• Tuberculosis and Respiratory Diseases
• /
• 제61권6호
• /
• pp.526-532
• /
• 2006

연구배경: 결핵성 흉막염은 대부분 초감염 결핵의 형태로 발생하는 것으로 알려져 왔다. 그러나 최근 결핵환자가 감소함에 따라 초감염 결핵보다 재발성 결핵으로 결핵성 흉막염이 발생하는 경향이 늘고 있다. 대상 및 방법: 2003년 1월부터 2006년 2월까지 단국대학교병원에서 결핵성 흉막염으로 진단받은 환자들의 과거력과 방사선 소견에 따라 초감염 결핵과 재발성 결핵으로 분류하고 두 군 사이에 임상 소견, 방사선 소견, 그리고 6 개월 동안 항결핵 약물치료 후 잔여 흉막비후에 있어서 차이가 있는지 알아보았다. 결 과: 1. 결핵성 흉막염 환자 141명 중에서 135명에서 초감염 결핵과 재발성 결핵의 구분이 가능하였는데 초감염 결핵의 소견을 보인 환자는 38명(28%), 재발성 결핵의 소견을 보인 환자는 97명(72%)으로 재발성 결핵의 소견을 보이는 환자가 더 많았다. 2. 초감염과 재발성 결핵 환자 사이에서 성별, 나이, 증상의 발현 시작부터 흉수검사까지의 기간, 진단 시의 흉수의 양, 흉수 총백혈구수, 림프구수, LDH, ADA 수치에 있어서 유의한 차이가 없었다. 3. 6개월 이상 추적관찰이 가능하였던 124명의 환자들의 잔여 흉막비후의 정도에 있어서 초감염 결핵과 재발성 결핵 사이에 차이가 없었다. 결 론: 결핵성 흉막염 환자 중에서 초감염 결핵보다 재발성 결핵의 소견을 보이는 환자가 더 많았으며 두 군 사이에 임상 소견, 방사선 소견, 흉수 소견에서 유의한 차이가 없었으며, 6 개월 치료 후의 잔여 흉막비후의 정도에 있어서도 유의한 차이가 없었다.

• Advances in pediatric surgery
• /
• 제10권2호
• /
• pp.99-106
• /
• 2004

1994년 1월부터 2003년 6월까지 경북대학교 의과대학 외과학 교실에서 경험한 선천성 장폐쇄증 환자 36명을 대상으로 재태기간과 출생시 체중, 산전진단 및 출생장소, 임상소견, 수술전 검사, 동반기형, 수술방법, 형태학적 분류, 합병증 및 사망률을 후향적으로 검토하였다. 총 36예의 환자중에서 십이지장 폐쇄증 17예, 공장 폐쇄증 11예, 회장 폐쇄증 8예 있었다. 남녀비는 십이지장 폐쇄증은 1.4:1, 공장 폐쇄증 2.7:1, 회장 폐쇄증의 경우는 7:1 이었다. 형태학적 분류에서 십이지장 폐쇄증은 3형이 7예로 가장 많았으며, 공장 및 회장 폐쇄증은 1형이 10예로 가장 많았으며, 3a형이 7예 있었다. 임상 소견은 담즙성 구토와 복부 팽만이 가장 흔한 증상이었다. 수술 전 검사는 십이지장 페쇄증은 전예에서 단순복부촬영만으로 정확하게 진단이 가능하였다. 동반 병변은 십이지장 폐쇄증 환자 중선천성 심기형 6예, 다운증후군이 3예 있었고, 공장 및 회장 폐쇄증에서는 3예에서 태변성 복막염이 동반되었다. 수술방법은 부분절제술을 시행한 경우가 13예로 가장 많았다. 술 후 합병증은 문합부 유출 3예, 장 폐색증 3예, 창상 감염이 3예 있었으며, 십이지장 폐쇄증 환자 2예 9사망률:11.8 %)에서 동반된 선천성 심 기형으로 사망하였으며, 공장 폐쇄증 환아 2예(사망률: 18 %)는 폐혈증과 3b 형에서 장 절제 후 단장 증후군으로 각각 사망하였다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권13호
• /
• pp.5349-5357
• /
• 2015

