• 한국정보과학회논문지:소프트웨어및응용
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• 제29권6호
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• pp.377-385
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• 2002

다양한 사건들의 무대로서의 시공간 상황의 구축을 위한 정통적 시뮬레이션 기반을 개발한다. 사이버 세계의 정통성, 다시 말해 실제에 대한 논리적 충실성은 그 세계에서 일어나는 사건들의 다양성과 예측 불가성을 최대화함으로써 실현한다. 시공간에서 일어나는 사건의 시뮬레이션을 위한 지식 컴포넌트는 환경 요인, 객체, 사건, 상관관계가 있다. 자유 재량적 사건의 정통 시뮬레이션을 실현하기 위해 사건 활성화, 실행 방법과 사건 인지 함수들을 고안하였다. 본 시뮬레이션 환경에서 자주적인 에이전트들은 독자적인 존재와, 사건의 실행과 분리된 계획을 하는 능력을 가지고 있다. 사람의 의도를 반영할 수 있는 자유 재량적 사건의 정통 시뮬레이션과 관련 있는 기본적인 구성 요소들을 확인하였다. 시뮬레이션 방법의 실행 가능성을 보이기 위해 핵심적인 기술들을 중심으로 구현의 예를 보인다.

• 대한인간공학회지
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• 제31권6호
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• pp.785-791
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• 2012

Objective: The aim of this study was to investigate the correlation between 3D visual fatigue and physiological measures by canonical correlation analysis enabling to categorical correlation. Background: Few studies have been conducted to investigate the physiological mechanism underlying the visual fatigue caused by processing 3D information which may make the cognitive mechanism overloaded. However, even the previous studies lack validation in terms of the correlation between physiological variables and the visual fatigue. Method: 9 Female and 6 male subjects with a mean age of $22.53{\pm}2.55$ voluntarily participated in this experiment. All participants were asked to report how they felt about their health sate at after viewing 3D. In addition, Low & Hybrid measurement test(Event Related Potential, Steady-state Visual Evoked Potential) and for evaluating cognitive fatigue before and after viewing 3D were performed. The physiological signal were measured with subjective fatigue evaluation before and after in watching the 3D content. For this study suggesting categorical correlation, all measures were categorized into three sets such as included Visual Fatigue set(response time, subjective evaluation), Autonomic Nervous System set(PPG frequency, PPG amplitude, HF/LF ratio), Central Nervous System set(ERP amplitude P4, O1, O2, ERP latency P4, O1, O2, SSVEP S/N ratio P4, O1, O2). Then the correlation of three variables sets, canonical correlation analysis was conducted. Results: The results showed a significant correlation between visual fatigue and physiological measures. However, different variables of visual fatigue were highly correlated to respective HF/LF ratio and to ERP latency(O2). Conclusion: Response time was highly correlated to ERP latency(O2) while the subjective evaluation was to HF/LF ratio. Application: This study may provide the most significant variables for the quantitative evaluation of visual fatigue using HF/LF ratio and ERP latency based human performance and subjective fatigue.

• 인지과학
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• 제18권3호
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• pp.223-244
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• 2007

이차원 공간에서 운동 자극의 진행 방향으로 위치 오류가 발생되는 명멸 지체효과(Flash lag effect: FLE)와 깊이 방향의 위치 오류가 발생하는 Pulfrich 효과는 각각 독립적으로 연구되어 왔지만 현상적 이론적 유사점이 많다. 본 연구에서는 두 현상의 오류의 크기를 직접적으로 비교하여 두 현상이 동일한 기제에 의해 발생되었을 가능성을 살펴보았다. 보다 구체적으로 각 눈에 제시된 운동 자극의 FLE의 크기가 다를 때 이 차이가 양안시차로 작용하여 Pulfrich 효과의 깊이로 산출될 수 있는 지를 알아보았다. 각 눈에 제시되는 두 운동 자극의 밝기 비율을 네 수준(1:2, 1:3.3, 1:5, 1:10)으로 나눈 다음 이들 자극으로부터 발생되는 Pulfrich 효과의 깊이를 측정하였고, 동일한 실험 상황하에서 Pulfrich 효과의 깊이 측정에 사용되었던 다섯 수준의 자기 자극(1, 2, 3.3, 5, 10)의 FLE 크기를 각각 측정하였다. 본 연구에 포함된 밝기 차 조건하에서 Pulfrich 깊이는 밝기 비율이 커질수록 증가하는 데 반해, FLE의 크기는 큰 차이를 보이지 않았다. 또한 FLE의 차가 양안 시차로 작용한다면 그로부터 예상할 수 있는 Pulfrich 깊이와 실제 측정된 Pulfrich 효과의 깊이는 다른 것으로 나타났다. 이러한 결과는 두 현상이 동일한 기제에 의해서 발생되는 것이 아님을 시사한다.

