillage treatment greatly affects soil microbial abundance and community structure, which may affect the amount and stability of soil organic matter.

• International Journal of Human Ecology
• /
• v.8 no.1
• /
• pp.109-116
• /
• 2007

Leisure time is a critical part of modern life and is increasingly important in modern society. Therefore, analyzing expectations and values of leisure and researching leisure practices are integral in measuring the quality of life. In this respect, differences between values and attitudes leading to the ideal leisure life and the actual leisure life could provoke negative influence on our lives, further, decreasing quality of life. Therefore, classifying leisure lifestyle through analyzing value of lifestyle and the actual state of leisure precisely is very necessary. Leisure lifestyle could be very useful standard satisfying various desires and demands related to leisure. In the research, we surveyed 3,000 people over 10 years of age, one on one interview method, asking value of life behaviors (Individualism vs. Collectivism, Pro-Stability vs. Pro-Change, Statistical way of life vs. Active way of life, Family-centered life vs. Work-centered life) and practices of leisure life (With whom, How frequently, Where, For what) in respect to both value and behaviors. Through this survey, five groups of leisure life type have been identified; "Community-oriented Type", "Cocoon Type", "Family-oriented Type", "Personal-stability Type" and "Multiplicity Type". These leisure lifestyles would provide effectual alternatives for reducing gaps between expectations for ideal leisure life and actual life. Furthermore, this could be used for ground work to develop measurements for satisfying various leisure demands.

• Journal of Fisheries and Marine Sciences Education
• /
• v.28 no.3
• /
• pp.630-644
• /
• 2016

We conducted a comprehensive review on artificial reefs (ARs) including seaweed reefs for marine afforestation in relation to their development and research from 1972 to 2016, and then systematically analyzed their current a state-of-the-art and practice. From the review, the followings conclusions are made. First, the objectives of AR projects in the Southeast Asia can be classified into three, i.e. protection and increase of fishery resources, local community's profits, and ecological tourism. Second, fish gathering effects by ARs can be determined in terms of wake region or wake length that tends to increase with the K-C (Keulegan-Carpenter) number. Third, ARs are desirable to deploy across a direction of the main flow but it is essential to keep the deployment interval two to four times the length of a single reef. Fourth, stability of ARs depends on how to evaluate drag coefficient, and Morison formula turns out to be practical. Fifth, local scours of ARs are likely to occur due to a downward flow around the center of the front surface. Finally, it is natural for ARs to positively contribute to the marine ecosystem but it is imperative to develop an evaluation method for the effects of ARs on the marine ecosystem.

• Journal of Information Technology Services
• /
• v.9 no.2
• /
• pp.179-192
• /
• 2010

In order to resolve the problems of traditional Enterprise Application Integration (EAI) for system integration and to establish flexible enterprise IT environments, Enterprise Service Bus(ESB) which have distributed architecture and support Service Oriented Architecture(SOA) has introduced. Particularly, JBI which developed by the Java Community Process is most widely used to implement ESB for advantages of Java technology. In ESB based on JBI, reliable message delivery is very important to ensure stability of services and systems because it is a message driven architecture. But, it is difficult to verify messages and trace messages when system fault or service error occurred because JBI specification is not enough to address them. In this paper we has proposed the Message Monitoring Framework for JBI-based ESBs which for using in monitoring messages efficiently. It provides foundations for gathering and tracing message-related information about component installation, message exchange, service deploy by using proxy-based change tracking and delegation mechanism for data processing. The proxy which used in our solutions collects data about message automatically when it changed, and the delegation mechanism provides users flexibility for data processing. Also, we describe the performance evaluation results of our solution which is acceptable. We expect to it enables users to ensure reliability and stability of the JBI-based ESB by systematic monitoring and managing messages being used to interact among components.

• Korea Trade Review
• /
• v.44 no.6
• /
• pp.285-302
• /
• 2019

Good faith is difficult to define due to the facts that there is not an objective and concrete concept of good faith, and good faith in contracts for the international sale of goods is a principle that parties to the contract must act with sincerity as members of a social community. The Korean Supreme Court shall pay attention to setting the applicable standards that can be universally applied to good faith based on the self-established criteria. Through such effort, it is possible not only to realize the value of concrete validity pursued by the general clause of good faith but also to realize the value of legal stability by assuring the predictability of results when applying good faith. In the modern sense, it can be said that the arbitrary application of general rules rather than the escape and general clauses is a problematic situation in the application of good faith, but this problem can be solved by setting a reasonable standard of good faith. This paper studies good faith in the view of Korean law, international laws, and related cases in contract law. The purpose of this paper is to find the problems and solutions of the practical application of good faith by analyzing the Korean case (2009Da86000), which undermined the legal stability of good faith in Korea.

