• Journal of the Society of Cosmetic Scientists of Korea
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• v.46 no.4
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• pp.361-369
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• 2020

Atopic dermatitis (AD) is a common and multifactorial inflammatory skin disease that is characterized by skin barrier dysfunction, inflammation, and chronic pruritus. AD has a complex etiology that includes genetic, immunological, and environmental factors that cause skin barrier abnormalities and immune dysfunctions. Sophora flavescens (SF) has been used in traditional Chinese medicine, but little research has been conducted on its anti-AD efficacy. In this study, we evaluated the effect of SF extract (SFE) on improving skin barrier function and immune abnormalities, which are the main symptoms of AD. SFE has the capacity to enhance the formation of cornified envelope (CE) that plays an important role in the skin barrier function. In addition, it was confirmed that SFE increased the expression of hyaluronic acid related to skin moisture. The effect of SFE against Staphylococcus aureus (S. aureus), which increases specifically in AD lesions, confirmed that SFE inhibited the production of pro-inflammatory cytokines induced by S. aureus. Furthermore, SFE was shown to inhibit the expression of pro-inflammatory cytokines induced by substance P (SP), the cause of skin neurogenic inflammation. These results demonstrate that SFE could be one of potential candidate agent for the treatment of AD by improving the skin barrier function and immune responses.

• Journal of Digital Convergence
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• v.20 no.4
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• pp.353-366
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• 2022

The study sets out to examine the relationship between the effects of government support, network capability, and knowledge sharing on the effects of innovative behavior on innovation performance. As digital-based networks and knowledge sharing activities are rapidly becoming common in the era of the spread of Covid-19, 357 questionnaires were analyzed for incumbent employees and the research hypotheses are verified using SPSS 24 and smart PLS 3 to prove the relationships between variables. As a result of the study, it is found that innovation performance increased when government support, network capability, and knowledge sharing increased. Innovative behavior is found to significantly mediate the relationship between network capability, knowledge sharing, and innovation performance, and government support was found to have a significant effect on network capabiltiy. Therefore, in order to induce innovative actions that are important in creating innovative results, various programs to enhance the network capabilities of entrepreneurs and promote knowledge sharing should be required as government support policies. This will serve as a driving force for entrepreneurs to voluntarily develop and implement ideas more flexibly and freely, thereby enhancing competitiveness through innovative growth of companies and industries. In other words, this study verified the effectiveness of government support in the network capability to help create innovative results by inducing innovative behavior along with knowledge sharing activities, and comprehensively demonstrated the relationship between factors in the overall structure.

• KIPS Transactions on Computer and Communication Systems
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• v.11 no.5
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• pp.133-138
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• 2022

Recently, as GPU performance has improved in HPC and artificial intelligence, its use is becoming more common, but GPU programming is still a big obstacle in terms of productivity. In particular, due to the difficulty of managing host memory and GPU memory separately, research is being actively conducted in terms of convenience and performance, and various CPU-GPU memory transfer programming methods are suggested. Meanwhile, recently many SoC (System on a Chip) products such as Apple M1 and NVIDIA Tegra that bundle CPU, GPU, and integrated memory into one large silicon package are emerging. In this study, data between CPU and GPU devices are used in such an integrated memory device and performance-related research is conducted during transmission. It shows different characteristics from the existing environment in which the host memory and GPU memory in the CPU are separated. Here, we want to compare performance by CPU-GPU data transmission method in NVIDIA SoC chips, which are integrated memory devices, and NVIDIA SMX-based V100 GPU devices. For the experimental workload for performance comparison, a two-dimensional matrix transposition example frequently used in HPC applications was used. We analyzed the following performance factors: the difference in GPU kernel performance according to the CPU-GPU memory transfer method for each GPU device, the transfer performance difference between page-locked memory and pageable memory, overall performance comparison, and performance comparison by workload size. Through this experiment, it was confirmed that the NVIDIA Xavier can maximize the benefits of integrated memory in the SoC chip by supporting I/O cache consistency.

• The Journal of Korean Academy of Prosthodontics
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• v.60 no.1
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• pp.127-134
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• 2022

Among many contributing factors of implant failure, excessive loading and inflammation contribute mainly to increasing implant failure rate. Especially, poor oral hygiene around implants is one of the most common reasons for implant failure. When implant prosthesis fails to function, the clinician should re-diagnose and plan treatment using the remaining implants. Additional implantation may be needed to make a new type of prosthesis or either implant-assisted RPD and implant overdenture treatment may be performed using the remaining implants. In this article, a patient whose fixed implant prosthesis in the maxilla had failed of poor oral hygiene maintenance was reported to be recovered with removable implant overdenture by using remaining implant abutments and a milled bar with additional retentive elements. Through this treatment, the clinical results were satisfactory in terms of esthetics, masticatory function recovery and oral hygiene management.

