• 대한한의진단학회지
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• 제16권3호
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• pp.41-48
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• 2012

Objectives: The aims of this study are to design a optimized mechanical structure of digital tongue imaging system (DTIS) equipped with LEDs in aspects of object distance and camera angle of coverage. Methods and Results: We tried to find optimized object distance while recording a rectangular object of common tongue size. In case object distance is 22 cm or less, edge of the rectangle was not taken beyond the shooting range. In contrast, if object distance is 40 cm or more, the rectangle image was too small. Therefore when considering the variation of subjects, we selected distance of 35-40 cm as appropriate object distance for the DTIS. We also tried to find optimized angle between camera view axis and horizontal line. We photographed from the side of the face of 7 adults with exposed tongue. We drew an exposed tongue lines to connect the tongue tip points and the tongue root points by using the photos acquired from the side faces. And then we calculated the tongue exposure angles between the vertical line and the exposed tongue lines. Mean tongue exposure angle was $28.3^{\circ}$ when tongue was lightly exposed and $13.3^{\circ}$ when maximally. So we determined $73^{\circ}$ as appropriate slope angle of part in contact with face of the DTIS and by considering that the standard variation was great, we designed control gears to adjust the slope of the camera view axis and to regulate the object distance. Conclusions: We designed a optimized mechanical structure in object distance and slope angle of part in contact with face of the DTIS.

• Genomics & Informatics
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• 제8권3호
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• pp.131-137
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• 2010

Genome-wide association studies (GWASs) have greatly contributed to the identification of common variants responsible for numerous complex traits. There are, however, unavoidable limitations in detecting causal and/or rare variants for traits in this approach, which depends on an LD-based tagging SNP microarray chip. In an effort to detect potential casual and/or rare variants for complex traits, such as type 2 diabetes (T2D) and triglycerides (TGs), we conducted a targeted resequencing of loci identified by the Korea Association REsource (KARE) GWAS. The target regions for resequencing comprised whole exons, exon-intron boundaries, and regulatory regions of genes that appeared within 1 Mb of the GWA signal boundary. From 124 individuals selected in population-based cohorts, a total of 0.7 Mb target regions were captured by the NimbleGen sequence capture 385K array. Subsequent sequencing, carried out by the Roche 454 Genome Sequencer FLX, generated about 110,000 sequence reads per individual. Mapping of sequence reads to the human reference genome was performed using the SSAHA2 program. An average of 62.2% of total reads was mapped to targets with an average 22X-fold coverage. A total of 5,983 SNPs (average 846 SNPs per individual) were called and annotated by GATK software, with 96.5% accuracy that was estimated by comparison with Affymetrix 5.0 genotyped data in identical individuals. About 51% of total SNPs were singletons that can be considered possible rare variants in the population. Among SNPs that appeared in exons, which occupies about 20% of total SNPs, 304 nonsynonymous singletons were tested with Polyphen to predict the protein damage caused by mutation. In total, we were able to detect 9 and 6 potentially functional rare SNPs for T2D and triglycerides, respectively, evoking a further step of replication genotyping in independent populations to prove their bona fide relevance to traits.

• 분석과학
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• 제28권4호
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• pp.270-277
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• 2015

비등점은 유기물의 물리화학적 성질을 특정하는데 있어 매우 근본적 요소 중 하나이다. 그러나 기존의 정량적 구조-물성 상관관계식들은 고에너지 물질 등과 같은 특정 물질 군에 대한 실험값들의 부족 등으로 인해 제한적인 응용성을 가지고 있었다. 본 연구에서는 서로 다른 출처로부터의 5,923개의 비등점 자료를 확보하였으며, 이에는 일반적 유기화합물과 더불어 특수목적을 가지는 분자들을 포함하였고, 이들 수집된 데이터 셋을 이용하여 새로운 비등점 예측모델을 개발하는데 사용하였다. 다양한 학습 방법을 이용하여 새로이 수집된 데이터 셋을 이용한 2차원 분자 표현자에 기반한 비등점 모델을 도출하였다. 개발된 예측모델의 적정성과 견고성을 확인하였고, 훈련 셋의 표현자에 기반한 비등점 예측모델의 적용구역을 도출하였다.

