• Herbal Formula Science
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• v.19 no.1
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• pp.131-144
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• 2011

Objectives : The objective of this study lies in theoretical establishment of formulas for invigorating five viscera for curing the asthenic syndrome of five viscera through analyzing the component medicines and combination principles of Hyeongok's formulas for invigorating five viscera, and furthermore, maximizing the clinical use of them. Methods : This study analyzed the component medicines and combination principles of Hyeongok's formulas for invigorating five viscera based on the theory for properties and tastes of herbal medicines from the "Yellow Emperor's Canon of Internal Medicine", the theory for principal herbal medicine, assistant herbal medicine, adjuvant herbal medicine, dispatcher herbal medicine, and the five elements doctrine. Hyeongok's formulas for invigorating five viscera are Bogantang, Boseemtang, Bobeetang, Bopyeotang, and Boshintang. Results : There are three methods for curing the asthenic syndrome of five viscera according to the five elements doctrine: in case of Bogantang invigorating the liver, invigorating the kidney and purging the lung; Boseemtang, invigorating the heart, invigorating the liver and purging the kidney; Bobeetang, invigorating the spleen, invigorating the heart and purging the liver; Bopyeotang, invigorating the lung, invigorating the spleen and purging the heart; Boshintang, invigorating the kidney, invigorating the lung and purging the spleen. Conclusions : First, to cure the asthenic syndrome of five viscera, the methods of invigorating five viscera, and purging five viscera should be used according to the five elements doctrine. Secondly, herbal medicines appropriate for those treatment methods should be chosen according to the theory for properties and tastes of herbal medicine and thirdly, the combination of those herbal medicines should be carried out according to the theory for principal herbal medicine, assistant herbal medicine, adjuvant herbal medicine, dispatcher herbal medicine. As a good example, Hyeongok's formulas for invigorating five viscera are combined according to the above theories. In conclusion, this formula was created by applying to the theory for properties and tastes of herbal medicines.

• Journal of Veterinary Science
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• v.19 no.6
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• pp.808-816
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• 2018

Bacterial biofilms have been demonstrated to be closely related to clinical infections and contribute to drug resistance. Berberine, which is the main component of Coptis chinensis, has been reported to have efficient antibacterial activity. This study aimed to investigate the potential effect of a combination of berberine with ciprofloxacin (CIP) to inhibit Salmonella biofilm formation and its effect on expressions of related genes (rpoE, luxS, and ompR). The fractional inhibitory concentration (FIC) index of the combination of berberine with CIP is 0.75 showing a synergistic antibacterial effect. The biofilm's adhesion rate and growth curve showed that the multi-resistant Salmonella strain had the potential to form a biofilm relative to that of strain CVCC528, and the antibiofilm effects were in a dose-dependent manner. Biofilm microstructures were rarely observed at $1/2{\times}MIC/FIC$ concentrations (MIC, minimal inhibition concentration), and the combination had a stronger antibiofilm effect than each of the antimicrobial agents used alone at $1/4{\times}FIC$ concentration. LuxS, rpoE, and ompR mRNA expressions were significantly repressed (p< 0.01) at $1/2{\times}MIC/FIC$ concentrations, and the berberine and CIP combination repressed mRNA expressions more strongly at the $1/4{\times}FIC$ concentration. The results indicate that the combination of berberine and CIP has a synergistic effect and is effective in inhibiting Salmonella biofilm formation via repression of luxS, rpoE, and ompR mRNA expressions.

• Transactions of the Korean Society of Automotive Engineers
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• v.24 no.3
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• pp.330-337
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• 2016

In this paper, component sizing and analysis of the novel plug-in hybrid electric vehicle powertrain configuration is conducted. Newly proposed powertrain configuration in prior study has an internal combustion engine and two electric motors. To optimize component size of the vehicle system and reduction gear ratio, component sizing methodology is proposed and conducted. Required power for vehicle's dynamic performance is calculated to decide minimum power requirement of powertrain component combination. Component size of engine and electric motor are optimized using vehicle simulation to maximize fuel economy performance. Optimized powertrain configuration and vehicle simulation results present validation of newly proposed vehicle system.

• YAKHAK HOEJI
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• v.51 no.5
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• pp.355-360
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• 2007

The essential oil fraction from the aerial parts of A. annua was analyzed by GC-MS. As the results, caryophyllene oxide (11.7%), caryophyllene (7.54%), camphor (7.32%), 1,8-cineol (4.98%), and borneol (3.99%) were confirmed as the main components of the oil fraction. The effects of this oil and its main components on antibiotic-susceptible and -resistant strains of Salmonella enteritidis and S. typhimurium were assessed. A. annua oil fraction significantly inhibited all strains of the two Salmonella species examined, with minimum inhibiting concentrations (MICs) ranging from 2.0 mg/ml to 8.0 mg/ml. Among the main components of the oil, borneol and camphor showed relatively strong inhibiting activity with MICs between 1.0 mg/ml and 4.0 mg/ml. The MICs of caryophyllene and caryophyllene oxide were higher than 16 mg/ml. The combination effects of the oils with kanamycin were evaluated using a checkerboard microtiter assay. Against S. typhimurium KCCM11862 and CCARM8009 strains, the oil fraction of A. annua, camphor, and 1,8-cineol exhibited significant synergistic with kanamycin with fractional inhibitory concentration (FIC) indices in the range of 0.085 to 0.375. In conclusion, a combination of kanamycin and A. annua oil or its main component, camphor, and cineol, may be useful for reducing the minimum effective dose of antibiotic required for the treatment of resistant S. typhimurium infections.