• Korean Security Journal
• /
• no.42
• /
• pp.7-36
• /
• 2015

This study aims at analyzing difference of social Security network, Community unity and local government trust according to socio-demographical features, exploring the relation of social Security network, Community unity and local government trust according to socio-demographical features, presenting results between each variable as a model and verifying the property of mutual ones. This study sampled general citizens in Gwangju for about 15 days Aug. 15 through Aug. 30, 2014, distributed total 450 copies using cluster random sampling, gathered 438 persons, 412 persons of whom were used for analysis. This study verified the validity and credibility of the questionnaire through an experts' meeting, preliminary test, factor analysis and credibility analysis. The credibility of questionnaire was ${\alpha}=.809{\sim}{\alpha}=.890$. The inout data were analyzed by study purpose using SPSSWIN 18.0, as statistical techniques, factor analysis, credibility analysis, correlation analysis, independent sample t verification, ANOVA, multi-regression analysis, path analysis etc. were used. the findings obtained through the above study methods are as follows. First, building a social Security network has an effect on Community institution. That is, the more activated a, the higher awareness on institution. the more activated street CCTV facilities, anti-crime design, local government Security education, the higher the stability. Second, building a social Security network has an effect on trust of local government. That is, the activated local autonomous anti-crime activity, anti-crime design. local government's Security education, police public oder service, the more increased trust of policy, service management, busines performance. Third, Community unity has an effect on trust of local government. That is, the better Community institution is achieved, the higher trust of policy. Also the stabler Community institution, the higher trust of business performance. Fourth, building a social Security network has a direct or indirect effect on Community unity and local government trust. That is, social Security network has a direct effect on trust of local government, but it has a higher effect through Community unity of parameter. Such results showed that Community unity in Gwangju Region is an important factor, which means it is an important variable mediating building a social Security network and trust of local government. To win trust of local residents, we need to prepare for various cultural events and active communication space and build a social Security network for uniting them.

• Journal of the Korean Society for Library and Information Science
• /
• v.48 no.2
• /
• pp.109-135
• /
• 2014

Library is a social institution that satisfies the intellectual needs of the community and provides information, cultural enjoyment, and continuing education to the community. However, it is true that a library may face with difficulties in satisfying the diverse and advanced needs of its users and performing its newly acquired roles because of the limited financial resources of state and local governments. Therefore, this study proposed the introduction of corporate donations as one of the options for library funding, both for expansion of critical library infrastructure and for the internal stability of library operations. To this end, this study determined corporate donation goals, donation targets, campaign donations, the number of libraries being built and renovated, and the effects on libraries that obtained corporate donations by investigating and analyzing known corporate donation cases. The results of this study could be used by libraries hoping to attract corporate donations.

• Journal of Microbiology and Biotechnology
• /
• v.27 no.10
• /
• pp.1798-1807
• /
• 2017

The differentiations in nitrogen-converting activity and microbial community structure between granular size fractions in a continuous completely autotrophic nitrogen removal over nitrite (CANON) reactor, having a superior specific nitrogen removal rate of $0.24g/(g\;VSS{\cdot}h)$, were investigated by batch tests and high-throughput pyrosequencing analysis, respectively. Results revealed that a high dissolved oxygen concentration (>1.8 mg/l) could result in efficient nitrite accumulation with small granules (0.2-0.6 mm in diameter), because aerobic ammonium-oxidizing bacteria (genus Nitrosomonas) predominated therein. Meanwhile, intermediate size granules (1.4-2.0 mm in diameter) showed the highest nitrogen removal activity of $40.4mg/(g\;VSS{\cdot}h)$ under sufficient oxygen supply, corresponding to the relative abundance ratio of aerobic to anaerobic ammonium-oxidizing bacteria (genus Candidatus Kuenenia) of 5.7. Additionally, a dual substrate competition for oxygen and nitrite would be considered as the main mechanism for repression of nitrite-oxidizing bacteria, and the few Nitrospira spp. did not remarkably affect the overall performance of the reactor. Because all the granular size fractions could accomplish the CANON process independently under oxygen limiting conditions, maintaining a diversity of granular size would facilitate the stability of the suspended growth CANON system.