• 대한원격탐사학회지
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• 제17권3호
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• pp.243-251
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• 2001

GPS(Global Positioning System)를 이용한 측위는 현재 가장 널리 쓰이는 측위 기법이다. 그러나 GPS 위치 측정시 일반 사용자는 전리층과 대류권의 영향으로 인해 항법이나 측위 등의 응용분야에서 만족할 만한 정확도를 얻을 수 없다. DGPS(Differential Global Positioning System)는 이러한 제약들을 해결할 수 있는 방법으로써, 이는 공통 오차를 제거하여 높은 정확도를 얻을 수 있다. 하지만 DGPS를 사용한 경우에도 정밀 측위에 있어서는 기준점으로부터의 거리 제한과 실시간 데이터 처리가 힘든 문제점을 내재하고 있다. 따라서 본 논문에서는 장기선 DGPS를 위한 실시간 보정신호 전송방법에 관하여 논한다. 이는 데이터 전송거리가 제한되는 종래의 무선 모뎀 방법에서의 문제를 해결하기 위하여 TCP와 UDP 또는 IP 프로토콜로 구성되는 TCP/IP 프로토콜 스택을 이용함으로써 어느 곳이나 RTK-GPS 위치 정보 데이터의 전송을 가능하게 한다.

• 대한원격탐사학회지
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• 제10권2호
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• pp.37-48
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• 1994

In spatial information processing, particularly in non-renewable resource exploration, the spatial data sets, including remote sensing, geophysical and geochemical data, have to be geocoded onto a reference map and integrated for the final analysis and interpretation. Application of a computer based GIS(Geographical Information System of Geological Information System) at some point of the spatial data integration/fusion processing is now a logical and essential step. It should, however, be pointed out that the basic concepts of the GIS based spatial data fusion were developed with insufficient mathematical understanding of spatial characteristics or quantitative modeling framwork of the data. Furthermore many remote sensing and geological data sets, available for many exploration projects, are spatially incomplete in coverage and interduce spatially uneven information distribution. In addition, spectral information of many spatial data sets is often imprecise due to digital rescaling. Direct applications of GIS systems to spatial data fusion can therefore result in seriously erroneous final results. To resolve this problem, some of the important mathematical information representation techniques are briefly reviewed and discussed in this paper with condideration of spatial and spectral characteristics of the common remote sensing and exploration data. They include the basic probabilistic approach, the evidential belief function approach (Dempster-Shafer method) and the fuzzy logic approach. Even though the basic concepts of these three approaches are different, proper application of the techniques and careful interpretation of the final results are expected to yield acceptable conclusions in cach case. Actual tests with real data (Moon, 1990a; An etal., 1991, 1992, 1993) have shown that implementation and application of the methods discussed in this paper consistently provide more accurate final results than most direct applications of GIS techniques.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2017년도 학술발표회
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• pp.467-467
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• 2017

