• Science of Emotion and Sensibility
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• v.22 no.1
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• pp.55-64
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• 2019

Stress is accompanied by changes in the responses of the autonomic nervous system, and the heart rate variability (HRV) index is a quantitative marker that reflects autonomic responses induced by stressors. In this study, we observed changes in the autonomic responses induced by combinations of 30% oxygen administration and color light for stress relaxation. In all, 42 participants produced stress symptoms over the preceding two weeks, as rated on the stress response scale. After stress assessment, they were exposed to three therapeutic conditions, and electrocardiogram (ECG) signals were recorded before, during, and after therapy. The three therapy conditions consisted of only 30% oxygen administration with white light, a combination of 30% oxygen and orange light, and a combination of 30% oxygen and blue light. The HRV indices extracted from ECG signals were heart rate (HR), the standard deviation of the RR interval (SDNN), the mean square root of consecutive RR interval difference values (RMSSD), the low frequency component of HRV (LF), the high frequency component (HF), and the LF/HF ratio. These indicators were used to compare mean values before and after therapy. The results showed that HR and the LF/HF ratio were significantly lower after therapy than before it. In particular, the condition with 30% oxygen and blue light yielded significantly greater RMSSD and HF increases, as well as decreases in LF/HF ratio than in other two conditions. Our results suggest that therapy with 30% oxygen and blue light is the most effective for the relaxation of stress, which implies autonomic balance by parasympathetic activation.

• Korean Journal of Clinical Pharmacy
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• v.32 no.2
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• pp.125-132
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• 2022

Background: Fixed-dose combinations have the advantage of improving patient compliance, but may increase the risk of duplicate prescriptions. As the use of fixed-dose combination antihypertensives increases, it is necessary to investigate the current status of class duplication prescriptions (CDP) in patients taking fixed-dose combination antihypertensives in Korea and to identify factors associated with CDP. Methods: We conducted a retrospective observational study using nationally representative claim data. Hypertensive patients aged 20 years or older taking fixed-dose combination antihypertensives were extracted. Among these patients, patients with CDP were identified. A chi-square test was applied to determine the differences between patients with CDP and non-CDP. The associated factors of CDP were identified through multiple logistic regression. Results: Of the 74,165 patients who were prescribed fixed-dose combination antihypertensives, 426 patients (0.6%) with CDP were identified. The most common antihypertensive class associated with CDP was calcium channel blockers (194 patients, 45.5%), followed by angiotensin II receptor blockers (136 patients, 31.9%). Patients aged 75 years or older (odds ratio [OR] 1.83, 95% confidence interval [CI] 1.02-3.52), chronic kidney disease (OR 4.45, 95% CI 2.15-8.25), chronic heart failure (OR 2.71, 95% CI 1.93-3.72), coronary artery disease (OR 2.22, 95% CI 1.60-3.03) and Medical Aid/Patriots and Veterans Insurance (OR 1.49, 95% CI 1.04-2.07) were significantly associated with increased CDP. Conclusions: The factors associated with CDP were the elderly, comorbidities, and low socioeconomic status. Since CDP can result in negative clinical outcomes, active intervention by the pharmacist is warranted.

• Proceedings of the Korea Air Pollution Research Association Conference
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• 2008.04a
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• pp.142-143
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• 2008

• Korean Journal of Veterinary Research
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• v.36 no.1
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• pp.209-219
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• 1996

This study examined the effect of alcohol(AL) and/or paraquat(PQ) on serum TSH, thyroid hormones and enzyme activities, and the protective effect of selenium(SE) againse alcohol and/or paraquat-induced thyroid toxicity in guinea pigs. The experomental group consisted of control, 15% alcohol(AL), 4ppm sodium selentite(SE), 200ppm paraquat(PQ), AL+PQ, AL+SE, PQ+SE and AL+PQ+SE mixed in drinking water-fed guinea pigs for 4 weeks. The morphological changes of thyroid gland were studies on paraffin-embedded sections stained with H-E stain. Body weight losses, high serum concentration in TSH and cholesterol, and low values on triiodothyronine($T_3$), thyrozine($T_4$), free $T_4$ and alkaline phosophatase(ALP) were produced in the groups fed AL and/or PQ. We also noted that AL+PQ-fed group was marked increase in serum TSH. In AL or AL+PQ-fed groups when cpmpared to control group had increased the ratio of thyroid weight to body weight(ratio Twt/Bwt), whereas the ratio Twt/Bwt was decresed in SE or PQ-fed groups. However, the serum TSH, $T_3$,$T_4$ free $T_4$ and cholesterol values, and the ratio Twt/Bwt were reversed in groups given the combination of SE, compared with AL and/or Pq-fed groups, also ALP values were reversed in groups given the combination of SE, compared with AL or AL+PQ-fed groups. In microscope, morphological changes showed a remarkable between the AL or PQ-fed group and controls. In AL+PQ+SE-fed guinca pig, follicular colloid is high density in thyroid follicle and increased in connective tissue around the thyroid cells, and thyroidal epithelia were composed of cuboidal or columnar epithelium. The indicated that the morphological changes of thyroid were direct action in the thyroid cell. The results of this study confirmed that the toxic effect of AL or PQ on thyroid occur independently of changes in liver function, and that SE confers marked protection against AL or PQ-induced thyroid toxicity.

