• 식물병연구
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• 제22권2호
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• pp.94-99
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• 2016

절화 백합 조직에 손상을 일으키지 않는 수준의 감마선을 이용한 검역 현장적용을 위해 수출용 오리엔탈 계통 백합 품종 중 흰색인 시베리아와 분홍색인 소르본느 절화 백합에 150 Gy 감마선 조사(irradiation)를 실시하였다. 감마선 150 Gy와 다양한 수준(0, 40, 100, $200{\mu}g/l$)의 NaDCC를 병용처리하여 두 품종의 절화 백합의 잎마름병 방제를 평가한 결과, 꽃잎의 발병률(incidence)은 대조구 93%-95%에 비해 150 Gy 감마선과 $100{\mu}g/l$ 이상 농도의 NaDCC 병용처리한 발병률은 76%-83%로 통계적으로 유의하게 감소하였다. 하지만 꽃잎의 발병도(severity)에서는 감마선 병용처리에 따른 발병 억제 효과는 없었다. 150 Gy 감마선 처리는 만개기간을 연장시키는 저장성 개선의 효과를 얻지는 못했지만, 엽록소를 파괴하거나 생중량을 감소시키는 절화 백합의 품질저하도 없었다. 또한 분홍색의 소르본느 꽃잎의 탈색도 보이지 않았다. 따라서 수출용 절화 백합의 잎마름병 방제를 위해 150 Gy의 감마선과 NaDCC $100{\mu}g/l$의 병용처리 방안을 수출검역 SOP에 제안한다.

• Nutritional Sciences
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• 제2권2호
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• pp.71-75
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• 1999

Epidemiologic studies consistently demonstrate an inverse relationship between risk for colon canter and consumption of fruits and vegetables. Wheat bran, flax and soy contain dietary fiber and phytochemicals, such as lignans and isoflavones, that may inhibit colon carcinogenesis. Orange juice contains hesperidin, a flavanone glucoside that protects against colon carcinogenesis. This study determined if feeding orange juice, wheat bran, soy and flaxseed (combined diet) would inhibit azoxymethane (AOM) induced colon cancer. Cancer was initiated in male Fisher 344 rats by injecting 15 mg AOM/kg of weight at 22 and 29 days of age. One week after the second AOM injection, rats (N = 30) in the combined diet group received dry diet containing wheat bran (4%), soy with ethanol soluble phytochemirals(13%) and flaxseed (8%) and orange juice replaced drinking water. The control group remained on the control diet and received distilled water to drink. The rats were killed 28 weeks later, and colon tissues and tumors were removed for histologic analysis. Feeding the combined diet significantly reduced tumor incidence (p < 0.05), however tumor multiplicity was not changed (p > 0.05, 0.9 tumors/rat fed the combined diet vs 1.2 for controls). Also, tumor burden was only marginally reduced in rats fed the combined diet vs control rats (65 vs 210 mg of tumor/rats, respectively). The reduction in tumor incidence was associated with a decreased labeling index and proliferation zone in normal appearing colon mucosa. Therefore, this study shows that phytochemicals in wheat bran, soy, flax and orange juice reduce colon carcinogenesis, presumably by decreasing cell proliferation and enhancing cell differentiation.

• 대한의용생체공학회:의공학회지
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• 제39권3호
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• pp.109-115
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• 2018

Obesity is a worldwide disease caused by the excessive proliferation of adipocytes. Multiple factors, including melatonin and physical loading, are involved in the control of obesity. Melatonin has been shown to induce apoptosis on preadipocytes while physical loading such as fluid shear stress (FSS) affects the proliferation and differentiation of adipocytes. Here, we studied the combined effects of melatonin and FSS on 3T3-L1 preadipocytes. For physical loading, preadipocytes were stimulated with a maximum dynamic fluid shear stress of 1 Pa at 1 Hz for 2 hours with/without melatonin. The experiment conditions were divided into four groups: (1) control, (2) 1 mM melatonin treatment, (3) FSS, and (4) combined 1 mM melatonin and FSS. All groups had a fixed duration time of 2 hours. ERK, p-ERK, COX-2, $C/EBP{\beta}$, $PPAR{\gamma}$, osteopontin, Bax, caspase-3 and caspase-8 proteins were assessed by Western blot analysis. GAPDH was used as a control. Results showed that combined melatonin and FSS treatment activated the ERK/MAPK pathway but not COX-2. Furthermore, combined melatonin and FSS treatment significantly decreased $C/EBP{\beta}$ and $PPAR{\gamma}$ compared to other groups. However, caspase-3 and caspase-8 did not result in significant changes. In summary, combined melatonin and FSS appears to have the potential to inhibit adipogenesis and treat obesity.