토양수분 및 황사발생 연구에 있어 효율적인 광역 분석을 위하여 위성자료가 활용되고 있다. 활용 시나리오에 따라서는 준실시간 자료 수신, 처리가 필요하며 본 연구에서는 이에 대한 방안을 연구하기 위하여 유럽 EUMETSAT(European Organisation for the Exploitation of Meteorological Satellites)의 ASCAT(Advanced Scatterometer) Metop-A 자료에 대하여 파악하였다. 자료 수신 프로토콜에 있어서 FTP, HTTP 등 전통적 방법에 대한 현황과 함께 비교적 최근 기법인 OGC(Open Geospatial Consortium)　 WMS(Web Map Service), WCS(Web Coverage Service) 방식의 지원 현황에 대하여 확인하였다. 제공되는 자료 Format부분은 EPS Native와 BUFR(Binary Universal Form for the Representation of meteorological data)을 살펴보되 데이터 프로바이더 측에서 대부분 채택되고 있는 NetCDF(network Common Data Form)를 중심으로 파악하였다. 수신된 자료의 처리 자동화를 위한 소프트웨어는 OSGeo(The Open Source Geospatial Foundation)의 GDAL(Geospatial Data Abstraction Library), 미국 NCAR(National Center for Atmospheric Research)의 NCL(NCAR Command Language)을 중심으로 확인하였다. 자료 가공기법은 격자(Raster) 자료에 대한 기본 메타정보 확인, 좌표참조체계 변환, 해상도 및 Format 변환을 중심으로 확인하였다. 한편 OGC WMS, WCS는 자료의 전송 프로토콜 기법이면서 동시에 서버 사이드에서의 자료 변환 기능을 구비하고 있다. 예를 들어 Http Request에서 영역(Extent), Format 형식, 좌표참조체계를 지정할 수 있다. OGC WMS에 대한 EUMETSAT 파일럿 서비스에서 반환 자료의 공간적 영역, 복수 시점 제공 현황, 반환 포맷 지원 상황은 실제 메서드를 사용하여 파악하였고, 향후 발전 방향을 전망하였다.

• 정보보호학회논문지
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• 제29권4호
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• pp.807-819
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• 2019

그레이박스 퍼징은 소프트웨어에 존재하는 알려지지 않은 보안 취약점을 찾는 효과적인 방법으로 최근까지 활발하게 연구되고 있다. 단, 대부분의 그레이박스 퍼징 도구들은 실행파일을 필요로 하기 때문에 직접 실행할 수 없는 라이브러리는 별도의 실행파일을 준비해야 한다. 이러한 실행파일을 만드는 것은 라이브러리에 대한 이해 및 퍼징에 대한 이해가 동시에 필요한 어려운 일이다. 본 연구에서는 라이브러리를 위한 실행파일을 자동으로 생성하는 방법을 제안하고 이를 LLVM 기반의 도구로 구현한다. 제안하는 방법은 대상 라이브러리 프로젝트에 존재하는 유닛테스트에 대한 정적/동적 분석을 통해 라이브러리를 테스트할 수 있는 실행파일 및 시드파일을 자동으로 생성한다. 생성한 실행파일은 기존 그레이박스 퍼징 도구들이 주로 사용하는 인터페이스를 보유하여 AFL과 같은 다양한 그레이박스 퍼징 도구와 호환된다. 우리는 이 도구를 사용해 오픈소스 프로젝트로부터 생성한 실행파일과 시드파일을 바탕으로 코드 커버리지 및 알려지지 않은 취약점을 찾음으로써 제안하는 방법의 성능을 보인다.

• Infection and chemotherapy
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• 제50권4호
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• pp.328-339
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• 2018

