• BMB Reports
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• v.57 no.4
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• pp.167-175
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• 2024

Cancer progression is driven by genetic mutations, environmental factors, and intricate interactions within the tumor microenvironment (TME). The TME comprises of diverse cell types, such as cancer cells, immune cells, stromal cells, and neuronal cells. These cells mutually influence each other through various factors, including cytokines, vascular perfusion, and matrix stiffness. In the initial or developmental stage of cancer, neurotrophic factors such as nerve growth factor, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor are associated with poor prognosis of various cancers by communicating with cancer cells, immune cells, and peripheral nerves within the TME. Over the past decade, research has been conducted to prevent cancer growth by controlling the activation of neurotrophic factors within tumors, exhibiting a novel attemt in cancer treatment with promising results. More recently, research focusing on controlling cancer growth through regulation of the autonomic nervous system, including the sympathetic and parasympathetic nervous systems, has gained significant attention. Sympathetic signaling predominantly promotes tumor progression, while the role of parasympathetic signaling varies among different cancer types. Neurotransmitters released from these signalings can directly or indirectly affect tumor cells or immune cells within the TME. Additionally, sensory nerve significantly promotes cancer progression. In the advanced stage of cancer, cancer-associated cachexia occurs, characterized by tissue wasting and reduced quality of life. This process involves the pathways via brainstem growth and differentiation factor 15-glial cell line-derived neurotrophic factor receptor alpha-like signaling and hypothalamic proopiomelanocortin neurons. Our review highlights the critical role of neurotrophic factors as well as central nervous system on the progression of cancer, offering promising avenues for targeted therapeutic strategies.

• Journal of Digital Convergence
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• v.12 no.1
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• pp.241-251
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• 2014

Mobile messenger services (MMSs), such as Kakaotalk, Wetalk, Line, and Whatsapp, are gaining popularity worldwide because of communicating with other people without any cost. We examined key antecedents of user loyalty to understand user's decision-making process in the MMS environment. To capture a long-term relationship with service providers, we posit relational commitment and user satisfaction as key predictors of user loyalty. Moreover, the effects of perceived usefulness, perceived enjoyment, and corporate image on user's decision-making processes were examined. The proposed model was tested by applying partial least squares to data from 220 experienced Kakaotalk users. The findings of this study found that both relational commitment and user satisfaction play an important role in enhancing user loyalty in the MMS context. The analysis results indicate that corporate image influences relational commitment and user loyalty through user satisfaction. The analysis results help MMS providers establish management or marketing strategies to effectively improve user loyalty.

• Journal of Korean Public Health Nursing
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• v.31 no.2
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• pp.296-310
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• 2017

Purpose: The aim of this study was to develop and test the validity and reliability of the Korean version of the Pre-Menstrual Coping Measure (PMCM-K). Methods: Translation of the PMCM-K was validated using forward-backward translation methods. The study was conducted as a cross-sectional survey from March 7 to April 30, 2016 and the data from a total of 362 young adult women were used for the final analysis. The content validity, construct validity and criterion-related validity were evaluated. The internal consistency was calculated to assess the reliability. Results: The PMCM-K consisted of five factors: premenstrual coping regarding avoiding harm, awareness and acceptance of premenstrual change, self-care, communicating, and adjusting energy, which all explained 62.0% of the total variance in PMCM-K. The total score of the PMCM-K showed a positive correlation with the shortened premenstrual assessment form (r=.50). The Cronbach's alpha reliability coefficient was .94 for the overall instrument and .77-.93 for five factors. Conclusion: PMCM-K provides a valid and reliable scale for quantifying the ways of coping specific to a negative premenstrual change for Korean young adult women. The PMCM-K will play an important role as a way to gain a sense of agency in coping with premenstrual changes.

• Information Systems Review
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• v.8 no.3
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• pp.245-259
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• 2006

In order to utilize BSC as an operational tool for communicating strategies across the hierarchies of the organization, a growing number of companies have tried to link BSC processes with other PI tools. Company D has carried out the SEM project to identify the causal structure between innovation activities and performance management in 2005 and 2006. The company synthesizes BSC and 6 Sigma methodologies at the BU level, and the new process made it possible to manage performances and make decision more "realistic" on the basis of information technologies. We expect that this study provide organizations, which have difficulties streamlining the performance management processes at the strategic level and those of operational level, with implications for realizing more "execution-oriented" RTE.

• Journal of Veterinary Clinics
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• v.18 no.4
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• pp.442-447
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• 2001

A 2-year-old 4.0-kg female Shih Tzu with history of hematemesis and melena was referred to Veterinary Medical Teaching Hospital, Seoul national University for further evaluation and treatment. During physical examination, the dog revealed mild depression, dry mucous membrane and abdominal pain. Hematologic values were normal and serum chemical values showed increased serum bile acid (53.47 umol/l, preprandial), fasting serum ammonia concentration (184 g/dl), alanine transferase (98 U/L), alkaline phosphatase (871 U/L) and gamma glutamyl transpeptidase (21 U/L), and decreased blood urea nitrogen (4 mg/dl), total protein (4.1 g/dl) and albumin (1.2 g/dl). Microhepatica was shown in abdominal radiography. During the ultrasound examination, dilated tortuous vein communicating with caudal vena cava ws observed near the stomach. Intraoperative jejunal vein portography was performed during laparotomy to confirm the location and size of shunt vessel. According to history taking, physical examination, hematologic and serum chemical examination and radiographic study, it was diagnosed as single extrahepatic portosystemic shunt. The anomalous vessel (7 mm, o.d.) that enter the caudal vena cava from the left gastric vein, near the level of the diaphragm, was identified. A Ameroid constrictor (5 mm, i.d.) was applied to the shunting vessel near the caudal vena cava. Hematologic and serum chemical values recovered gradually and were revealed normal values 4 months after surgery. Four month after surgery serum bile acids concentrations were 0.56 $\mu$mol/l (preprandial) and 18.45 umol/l (postprandial). Abdominal radiograph showed normal gastric axis and it revealed normal size of the liver. Fine texture and increased echogenecity of liver and enlargement of portal vein were shown in ultrasonography. Single extrahepatic portosystemic shunt might be treated surgically using Ameroid constrictor.

