• Title/Summary/Keyword: coefficient-based method

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The Polymerase Chain Reaction in Diagnosis of Small B-Cell Non-Hodgkin Lymphomas

  • Antoro, Ester Lianawati;Dwianingsih, Ery Kus;Indrawati, Indrawati;Triningsih, FX Ediati;Harijadi, Harijadi
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.2
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    • pp.491-495
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    • 2016
  • Background: Small B-cell non-Hodgkins lymphoma (NHL) is difficult to be distinguished from non-neoplastic reactive processes using conventional haematoxylin-eosin (HE) staining due to different interpretations among pathologists with diagnosis based on morphologic features. Ancillary examinations such as immunohistochemical (IHC) staining are essential. However, negative or doubtful results are still sometimes obtained due to unsatisfactory tissue processing or IHC technique. The polymerase chain reaction (PCR) as a molecular diagnostic technique is very sensitive and specific. Clonality detection of heavy chain immunoglobulin (IgH) gene rearrangement has been widely used to establish diagnosis of B-cell NHL. Aims: To elaborate interobserver variation in small B-cell NHL diagnosis based on morphologic features only and to confirm sensitivity and specificity of the PCR technique as an ancillary method. Materials and Methods: A toptal of 28 samples of small B cell NHL and suspicious lymphoma were interpreted by 3 pathologists in Sardjito General Hospital based on their morphology only. The reliability of assessment and the coefficient of interobserver agreement were calculated by Fleiss kappa statistics. Interpretation results were confirmed with IHC staining (CD20, CD3, Bcl2). PCR was performed to analyze the clonality of IgH gene rearrangement. Results: Interobserver agreement in morphologic evalution of small B cell NHL and chronic lymphadenitis revealed kappa coefficient 0.69 included in the substantial agreement category. The cases were divided into 3 groups based on morphology and IHC results; lymphoma, reactive process and undetermined group. PCR analysis showed 90% sensitivity and 60% specificity. Conclusions: The present study revealed a substantial agreement among pathologists in small B-cell NHL diagnosis. For difficult cases, PCR is useful as complementary method to morphologic and IHC examinations to establish definitive diagnosis.

Preferences for Home Economics Curriculum Models (가정과 교육과정 모형에 대한 선호도)

  • 채정현
    • Journal of Korean Home Economics Education Association
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    • v.8 no.1
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    • pp.33-49
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    • 1996
  • The objectives of this study were (1) to determine the preferences for three home economics curriculum Models(Concept-based curriculum Model, Competency-based curriculum Model, and Practical Problem-based curriculum Model) of Korean home economics(HE) teachers and HE teacher educators, (2) to determine the difference between HE teachers and HE teacher educators according to purposes of HE, focus of learning, organization of HE subject matter, focus of HE curriculum, focus of HE content, HE knowledge, main questions addressed through HE curriculum, teaching strategies, students’progress, and systems of action, and (3) to determine the relationships between preferences for three curriculum Models and personal and professional characteristics of HE teachers. Respondents in this study were 225 HE teachers and 35 HE teacher educators. The survey method was used in this descriptive study. The survey method was used in this descriptive study. The overall curriculum Model preference of each teacher respondent was determined by counting number of times a given Model among 10 identified variables. The data were analyzed by using Chi-square to compare the differences between the two groups. To determine the relationships between preferences for three curriculum Models and personal and professional characteristics of HE teachers, coefficient of contingency tables was used. Both of HE teacher group(79.4%) and HE teacher educator group(67.6%) preferred the practical problem-based curriculum Model the most. There was a difference between the two groups on preferences for the curriculum Models related to systems of action. No significant difference emerged when Chi-square was applied to determine difference between the two groups on overall preferences for three HE curriculum Model. The chi square values between preferences for three curriculum Model and level of school, type of school were statistically significant. Each contingency coefficient for level of school(middle school and high school) and form of school(private and public school) was 27, which means there is a low association between the preferences and level of school and the preferences and form of school.

