• 비교문화연구
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• 제27권
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• pp.59-79
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• 2012

China and Japan are geographically close and the two countries had shared the Chinese Character Culture and the thoughts of Confucianism, Buddhism and Taoism since the ancient age. They also actively exchanged culture in various areas. Some cultural exchanges had been caused by surrounding environment and culture had been introduced to other country in a natural way; while some cultural exchanges had been forcibly introduced through artificial process. It is believed that such cultural phenomenon must have had impact on the make-up cultures of the two countries and it was assumed that there must have been commons and differences in the make-up cultures of the two countries. This study explored the historical background of the Ching dynasty of China and the Edo Age in Japan, which are in the same time frame, and studied the aesthetic consciousness of the two countries at the time. Then the make-up style of ladies in the two countries had been studied to find out how their aesthetic consciousnesses had been expressed in the make-ups of the two countries. Then the commons and differences in make-up skills between the two countries had been identified. According to the study results, the main stream of aesthetics during the Ching dynasty in China can be classified into Confucianism aesthetics and Taoism aesthetics. On the other hand, the main stream of aesthetics during the Edo Age in Japan can be classified into "mitate(見立)", "ikki(いき)" and "garumi(かるみ). The skin care in the make-up culture of Ching dynasty in China was based on "rouge (?脂, yanzhi)" and "powder(粉, fen)". The Ching ladies loved the make-up style using rouge. It had been same both in the high society and common people. The eyebrow care was delicate and curved so that the feminine beauty with elegant spirit could be emphasized. The lips had been expressed to be smaller and the ladies tried to express elegance and reliability, rather than frail and tender feminine image. The skin care in the make-up culture of Edo Age in Japan focused on even applying of white powder so that the face would look soft. The eyebrow make-up was a very important part of the make-up. The shapes of eyebrow had been advanced in various styles and there had been eyebrow make-up styles such as "crescent-shaped brow (三日月), "crane style brow (鶴眉) and "Tang style brow (唐眉). The lips had been applied of thick red color, imitating the make-up skill of the ladies in the entertainment business. The lips make-up skill expressing the lips in two colors had been quite popular. Among the make-up skills during the Edo Age in Japan, the "black teeth (齒黑)" can be said as the most unique make-up style of Edo Age.

• 대한기관식도과학회지
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• 제3권1호
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• pp.70-78
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• 1997

The development of preneoplastic and neoplastic squamous cell proliferations of body sites such as the skin, female lower genital tract, and larynx is strongly associated with specific types of human papillomaviruses (HPV). Antitumor $CD^{8+}$ cells recognize peptide antigens presented on the surface of tumor cells by major histocompatibility complex (MHC) class I molecules. The MHC class I molecule is a heterodimer composed of an integral membrane glycoprotein designated the alpha chain and a noncovalently associated, soluble protein called beta-2-microglobulin( $\beta$ -2-m). Loss of $\beta$-2-m generally eliminates antigen recognition by antitumor $CD^{8+}$ T cells. We evaluated the expression of $\beta$-2-m as a potential means of tumor escape from immune recognition and the presence of HPV DNA as a cause of laryngeal squamous cell carcinomas (SCCs). Laryngeal SCCs (n=39) were analyzed for MHC class I expression by immunohistochemistry and for presence of HPV by in situ hybridization technique. The results were as follows : 1) HPV DNA was detected in 10 (25.64%) out of 39 cases in laryngeal squamous cell carcinomas. 2) MHC class I down-regulation (heterogenous and negative expression) in HPV positive lesions was higher than HPV negative lesions. 3) The expression of MHC class I was related to cellular differentiation regardless of T-stage and nodal involvement. In conclusion, HPV was thought to be the etiological factor of SCC of larynx, and we found that the down-regulation of MHC class I was a common phenomenon In laryngeal SCC and may provide a way for tumor cells to escape from immune surveillance.

