• Structural Engineering and Mechanics
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• 제12권3호
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• pp.249-266
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• 2001

Current seismic design provisions allow structures to deform into inelastic range during design level earthquakes since the chance to meet such event is quite rare. For this purpose, design base shear is defined in current seismic design provisions as the value of elastic seismic shear force divided by strength reduction factor, R (${\geq}1$). Strength reduction factor generally consists of four different factors, which can account for ductility capacity, overstrength, damping, and redundancy inherent in structures respectively. In this study, R factor is assumed to account for only the ductility rather than overstrength, damping, and redundancy. The R factor considering ductility is called "ductility factor" ($R_{\mu}$). This study proposes ductility factor with correction factor, C, which can account for dynamic P-${\Delta}$ effect. Correction factor, C is established as the functional form since it requires computational efforts and time for calculating this factor. From the statistical study using the results of nonlinear dynamic analysis for 40 earthquake ground motions (EQGM) it is shown that the dependence of C factor on structural period is weak, whereas C factor is strongly dependant on the change of ductility ratio and stability coefficient. To propose the functional form of C factor statistical study is carried out using 79,920 nonlinear dynamic analysis results for different combination of parameters and 40 EQGM.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5699-5703
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• 2013

Objective: To investigate the clinical effects of whole brain radiotherapy concomitant with targeted therapy for brain metastasis in non-small cell lung cancer (NSCLC) patients with chemotherapy failure. Materials and Methods: Of the 157 NSCLC patients with chemotherapy failure followed by brain metastasis admitted in our hospital from January 2009 to August 2012, the combination group (65 cases) were treated with EGFR-TKI combined with whole brain radiotherapy while the radiotherapy group (92 cases) were given whole brain radiotherapy only. Short-term effects were evaluated based on the increased MRI in brain 1 month after whole brain radiotherapy. Intracranial hypertension responses, hematological toxicity reactions and clinical effects of both groups were observed. Results: There were more adverse reactions in the combination group than in radiotherapy group, but no significant differences were observed between the two groups in response rate (RR) and disease control rate (DCR) (P>0.05). Medium progression free survival (PFS), medium overall survival (OS) and 1-year survival rate in combination group were 6.0 months, 10.6 months and 42.3%, while in the radiotherapy group they were 3.4 months, 7.7 months and 28.0%, respectively, which indicated that there were significant differences in PFS and OS between the two groups (P<0.05). Additionally, RPA grading of each factor in the combination group was a risk factor closely related with survival, with medium PFS in EGFR and KRAS mutation patients being 8.2 months and 11.2 months, and OS being 3.6 months and 6.3 months, respectively. Conclusions: Whole brain radiotherapy concomitant with target therapy is favorable for adverse reaction tolerance and clinical effects, being superior in treating brain metastasis in NSCLC patients with chemotherapy failure and thus deserves to be widely applied in the clinic.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.1979-1985
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• 2016

Background: Complementary and alternative medicine has been highly appreciated as a supportive regimen for classical treatment strategies. Here we offer a nutrition-based adjuvant therapy for liver fibrosis, a major risk factor for cirrhosis and hepatocellular carcinoma. Aim of the study: To evaluate the possible hepatoprotective effects of Jerusalem artichoke tubers (JAT) in combination with interferon and ribavirin. Materials and Methods: Twelve groups of rats were administered JAT, interferon and ribavirin either separately or in combination from day one of $CCL_4$ administration until the end of the study. Animals were killed after 8 weeks of $CCL_4$-induced hepatotoxicity. Results: Hepatocytes from rats treated with triple combination of interferon, ribavirin, and JAT showed more less normal architecture compared to $CCL_4$-treated rats. We also detected significantly higher hepatic protein expression levels of p53, BAX and transforming growth factor-${\beta}$ (TGF-${\beta}$) in the $CCL_4$-intoxicated group compared to normal controls, as evidenced by immunohistochemical staining and western blotting analyses. Addition of JAT as a supportive regimen improved response to ribavirin and interferon and effectively participated in retaining normal histopathological and biochemical criteria and significantly lowered protein expression of p53, BAX, and TGF-${\beta}$. Conclusions: We suggest that addition of JAT as a supportive r egimen to interferon and ribavirin effectively potentiates their anti-fibrotic effects.

