• Journal of KIISE:Software and Applications
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• v.32 no.4
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• pp.247-257
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• 2005

Generally, the network topology design problem is characterized as a kind of NP-hard combinatorial optimization problem, which is difficult to solve with the classical method because it has exponentially increasing complexity with the augmented network size. In this paper, we propose the efficient approach with two phase that is comprised of evolutionary computation approach based on Prufer number(PN), which can efficiently represent the spanning tree, and a heuristic method considering 2-connectivity, to solve the highly reliable network topology design problem minimizing the construction cost subject to network reliability: firstly, to find the spanning tree, genetic algorithm that is the most widely known type of evolutionary computation approach, is used; secondly, a heuristic method is employed, in order to search the optimal network topology based on the spanning tree obtained in the first Phase, considering 2-connectivity. Lastly, the performance of our approach is provided from the results of numerical examples.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1997.11a
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• pp.47-50
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• 1997

Drug development began with the finding of biologically active compounds which are obtained by chemical synthesis or from natural sources. The advent of Combinatorial Chemistry is recognized as a strategy which has a potential to change the methodology of research and development(R&D) of new drugs. Drug development has been carried out with diverse strategies. In the past several decades a variety of new methodology have been introduced in R&D. Random screening of accumulated synthetic samples which had been synthesized for development of other drugs led to the discovery of new drugs. The typical examples are anti-asthma drug trimethoquinol and calcium antagonist diltiazem. (herbesser). In particular the latter drug has been used as a calcium antagonist worldwide, however it was first synthesized to find new tranquilizer and this is the reason why diltiazem has benzodiazepam skeleton. The random screening contributed in the finding of new drugs were carried out with whole animal test and it is a standard methodology in R&D of new drugs. Aspirin is the first synthetic non-steroidal antiinflammatory drug(NSAID) and has been used for more than one hundred years. It is the first example of drug developed from natural product. Salicin is the main constituent of willow bark which had been used in Europe for a long time to treat arthritis and aspirin was developed from salicin. Most of NSAID used clinically were developed from the structure of aspirin, however it took 70 years to clarify why aspirin exhibits its antiinflammatory, analgesic and antipyretic activities. The target of aspirin is cyclooxygenase(COX)which is the first enzyme involved in arachidonate cascade leading to the production of prostaglandins(PG) and thromboxan(TX). Side effect of aspirin causing ulcer in stomach is rather serious problem, since aspirin is so popular drug easily obtained in drug store(OTP). This problem is now going to be solved by a new finding on COX, which have two different types, one is constitutionally expressed COX 1 in almost all organs and the other is inducible COX 2. COX 2 is the responsible enzyme in inflammation etc and now the search of COX 2 specific inhibitors is the target of R&D of next generation NSAID.

• Journal of Mechanical Science and Technology
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• v.19 no.5
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• pp.1072-1079
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• 2005

Conceptual design is the first step in the overall process of product design. Its intrinsic uncertainty, imprecision, and lack of information lead to the fact that current conceptual design activities in engineering have not been computerized and very few CAD systems are available to support conceptual design. In most of the current intelligent design systems, approach of principle synthesis, such as morphology matrix, bond graphic, or design catalogues, is usually adopted to deal with the concept generation, in which optional concepts are generally combined and enumerated through function analysis. However, as a large number of concepts are generated, it is difficult to evaluate and optimize these design candidates using regular algorithm. It is necessary to develop a new approach or a tool to solve the concept generation. Generally speaking, concept generation is a problem of concept synthesis. In substance, this process of developing design candidate is a combinatorial optimization process, viz., the process of concept generation can be regarded as a solution for a state-place composed of multi-concepts. In this paper, genetic algorithm is utilized as a feasible tool to solve the problem of combinatorial optimization in concept generation, in which the encoding method of morphology matrix based on function analysis is applied, and a sequence of optimal concepts are generated through the search and iterative process which is controlled by genetic operators, including selection, crossover, mutation, and reproduction in GA. Several crucial problems on GA are discussed in this paper, such as the calculation of fitness value and the criteria for heredity termination, which have a heavy effect on selection of better concepts. The feasibility and intellectualization of the proposed approach are demonstrated with an engineering case. In this work concept generation is implemented using GA, which can facilitate not only generating several better concepts, but also selecting the best concept. Thus optimal concepts can be conveniently developed and design efficiency can be greatly improved.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.43 no.1
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• pp.1-6
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• 2020

Fast service access involves keeping track of the location of mobile users, while they are moving around the mobile network for a satisfactory level of QoS (Quality of Service) in a cost-effective manner. The location databases are used to keep track of Mobile Terminals (MT) so that incoming calls can be directed to requested mobile terminals at all times. MT reporting cell system used in location management is to designate each cell in the network as a reporting cell or a non-reporting cell. Determination of an optimal number of reporting cells (or reporting cell configuration) for a given network is reporting cell planning (RCP) problem. This is a difficult combinatorial optimization problem which has an exponential complexity. We can see that a cell in a network is either a reporting cell or a non-reporting cell. Hence, for a given network with N cells, the number of possible solutions is 2^N. We propose a biogeography based optimization (BBO) for design of mobile station location management system in wireless communication network. The number and locations of reporting cells should be determined to balance the registration for location update and paging operations for search the mobile stations to minimize the cost of system. Experimental results show that our proposed BBO is a fairly effective and competitive approach with respect to solution quality for optimally designing location management system because BBO is suitable for combinatorial optimization and multi-functional problems.