• BMB Reports
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• 제54권6호
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• pp.311-316
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• 2021

Ethanol often causes critical health problems by altering the neuronal activities of the central and peripheral nerve systems. One of the cellular targets of ethanol is the plasma membrane proteins including ion channels and receptors. Recently, we reported that ethanol elevates membrane excitability in sympathetic neurons by inhibiting Kv7.2/7.3 channels in a cell type-specific manner. Even though our studies revealed that the inhibitory effects of ethanol on the Kv7.2/7.3 channel was diminished by the increase of plasma membrane phosphatidylinositol 4,5-bisphosphate (PI(4,5)P₂), the molecular mechanism of ethanol on Kv7.2/7.3 channel inhibition remains unclear. By investigating the kinetics of Kv7.2/7.3 current in high K⁺ solution, we found that ethanol inhibited Kv7.2/7.3 channels through a mechanism distinct from that of tetraethylammonium (TEA) which enters into the pore and blocks the gate of the channels. Using a non-stationary noise analysis (NSNA), we demonstrated that the inhibitory effect of ethanol is the result of reduction of open probability (P_O) of the Kv7.2/7.3 channel, but not of a single channel current (i) or channel number (N). Finally, ethanol selectively facilitated the kinetics of Kv7.2 current suppression by voltage-sensing phosphatase (VSP)-induced PI(4,5)P₂ depletion, while it slowed down Kv7.2 current recovery from the VSP-induced inhibition. Together our results suggest that ethanol regulates neuronal activity through the reduction of open probability and PI(4,5)P₂ sensitivity of Kv7.2/7.3 channels.

• 생명과학회지
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• 제26권1호
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• pp.129-139
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• 2016

운동은 중추와 말초의 각종 성장인자(BDNF, IGF-1, VEGF)들의 상호작용에 의해 뇌신경가소성을 증진시키고 인지기능을 향상시킨다. 지금까지 저·중강도 지속성 유산소 운동의 효과를 검증하는 선행연구가 주로 이루어졌기 때문에 고강도 운동에 따른 뇌신경성장인자의 발현 및 인지기능 개선 효과에 대한 연구는 미흡한 실정이다. 하지만 최근의 과학적 증거들은 고강도 인터벌 운동이 시간 효율성, 안전성, 심폐지구력 개선 및 체중 감소에 효과적임을 암시하고 있으며, 미스포츠의학회(ACSM)에서 권장하는 일반인을 위한 운동지침에서도 무리가 되지 않는 수준에서 고강도 인터벌 운동 수행을 강조하고 있다. 특히 최근에 발표된 선행 연구에서 고강도 인터벌 운동은 말초조직과 뇌에서의 BDNF, IGF-1, VEGF의 발현을 증가시키고 그로 인한 인지기능 발달에 기여한다는 것을 보고하였으며, 관련된 유력한 생리학적 기전으로 고강도 인터벌 운동으로 인한 뇌의 저산소화와 뇌신경대사의 부가적인 에너지원이 될 수 있는 젖산 이용성 증가가 대두되고 있다. 따라서 향후 저산소화 및 젖산 이용성 증가에 따른 뇌신경성장인자 발현 개선에 어떤 분자생물학적 기전이 관여하는지를 탐구할 필요가 있으며, 또한 동일한 운동량을 가진 저·중강도 지속성 유산소 운동과의 비교 연구를 통해 뇌신경성장인자의 발현 및 인지기능 개선에 있어 고강도 인터벌 운동의 우수성을 입증하는 연구가 요구된다.

• 한국초등과학교육학회지:초등과학교육
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• 제26권1호
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• pp.49-62
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• 2007

The higher cognitive functions of the human brain including teaming are hypothesized to be selectively distributed across large-scale neural networks interconnected to the cortical and subcortical areas. Recently, advances in functional imaging have made it possible to visualize the brain areas activated by certain cognitive activities in vivo. Neural substrates for teaming and motivation have also begun to be revealed. Functional magnetic resonance imaging (fMRI) provides a non-invasive indirect mapping of cerebral activity, based on the blood- oxygen level dependent (BOLD) contrast which is based on the localized hemodynamic changes following neural activities in certain areas of the brain. The fMRI method is now becoming an essential tool used to define the neuro-functional mechanisms of higher brain functions such as memory, language, attention, learning, plasticity and emotion. Further research in the field of education will accelerate the verification of the effects on loaming or help in the selection of model teaching strategies. Thus, the purpose of this study was to review brain study methods using fMRI in science education. In conclusion, a number of possible strategies using fMRI for the study of elementary science education were suggested.

