• Korean Journal of Clinical Pharmacy
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• v.24 no.1
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• pp.45-52
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• 2014

Objective: To evaluate the clinical manifestations and causative drugs of the outpatient adverse drug reactions (ADRs) reported by community pharmacy. Methods: From April 2013 to September 2013, all outpatient ADRs reported by community pharmacy to Regional Pharmacovigilance Center of Korean Pharmaceutical Association were included. The causality of ADRs was assessed by the criteria of WHO-Uppsala Monitoring Centre. The clinical features and the offending drugs were analyzed using the WHO-Adverse Reaction Terminology and the classification of American Hospital Formulary Service Drug Information, respectively. Results: 2,826 (97.0%) of the total 2,912 ADRs had causal relationship. The 1,923 patients with mean age of 55.1 years and female fraction of 66.5% were included in the ADRs. Gastrointestinal (33.6%), nervous system (14.9%), and skin (13.5%) symptoms were common in ADRs. Analgesic drugs (19.7%), gastrointestinal drugs (17.7%), and central nervous system drugs (11.0%) were prevalent offending drugs. The leading causative generic drug was the complex of acetaminophen and tramadol. Among 203 ADRs by the nonprescription drugs, the most common clinical features were skin (37.4%) and gastrointestinal (23.6%) symptoms and the most prevalent offending drugs were analgesic drugs (40.0%) and mucocutaneous system drugs (16.3%). The combination of acetaminophen and chlorzoxazone was the leading causative generic in nonprescription drugs. Conclusion: In this study, gastrointestinal symptom was the most common manifestation and analgesic drug was the most common causative drug in outpatient ADRs reported by community pharmacy.

• Journal of Microbiology and Biotechnology
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• v.20 no.3
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• pp.485-493
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• 2010

A modified graphite felt electrode with neutral red (NR-electrode) was shown to catalyze the chemical oxidation of nitrite to nitrate under aerobic conditions. The electrochemically oxidized NR-electrode (EO-NR-electrode) and reduced NR-electrode (ER-NR-electrode) catalyzed the oxidation of $1,094{\pm}39$ mg/l and $382{\pm}45$ mg/l of nitrite, respectively, for 24 h. The electrically uncharged NR-electrode (EU-NR-electrode) catalyzed the oxidation of $345{\pm}47$ mg/l of nitrite for 24 h. The aerobic bacterial community immobilized in the EO-NR-electrode did not oxidize ammonium to nitrite; however, the aerobic bacterial community immobilized in the ER-NR-electrode bioelectrochemically oxidized $1,412{\pm}39$ mg/l of ammonium for 48 h. Meanwhile, the aerobic bacterial community immobilized on the EU-NR-electrode biochemically oxidized $449{\pm}22$ mg/l of ammonium for 48 h. In the continuous culture system, the aerobic bacterial community immobilized on the ER-NR-electrode bioelectrochemically oxidized a minimal $1,337{\pm}38$ mg/l to a maximal $1,480{\pm}38$ mg/l of ammonium to nitrate, and the community immobilized on the EU-NR-electrode biochemically oxidized a minimal $327{\pm}23$ mg/l to a maximal $412{\pm}26$ mg/l of ammonium to nitrate every two days. The bacterial communities cultivated in the ER-NR-electrode and EU-NR-electrode in the continuous culture system were analyzed by TGGE on the $20^{th}$ and $50^{th}$ days of incubation. Some ammonium-oxidizing bacteria were enriched on the ER-NR-electrode, but not on the EU-NR-electrode.

• Journal of Agricultural Extension & Community Development
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• v.16 no.1
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• pp.201-235
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• 2009

This study analyzed the demographic characteristics, strengths and weaknesses related to information acquisition of local innovation diffusion types. This study use ordered probit model to find strengths and weaknesses of innovation diffusion type in rural area. The individual characteristics of 'formal extension type', 'situational reaction diffusion type', 'agriculturist connection type', and 'systematic approach type', all differentiated according to innovation diffusion type, were analyzed. Following Choi & Choe(2008), immediacy, accessibility, referability, applicability, and satisfaction were the highest in the situational reaction diffusion type, systematic approach type, formal extension type, and farmers connection type, in the order. And there existed organic contexts among individual characteristics. So this study tried to analyze strengths and weaknesses of innovation diffusion type with a focus on immediacy, which emerged as the most important variable in the process of interpreting innovation diffusion. And the strengths and weaknesses of each innovation diffusion type were presented.

• Korean Journal of Rural Living Science
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• v.5 no.1
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• pp.43-56
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• 1994

This study examines the father involvement during the infancy period. In order to explore the influence of the father's characteristics, the infant's characteristics and the contextual sources of stress and support on reports of father-infant interaction and paternal responsibility 500 fathers are studied. Results show that fathers in this sample are not regularly involved in the caretaking and the play tasks. The caretaking tasks are most significantly associated with fathers' emotional reaction while indirectly with the first baby, the difficult baby, and the marital satisfaction. The play tasks differ somewhat by their work hours and the marital satisfaction.