Background: Breast cancer is the most common cancer and the leading cause of cancer mortality among women of all ethnic and age groups in Malaysia. Delay in seeking help for breast cancer symptoms is preventable and by identifying possible factors for delayed diagnosis, patient prognosis and survival rates could be improved. Objectives: This narrative review aimed to understand and evaluate the level of in-depth breast cancer knowledge in terms of clinical breast examination and breast self-examination, and other important aspects such as side-effects and risk factors in Malaysian females. Since Malaysia is multicultural, this review assessed social perceptions, cultural beliefs and help-seeking behaviour in respect to breast cancer among different ethnic groups, since these may impinge on efforts to 'avoid' the disease. Materials and Methods: A comprehensive literature search of seven databases was performed from December 2015 to January 2015. Screening of relevant published journals was also undertaken to identify available information related to the knowledge, perception and help-seeking behaviour of Malaysian women in relation to breast cancer. Results: A total of 42 articles were appraised and included in this review. Generally, women in Malaysia had good awareness of breast cancer and its screening tools, particularly breast self-examination, but only superficial in-depth knowledge about the disease. Women in rural areas had lower levels of knowledge than those in urban areas. It was also shown that books, magazines, brochures and television were among the most common sources of breast cancer information. Delay in presentation was attributed mainly to a negative social perception of the disease, poverty, cultural and religion practices, and a strong influence of complementary and alternative medicine, rather than a lack of knowledge. Conclusions: This review highlighted the need for an intensive and in-depth breast cancer education campaigns using media and community health programmes, even with the existing good awareness of breast cancer. This is essential in order to avoid misconceptions and to frame the correct mind-set about breast cancer among women in Malaysia. Socio-cultural differences and religious practices should be taken into account by health care professionals when advising on breast cancer. Women need to be aware of the risk factors and symptoms of breast cancer so that early diagnosis can take place and the chances of survival improved.

• Tuberculosis and Respiratory Diseases
• /
• 제52권6호
• /
• pp.590-596
• /
• 2002

목 적 : 폐암은 악성 흉막 삼출액의 가장 흔한 원인으로 흉관 삽입후 흉막유착술을 시행하는 것이 치료에 널리 이용 되어왔다. 흉막경화제는 여러 종류가 알려져 있으나 그 효과나 부작용은 약제마다 차이가 있다. 이에 저자들은 대표적 흉막경화제인 doxycycline과 새로운 약제인 OK-432의 효과, 부작용 및 무병기간의 차이를 알아보기 위해 본 연구를 시행하였다. 방 법 : 1994년 1월부터 2001년 8월까지 흉막천자 세포진검사 혹은 흉막조직검사상 악성 흉막염이 확인된 폐암환자 중 OK-432나 doxycycline으로 흉막유착술을 시행한 79명의 환자에게서 흉막 유착술 후 30일째의 성공률을 조사하였으며, 약제의 부작용과 무병 생존기간을 후향적으로 조사하였다. 결 과 : OK-432와 doxycycline을 이용한 흉막유착술 후 30일째의 성공률은 각각 83%와 87%으로 유의한 차이가 없었으며 (p=0.677), 부작용으로 발열은 OK-432군 (59%, p=0.001)에서 유의하게 많았고, 통증은 doxycycline군 (73%, p=0.008)에서 유의하게 많았다 무병기간은 두 군 사이에 유의한 차이가 없었다(OK-432 : 13.6개월, doxycycline : 11.6개월)(p=0.532). 결 론 : 폐암으로 인한 악성 흉막액을 치료하는 OK-432는 doxycycline과 비슷한 흉막유착술치료 효과가 있을 것으로 생각된다.

• Clinical and Experimental Pediatrics
• /
• 제54권4호
• /
• pp.176-178
• /
• 2011

Hemolytic-uremic syndrome (HUS) is the most common cause of acute renal failure in young children. It is classically characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and uremia. Further, not only is intussusception one of the differential diagnoses of HUS but it may also become a complication during disease progression. We report a case of HUS. preceded by intussusception in a previously healthy 17-month-old boy. The patient presented at the emergency department with bloody stools that developed the day after reduction of intussusception. HUS was diagnosed 4 days after the reduction of intussusception. The patient was provided only supportive care and his laboratory test findings were normal at discharge.