• 한국컴퓨터정보학회논문지
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• 제18권12호
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• pp.197-205
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• 2013

본 연구에서는 동적 임분 생장모델과 Simulated Annealing 휴리스틱 기법을 적용하여 최적의 산림시업체계를 도출하기 위한 임분탄소최적화 프로그램을 개발하였다. SA 휴리스틱 알고리즘은 다양한 경영목표를 다룰 때 비교적 짧은 시간 내에 만족할만한 수준의 경영안을 제공할 수 있는 최적화 기법으로서, 더 이상 최적해를 찾지 못하고 목표 값이 어떤 일정한 값(Local Optimum)에 계속 머무는 현상을 해결하기 위해 열균형 테스트를 이용하고 있다. 열균형 테스트에 적용되는 온도저감율 파라미터 값이 최적화 프로세스의 목적함수 값과 반복횟수에 미치는 영향을 분석하기 위해 본 연구에서는 온도저감율에 따른 민감도 분석을 실시하였다. 개발된 프로그램을 이용하여 기존의 산림경영에 주로 적용되고 있는 시업체계(베이스라인), 목재수확량 최대와 탄소저장량 최대의 3가지 산림시업 시나리오에 대해 비교 분석을 한 결과, 목재수확량 최대를 목표로 한 시나리오가 3개 시나리오 가운데 목재수확량이 가장 높은 것으로 나타났으며, 또한 탄소저장량을 최대로 하는 시나리오가 탄소저장량이 가장 높은 것으로 나타나, 본 연구에서 개발된 프로그램이 최적화된 결과를 도출하는 것으로 판단됐다. 온도저감율 파라미터 값에 대한 민감도 분석에서는 온도저감율에 따라 목적함수의 최적 값과 최적화 프로세스 반복횟수가 뚜렷한 영향을 받는 것으로 나타났다. 본 연구를 통해 개발된 임분탄소 최적화 프로그램은 앞으로 우리나라 산림의 탄소 최적화 시업체계 개발에 활용 될 것으로 기대된다.

• 한국주조공학회지
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• 제41권5호
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• pp.419-433
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• 2021

Al-Si-Cu 합금은 구리 첨가에 따른 석출경화로 경도와 강도가 현저하게 강한 합금을 생성하는 장점이 있습니다. 그러나 구리를 첨가하면 Al-Si-Cu 합금의 응고 범위가 확장되고 합금은 응고 중에 발생하는 가장 흔하고 심각한 파단 현상 중 하나 열간 균열이 발생하기 쉽습니다. 합금의 열간 균열 특성에 대한 기존의 평가 방법은 이 특성에 대한 정량적 데이터를 제공하지 않는 상대적이고 정성적인 분석 방법입니다. 이 연구에서 Al-Si-Cu 주조 합금의 열간 균열 특성에 대한 더 신뢰할 수있는 정량 데이터를 얻기 위해 Instone et. al 이 개발 한 장치를 부분적으로 수정되었습니다. Cu 원소의 영향을 평가하기 위해 Al-Si-Cu 계 합금에서 4 가지 수준의 Cu 함량을 (0.5, 1.0, 3.0, 5.0) wt. %로 설정하고 각 합금에 대해 열간 균열 특성을 평가했습니다. Cu 함량이 증가함에 따라 열간 균열 강도는 (2.26, 1.53, 1.18, 1.04) MPa)로 감소했습니다. 열간 균열이 발생하는 시점, Cu 함량이 증가함에 따라 고액 공존 범위가 증가하여 동일 온도에서 해당 고상율 및 응고 속도가 감소하였다. 파단면의 형태는 수상 돌기에서 잔류 액상으로 덮인 수상 돌기로 바뀌었고, 열간 균열 발생 인근에서 CuAl₂ 상이 관찰되었다.

