• Structural Engineering and Mechanics
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• v.55 no.5
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• pp.953-964
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• 2015

A model has been proposed that can predict the ultimate torsional strength of single-box multi-cell reinforced concrete box girder under combined loading of bending, shear and torsion. Compared with the single-cell box girder, this model takes the influence of inner webs on the distribution of shear flow into account. According to the softening truss theory and thin walled tube theory, a failure criterion is presented and a ultimate torsional strength calculating procedure is established for single-box multi-cell reinforced concrete box girder under combined actions, which considers the effect of tensile stress among the concrete cracks, Mohr stress compatibility and the softened constitutive law of concrete. In this paper the computer program is also compiled to speed up the calculation. The model has been validated by comparing the predicted and experimental members loaded under torsion combined with different ratios of bending and shear. The theoretical torsional strength was in good agreement with the experimental results.

• Journal of the Korean Geosynthetics Society
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• v.19 no.3
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• pp.9-21
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• 2020

In this study, the design method of the combined sheet pile was considered in the coastal landfill where sandy and clayey soils are mixed, and the behavior in excavation was analyzed. It was confirmed from the elasto-plastic analysis that the predicted behavior of the temporary facilities of earth retaining differs according to the type of the combined sheet pile method (Built up, Interlocking, Welding) and the analysis method (soldier pile method, continuous wall method). In the case of sheet pile member force, the results of the continuous wall analysis method predicted the most conservative results. When the stress ratio (calculation/allowance) of each member was analyzed based on the maximum member force of the combined sheet pile method, the maximum value was obtained for bending moment in the side pile and combined stress in the case of the strut. As a result of finite element analysis, the member force of the side pile was the largest in the short-term effective stress analysis condition, while the compressive force of the strut was large in the consolidation analysis. When comparing the results of the elasto-plastic analysis and the finite element analysis, the shear force of the side pile and the axial force of the strut were greatly evaluated in the elasto-plastic analysis, and the bending moment of the side pile was the largest in the short-term effective stress condition of the finite element analysis. In addition, the displacement of the side pile was predicted to be greater in the finite element analysis than in the elasto-plastic analysis.

• Journal of Industrial Convergence
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• v.19 no.1
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• pp.87-97
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• 2021

This study aimed to systematically review the literature on the stress reduction of meaning-centered therapy (MCT) studies in Korea and to identify the characteristics of MCT for stress reduction. MCT studies aimed at reducing stress symptoms were searched among peer reviewed journal articles and unpublished dissertations until April, 2020. Two independent researchers assessed the risk of bias and the quality of the report using Scottish Intercollegiate Guidelines Network criteria. As a result of searching with 7 databases, 7 studies were finally selected. Seven MCTs were for all age groups, and 5 studies reported MCT was effective in reducing stress symptoms. Both single and combined type interventions were effective in reducing stress symptom, Researchers used the combined MCT more than single MCT program. The study with no significant effect was related to school test stress. There is a need to develop MCTs suitable for school-age youth with test stress in the future.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.38 no.11
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• pp.1207-1214
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• 2014

Under excessive plasticity, the fracture toughness of a material depends on its size and geometry. Under fully yielded conditions, the stresses in a material near its crack tip are not unique but rather depend on the geometry. Therefore, the single-parameter J-approach is limited to a high-constraint crack geometry. The JQ theory has been proposed for establishing the crack geometry constraints. This approach assumes that the crack-tip fields have two degrees of freedom. In this study, the crack-tip stress field of a fully circumferential surface-cracked pipe under combined loads is investigated on the basis of the JQ theory by using finite element analysis. The combined loads are a tensile axial force and the thermal gradient in the radial direction. Q-stresses of the crack geometry and its loading state are used to determine the constraint effects. The constraint effects of secondary loading are found to be greater than those of primary loading. Therefore, thermal shock is believed to be the most severe loading condition of constraint effects.

• Journal of the Society of Naval Architects of Korea
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• v.56 no.1
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• pp.82-93
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• 2019

In this paper, the ductile fracture criteria for a marine structural steel (EH36) are presented and validated. The theoretical background of the recently developed Hosford-Coulomb (HC) fracture strain model and the DSSE fracture strain model which was developed to apply to the shell elements is described. In order to accurately estimate the flow stress in the large strain range up to the fracture, the material constants for the combined Swift-Voce constitutive equation were derived by the numerical analyses of the smooth and notched specimens made from the EH36 steel. As a result of applying the Swift-Voce flow stress to the other notched specimen model, a very accurate load - displacement curve could be derived. The material constants of the HC fracture strain and DSSE fracture strain models were independently calibrated based on the numerical analyses for the smooth and notch specimen tests. The user subroutine (VUMAT of Abaqus) was developed to verify the accuracy of the combined HC-DSSE fracture strain model. An asymmetric notch specimen was used as verification model. It was confirmed that the fracture of the asymmetric specimen can be accurately predicted when a very small solid elements are used together with the HC fracture strain model. On the other hand, the combined HC-DSSE fracture strain model can predict accurately the fracture of shell element model while the shell element size effect becomes less sensitive.