• Journal of the Korea Society of Computer and Information
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• v.27 no.12
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• pp.259-266
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• 2022

In this paper, we propose a study is to prepare basic data for integrated health promotion education by preventing dry mouth and dry eyes through lifestyle management. From October 7 to 17, 2022, a total of 516 respondents who voluntarily agreed and responded through a self-written structured questionnaire were statistically analyzed for university students in their 20s across the country. As for the factor of feeling dry mouth among the living habits of the study subjects, the more smoking per day, the higher(8.41±2.041) and very high(7.75±2.927) felt dry mouth(p=.015), and the time spent using smart phones. The shorter this was, the lower(1.16±0.784) and very low(1.83±1.672) felt dry mouth(p=.022). The main factors contributing to dry mouth and dry eyes were dry eyes (odds ratio 3.651, p=.000), and high smoking(odds ratio 0.916, p=.038), and the more you use your smart phone (odds ratio 0.256, p=.004), the more you feel dry mouth. When feeling dry eyes, they felt dry mouth more(odds ratio 4.002, p=.000), and the more they exercised, the more dry eyes they felt(odds ratio 1.600, p=.009). As a result, since dry mouth and dry eyes appear as common inconveniences, it was found that lifestyle management is necessary to maintain and promote a healthy life. Therefore, it is proposed to build an integrated health platform that can improve the quality of life and implement personalized health management programs.

• Journal of the Korean Society of Safety
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• v.37 no.4
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• pp.120-128
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• 2022

Printed circuit boards (PCBs) are a basic component in the electronics industry and are widely used in nearly all electronic products, such as mobile phones, tablet computers, and digital cameras, as well as in electric equipment. PCB manufacturing involves the use of many chemicals and chemical processes and therefore has more risks than other manufacturing sectors. This study aims to identify the causes of possible accidents during PCB manufacturing through risk assessment, develop and implement safety measures, and evaluate the effectiveness of these measures. Note that the safety measures developed to mitigate the risks of a certain process were also implemented for other similar processes. The risk assessments conducted over seven years, from 2015 to 2021, at a PCB manufacturing company identified 361 hazardous processes. Between 2016 and 2019, 41-56 hazardous processes were identified per year; such processes decreased to fewer than 20 per year after 2020. Application of the risk assessment results to the improvement of the hazardous processes with the similar characteristics seems to be effective in decreasing the risks. Equipment-related factors such as lack of appropriate maintenance, low work standards, and defective protection devices were responsible for 59.8% of all possible accidents. Because PCB manufacturing involves many chemicals, skin contact with hazardous substances, electric shock, fire, and explosion were the most common types of possible accidents (81.7%). In total, 505 safety measures were implemented, including 157 related to purchase and improvement of equipment and devices for safety (31.1%), 147 related to the installation/modification of fire prevention facilities (29.1%), and 69 related to the use of standard electrical appliances (13.7%). Risk assessment conducted after implementing the safety measures showed that these measures significantly decreased risk; 247 processes (68.4%) had a risk level of 3, corresponding to "very low," and 114 processes (31.6%) showed a risk level of 4, corresponding to "low." In particular, risk assessment of 104 processes with risk scores of 12 and 10 other processes with risk score of 16 showed that the risk decreased to 4 after implementing the safety measures. Thus, implementing these measures in similar manufacturing sectors that involve chemical processes can mitigate risk.

• Journal of Life Science
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• v.33 no.3
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• pp.295-303
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• 2023

Immune and metabolic systems are important factors in maintaining homeostasis. Immune response and metabolic regulation are highly associated, so, when the normal metabolism is disturbed, the immune response changed followed the metabolic diseases occur. Likewise, obesity is highly related to immune response. Obesity, which is caused by an imbalance in energy metabolism, is associated with metabolic diseases, such as insulin resistance, type 2 diabetes, fatty liver diseases, atherosclerosis and hypertension. As known, obesity is characterized in chronic low-grade inflammation. In obesity, the microenvironment of immune cells became inflammatory by the unique activation phenotypes of immune cells such as macrophage, natural killer cell, T cell. Also, the immune cells interact each other in cellular or cytokine mechanisms, which intensify the obesity-induced inflammatory response. This phenomenon suggests the possibility of regulating the activation of immune cells as a pharmacological therapeutic strategy for obesity in addition to the common pharmacological treatment of obesity which is aimed at inhibiting enzymes such as pancreatic lipase and α-amylase or inhibiting differentiation of preadipocytes. In this review, we summarize the activation phenotypes of macrophage, natural killer cell and T cell, and their aspects in obesity. We also summarize the pharmacological substances that alleviates obesity by regulating the activation of immune cells.