• The Korean Journal of Physiology and Pharmacology
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• 제24권2호
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• pp.129-135
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• 2020

SHP2 is an unusual protein phosphatase that functions as an activator for several signaling pathways, including the RAS pathway, while most other phosphatases suppress their downstream signaling cascades. The physiological and pathophysiological roles of SHP2 have been extensively studied in the field of cancer research. Mutations in the PTPN11 gene which encodes SHP2 are also highly associated with developmental disorders, such as Noonan syndrome (NS), and cognitive deficits including learning disabilities are common among NS patients. However, the molecular and cellular mechanism by which SHP2 is involved in cognitive functions is not well understood. Recent studies using SHP2 mutant mice or pharmacological inhibitors have shown that SHP2 plays critical role in learning and memory and synaptic plasticity. Here, we review the recent studies demonstrating that SHP2 is involved in synaptic plasticity, and learning and memory, by the regulation of the expression and/or function of glutamate receptors. We suggest that each cell type may have distinct paths connecting the dots between SHP2 and glutamate receptors, and these paths may also change with aging.

• 인지과학
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• 제30권4호
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• pp.239-268
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• 2019

영상기억은 시각기억 처리 과정의 최초 저장 기제로서 오랫동안 이론적인 타당성을 인정받아왔다. 그러나 최근 관심이 대폭 증가한 시각단기기억과 시각장기기억에 비해 영상기억에 대한 연구자들의 관심은 상대적으로 부족했던 것이 사실이다. 이러한 관심의 부족은 영상기억 및 시각지속 현상에 대한 이론 및 방법론적 이해의 결여가 그 원인인 것으로 짐작된다. 본 연구는 영상기억 및 시각지속 현상에 대한 이론적 배경과 경험적 연구 사례를 개관해 영상기억에 대한 상세한 이해를 도모하였다. 더 나아가 영상기억의 타당성에 대한 현상학적, 생태학적 비판들의 핵심 내용들을 토대로 향후 영상기억 연구의 방향을 가늠하는데 목적을 두었다.

• Molecules and Cells
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• 제38권7호
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• pp.587-596
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• 2015

Obesity and diabetes arise from an intricate interplay between both genetic and environmental factors. It is well recognized that obesity plays an important role in the development of insulin resistance and diabetes. Yet, the exact mechanism of the connection between obesity and diabetes is still not completely understood. Metabolomics is an analytical approach that aims to detect and quantify small metabolites. Recently, there has been an increased interest in the application of metabolomics to the identification of disease biomarkers, with a number of well-known biomarkers identified. Metabolomics is a potent approach to unravel the intricate relationships between metabolism, obesity and progression to diabetes and, at the same time, has potential as a clinical tool for risk evaluation and monitoring of disease. Moreover, metabolomics applications have revealed alterations in the levels of metabolites related to obesity-associated diabetes. This review focuses on the part that metabolomics has played in elucidating the roles of metabolites in the regulation of systemic metabolism relevant to obesity and diabetes. It also explains the possible metabolic relation and association between the two diseases. The metabolites with altered profiles in individual disorders and those that are specifically and similarly altered in both disorders are classified, categorized and summarized.

• Biomolecules & Therapeutics
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• 제22권5호
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• pp.467-473
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• 2014

The purpose of this study is to investigate the memory enhancing effect and underlying molecular mechanism of arabinoxylan (AX), a major component of dietary fiber in wheat against scopolamine (SCO)-induced amnesia in Sprague-Dawley (SD) rats. Diverse behavior tests including Y-maze, Morris water maze, and passive avoidance tests were performed to measure cognitive functions. SCO significantly decreased the spontaneous alterations in Y-maze test and step-through latency in passive avoidance test, whereas increased time spent to find the hidden platform in Morris water maze test compared with the sham control group. In contrast, oral administration of AX (25 mg/kg and 50 mg/kg) effectively reversed the SCO-induced cognitive impairments in SD rats. Furthermore, AX treatment up-regulated the expression of brain-derived neurotrophic factor (BDNF) in the cortex and hippocampus via promoting activation of cAMP response element binding protein (CREB). Therefore, our findings suggest that AX can improve SCO-induced learning and memory impairment possibly through activation of CREB and up-regulation of BDNF levels, thereby exhibiting a cognition-enhancing potential.