• 비교문화연구
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• 제50권
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• pp.131-172
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• 2018

오늘날 아프리카 사회에서는 신부대 관습이 지극히 왜곡된 형태로 나타나고 있다. 이러한 현상은 남성 지배적인 문화, 서구 종교 및 자본주의 경제 체제가 부정적으로 결합한 결과다. 이것은 신부대가 '전통'과 '근대성'의 충돌과 갈등 속에서 끊임없이 재구성되었음을 의미한다. 신부대 관행이 생계 방식, 조혼, 일부다처제, 친족(가족) 구조, 빈곤, 이주 노동 등과 서로 밀접하게 얽혀 있는 것도 사실이다. 자본주의 경제 체제하에서 신부대는 점점 상업화되고 있다. 이에 따라 신부대의 전통적 상징성은 약화하고 있는 반면, 여성이 물화되는 경향은 강해지고 있다. 신부대의 상업화는 여성 인권 침해, 양성 불평등, 가정 폭력 등을 부추기는 결과를 초래한다. 행위 주체들은 성별, 세대, 계층, 종족 등의 인구학적 사회경제적 배경에 따라 신부대를 다르게 인식한다. 자본주의의 영향으로 신부대가 상업화될수록, 이 제도를 부정적으로 인식하는 사람도 더욱 늘어나게 될 것이다. 신부대라는 관습의 빛깔은 이것을 실천하는 주체들이 사회경제적 변화에 어떤 식으로 반응하느냐에 따라 달라진다. 그들은 주어진 환경 속에서 신부대를 끊임없이 재해석하고 재구성할 것이다.

• 기호학연구
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• 제57호
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• pp.155-176
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• 2018

이 논문은 칼 맑스의 선언문과 폐정 개혁문의 모달리떼와 그 상징성에 대한 연구이다. 이를 위한 텍스트로는 칼 맑스와 프리드리히 엥겔스의 공산 동맹 선언문과 동학 농민군의 폐정 개혁안을 채택했다. 이 선언문과 개혁문은 이 논문에서 1800년대의 철학적 실천담론을 모달리떼 양상으로 전개하며 기호학적 의미에서 그 공통의 상징성을 도출하고, 소유와 소외 그리고 계급에서 자유로워지는 민주주의를 향해 전진하는 사상적 흐름에 그 촛점을 맞추고 있다. 궁극적으로 동시대의 숨결 속에서 발표된 이 두 선언문은 감시와 처벌이라는 비인륜적 정책에 대한 고발장이다. 1일 2회 교회에서의 공간이 공장으로 바뀌고, 자본과 노동으로 2분법적 사고로 갈라치기 해서 이 범주 안으로 몰아넣는 행위가 마치 사회 윤리인 냥 치장되었으며, 사냥하는 식의 강요는 처벌 방식으로 이루어져 더 이상 사람이 존재하기 힘든 구조가 제도화 되어버린 현상에 대한 대항이다. 이 사냥의 틀을 깨부수려는 혁명운동이 바로 위 두 선언문으로 나타나며 칼 맑스는 자신의 존재를 '영원한 난민'의 위치에 둠으로서 공산동맹 선언을 통해 이루고자 한 유토피아의 절정을 완성하며, 동학농민군은 전봉준의 재판 취조과정에서 전개되는 그의 자유함에서 죽음을 택함으로써 자신은 물론 민중의 혁명정신을 완성한다. 동서양에서 동시에 폭발한 억압의 형태는 지배와 통치의 자본에 대한 철퇴이며, 이에 대한 새로운 대안이 '사람이 가장 큰 자본이다'로 새로운 패러다임 구축을 가능하게 하는 원천적인 철학적 배경이 된다는 점에서 이 논문은 그 의의를 ?고 있다.

• Journal of Breast Cancer
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• 제21권4호
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• pp.371-381
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• 2018