• Journal of Agricultural Extension & Community Development
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• v.4 no.1
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• pp.305-315
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• 1997

The propose of this study was to analyze the relationships among the levels of training & development evaluation (reaction, learning, transfer). The study has been conducted on 730 trainees who attended in the basic accounting program in L training and development institution through three incidents of tracked research such as reaction survey right after the conclusion of training, learning evaluation through test, and an evaluation of the transferability after 3 months of training. Questionnaires and test papers for analyses were used after their reliability, validity, difficulty, and discrimination have been verified on a pre-test. The research has been conducted for six months from 4 March 1996 to the end of August 1996, and data have been collected through direct research and survey through mail. The collected data have been worked on at SAS program for Windows with a statistical significance level of 5%. Statistical method that had been used was Pearson's correlation coefficient. The result and conclusion acquired from this study were as follows: Between reaction and learning, learning and transfer of training, only a weak positive correlation exists and explanation or prediction variance showing hierarchical relationship was quite weak with 1%. Thus, this research not only does not strongly support Kirkpatrick(1976)'s hierarchical model of $reaction{\rightarrow}learning{\rightarrow}transfer$, but also indicates that the separate measurement on each levels of training evaluation needs to be done. On the other hand, there was a relatively strong positive correlation between reaction and transfer of training. Based on the result, the conclusion, and the restriction perceived through this study, the following suggestions were made. 1. There is a need to empirically analyze and verify the hierarchy of all levels of training evaluation including the evaluation of the fourth level (result) such as organizational productivity, organizational satisfaction, and separation rate. 2. A great deal of efforts will be needed to systematically analyze what the relationships are among the methods measuring the level of evaluation of the training and development, and to apply this result to the training field.

• Journal of the Economic Geographical Society of Korea
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• v.10 no.4
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• pp.444-460
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• 2007

The purpose of this study is to investigate the logical bases and the real situation of the CSR(corporate social responsibility) execution in the context of local governance. Basically, some management necessities to establish a strategic relationship between a firm and its regional community, is the main reason of CSR execution in the region or in general. Although some costs in forms of money or manpower or resources, should be paid to execute the CSR in a short term, there are so many advantages resulting from it in terms of long time periods. Corporate social responsibility seeks to induce a sustainable harmony or interdependent relationship between the firm and its regional community. In case of POSCO Gwangyang works, so much various forms of community contributions are promoted as a part of CSR executions from the passive reaction for civil petitions to the good corporate citizenship activities. In spite of such an active CSR execution in Gwangyang works, there seems to be required that another way within the works should be explored in order to make it much more effective. Optimal distribution of various resources which are called out for the CSR, is one of the key factors that can affect the strategic result of CSR.

• Asian-Australasian Journal of Animal Sciences
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• v.12 no.1
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• pp.129-138
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• 1999

If rumen bacteria can be manipulated to utilize nutrients (i.e., ammonia and plant cell wall carbohydrates) more completely and efficiently, the need for protein supplementation can be reduced or eliminated and the digestion of fiber in forage or agricultural residue-based diets could be enhanced. However, these approaches require a complete and accurate description of the rumen community, as well as methods for the rapid and accurate detection of microbial density, diversity, phylogeny, and gene expression. Molecular ecology techniques based on small subunit (SSU) rRNA sequences, nucleic acid probes and the polymerase chain reaction (PCR) can potentially provide a complete description of the microbial ecology of the rumen of ruminant animals. The development of these molecular tools will result in greater insights into community structure and activity of gut microbial ecosystems in relation to functional interactions between different bacteria, spatial and temporal relationships between different microorganisms and between microorganisms and reed panicles. Molecular approaches based on SSU rRNA serve to evaluate the presence of specific sequences in the community and provide a link between knowledge obtained from pure cultures and the microbial populations they represent in the rumen. The successful development and application of these methods promises to provide opportunities to link distribution and identity of gastrointestinal microbes in their natural environment with their genetic potential and in situ activities. The use of approaches for assessing pupulation dynamics as well as for assessing community functionality will result in an increased understanding and a complete description of the gastrointestinal communities of production animals fed under different dietary regimes, and lead to new strategies for improving animal growth.