• Spatial Information Research
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• v.6 no.2
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• pp.183-199
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• 1998

The motivation of this paper comes from a recognition that GIS educators in the private and public sectors are faced with both an opportunity and a dilemma. As the GIS vendors move to open systems which can be integrated with many traditional operations, the use of spatial data and analysis will become widespread throughout business, government and education. Hence the need for standardization in GIS fields is expanding rapidly. Especially non-standardized terminology of GIS prevents GIS-users from communicating among the GIS application fields. This paper will assist this shifting foundation by providing terminology control procedures for ISO/TC2ll family of standards and KS(Korea Standards) information terminology and make recommendations for the improvement and harmonization of terminology.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.26 no.6
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• pp.1387-1399
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• 2016

In a hyper-connected society realized through IoT-enabled technology, a large amount of data is collected by various devices and is processed to provide new services to users. While communicating through a network, it is essential for devices to execute mutual authentication since users' privacy can be infringed by malicious attackers. ID-based signature enables authentication and key exchange with a unique ID of a device. However, most of the previous ID-based signature schemes based on RSA require an additional step to share parameters for key exchange so that they are not suitable for resource-constrained devices in terms of efficiency. In this paper, we design an efficient ID-based signature and thereby propose an efficient ID-based authentication and key exchange protocol in which sessions for both an authentication and a key exchange are executed simultaneously. In addition, we prove the security of our scheme under the RSA onewayness problem and analyze the efficiency by comparing with the previous schemes.

• The KIPS Transactions:PartC
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• v.16C no.2
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• pp.183-188
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• 2009

Wireless sensor networks will be broadly deployed in the real world and widely utilized for various applications. A prerequisite for secure communication among the sensor nodes is that the nodes should share a session key to bootstrap their trust relationship. The open problems are how to verify the identity of communicating nodes and how to minimize any information about the keys disclosed to the other side during key agreement. At any rate, any one of the existing schemes cannot perfectly solve these problems due to some drawbacks. Accordingly, we propose a new pre-distribution scheme with the following merits. First, it supports authentication services. Second, each node can only find some indices of key spaces that are shared with the other side, without revealing unshared key information. Lastly, it substantially improves resilience of network against node capture. Performance and security analyses have proven that our scheme is suitable for sensor networks in terms of performance and security aspects.

• Journal of muscle and joint health
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• v.27 no.1
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• pp.12-21
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• 2020

Purpose: The study was to develop a tailored education and coaching program (TECP) for cancer patients, and to identify the effects of TECP on pain severity, daily living impairment, barriers on pain management, self-efficacy, and pain management satisfaction. Methods: A randomized controlled trial was used. Patients referred to an oncology nurse specialist from oncologists for pain management were randomly assigned to TECP (25) or usual education program (UEP, 22). The intervention was offered by educating the method of taking opioid medication, managing opioid-induced side effects, reducing pain misconceptions and enhancing self-efficacy for communicating with a medical team on cancer pain severity, and pain-related impairment. Patients completed questionnaires before the education program and on the next visit 3~4 weeks later. Data were analyzed by SPSS 19.0 program using percentage, frequency, mean, standard deviation, x² test and independent t-test. Results: At all levels, pain severity improved significantly in the experimental group-worst pain (8.16 to 3.80, p<.001), average pain (6.16 to 2.52 p=.008), and least pain (3.32 to 0.96, p=.038)-but not in the control group. Pain management satisfaction also showed significant differences (t=2.93, p=.005) between experimental (4.70±0.49) and control (4.17±0.73) groups. Interference with daily living, barriers to managing cancer pain, and self-efficacy for managing pain improved in both groups but there were no significant differences. Conclusion: The findings suggest that TECP should be considered for outpatients who need cancer pain management.

• Translational and Clinical Pharmacology
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• v.26 no.3
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• pp.128-133
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• 2018

Appropriate prescription writing is one of the critical medical processes affecting the quality of public health care. However, this is a complex task for newly qualified intern doctors because of its complex characteristics requiring sufficient knowledge of medications and principles of clinical pharmacology, skills of diagnosis and communication, and critical judgment. This study aims to gather data on the current status of undergraduate prescribing education in South Korea. Two surveys were administered in this study: survey A to 26 medical schools in South Korea to gather information on the status of undergraduate education in clinical pharmacology; and survey B to 244 intern doctors in large hospitals to gather their opinions regarding prescribing education and ability. In survey A, half of the responding institutions provided prescribing education via various formats of classes over two curriculums including lecture, applied practice, group discussions, computer-utilized training, and workshops. In survey B, we found that intern doctors have the least confidence when prescribing drugs for special patient populations, especially pregnant women. These intern doctors believed that a case-based practical training or group discussion class would be an effective approach to supplement their prescribing education concurrently or after the clerkship in medical schools or right before starting intern training with a core drug list. The results of the present study may help instructors in charge of prescribing education when communicating and cooperating with each other to improve undergraduate prescribing education and the quality of national medical care.