Purpose: Immune suppression is common in patients with advanced breast cancer but the mechanisms underlying this phenomenon have not been sufficiently studied. In this study, we aimed to identify B7 family members that were able to predict the immune status of patients, and which may serve as potential targets for the treatment of breast cancer. We also aimed to identify microRNAs that may regulate the expression of B7 family members. Methods: The Cancer Genome Atlas data from 1,092 patients with breast cancer, including gene expression, microRNA expression and survival data, were used for statistical and survival analyses. Polymerase chain reaction and Western blot were used to measure messenger RNA and protein expression, respectively. Luciferase assay was used to investigate direct microRNA target. Results: Bioinformatic analysis predicted that microRNA (miR)-93, miR-195, miR-497, and miR-340 are potential regulators of the immune evasion of breast cancer cells, and that they exert this function by targeting CD274, PDCD1LG2, and NCR3LG1. We chose CD274 for further investigations. We found that miR-195, miR-497, and CD274 expression levels were inversely correlated in MDA-MB-231 cells, and miR-195 and miR-497 expressions mimic inhibited CD274 expression in vitro. Mechanistic investigations demonstrated that miR-195 and miR-497 directly target CD274 3' untranslated region. Conclusion: Our data indicated that the level of B7 family members can predict the prognosis of breast cancer patients, and miR-195/miR-497 regulate CD274 expression in triple negative breast cancer. This regulation may further influence tumor progression and the immune tolerance mechanism in breast cancer and may be able to predict the effect of immunotherapy on patients.

• Asian Spine Journal
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• 제12권6호
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• pp.1043-1052
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• 2018

Study Design: Level III retrospective cross-sectional study. Purpose: To define and characterize the presentation, symptom duration, and patient/surgical risk factors associated with 'post-decompressive neuropathy (PDN).' Overview of Literature: PDN is characterized by lower extremity radicular pain that is 'different' from pre-surgical radiculopathy or claudication pain. Although it is a common constellation of postoperative symptoms, PDN is incompletely characterized and poorly understood. We hypothesize that PDN is caused by an intraoperative neuropraxic event and may develop early (within 30 days following the procedure) or late (after 30 days following the procedure) within the postoperative period. Methods: Patients who consented to undergo lumbar laminectomy with or without an instrumented fusion for degenerative lumbar spine disease were followed up prospectively from July 2013 to December 2014. Relevant data were extracted from the charts of the eligible patients. Patient demographics and surgical factors were identified. Patients completed postoperative questionnaires 3 weeks, 3 months, 6 months, and 1 year postoperatively. Questions were designed to characterize the postoperative pain that differed from preoperative pain. A diagnosis of PDN was established if the patient exhibited the following characteristics: pain different from preoperative pain, leg pain worse than back pain, a non-dermatomal pain pattern, and nocturnal pain that often disrupted sleep. A Visual Analog Scale was used to monitor the pain, and patients documented the effectiveness of the prescribed pain management modalities. Patients for whom more than one follow-up survey was missed were excluded from analysis. Results: Of the 164 eligible patients, 118 (72.0%) completed at least one follow-up survey at each time interval. Of these eligible patients, 91 (77.1%) described symptoms consistent with PDN. Additionally, 75 patients (82.4%) described early-onset symptoms, whereas 16 reported symptoms consistent with late-onset PDN. Significantly more female patients reported PDN symptoms (87% vs. 69%, p=0.03). Patients with both early and late development of PDN described their leg pain as an intermittent, constant, burning, sharp/stabbing, or dull ache. Early PDN was categorized more commonly as a dull ache than late-onset PDN (60% vs. 31%, p=0.052); however, the difference did not reach statistical significance. Opioids were significantly more effective for patients with early-onset PDN than for those with late-onset PDN (85% vs. 44%, p=0.001). Gabapentin was most commonly prescribed to patients who cited no resolution of symptoms (70% vs. 31%, p=0.003). Time to symptom resolution ranged from within 1 month to 1 year. Patients' symptoms were considered unresolved if symptoms persisted for more than 1 year postoperatively. In total, 81% of the patients with early-onset PDN reported complete symptom resolution 1 year postoperatively compared with 63% of patients with late-onset PDN (p=0.11). Conclusions: PDN is a discrete postoperative pain phenomenon that occurred in 77% of the patients who underwent lumbar laminectomy with or without instrumented fusion. Attention must be paid to the constellation and natural history of symptoms unique to PDN to effectively manage a self-limiting postoperative issue.