• Journal of Microbiology and Biotechnology
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• v.26 no.6
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• pp.1057-1062
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• 2016

Kimchi is a traditional Korean fermented vegetable food, the production of which involves brining of Korean cabbage, blending with various other ingredients (red pepper powder, garlic, ginger, salt-pickled seafood, etc.), and fermentation. Recently, kimchi has also become popular in the Western world because of its unique taste and beneficial properties such as antioxidant and antimutagenic activities, which are derived from the various raw materials and secondary metabolites of the fermentative microorganisms used during production. Despite these useful activities, analysis of the microbial community present in kimchi has received relatively little attention. The objective of this study was to evaluate the bacterial community structure from the raw materials, additives, and final kimchi product using the culture-independent method. Specifically, polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) was used to analyze the 16S rRNA partial sequences of the microflora. One primer set for bacteria, 341F^GC-518R, reliably produced amplicons from kimchi and its raw materials, and these bands were clearly separated on a 35-65% denaturing gradient gel. Overall, 117 16S rRNA fragments were identified by PCR-DGGE analysis. Pediococcus pentosaceus, Leuconostoc citreum, Leuconostoc gelidum, and Leuconostoc mesenteroides were the dominant bacteria in kimchi. The other strains identified were Tetragenococcus, Pseudomonas, Weissella, and uncultured bacterium. Comprehensive analysis of these microorganisms could provide a more detailed understanding of the biologically active components of kimchi and help improve its quality. PCR-DGGE analysis can be successfully applied to a fermented food to detect unculturable or other species.

• Asian-Australasian Journal of Animal Sciences
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• v.32 no.1
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• pp.92-102
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• 2019

Objective: To investigate changes in rumen fermentation characteristics and bacterial community by a sudden change to a high concentrate diet (HC) in Korean domestic ruminants. Methods: Major Korean domestic ruminants (each of four Hanwoo cows; $545.5{\pm}33.6kg$, Holstein cows; $516.3{\pm}42.7kg$, and Korean native goats; $19.1{\pm}1.4kg$) were used in this experiment. They were housed individually and were fed ad libitum with a same TMR (800 g/kg timothy hay and 200 g/kg concentrate mix) twice daily. After two-week feeding, only the concentrate mix was offered for one week in order to induce rapid rumen acidosis. The rumen fluid was collected from each animals twice (on week 2 and week 3) at 2 h after morning feeding using an oral stomach tube. Each collected rumen fluid was analyzed for pH, volatile fatty acid (VFA), and $NH_3-N$. In addition, differences in microbial community among ruminant species and between normal and an acidosis condition were assessed using two culture-independent 16S polymerase chain reaction (PCR)-based techniques (terminal restriction fragment length polymorphism and quantitative real-time PCR). Results: The HC decreased ruminal pH and altered relative concentrations of ruminal VFA (p<0.01). Total VFA concentration increased in Holstein cows only (p<0.01). Terminal restriction fragment length polymorphism and real-time quantitative PCR analysis using culture-independent 16S PCR-based techniques, revealed rumen bacterial diversity differed by species but not by HC (p<0.01); bacterial diversity was higher in Korean native goats than that in Holstein cows. HC changed the relative populations of rumen bacterial species. Specifically, the abundance of Fibrobacter succinogenes was decreased while Lactobacillus spp. and Megasphaera elsdenii were increased (p<0.01). Conclusion: The HC altered the relative populations, but not diversity, of the ruminal bacterial community, which differed by ruminant species.

• Research in Community and Public Health Nursing
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• v.13 no.4
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• pp.732-742
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• 2002

There are few research on the social drinking experience reported by women. Thus, it is necessary to understand the increasing tendency of womens drinking experience in the sociocultural context. This study was aimed to explore and delineate the drinking experience of full-time house wives base don Strauss and Corbin's grounded theory (1998). The subjects of this study were 10 full-time middle-aged house wives who were living in Seoul region. The data were collected through several in-depth interviews and observations until the theoretical saturation was achieved. The data were analyzed using Strauss and Corbin's grounded theory method. The results of this study generated a paradigm that the drinking experience of the full-time middle-aged house wives has a core category of 'free-oneself-from' and is also connected with mingling, anguish, accessibility, reaction of other people, change, personal resources, self-expression and building relationships by drinking. All processes from the occurrence of the central phenomenon to extinction are as follows; 1) Starting the process of the drinking experience for mingling and resolving anguish, and by having an easy accessibility; 2) Perceiving the process of reaction by other people, physical change of herself. and psycho-behavioral change; 3) Experiencing the process of free-oneself from thorough drinking; 4) Acknowledging the process of the resources for free-oneself-from; 5) Selecting the process of self-expression according to the resources; 6) Building the process of the relationship with drinking as a way of self-expression. Based on this paradigm, 4 hypothesis and 4 types are generated. Thus, this study suggests that it is useful to develop nursing interventions to improve the self-esteem of the full-time middle-aged house wives and to provide them various methods of problem solving strategies. This study also proposes that there should be a strategic program for the women so that they could make a route for positive self-expression by achieving a proper relationship with drinking.