• Journal of Life Science
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• v.33 no.1
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• pp.25-33
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• 2023

The fermentation process of kimchi, which is a traditional Korean food, influences the resulting compo- sition of microorganisms, such as the genera Leuconostoc, Weissella, and Lactobacillus. In addition, several factors, including the type of kimchi, fermentation conditions, materials, and ingredients, can influence the distribution of the kimchi microbial community. In this study, next-generation sequencing (NGS) of kimchi samples obtained from central (Gangwon-do and Gyeonggi-do) and southern (Jeolla-do and Gyeongsang-do) regions in Korea was performed, and the microbial communities in samples from the two regions were compared. Good's coverage prediction for all samples was higher than 99%, indicating that there was sufficient reliability for comparative analysis. However, in a α -diversity analysis, there was no significant difference in species richness and diversity between samples. The Firmicutes phylum was common in both regions. At the species level, Weissella kandleri dominated in central (46.5%) and southern (30.8%) regions. Linear discriminant analysis effect size (LEfSe) analysis was performed to identify biomarkers representing the microbial community in each region. The LEfSe results pointed to statistically significant differences between the two regions in community composition, with Leuconostocaceae (71.4%) dominating in the central region and Lactobacillaceae (61.0%) dominating in the southern region. Based on these results, it can be concluded that the microbial communities of kimchi are significantly influenced by regional properties and that it can provide more useful scientific data to study the relationship between regional characteristics of kimchi and their microbial distribution.

• Korean Journal of Culture and Social Issue
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• v.21 no.2
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• pp.177-203
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• 2015

The aims of this study were 1) to compare irrational gambling beliefs of gamblers and non-gamblers, 2) to investigate the role of cognitive error on winning probability thinking error, and 3) to examine the relationship between attributional bias and gambling behavior. A total of 248 subjects were recruited for this study. All subjects were classified into non-gamblers, social gamblers and pathological gamblers, and administered self-report questionnaires to measure irrational gambling beliefs, the probability inference error, the attriburional style, and the attributional bias. A pathological gambler group scored highest on irrational gambling beliefs, especially the overestimation of self-ability factor, and a social gambler group and a non-gambler group follow. All three groups scored higher on the magnification of gambling skills than the mean (4.0) of the scale. Pathological gamblers and social gamblers scored higher on the probability thinking error than non-gamblers. Pathological gamblers displayed higher external attribution, lower internal attribution in their daily life events and higher internal attribution in failure situation than social gamblers and non-gamblers. The results indicate that cognitive errors would be a factor that differentiates pathological gamblers from social gamblers and non-gamblers. In predicting gambling behaviors, overestimation of self-ability of irrational gambling beliefs, internal attribution in failure situation, external attribution in daily live event, and probability thinking error were identified as significant factors. It is concluded that a public education about common cognitive bias featured in gamblers might be important in prevention of pathological gambling behaviors.

• Journal of Korea Entertainment Industry Association
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• v.13 no.4
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• pp.173-184
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• 2019

The data processing of this study is based on the word data search in social media through textom and the big data analysis is carried out and three areas (2019 Gwangju World Swimming Championships, 2019 Gwangju World Swimming Masters Competition, 2019 World Swimming Championships Problem) was consistently handled through data collection and refinement in the web environment. We applied the collected words to the program of Ucinet6, visualized them, and conducted a CONCOR analysis to grasp the similar relationship of words and to identify the cluster of common factors. As a result of the analysis, the clusters related to the 2019 Gwangju World Swimming Championships mainly consisted of four major areas of recognition and perception, mainly searching for operational aspects related to the swimming championship, and the community related to the 2019 Gwangju World Swimming Masters Competition Is mainly searched for the promotion of the Masters Competition and the aspect of the competition divided into two areas of major recognition and peripheral recognition. The cluster related to the problems of the 2019 Gwangju World Swimming Championships is divided into five areas, And they are mainly searching for the place, operation, institution, event, etc. of the problem of the swimming championship.