• Journal of Yeungnam Medical Science
• /
• 제34권2호
• /
• pp.149-160
• /
• 2017

Streptococcus pneumoniae, pneumococcus, is the most common cause of community-acquired pneumonia (CAP). CAP is an important infectious disease with high morbidity and mortality, and it is still one of the leading causes of death worldwide. Many genetic factors of the host and various environmental factors surrounding it have been studied as important determinants of the pathophysiology and outcomes of pneumococcal infections. Various cytokines, including transforming growth factor $(TGF)-{\beta}1$, are involved in different stages of the progression of pneumococcal infection. $TGF-{\beta}1$ is a cytokine that regulates a wide range of cellular and physiological functions, including immune and inflammatory responses. This cytokine has long been known as an anti-inflammatory cytokine that is critical to preventing the progression of an acute infection to a chronic condition. On the other hand, recent studies have unveiled the diverse roles of $TGF-{\beta}1$ on different stages of pneumococcal infections other than mitigating inflammation. This review summarizes the recent findings of the role of $TGF-{\beta}1$ on the pathophysiology of pneumococcal infections, which is fundamental to developing novel therapeutic strategies for such infections in immune-compromised patients.

• Journal of Oral Medicine and Pain
• /
• 제44권3호
• /
• pp.133-139
• /
• 2019

Osteomyelitis is an inflammatory condition of the bone caused by pathogenic bacteria. The causative pathogen is usually oral residing bacteria, but this is a report of patients with osteomyelitis infected with Enterobacteriaceae, which is not common. Enterobacteriaceae has been known to cause in-hospital infections for over last 30 years and is known to have multiple antibiotic resistances. Both cases in this study developed osteomyelitis after removal of the dentigerous cyst. Enterobacter aerogenes was cultured in one patient and Serratia marcescens in the other. After changing antibiotics through antibiotic susceptibility testing, clinical symptoms subsided and radiographic images confirmed that the callus formed and recovered at the same time.

• 대한물리치료과학회지
• /
• 제12권4호
• /
• pp.89-97
• /
• 2005

Objective: The purpose of this study was to access quality of life and evaluate pre and post surgery management for persons with lower limb amputations. Method: This study was designed as a telephone survey. The subjects were patients who underwent their lower limb amputation between January 1994, and February 2005 at Asan Medical Center in seoul. sixty one of 203 subjects had granted consent and were studied. Results: The major cause of below knee amputations was vascular disease. Traumatic injuries were more common among subjects with above knee amputations. 93.4% of subjects were in use of prosthesis and 70.1 days were required to fit the prosthesis. 68.4% of subjects were able to ambulate with single point cane or without assistive devices. 80.3% of subjects complained phantom pain. Most subjects expressed the unsatisfactory result regarding the functional usage of prosthesis and education from hospital. Conclusion: Pre and post surgery rehabilitation program will benefit to promote better functional status and quality of life for persons with lower limb amputations.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권4호
• /
• pp.1533-1537
• /
• 2012

In general, breast cancer is the most common malignancy among women in developed as well as some developing countries, often being the second leading cause of cancer mortality after lung cancer. Using a parametric log-logistic model to consider the effects of prognostic factors, the present study focused on the 5-year survival of women with the diagnosis of breast cancer in Southern Iran. A total of 1,148 women who were diagnosed with primary invasive breast cancer from January 2001 to January 2005 were included and divided into three prognosis groups: poor, medium, and good. The survival times as well as the hazard rates of the three different groups were compared. The log-logistic model was employed as the best parametric model which could explain survival times. The hazard rates of the poor and the medium prognosis groups were respectively 13 and 3 times greater than in the good prognosis group. Also, the difference between the overall survival rates of the poor and the medium prognosis groups was highly significant in comparison to the good prognosis group. Use of the parametric log-logistic model - also a proportional odds model - allowed assessment of the natural process of the disease based on hazard and identification of trends.

• 한방안이비인후피부과학회지
• /
• 제18권2호
• /
• pp.99-103
• /
• 2005

The tinnitus is a very common otorhinolaryngologic disease. But, we do not know the exact cause and the healing method of that. We have a case report of the patient who has both tinnitus during two years. He has also chest distress, chest pain, shoulder.neck pain, obesity. In Oriental Medicine, the cuases of tinnitus have diagnosed as the hepatic fire, phlegm-fire, heart fire, deficiency of the kidney, deficiency of vital energy and blood, and so on. In this study the patient classified by Sasang constitutional medicine, and the cuase of tinnitus diagnosed as cold turbid phlegm in Middle Cho, had a medical effects. And in the result, the other symptoms are reduced. So we report the healing process and result of this patient in this study.