• 대한수의학회지
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• 제34권2호
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• pp.335-338
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• 1994

The tests on the oocysticidal effects of three formulations (75% o-dichlorobenzene, 7.5% cresol combined with morestan 0.5%, 1.0%, 1.5%, respectively) against immature oocysts of Eimeria tenella, were carried out. A o-dichlorobenzene preparation (72.5% o-dichlorobenzene, 7.5% cresol) on the market was selected and tested as the control. The tests were divided into two ways, the one was evaluated at different dilutions and contact times. The other was performed at different storage days. The test results are summarized as follows. Oocysticidal effects of 100% were revealed at 1 to 3 hours contact time of all morestan combined preparations. On the other hand, the perfect oocysticidal effect was revealed only at 24 hours exposure time of 100 times dilution among dilutes of control preparation. Combined rate of morestan was higher, oocysticidal effect was better. In the latter test, all morestan combined formulations had 100% of oocysticidal effect up to 5 days storage after dilution and 86.4% to 96.7% at two weeks storage after dilution, whereas the oocysticidal effects of the control preparation was gradually decreased by the storage time was passed and there was no effect at 2 weeks storage after dilution. With these results, morestan combined preparations have synergistic effect against oocysts of E tenella and can be used as the most effective oocysticidal disinfectant for broiler industry in future.

• 대한한의학회지
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• 제16권2호
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• pp.386-413
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• 1995

In order to prove the antitumor effect of Taraxaci Herba experimentally, studies were done. The antitumor effect against hepatic cancers such as Hep G2. Hep 3B & PLC and also the synergstric action was evaluated in the combined treatment with anticancer drugs using chiefly for liver cancer. such as. The results were obtained as follows: 1.$IC_{50}$ against Hep G2. Hep 3B and PLC was $15.5{\mu}g/ml.\;25.4{\mu}g/ml,\;31.25{\mu}g/ml$ in Mitomycin C(MMC), $92.5{mu}g/ml,\;50.2{\mu}g/ml,\;62.5{\mu}g/ml $in cisplatin(CPT) and 125 in 5-flurouracil(5-FU) respectively. 2. In cytotoxic effect against Hep G2 every fractions showed the anti tumor effect as compared with the data of control but EE fraction of Taraxaci Herba was most effective and also hexane fraction was most effective in the combined treatment with anticancer drugs. 3. In cytotoxic effect against Hep 3B every fractions showed the antitumor effect as compared with the data of control but EE fraction of Taraxaci Herba was most effective and also hexane fraction was most effective in the combined treatment with anticancer drugs. 4. In cytotoxic effect against PLC every fractions showed the anti tumor effect in the concentrations of $10^{-5}g/ml$ above as compared with the data of control and also the combined treatment with MMC was most effective. 5. Fractions of Taraxaci Herba showed the most antitumor effect against Hep 3B and also the combined treatment with MMC was most effective. From the above result it was concluded that ethyl ether fraction of Taraxaci Herba was most effective fraction, every fraction showed more antitumor effect against Hep 3B and Hep G2 than PLC.

• 대한물리의학회지
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• 제17권4호
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• pp.93-101
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• 2022

PURPOSE: This study sought to investigate the effects of treadmill gait training combined with a thoracic mobility exercise on gait and balance in patients with stroke. METHODS: In this single-blinded, randomized, controlled, comparative study, a total of 20 patients at a rehabilitation hospital who had suffered a hemiplegic stroke were randomly assigned to the experimental group (treadmill gait training combined with a thoracic mobility exercise, n = 11) or control group (treadmill gait training without the thoracic mobility exercise, n = 9). All the participants underwent comprehensive rehabilitation therapy (5 × /week for 4 weeks). Additionally, the experimental group underwent 20 min of treadmill gait training combined with 10 min of a thoracic mobility exercise (3 × / week for 4 weeks) and the control group underwent the former but not the latter. Gait and balance were measured before and after the 4-week training. RESULTS: Significant improvements were observed in the 10-m walking test (10 MWT), timed up-and-go (TUG) test, center of pressure (COP) velocity, and COP length in the experimental group (p < .05). This group also showed a larger decrease in the 10 MWT and COP velocity than the control group (10 MWT, -3.02 sec vs. -1.68 sec, p < .05; COP velocity, -.07 mm/sec vs. .08 mm/sec, p < .05). CONCLUSION: Treadmill gait training, combined with the thoracic mobility exercise, could be effective in improving the gait and balance of stroke patients. It could also be more effective in improving walking speed and static balance than the treadmill gait training alone.

