• Journal of Animal Science and Technology
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• v.63 no.4
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• pp.740-750
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• 2021

This study was performed to investigate genetic relationship of age at first calving (AFC) with body development and reproduction capacity in female Hanwoo. The data sets of 52,299 reproduction records of 19,566 heads calved from 2011 to 2019 and conformation records of 19565 heads born from 1997 to 2017 were analyzed by separating them based on age at first calving. In the analysis, conformation traits included the body condition score (BCS), height (HT), body width (BW), hip bone length (HL), hip bone width (HW), and final score (FS). The heritability and genetic correlation of AFC with conformation traits and calving interval (CI) were analyzed. The heritability for AFC was 0.716, 0.087, and 0.097 for the before and after 24 months and combined data, respectively. The genetic correlation of AFC before 24 months with BCS was -0.778, -0.600 with BW, and 0.442 with HT. The genetic correlation of AFC after 24 months with HT was -0.826, -0.706 with BW, -0.623 with HL, -0.456 with HW, and -0.675 with FS. When the first calving age of young heifers approached 24 months, BCS and BW decreased, and HT increased. When first calving is delayed to after 24 months, the conformation traits become smaller, which indicates that conformation to some extent affects the delay in AFC. The genetic correlation between CI and AFC was -0.116, 0.307, and 0.250 for the before and after 24 month of AFC and combined data, respectively. When first calving date approached 24 months, CI was reduced. The obtained results suggest that it is important that first calving occurs at an appropriate age. Additional research is needed to perform proper genetic evaluation of first calving age in Hanwoo cattle in Korea.

• Korean Journal of Radiology
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• v.24 no.9
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• pp.849-859
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• 2023

Objective: The prognostic value of the volume and density of skeletal muscles in the abdominal waist of patients with colon cancer remains unclear. This study aimed to investigate the association between the automated computed tomography (CT)-based volume and density of the muscle in the abdominal waist and survival outcomes in patients with colon cancer. Materials and Methods: We retrospectively evaluated 474 patients with colon cancer who underwent surgery with curative intent between January 2010 and October 2017. Volumetric skeletal muscle index and muscular density were measured at the abdominal waist using artificial intelligence (AI)-based volumetric segmentation of body composition on preoperative pre-contrast CT images. Patients were grouped based on their skeletal muscle index (sarcopenia vs. not) and muscular density (myosteatosis vs. not) values and combinations (normal, sarcopenia alone, myosteatosis alone, and combined sarcopenia and myosteatosis). Postsurgical disease-free survival (DFS) and overall survival (OS) were analyzed using univariable and multivariable analyses, including multivariable Cox proportional hazard regression. Results: Univariable analysis showed that DFS and OS were significantly worse for the sarcopenia group than for the non-sarcopenia group (P = 0.044 and P = 0.003, respectively, by log-rank test) and for the myosteatosis group than for the non-myosteatosis group (P < 0.001 by log-rank test for all). In the multivariable analysis, the myosteatotic muscle type was associated with worse DFS (adjusted hazard ratio [aHR], 1.89 [95% confidence interval, 1.25-2.86]; P = 0.003) and OS (aHR, 1.90 [95% confidence interval, 1.84-3.04]; P = 0.008) than the normal muscle type. The combined muscle type showed worse OS than the normal muscle type (aHR, 1.95 [95% confidence interval, 1.08-3.54]; P = 0.027). Conclusion: Preoperative volumetric sarcopenia and myosteatosis, automatically assessed from pre-contrast CT scans using AI-based software, adversely affect survival outcomes in patients with colon cancer.

• Journal of Preventive Medicine and Public Health
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• v.51 no.5
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• pp.227-233
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• 2018