• Journal of Microbiology and Biotechnology
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• v.31 no.3
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• pp.398-407
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• 2021

Using salt-tolerant bacteria to protect plants from salt stress is a promising microbiological treatment strategy for saline-alkali soil improvement. Here, we conducted research on the growth-promoting effect of Brevibacterium frigoritolerans on wheat under salt stress, which has rarely been addressed before. The synergistic effect of B. frigoritolerans combined with representative salt-tolerant bacteria Bacillus velezensis and Bacillus thuringiensis to promote the development of wheat under salt stress was also further studied. Our approach involved two steps: investigation of the plant growth-promoting traits of each strain at six salt stress levels (0, 2, 4, 6, 8, and 10%); examination of the effects of the strains (single or in combination) inoculated on wheat in different salt stress conditions (0, 50, 100, 200, 300, and 400 mM). The experiment of plant growth-promoting traits indicated that among three strains, B. frigoritolerans had the most potential for promoting wheat parameters. In single-strain inoculation, B. frigoritolerans showed the best performance of plant growth promotion. Moreover, a pot experiment proved that the plant growth-promoting potential of co-inoculation with three strains on wheat is better than single-strain inoculation under salt stress condition. Up to now, this is the first report suggesting that B. frigoritolerans has the potential to promote wheat growth under salt stress, especially combined with B. velezensis and B. thuringiensis.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.26 no.6
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• pp.1099-1106
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• 2002

This paper provides engineering J-integral and crack opening displacement (COD) estimation equations for circumferential through-wall cracked pipes under internal pressure and under combined internal pressure and bending. Based on selected 3-D finite element calculations for the circumferential through-wall cracked pipes under internal pressure using the idealized power law materials, the elastic and plastic influence functions for fully plastic J-integral and COD solutions are found as a function of the normalized crack length and the mean radius-to-thickness ratio. These developed GE/EPRI-type solutions are then re-formulated based on the enhanced reference stress method. Such re-formulation not only provides simpler equations for J-integral and COD estimations, but also can be easily extended to combined internal pressure and bending. The proposed equations are compared with elastic-plastic finite element results using actual stress-strain data, which shows overall excellent agreement.

• Journal of the Society of Naval Architects of Korea
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• v.44 no.6
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• pp.598-604
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• 2007

The purpose of this study is to establish the predictive method of welding distortion and residual stress for the channel I butt SA (submerged arc) weldment using FEA. In order to do it, the heat input model for the weldment was defined as the combined heat source with the surface heat flux of gaussian distribution and volumetric heat source uniformly distributed within weld groove by comparing the shapes of molten pool and temperature distribution obtained by FEA with those of experiments. The arc efficiency of SA welding for two-dimensional FE analysis was evaluated as 0.85. The welding distortion and residual stress of the weldment obtained by FEA and heat input model proposed have a good agreement with those obtained by experiment. Based on the results, it was suggested that the proper heat input model should be required to evaluate the welding distortion for weldment.

• Biomolecules & Therapeutics
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• v.29 no.4
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• pp.434-444
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• 2021

BRAF inhibitors are insufficient monotherapies for BRAF-mutated cancer; therefore, we investigated which inhibitory pathway would yield the most effective therapeutic approach when targeted in combination with BRAF inhibition. The oncogenic BRAF inhibitor, PLX4720, increased basal autophagic flux in BRAF-mutated cells compared to wild-type (WT) BRAF cells. Interestingly, early autophagy inhibition improved the effectiveness of PLX4720 regardless of BRAF mutation, whereas late autophagy inhibition did not. Although ATG5 knockout led to PLX4720 resistance in both WT and BRAF-mutated cells, the MEK inhibitor trametinib exhibited a synergistic effect on PLX4720 sensitivity in WT BRAF cells but not in BRAF-mutated cells. Conversely, the prolonged inhibition of endoplasmic reticulum (ER) stress reduced basal autophagy in BRAF-mutated cells, thereby increasing PLX4720 sensitivity. Taken together, our results suggest that the combined inhibition of ER stress and BRAF may simultaneously suppress both pro-survival ER stress and autophagy, and may therefore be suitable for treatment of BRAF-mutated tumors whose autophagy is increased by chronic ER stress. Similarly, for WT BRAF tumors, therapies targeting MEK signaling may be a more effective treatment strategy. Together, this study presents a rational combination treatment strategy to improve the efficacy of BRAF inhibitors depending on BRAF mutation status.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.8 no.2
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• pp.73-79
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• 1999

Most of mechanical structures are combined of substructures such as beams and/or plates. There are few systems with unibody structures but are many systems with united body structures. Generally the dynamic a nalysis of whole structures is performed under alternation load. In the structure design, the analysis of each bolted joint is more important than others for zero severity. This paper presents the analysis method of contact stress distribution factor in the bolted joint with variable fastening torque on joints in the structure. At first, a static vibration test was performed to find out a nominal stress of bolt jointed plates from the relationship between natural frequency and nominal stress. Then a contact stress was computed at contact point between bolt and plate in the structure. It is believed that the proposed method has promisiong implications for safer design with index of contact stress distribution factor and has merits for cost-down and saving time at the beginning of vehicle development.