• 복식문화연구
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• 제20권2호
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• pp.154-168
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• 2012

This study examined size combination suitability of the underwear sets in home shopping and discussed the degree of consumer satisfaction as well as purchase criteria and evaluation after purchase of women's underwear. The survey was conducted from 1st to 15th September 2010 on a total of 300 women aged between 20 to 50, living in Seoul and Gyeonggi-do region who had bought women's underwear through home shopping. The completed data, 245 out of 300, was used for the final analysis. The analysis conducted in the study with SPSS statistics package includes frequency analysis, reliability analysis, factor analysis, chi-square analysis, $t$-test, ANOVA and Duncan's Multiple Range test. Evaluation items on purchase criteria and evaluation after purchase were processed with factor analysis. The results of the present study showed that product differentiation strategies are required based on age in order to improve consumer satisfaction and repurchase intention in home shopping underwear. Moreover, most of underwear products sold in sets in home shopping are provided based on the brassiere size. As a result, women who do not fit into the home shopping underwear size combination may be less satisfied. When consumers choose their own brassier and briefs size or combinations of various brassier and briefs sizes, it would increase consumer satisfaction.

• Structural Engineering and Mechanics
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• 제25권4호
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• pp.481-500
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• 2007

The dynamic instability of doubly curved panels, subjected to non-uniform tensile in-plane harmonic edge loading $P(t)=P_s+P_d\;{\cos}{\Omega}t$ is investigated. The present work deals with the problem of the occurrence of combination resonances in contrast to simple resonances in parametrically excited doubly curved panels. Analytical expressions for the instability regions are obtained at ${\Omega}={\omega}_m+{\omega}_n$, (${\Omega}$ is the excitation frequency and ${\omega}_m$ and ${\omega}_n$ are the natural frequencies of the system) by using the method of multiple scales. It is shown that, besides the principal instability region at ${\Omega}=2{\omega}_1$, where ${\omega}_1$ is the fundamental frequency, other cases of ${\Omega}={\omega}_m+{\omega}_n$, related to other modes, can be of major importance and yield a significantly enlarged instability region. The effects of edge loading, curvature, damping and the static load factor on dynamic instability behavior of simply supported doubly curved panels are studied. The results show that under localized edge loading, combination resonance zones are as important as simple resonance zones. The effects of damping show that there is a finite critical value of the dynamic load factor for each instability region below which the curved panels cannot become dynamically unstable. This example of simultaneous excitation of two modes, each oscillating steadily at its own natural frequency, may be of considerable interest in vibration testing of actual structures.

• Structural Engineering and Mechanics
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• 제86권2호
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• pp.277-290
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• 2023

A supplementary reinforced concrete wall can be used to improve the seismic behavior of a buckling restrained braced frame as a mixed system. In such a novel system, the total lateral force is resisted by the combination of the RC wall system and the BRBF. There is not enough research on the response modification factor of such a mixed system. This paper investigates the response modification factor, and such relevant factors as ductility reduction factor and over strength factor for a system consisting of reinforced concrete wall and buckling restrained braced frame. To this purpose, nonlinear incremental dynamic analysis as well as static push over analysis are used for 6- to 14-story sample structures. The results show that for mixed considered systems, the mean value of response modification factor varies approximately from 7 to 9.

• Journal of Acupuncture Research
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• 제34권2호
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• pp.1-18
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• 2017

Objectives : The purpose of this study was to evaluate the effects of water extracts of Eucommiae cortex (EC), Psoraleae semen (PS), and their combination on receptor activator of nuclear factor-kappa-B ligand (RANKL)-induced osteoclast differentiation. Methods : We assayed the protein expression levels of nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), c-Fos, mitogen-activated protein kinases (MAPKs), and ${\beta}-actin$ in cell lysates using western blotting. Similarly, mRNA expression levels of NFATc1, c-Fos, tartrateresistant acid phosphate (TRAP), and glyceraldehyde-3-phosphate dehydrogenase, spermatogeni (GAPDHS) from bone marrow macrophages (BMMs) were analyzed using reverse transcription-polymerase chain reaction (RT-PCR). Furthermore, we determined the anti-osteoporotic effects of the water extracts of EC, PS, and their combination in a lipopolysaccharide (LPS)-induced bone-loss mouse model. Results : The in vitro data revealed showed that the combination of EC and PS extract showed a more remarkable inhibition of osteoclast differentiation than each herb did alone. The combination downregulated the induction of c-Fos, NFATc1, and TRAP by suppressing the phosphorylation of p38 and c-Jun N-terminal kinases (JNKs) and inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells ($NF-{\kappa}B$). Lastly, the in vivo data showed that PS reduced the LPS-induced bone erosion. Conclusion : The result of this study suggests that EC and PS could be potential therapeutic agents for bone loss diseases such as osteoporosis.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제26권4호
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• pp.345-354
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• 2000