Objectives: Chronic diseases, including back pain, result in significant patient morbidity and societal burden. Overall improvement in physical fitness is recommended for prevention and treatment. Walking is a convenient modality for achieving initial gains. Our objective was to determine whether neighbourhood walkability, acting as a surrogate measure of physical fitness, was associated with the presence of chronic disease. Methods: We conducted a cross-sectional study of prospectively collected data from a prior randomized cohort study of 227 patients referred for tertiary assessment of chronic back pain in Ottawa, ON, Canada. The Charlson Comorbidity Index (CCI) was calculated from patient-completed questionnaires and medical record review. Using patients' postal codes, neighbourhood walkability was determined using the Walk Score, which awards points based on the distance to the closest amenities, yielding a score from 0 to 100 (0-50: car-dependent; 50-100: walkable). Results: Based on the Walk Score, 134 patients lived in car-dependent neighborhoods and 93 lived in walkable neighborhoods. A multivariate logistic regression model, adjusted for age, gender, rural postal code, body mass index, smoking, median household income, percent employment, pain, and disability, demonstrated an adjusted odds ratio of 2.75 (95% confidence interval, 1.16 to 6.53) times higher prevalence for having a chronic disease for patients living in a car-dependent neighborhood. There was also a significant dose-related association (p=0.01; Mantel-Haenszel chi-square=6.4) between living in car-dependent neighbourhoods and more severe CCI scores. Conclusions: Our findings suggest that advocating for improved neighbourhood planning to permit greater walkability may help offset the burden of chronic disease.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.20 no.2
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• pp.136-140
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• 2009

Background and Objectives: Recurrent respiratory papillomatosis (RRP) is difficult to treat because of its tendency to recur and spread throughout the aerodigestive tract. We aimed to estimate the effect of intralesional injections of cidofovir in patients with RRP. Materials and Method: Within the period from January 2003 to July 2007, 13 patients aged 2 to 61 years were treated with intralesional injections of cidofovir combined with surgical excision of RRP. Cidofovir was injected intralesionaly at a concentration of 5 mg/cc after complete removal of the papilloma with $CO_2$ laser or microdebrider. We evaluated the effect of intralesional cidofovir therapy by comparing pre-treatment mean interval of recurrence with post-treatment interval of recurrence. Results: Of 13 patients, two patients showed complete response during follow up period and four patients showed partial response. Seven patients did not respond to cidofovir at all. Mean pre-treatment mean interval of recurrence was 9 months and mean post-treatment interval of recurrence was 13.1 months (p=0.039). There was a statistical significance between the injected dose of cidofovir and post-treatment interval of recurrence (p=0.009). There were no local or systemic side effects caused by cidofovir. Conculsion : Intralesional injection of cidofovir seems to have a potential of a safe and effective adjuvant therapy of RRP. There was a positive correlation between the injected dose of cidofovir and patient clinical outcomes so that administration of higher doses and more frequency of injections should be needed to reduce recurrence. Further study regarding injection therapy regimen for RRP is required.

• Korean Journal of Agricultural Science
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• v.37 no.1
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• pp.123-130
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• 2010

A steering control system based on CAN(Controller Area Network) for autonomous tractor was developed to reduce duty of a central processing computer and to improve performance of steering control in terms of reduced control interval and error. The steering control system consisted of a SCU (Steering Control Unit), an EHPS system, and a potentiometer. The SCU consisted of an MCU (Micro Controller unit), an A/D converter, and a DC-DC converter, and a PID controller was used to control steering angle. The steering control system was communicated with the computer by CAN-bus. Each actuator and implement was connected to a multi-function board interfacing with the computer through a USB cable. Without CAN, control interval of the autonomous tractor was 1.5 seconds. When the CAN-based steering control system was combined with the autonomous tractor, however, control interval of the integrated system was reduced to those less than 0.05 seconds. When the autonomous tractor was operated with 1.5-s and 0.05-s control cycles at a 0.63-m/s travelling speed, the trajectories were close to straight lines for both of the control cycles. For a 1.34-m/s traveling speed, tractor trajectory was close to sine wave with a 1.5-s control cycle, but was straight line with a 0.05-s control cycle.

• Environmental Engineering Research
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• v.24 no.2
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• pp.298-308
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• 2019

This work deals with the membrane fouling mode and the unclogging in seawater ultrafiltration process. The identification of the fouling mechanism by modeling the experimental flux decline was performed using both the classical models of Hermia and the combined models of Bolton. The results show that Bolton models did not bring more precise information than the Hermia's and the flux decline can be described by one of the four Hermia's models since the backwash interval is ${\leq}60$ min. An experimental screening study has been then conducted to choose among 5 parameters (backwash interval, duration, pulses and the flow-rate or injected hypochlorite concentration) those that are the most influential on the fouling and the net water production. It has emerged that fouling is mainly affected by the backwash interval; its prolongation from 30 to 60 min engenders an increase in the reversible fouling and a decrease in the irreversible fouling. This later is also significantly reduced when the hypochlorite concentration increases from 4.5 to 10 ppm. Moreover, the net water production significantly increases with increasing the filtration duration up to 60 min and decreases with decreasing the backwash duration and backwash flow-rate from 10 to 40 s and from 15 to ${\geq}20L.min^{-1}$, respectively.