Background: Pneumococcal disease is a major cause of morbidity and mortality worldwide, especially in patients with comorbidities and advanced age. This study evaluated trends in epidemiology of adult pneumococcal disease in Crete, Greece, by identifying serotype distribution and antimicrobial resistance of consecutive Streptococcus pneumoniae strains isolated from adults during an 8-year time period (2009-2016) and the indirect effect of the infant pneumococcal higher-valent conjugate vaccines 10-valent pneumococcal conjugate vaccine (PCV10) and 13-valent pneumococcal conjugate vaccine (PCV13). Materials and Methods: Antimicrobial susceptibility was performed by E-test and serotyping by Quellung reaction. Multidrug resistance (MDR) was defined as non-susceptibility to penicillin (PNSP) combined with resistance to ${\geq}2$ non-${\beta}$-lactam antimicrobials. Results: A total of 135 S. pneumoniae strains were isolated from adults during the study period. Twenty-one serotypes were identified with 17F, 15A, 3, 19A, and 11A, being the most common. The coverage rates of PCV10, and PCV13 were 17.8% and 37.8%, respectively. PCV13 serotypes decreased significantly from 68.4% in 2009 to 8.3% in 2016 (P = 0.002). The most important emerging non-PCV13 serotypes were 17F, 15A, and 11A, with 15A being strongly associated with antimicrobial resistance and MDR. Among all study isolates, penicillin-resistant and MDR strains represented 7.4% and 14.1%, respectively. Predominant PNSP serotypes were 19A (21.7%), 11A (17.4%), and 15A (17.4%). Erythromycin, clindamycin, tetracycline, trimethoprim-sulfamethoxazole, and levofloxacin resistant rates were 30.4%, 15.6%, 16.3%, 16.3%, and 1.5%, respectively. Conclusion: Although pneumococcal disease continues to be a health burden in adults in Crete, our study reveals a herd protection effect of the infant pneumococcal higher-valent conjugate vaccination. Surveillance of changes in serotype distribution and antimicrobial resistance among pneumococcal isolates are necessary to guide optimal prevention and treatment strategies.

• Archives of Plastic Surgery
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• 제48권1호
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• pp.3-9
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• 2021

Background For an attractive and natural tip contour in Asian rhinoplasty, insertion of a nasal implant and reinforcement of the cartilaginous framework are essential. However, scar contracture, which often results from augmentation with implant insertion and inadequate soft tissue coverage of the framework, is one of the most common causes of alar retraction. This study reports a novel method of redraping soft tissue along the alar rim to prevent alar retraction in Asians. Methods Twenty young Asian men who underwent primary rhinoplasty with septoplasty were retrospectively reviewed. After the usual rhinoplasty procedures, alar rim redraping was conducted for the soft tissue along the transcolumellar and bilateral infracartilaginous incisions. The longest axis of the nostril (a) and the height of the nostril from that axis (b) were measured in anterior-posterior and lateral views. The preoperative and postoperative ratios (b/a) were analyzed using the paired t-test. Results All 20 patients showed natural contours of the nasal tip, nostrils, and alae after a mean follow-up of 53.6 weeks (range, 52-60 weeks). The ratio of the nostril axes significantly decreased postoperatively in all patients except one, by an average of 11.08%±6.52% in the anterior-posterior view and 17.74%±8.49% in the lateral view (P<0.01). There were no complications, including asymmetry, contracture, subdermal plexus injury, flap congestion, or infection. Conclusions A quantitative analysis of alar retraction by evaluating the ratio of nostril axes showed that alar rim redraping is a simple and effective adjuvant technique for preventing alar retraction in rhinoplasty for young Asian men.

• Archives of Plastic Surgery
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• 제49권1호
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• pp.108-114
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• 2022

Reconstruction of defects around the knee region requires thin and pliable skin. The superior lateral genicular artery (SLGA) flap provides an excellent alternative to muscle-based flaps. The anatomy and the surgical techniques of the SLGA flap were reviewed and the results of cases using the SLGA flap for coverage of knee and proximal leg defects were analyzed. SLGA flaps were performed in two cases and followed up for at least 6 months. Twelve articles on the use of the SLGA flap were also identified. A review of 39 cases showed that the mean diameter of the perforator supplying the skin of the flap was 1.04 mm, while the mean diameter of the SLGA at its origin was 1.78 mm. The mean length of the pedicle measured from the origin of the popliteal artery was 7.44 cm. The average dimensions of the flap were 14.8×6.6 cm with primary closure of the donor site in 61.5% of cases. Of these cases, 38.5% were due to trauma, 23.1% were post-burn complications, 12.8% were defects after resection of tumors, and 10.3% were for ulcers post-bursectomy. The most common complication was flap tip necrosis. All studies reported favorable outcomes with complete wound healing.