• Journal of Intelligence and Information Systems
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• v.3 no.2
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• pp.1-9
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• 1997

These papers propose an evolutionary algorithm for re-using output of waste fuel of light water reactor system in nuclear power plants. Evolutionary algorithm is useful for optimization of the large space problem. The wastes contain several re-useable elements, and they should be carefully selected and blended to satisfy requirements as input material to the heavy water nuclear reactor system. This problem belongs to a NP-hard like the 0/1 Knapsack problem. Two evolutionary strategies are used as a, pp.oximation algorithms in the highly constrained combinatorial optimization problem. One is the traditional strategy, using random operator with evaluation function, and the other is heuristic based search that uses the vector operator reducing between goal and current status. We also show the method, which performs the feasible teat and solution evaluation by using the vectorized data in problem. Finally, We compare the simulation results of using random operator and vector operator for such combinatorial optimization problems.

• Journal of Digital Convergence
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• v.11 no.11
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• pp.443-448
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• 2013

Ant Colony System(ACS) is a meta heuristic approach based on biology in order to solve combinatorial optimization problem. It is based on the tracing action of real ants which accumulate pheromone on the passed path and uses as communication medium. In order to search the optimal path, ACS requires to explore various edges. In existing ACS, the local updating rule assigns the same pheromone to visited edge. In this paper, our local updating rule gives the pheromone according to the total frequency of visits of the currently selected node in the previous iteration. I used the ACS algoritm using subpath for search. Our approach can have less local optima than existing ACS and find better solution by taking advantage of more informations during searching.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.12 no.12
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• pp.2343-2348
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• 2008

Ant algorithm is new meta heuristic for hard combinatorial optimization problem. It is a population based approach that uses exploitation of positive feedback as well as greedy search. It was first proposed for tackling the well known Traveling Salesman Problem. In this paper, we propose the improved $AS_{rank}$ algorithms. The original $AS_{rank}$ algorithm accomplishes a pheromone updating about only the paths which will be composed of the optimal path is higher, but, the paths which will be composed the optimal path is lower does not considered. In this paper, The proposed method evaporate the pheromone of the paths which will be composed of the optimal path is lowest(worst tour path), it is reducing the probability of the edges selection during next search cycle. Simulation results of proposed method show lower average search time and average iteration than original ACS.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.3
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• pp.1451-1458
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• 2013

This paper deals with the programs and algorithms that generate the full data set that satisfy the basic combinatorial requirement of combination, permutation, partial permutation or shortly r-permutation, which are used in the application of the total data testing or the simulation input. We search the programs able to meet the rules which is permutations and combinations, r-permutations, select the fastest program by field. With further study, we developed a new program reducing the time required to processing. Our research performs the following pre-study. Firstly, hundreds of algorithms and programs in the internet are collected and corrected to be executable. Secondly, we measure running time for all completed programs and select a few fast ones. Thirdly, the fast programs are analyzed in depth and its pseudo-code programs are provided. We succeeded in developing two programs that run faster. Firstly, the combination program can save the running time by removing recursive function and the r-permutation program become faster by combining the best combination program and the best permutation program. According to our performance test, the former and later program enhance the running speed by 22% to 34% and 62% to 226% respectively compared with the fastest collected program. The programs suggested in this study could apply to a particular cases easily based on Pseudo-code., Predicts the execution time spent on data processing, determine the validity of the processing, and also generates total data with minimum access programming.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.47 no.12
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• pp.856-864
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• 2019

The weapon-target assignment (WTA) problem is a matter of effectively allocating weapons to a number of threats. The WTA in a rapidly changing dynamic environment of engagement must take into account both of properties of the threat and the weapon and the effect of the previous decision. We propose a method of applying the Greedy Randomized Adaptive Search Procedure (GRASP) algorithm, a kind of meta-heuristic method, to derive optimal solution for a dynamic WTA problem. Firstly, we define a dynamic WTA problem and formulate a mathematical model for applying the algorithm. For the purpose of the assignment strategy, the objective function is defined and time-varying constraints are considered. The dynamic WTA problem is then solved by applying the GRASP algorithm. The optimal solution characteristics of the formalized dynamic WTA problem are analyzed through the simulation, and the algorithm performance is verified via the Monte-Carlo simulation.

• Journal of the Korea Society of Computer and Information
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• v.14 no.1
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• pp.9-15
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• 2009

Ant Colony System is new meta heuristic for hard combinatorial optimization problem. The original ant colony system accomplishes a pheromone updating about only the global optimal path using global updating rule. But, If the global optimal path is not searched until the end condition is satisfied, only pheromone evaporation happens to no matter how a lot of iteration accomplishment. In this paper, the length of the global optimal path does not improved within the limited iterations, we evaluates this state that fall into the local optimum and selects the next node using changed parameters in the state transition rule. This method has effectiveness of the search for a path through diversifications is enhanced by decreasing the value of parameter of the state transition rules for the select of next node, and escape from the local optima is possible. Finally, the performance of Best and Average_Best of proposed algorithm outperforms original ACS.