• Journal of the Korean Operations Research and Management Science Society
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• v.19 no.2
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• pp.75-84
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• 1994

The uncertainty in the relative weights of a pairwise comparison matrix n Multi-attribute Decision Making (MADM) is caused by imprecise preference information of decision maker. In this paper, it is shown how weight of attributes can be derived from the pairwise comparison matrix with interval pairwise comparison. The preference information of each pair of attributes with a point pairwise comparison is combined with an interval pairwise comparison in order to estimate a point pairwise comparison for a pair of attributes with the imprecise preference information. A numerical example shows the suggested procedure for deriving weights of attributes.

• Journal of Industrial Technology
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• v.28 no.B
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• pp.101-109
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• 2008

In general, non-stationary or chaos time series forecasting is very difficult since there exists a drift and/or nonlinearities in them. To overcome this situation, we suggest a new prediction method based on multiple model TS fuzzy predictors combined with preprocessing of time series data, where, instead of time series data, the differences of them are applied to predictors as input. In preprocessing procedure, the candidates of optimal difference interval are determined by using con-elation analysis and corresponding difference data are generated. And then, for each of them, TS fuzzy predictor is constructed by using k-means clustering algorithm and least squares method. Finally, the best predictor which minimizes the performance index is selected and it works on hereafter for prediction. Computer simulation is performed to show the effectiveness and usefulness of our method.

• Journal of applied mathematics & informatics
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• v.12 no.1_2
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• pp.233-241
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• 2003

The rolling schedule procedure has been an important part of the Enterprise Resource Planning (ERP) systems. The performance of production planning in an ERP system depends on the selection of the three parameters in rolling schedule procedure: frozen interval, replanning interval, and planning horizon (forecast window). This research investigated, in a theoretical approach, the combined impact of selections of those three parameters. The proven mathematical theorems provided guidance to re-duction of instability (nervousness) and to seek the optimal balance between stability and responsiveness of ERP systems. Further the theorems are extended to incorporate the cost structure.

• Korean Journal of Veterinary Service
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• v.32 no.3
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• pp.201-207
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• 2009

Porcine transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV) and rotaviruses are considered as the most important causative agents of diarrhea in piglets. The study established 3 method vaccination programs to prevent PEDV. A (LL)group inoculated twice vaccinations on 2-weeks-interval during the late term of pregnant sows with PEDV live vaccine. The B (LKK) group was applied that one time single PEDV live vaccine at the pre-mate followed by the TGEV PEDV combined inactivated vaccine (twice vaccination on 2-weeks interval at the third-trimester). C (KK) group was applied to sow which inoculated twice vaccination on 2-weeks-interval during the late term of pregnant sows with by the TGEV, PEDV combined inactivated vaccine. As the result of SN test on sows in the pig farm before vaccination, antibody titers was showed 9/45 (20.0%). By comparison with the serum neutralizing antibody titers against PEDV of the vaccination programs after PEDV of the vaccination, A group and B group vaccination method was higher than those of C group in sows. In the piglets up to 2 weeks of age, A group was showed antibody titers of 17/22 (81.8%) that showed 2-128, and B group was showed antibody titers of 30/37 (81.1%) that showed 2-512, and C group was showed antibody titers of 14/28 (50.0%) that showed 2-32. On the other hand, PEDV antibody titers were tested for the survey. As the results of SN test, Aujeszky's disease survey in 54 pig farms from november 2005 to august 2006, antibody titers of 47/286 (16.4%) showed above 2. Five breeding farms were antibody titers of 38/77 (49.4%), Wanggung zone farms antibody titers of 59/85 (69.4%). In pigs farms vaccinated the first of twice PEDV live vaccine, and after 6 month, the second of twice TGEV PEDV combined inactivated vaccine (LLKK, 256-1024 titer) method was higher than those of vaccinated twice the early term of pregnant, and twice the late term of pregnant sows of PEDV live vaccine (LLLL, 32 titer).