• PNF and Movement
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• 제22권1호
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• pp.13-21
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• 2024

Purpose: This study investigated the effects of side walking training combined with squats on the balance and gait ability of stroke patients. The purpose of this study was to provide fundamental data regarding the use of side walking training combined with squats among stroke patients. Methods: Thirty patients with stroke were randomly divided into an experimental group (n=15) that underwent side walking training combined with squats and a control group (n=15) that performed general rehabilitation exercises. Both groups performed their respective exercises for 30 minutes, five times a week for six weeks. Balance was assessed using the functional reach test and timed up and go test, while gait ability was evaluated using the 10-meter walk test. A paired t-test was performed to compare within-group changes before and after the intervention. Differences between the experimental and control groups were analyzed using an independent t-test. For all tests, the level of statistical significance was set at α=0.05. Results: After the exercise, significant within-group improvements in balance and gait ability were observed in both the experimental and control groups (p<0.05). There was also a significant between-group difference in balance and gait ability following the intervention (p<0.05). Conclusion: While general rehabilitation is commonly employed in treating stroke patients and is relatively effective, the application of side walking training combined with squats may offer additional benefits in terms of improving balance and gait ability in these patients.

• Radiation Oncology Journal
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• 제34권2호
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• pp.113-120
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• 2016

Purpose: The association between metabolism and cancer has been recently emphasized. This study aimed to find the prognostic significance of obesity in advanced stage rectal cancer patients treated with surgery and radiotherapy (RT). Materials and Methods: We retrospectively reviewed the medical records of 111 patients who were treated with combined surgery and RT for clinical stage 2-3 (T3 or N+) rectal cancer between 2008 and 2014. The prognostic significance of obesity (body mass index [BMI] ${\geq}25kg/m^2$) in local control was evaluated. Results: The median follow-up was 31.2 months (range, 4.1 to 85.7 months). Twenty-five patients (22.5%) were classified as obese. Treatment failure occurred in 33 patients (29.7%), including local failures in 13 patients (11.7%), regional lymph node failures in 5, and distant metastases in 24. The 3-year local control, recurrence-free survival, and overall survival rates were 88.7%, 73.6%, and 87.7%, respectively. Obesity (n = 25) significantly reduced the local control rate (p = 0.045; 3-year local control, 76.2%), especially in women (n = 37, p = 0.021). Segregation of local control was best achieved by BMI of $25.6kg/m^2$ as a cutoff value. Conclusion: Obese rectal cancer patients showed poor local control after combined surgery and RT. More effective local treatment strategies for obese patients are warranted.

• 한국정보통신학회논문지
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• 제4권3호
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• pp.603-610
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• 2000

본 논문에서는 직접 적응제어기와 간접 적응제어기를 Lyapunov 안정도 이론에 근거하여 결합하였다. 제어기는 RBF 신경망을 이용하여 구성하였으며 하중파라미터들은 적응칙에 의하여 조정되도록 하였다. 또한 시스템의 성능에 영향을 미치는 결합 가중치는 퍼지 If-THEN 규칙을 이용하여 결정되도록 하였다. 이렇게 함으로써 직접 적응제어기와 간접 적응제어기의 장점을 지니는 직 간접 혼합 신경망 적응제어기를 구성할 수 있었다. 제안한 알고리즘의 효용성을 보이기 위하여 일축 강페 로봇 매니퓰레이터를 대상으로 시뮬레이션한 결과 만족할 만한 성능을 보였다.

• 한국식품영양학회지
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• 제11권4호
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• pp.460-465
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• 1998

The effects of food restriction on the fecal microflora, moisture, pH, indole, ${\beta}$-glucosidas, and ${\beta}$-glucuronidase in rate were studied for 4 weeks. Four groups of rats for feeding was allocated to the following experimental trials : (1) control containing 1% cellulose, (2) control with food restriction, (3) treatment of diet containing butterbur, (4) treatment of butterbur combined with diet restriction. Treatment of butterbur combined food restriction significantly (p<0.05) reduced the growth of Bacteroides, Peptococus, Streptococcus, Staphylococcus, and Escherchia coli, respectively. No remarkable changes in the ${\beta}$-glucosidase and ${\beta}$-glucuronidase activities were observed but indole content significanlty decreased. Based on these results, treatment of butterbur combined with diet restriction in rats had a significantly effect for preventing the growth of those pathogenic microorganims.