TGF-${\beta}_1$ is a potent chemotactic factor for inflammatory cells and fibroblasts. It also stimulates the celluar source and components of extracellular matrix and the production of proteinase inhibitors. Collectively, these biologic activities lead to the accumulation and stabilization of the nascent matrix, which is vital to wound healing. The objective of this study is to investigate production of TGF-${\beta}_1$ in vitro fibroblast culture in the presence of Staphylococcus enterotoxin B(SEB) and/or lipopolysaccharide(LPS) and to elucidate the role of TGF-${\beta}_1$ which may be responsible for wound healing. The fibroblasts were originated from facial dermis and hypertrophic scar in 26 year-old male patient. In the presence of LPS($0.01{\mu}g$, $0.1{\mu}g$, $1.0{\mu}g$), SEB($0.01{\mu}g$, $0.1{\mu}g$, $1.0{\mu}g$) respectively, cells($5{\times}10^3ml$) were cultivated in vitro. At 1, 3, and 5 days after incubation, cells were counted. Also, cells($2.5{\times}10^5ml$) were cultivated in EMEM with LPS(0.01, 0.1 and $1.0{\mu}g$), SEB(0.01, 0.1 and $1.0{\mu}g$) respectively and LPS($0.1{\mu}g$) and SEB($0.1{\mu}g$) in combination for 24, 48, and 72 hours respectively. Culture supernatants were harvested at 1, 2, and 3 days after incubation period and triplicate culture supernatants were pooled and TGF-${\beta}_1$ was assayed in duplicate. The results were as follows. 1. In facial dermal fibroblast induced with SEB and LPS respectively or in combination, the suppression of cell proliferation occurred very significantly at 1 day after incubation, compared with the control. In SEB exposure, the production of TGF-${\beta}_1$ was decreased very significantly at 1 day after incubation, compared with the control. However, in LPS, SEB and LPS exposure, the production of TGF-${\beta}_1$ was increased very significantly at 1 day after incubation, compared with the control. 2. In hypertrophic scar fibroblast induced with SEB and LPS respectively or in combination, the suppression of cell proliferation did not occur at 1 day after incubation, compared with the control. In SEB and LPS exposure in combination, the production of TGF-${\beta}_1$ was increased very significantly at 1 day after incubation, compared with the control. However, the production of TGF-${\beta}_1$ did not occur in SEB and LPS exposure respectively. In conclusion, the concentration of bacterial toxins and the incubation period correlated with cell proliferation and production of TGF-${\beta}_1$ very significantly and both fibroblasts have different phenotype each other in this regard. This data suggest that the significant production of TGF-${\beta}_1$ may develope abnormal wound healing associated with tissue fibroproliferative disorder, such as hypertrophic scar and keloid formation.

• 전기학회논문지P
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• 제58권1호
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• pp.33-37
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• 2009

In this paper, a printed small Ultra-Wideband (UWB) antenna with directive radiation characteristics based on combination of electric-magnetic radiators is presented. The combinations of the electric and magnetic type antennas result in the directive radiation patterns for all observed UWB frequency band. Simple combination of dipole antenna and loop antenna is also presented to show that proper configuration of electric radiator and magnetic radiator can produces directive radiation characteristics. The target frequency is from 3.1 GHz to 10.6 GHz with size of $15\;mm{\times}31\;mm$. A proto-type of the combined antenna is simulated, fabricated and measured. Simulation and experimental results of input impedance and gain characteristics of the proposed antenna are presented. There are good agreements between the simulated and measured VSWR curves. Also, the results show the directive radiation characteristics with small antenna form factor over the target frequency range.

• 대한두개안면성형외과학회지
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• 제18권1호
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• pp.54-58
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• 2017

Lymphangioma is a congenital malformed lymphatic tumor that rarely involves the tongue. In our clinic, a 10-year-old female presented with lymphangioma circumscriptum involving the right two-thirds of the tongue. We administered an intralesional combination injection of triamcinolone, bleomycin, and bevacizumab as a treatment. Almost complete remission after combination therapy was achieved without complications such as edema, swallowing difficulties or recurrence. Bevacizumab, an inhibitor of vascular endothelial growth factor, was effective for the treatment of lymphangioma of the tongue in this case. No recurrence was noted at the 1-year follow up.