• 한국결정성장학회지
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• 제29권2호
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• pp.71-76
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• 2019

자동화 시스템이 일반화되면서 제품 관리를 위한 라벨지(label)의 수요는 증가하고 있으며, 다양한 환경에서 사용할 수 있는 기능성 라벨지 개발이 빠르게 진행되고 있다. 인쇄회로기판의 경우 제작 과정에서 $300^{\circ}C$ 이상의 리플로우 솔더링 공정과 여러 차례의 세정 공정을 거치기 때문에 열적 화학적 안정성을 갖는 바코드 라벨지(barcode label)가 사용되고 있으나 황변(yellowing) 현상 발생으로 인한 인식률 저하의 문제가 발생하고 있다. 본 연구에서는 실리카 무기 바인더와 이산화티탄 백색안료를 사용한 복합 코팅층을 개발하고, 열적 화학적 안정성을 확보한 기능성 라벨지 연구를 진행하였다. 졸-겔 공정으로 제조한 실리카 무기 바인더는 기재(substrate)로 사용하는 폴리이미드 필름과 우수한 밀착성과 내마모성 특성을 갖는 것으로 확인하였다. 또한 이산화티탄 백색안료와 혼합하여 폴리이미드 필름에 백색의 코팅층을 제조할 수 있었으며, 복합 코팅층은 $400^{\circ}C$ 이상의 고온에서도 우수한 백색도와 광택도를 특성을 유지하는 것을 알 수 있었다. 또한 산성(pH 1.6)과 염기성(pH 13.6) 세정제를 통한 화학 처리 후에도 백색도와 광택도 변화가 일어나지 않는 우수한 화학적 안정성을 확인하였다.

• 한국가족관계학회지
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• 제22권4호
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• pp.53-80
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• 2018

Objectives: The purpose of this study was to investigate individual awareness variables influencing emotional, normative, and functional marriage intentions of unmarried men and women. Independent variables were values of offspring, perceptions to unmarried life, attitudes toward multiple role planning, perceptions and availabilities of marriage-related policies, views on the marriageable age, psychological burdens of pressure to marriage by significant people, and views on parents' support for marriage fund. Method: 553 unmarried men and women in Daegu, Korea were surveyed, and the data were analyzed using descriptive statistics, factor analysis, multivariate analysis of variance(MANOVA), multiple regression analysis, and hierarchical regression analysis with SPSS 22.0. Results: First, this study was more exploratory and in-depth approach to marriage intentions than precedent studies. The sub factors of marriage intentions were emotional, normative, and functional marriage ones. Second, emotional marriage intention showed significant differences depending on gender, dating, views on the marriageable age, and degree of acceptance of parents' support for marriage fund. Among the individual awareness variables, values of offspring, perceptions to unmarried life, attitudes toward multiple role planning, and psychological burdens of pressure to marriage personally or by friends influenced emotional marriage intention. Third, normative marriage intention showed significant differences depending on gender, religion, occupational status, employment condition, dating, views on the marriageable age, and degree of acceptance of parents' support for marriage fund. Among the individual awareness variables, values of offspring, perception to unmarried life, attitudes toward multiple role planning, view on the marriageable age, availabilities of marriage-related information offering policies, and psychological burdens of pressure to marriage by mother influenced normative marriage intention. Fourth, functional marriage intention showed significant differences depending on gender, job, parents' support for marriage fund, views on the marriageable age, and degree of acceptance of parents' support for marriage fund. Among the individual awareness variables, functional marriage intention was influenced by values of offspring, perception about unmarried life, attitudes toward multiple role planning, and degree of acceptance of parents' support for marriage fund. Finally, the hierarchical regression analysis showed that individual awareness variables influenced on marriage intentions. Especially, values of offspring, perceptions to unmarried, and attitudes toward multiple role planning influenced on emotional, normative, and functional marriage intentions in common. Conclusions: The findings from these analyses suggest that the selective process based on the individual awareness has become very significant to having marriage intentions. Therefore, this study will contribute as the basic data on national marriage-related policies. Furthermore, this study will be able to use to think about the marriage intention as a task to be preceded by the national policy in order to prepare for Korea 's low fertility and aging phenomenon.