• Journal of the Korean Solar Energy Society
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• v.29 no.3
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• pp.19-27
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• 2009

In this study, Urban Climate Simulation was performed by 3-Dimensional Urban Canopy Model. The characteristics of urban climate were analyzed combining artificial land coverage, building size, heat production from the air conditioning and topographic conditions as physical variables which affects urban climate characteristics. The results are as follows. (1) The aspects of the urban climatal change is derived to be related to the combination of the building coverage ratio, building height and shading area. According to the building height, the highest temperature was increased by $2.1^{\circ}C$ from 2-story to 5-story building and the absolute humidity by 2.1g/kg maximum and the wind velocity by 1.0m/s was decreased from 2-story to 20-story building. (2) Whole heat generation was influenced by the convective sensible heat at the lower building height and by the artificial heat generation at the higher one over 20-story building influence to some extent of the building coverage ratio. The effect of the altitude is not more considerable than the other variables as below $1^{\circ}C$ of the air temperature. In the last, deriving the combination of building coverage and building height is needed to obtain effectiveness of the urban built environment planning at the point of the urban climate. These simulation results need to be constructed as DB which shows urban quantitative thermal characters by the urban physical structure. These can be quantitative base for suggesting combinations of the building and urban planning features at the point of the desirable urban thermal environment as well as analyzing urban climate phenomenon.

• 한국신재생에너지학회:학술대회논문집
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• 2011.05a
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• pp.194.2-194.2
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• 2011

Heating and cooling performance has been analyzed for the water-source heat pump system using raw water from Daechung reservoir. During heating operation from March to May, water temperature is not good condition for a heat source due to the higher atmospheric temperature. Avearged heating load ratio is only 14.3%, and the averaged unit COP and system COP are estimated to be 2.46 and 2.15 respectively. The COP is affected considerably by the water temperature, and the unit COP is increased from 2.16 at $5^{\circ}C$ to 2.95 at $11^{\circ}C$. Cooling performance is analyzed with the measured data from June to August. During cooling operation, raw water has lower temperature by 4. $5^{\circ}C{\sim}4.7^{\circ}C$ than the atmosphere. The load ratio is 39.2%, and the averaged unit COP and system COP are estimated to be 7.25 and 6.13 respectively. The heating COP is affected by the load ratio rather than water temperature. The COP is increased for 20%~40% load ratio, while is decreased for 40%~60% load ratio. It is estimated that the compressor operation combination for 3 (two constant speed and one inverter) compressors is changed for the load ratio.

• International Journal of Automotive Technology
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• v.6 no.3
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• pp.259-268
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• 2005

In order to analyze the sheet drawability, the measurement of the plastic strain ratio was carried out for the 5182 aluminum alloy sheets in which were cold rolled without lubrication and subsequent recrystallization annealing. The average plastic strain ratio of the 5182 aluminum sheets was 1.50. It was considered that the higher plastic strain ratio was resulted from the ND//<111> component evolved during rolling and maintained during annealing. The AA5182/polypropylene/AA5182 (AA/PP/AA) sandwich sheets of the 5182 aluminum alloy skin sheet and the polypropylene core sheet with high formability have been developed for application for automotive body panels in future light weight vehicles with significant weight reduction. The AA/PP/AA sandwich sheets were fabricated by the adhesion of the core sheet and the upper and lower skin sheets. The AA/PP/AA sandwich sheet had high plastic strain ratio (1.58), however, the planar anisotropy of the sandwich sheet was little changed after fabrication. The optimum combination of directionality of the upper and lower skin sheets having high plastic strain ratio and low planar anisotropy was calculated theoretically and an advanced process for producing the sandwich sheets with high plastic strain ratio was proposed. The developed sandwich sheets have a high average plastic strain ratio of 1.55 and a low planar anisotropy of 0.17, which was improved more by 3.2 times than that of 5182 aluminum single sheet.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2001.11a
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• pp.85-90
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• 2001

The microstructure and mechanical property of 0.19C-1.17Cr steel were investigated with cold drawing. This commercial steel has the microstructure that is consist of ferrite and pearlite. The tensile and yield strength are increased as the reduction ratio of cold drawing is increased. It was clear that mechanical properties could be improved by combination of the heat treatments and reduction ratio. Yield strength. tensile strength, and impact value were formulated as a constitutive function of cold drawing ratio, respectively.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.21 no.4
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• pp.625-632
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• 2012

Optimization of process parameters in polymer extrusion is an important task to reduce manufacturing cost. To determine the optimum values of the process parameters, it is essential to find their influence on the strength of polymer breathable thin film. The significance of six important process parameters namely, extruder cylinder temperature, extruder speed, extruder dies temperature, cooling roll temperature, stretching ratio, stretching roll temperature on breathable film strength of polymer extrusion was determined. Moreover, this paper presents the application of Taguchi method and analysis of variance (ANOVA) for maximization of the breathable film strength influenced by extrusion parameters. The optimum parameter combination of extrusion process was obtained by using the analysis of signal-to-noise ratio. The conclusion revealed that extruder speed and stretching ratio were the most influential factor on the film strength, respectively. The best results of film strength were obtained at higher extruder speed and stretching ratio.

• Proceedings of the Korea Concrete Institute Conference
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• 2005.11a
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• pp.761-764
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• 2005

Epoxy resin, as no-hardening, applied for repair and finish materials is used to mix together with hardener. It is advantages that epoxy resin has reaction shrinkage less than other materials and has excellent in water proofing, thermal resistance. The other hands, because ratio of combination of epoxy resin and hardener is fixed, it is not possible to change according to field condition. This investigated suspended time by temperature and hardener ratio. As a results of study, it can select economical ratio of the epoxy resin and hardener according to site situation.