• Journal of the Korean Society for Precision Engineering
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• v.21 no.2
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• pp.52-59
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• 2004

In this paper, the automatic system generation algorithm based on the element combination algorithm discussed in the first part of this paper for designing an arbitrary type of the automatic transmissions is proposed. The powertrain design software using these algorithms is developed. This automotive powertrain design software with user-friendly graphic user interface has two main modules. The first module, the automatic power flow generation module, is already discussed in the previous paper. The second module dealing with the automatic system generation algorithm is discussed in this paper. The power-flow simulation software fur the arbitrary type of powertrain is then developed. The simulation and experimental results of the vehicle equipped with two planetary gear type automatic transmission are compared to validate the proposed algorithms and developed software. The simulation results demonstrate the good agreement with the experimental results.

• Biomedical Science Letters
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• v.25 no.4
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• pp.293-301
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• 2019

Combination chemotherapy is more effective than mono-chemotherapy and is widely used in clinical practice for enhanced cancer treatment. In this study, we investigated the potential synergistic effects of acetaminophen, a common component in many cold medicines, and romidepsin, a histone deacetylase (HDAC) inhibitor, in the A549 non-small cell lung cancer (NSCLC) cell line. The combination of acetaminophen and romidepsin also exerted significant cytotoxicity and apoptosis induced by activation of caspase-3 on tumor cells in vitro. Moreover, combination therapy significantly induced increased production of chemokines that stimulate migration of activated T-cells into tumor cells. This mechanism can lead to active T-cell mediated anti-tumor immunity in addition to the direct cytotoxic chemotherapeutic effect. Activated T-cells led to enhanced cytotoxicity in drug-treated A549 cells through interaction with tumor cells. These results suggested that the interaction between the two drugs is synergistic and significant. In conclusion, our data showed that the use of romidepsin and low concentrations acetaminophen could induce effective anti-tumor effects via enhanced tumor immune and direct cytotoxic chemotherapeutic responses. The combination of acetaminophen with romidepsin should be considered as a promising strategy for the treatment of lung cancer.

• Korean Journal of Human Ecology
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• v.10 no.1
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• pp.37-48
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• 2007

The purpose of this study was to investigate the proper combination of ensemble suit details for the body silhouette of elderly women. In this study, the principal component analysis was used to search for the proper combination of suit details for covering defects of body which has been changed unbalanced. The designs of evaluated suits were manipulated in 18 different kinds by the essential elements such as collars, neckline(round neckline, shirt collar, tailored collar), types of one-piece dress(pleats type, gather type, flare type), and opening(opened, closed). The data evaluated by a multiple ranking test was analyzed by mean, paired t-test, ANOVA and Duncan's multiple ranged test. The results were summarized as follows: In case of normal body type, it had complementary effects for upper body with closed round neckline jacket or shirt collar jacket, and for lower and the whole body with a combination of closed tailored collar jacket or shirt collar jacket with pleats or gored type one piece dress. The visual effect for elderly women's body shape was different in opened or closed jacket. And that enhanced by Jacket with collar.

• Proceedings of the KIEE Conference
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• 2002.07a
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• pp.286-288
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• 2002

The rapid development of measurement systems for high power tests makes it possible to measure signals as well as analyze with the help of computer. Also, methods to evaluate such measurement systems are required recently. Uncertainty has been regarding as the most important factor in evaluating the measurement systems. Because of the character of the measurement systems for high power tests. the uncertainty shall be evaluated by each component. If the uncertainty evaluated by each component, it is convenient to evaluate total uncertainty of the measurement systems according to each component setting's combination. In this paper each component of high current measurement system of high power testing Dept. II in Korea Electrotechnology Research Institute is evaluated except sensors such as shunts and CTs. The total uncertainty of the measurement systems can be determined by that of each component including uncertainty of sensors.

• Korean Journal of Food Science and Technology
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• v.13 no.1
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• pp.74-89
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• 1981

Breadmaking is a complex system in which many variables govern the production of acceptable bread. Lipids, a minor component of wheat flour, function importantly in bread-making. Shortening, or fat, is one of the essential ingredients in commercial baking. Beneficial shortening effect depends on type and quantity of lipids present in wheat flour and also on wheat flour quality. Surfactants have been used in baking industry during last decade because certrain surfactants can replace shortening and/or natural flour lipids. A proper combination of lipidshortening-surfactant is more useful in the production of specialty breads such as whole wheat breads, high protein breads, high fiber breads or even non-wheat composite breads rather than in the production of regular white breads. This presentation is a review of recent studies on the contribution of flour lipids, shortening, and surfactants, alone or in combination in the production of breads; illustrations are mainly from data obtained in the author's laboratory.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.10a
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• pp.674-680
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• 2005

The top spindle, end coupling and slipper metal are important components of the hot rolling process and are used for transmission of heavy rotational power. In this study, kinematic analysis is conducted using finite element method for hot rolling process under slipper metal combination types and operation situations. The structural analysis is performed by applying the combination type, rotational boundary condition of top spindle, end coupling and slipper metal. This study aims to minimize the mechanical problems which might happen in the production process.