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Object-based Image Classification by Integrating Multiple Classes in Hue Channel Images (Hue 채널 영상의 다중 클래스 결합을 이용한 객체 기반 영상 분류)

  • Ye, Chul-Soo
    • Korean Journal of Remote Sensing
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    • v.37 no.6_3
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    • pp.2011-2025
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    • 2021
  • In high-resolution satellite image classification, when the color values of pixels belonging to one class are different, such as buildings with various colors, it is difficult to determine the color information representing the class. In this paper, to solve the problem of determining the representative color information of a class, we propose a method to divide the color channel of HSV (Hue Saturation Value) and perform object-based classification. To this end, after transforming the input image of the RGB color space into the components of the HSV color space, the Hue component is divided into subchannels at regular intervals. The minimum distance-based image classification is performed for each hue subchannel, and the classification result is combined with the image segmentation result. As a result of applying the proposed method to KOMPSAT-3A imagery, the overall accuracy was 84.97% and the kappa coefficient was 77.56%, and the classification accuracy was improved by more than 10% compared to a commercial software.

The Study on the Compaction Characteristics of Underground Structural Backfill with Reclaimed Soil (준설토를 이용한 지하구조물 뒷채움 다짐특성에 관한 연구)

  • 김영웅;박기순;손형호;김종국
    • Proceedings of the Korean Geotechical Society Conference
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    • 1999.03a
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    • pp.357-364
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    • 1999
  • The purpose of this study is to analysis the grain distribution and compaction characteristics of structural backfill with reclaimed soil. Five(5) reclaimed soil samples which passed #200 sieve have been used in the test. The study showed that the maximum dry density and the bearing value rate turned out to be becoming smaller when the more the quantity passed #200 sieve, the smaller the soil grain. The maximum dry density value calculated from the compaction md relative density test showed wet method > compaction method > dry method. The correlation coefficient between Rc and Dr based on the grain distribution and the compaction characteristics showed that the maximum dry density value by the wet method is little higher than the compaction method and dry method.

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Motion Vector Based Overlay Metrology Algorithm for Wafer Alignment (웨이퍼 정렬을 위한 움직임 벡터 기반의 오버레이 계측 알고리즘 )

  • Lee Hyun Chul;Woo Ho Sung
    • KIPS Transactions on Software and Data Engineering
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    • v.12 no.3
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    • pp.141-148
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    • 2023
  • Accurate overlay metrology is essential to achieve high yields of semiconductor products. Overlay metrology performance is greatly affected by overlay target design and measurement method. Therefore, in order to improve the performance of the overlay target, measurement methods applicable to various targets are required. In this study, we propose a new algorithm that can measure image-based overlay. The proposed measurement algorithm can estimate the sub-pixel position by using a motion vector. The motion vector may estimate the position of the sub-pixel unit by applying a quadratic equation model through polynomial expansion using pixels in the selected region. The measurement method using the motion vector can calculate the stacking error in all directions at once, unlike the existing correlation coefficient-based measurement method that calculates the stacking error on the X-axis and the Y-axis, respectively. Therefore, more accurate overlay measurement is possible by reflecting the relationship between the X-axis and the Y-axis. However, since the amount of computation is increased compared to the existing correlation coefficient-based algorithm, more computation time may be required. The purpose of this study is not to present an algorithm improved over the existing method, but to suggest a direction for a new measurement method. Through the experimental results, it was confirmed that measurement results similar to those of the existing method could be obtained.

Differencing Multiuser Detection Using Error Feedback Filter for MIMO DS-UWB System in Nakagami Fading Channel

  • Kong, Zhengmin;Fang, Yanjun;Zhang, Yuxuan;Peng, Shixin;Zhu, Guangxi
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.6 no.10
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    • pp.2601-2619
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    • 2012
  • A differencing multiuser detection (MUD) method is proposed for multiple-input multiple-output (MIMO) direct sequence (DS) ultra-wideband (UWB) system to cope with the multiple access interference (MAI) and the computational efficiency in Nakagami fading channel. The method, which combines a multiuser-interference-cancellation-based decision feedback equalizer using error feedback filter (MIC DFE-EFF), a coefficient optimization algorithm (COA) and a differencing algorithm (DA), is termed as MIC DFE-EFF (COA) with DA for short. In the paper, the proposed MUD method is illuminated from the rudimental MIC DFE-EFF to the advanced MIC DFE-EFF (COA) with DA step by step. Firstly, the MIC DFE-EFF system performance is analyzed by minimum mean square error criterion. Secondly, the COA is investigated for optimization of each filter coefficient. Finally, the DA is introduced to reduce the computational complexity while sacrificing little performance. Simulations show a significant performance gain can be achieved by using the MIC DFE-EFF (COA) with DA detector. The proposed MIC DFE-EFF (COA) with DA improves both bit error rate performance and computational efficiency relative to DFE, DFE-EFF, parallel interference cancellation (PIC), MIC DFE-EFF and MIC DFE-EFF with DA, though it sacrifices little system performance, compared with MIC DFE-EFF (COA) without DA.

Analysis on the Wave Characteristics of Submerged Breakwater Considering Energy Dissipation of Seabed (해저면의 에너지 감쇠를 고려한 불투과 잠제의 파랑특성해석)

  • Kim Nam-Hyeong;Yang Soon-Bo;Park Min-Su;Kim Sang-Jin
    • Journal of the Korean Society for Marine Environment & Energy
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    • v.7 no.3
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    • pp.131-136
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    • 2004
  • The transmission coefficients of impermeable submerged breakwater on permeable bottom are computed numerically using a boundary element method. The analysis method is based on the wave pressure function with the continuity in the analytical region including fluid and structures. Wave motion over permeable bottom is simulated by introducing a linear dissipation coefficient and an added mass coefficient. The results indicate that the wave over permeable bottom travels being damped, and that transmission coefficients for permeable bottom are smaller than those for impermeable bottom, and result from the change of width and height of submerged breakwater.

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Estimation of Design Wind Speed for Building Using Spatial Information Analysis (공간정보 분석을 통한 건축물의 설계풍속 산정)

  • Lee, Seong-Yun;Jo, Hyun-Jae;Lee, Hyun-Ki;Choi, Se-Hyu
    • Spatial Information Research
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    • v.23 no.3
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    • pp.79-89
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    • 2015
  • Once the building is higher than certain size, the wind effect plays very important role in structure design. Moreover, this is more important in Korea because dangerous phenomena like typhoons are common. Rational wind resistant design is being magnified considering the global flow and climate changes. This research presented the estimation method of design wind load using spatial information analysis based on 1:5,000 digital map and performed comparative analysis with actual application cases. The wind velocity pressure exposure coefficient and topographic coefficient turned out to be more quantitative and rational when calculated through the proposed method. The time and cost are comparatively low when compared with traditional method which contribute to the economic and rational wind resistant design.

Cavity Design for Injection Molded Gears by the Compensation Method of Design Parameters (설계인자 보정방법에 의한 사출성형기어의 캐비티 설계)

  • Lee, Sung-Chul;Kim, Choong-Hyun;Kwon, Oh-Kwan;Huh, Yong-Jeong
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.20 no.10
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    • pp.3142-3151
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    • 1996
  • As plastics shrink when changing from a molten to a solid state, mold cavities must by made larger than the product specification, In making molded gears, the teeth in the cavity must be carefully compensated for shrinkage so that the teeth of gears will have the correct profile. Two compensation methods are widely used in the cavity design. One is the compensation of a module and the other is the modification of a pressure angle and profile shifting coefficient. These methods, however, do not provide a gear cavity with all disign parameters for gears and several parameters are determined by experience. In this paper, the new design technique, namely the compensation method of design parameters, was proposed , which is based on the three kinds of shrinkage rates obtained from the measuring data of the prototype of molded gears. Using the shrinkage rates in the tip circle, tooth heigth and tooth thickness, we calculate the whole design parameters of a gear cavity. Thus, the gear cavity is considered as a complete gear with the compensated module, pressure angle, profile shifting coefficient, clearance coefficient and back lash amount so that the formula of gears can be applied to the cavity design effectively. Experimental results show that more precision molded gears can be made by using the proposed design method.

The Boundary Element Analysis of Waves coming with Oblique Angle to a Submerged Breakwater (잠제에 경사로 입사하는 파랑의 경계요소 해석)

  • Kim, Nam Hyeong;Woo, Su Min
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.32 no.5B
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    • pp.295-300
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    • 2012
  • Reflection coefficients of wave due to the types of a submerged breakwater on the inclined incident wave are numerically computed by using boundary element method. The analysis method is based on the wave pressure function with the continuity in the analytical region including fluid and structures. When compared with the existing results on the inclined incident wave, the results of this study show good agreement. It is found that both maximum and minimum values of the reflection coefficient are appeared frequently, as the width of a submerged breakwater becomes wider, and the reflection coefficient increase, as the wave period is longer. In addition, the effect on the reflection coefficient due to the change of submerged breakwater hight is lager than that due to the change of submerged breakwater width. The results indicate that dissipating characteristics of wave due to the types of a submerged breakwater own high dependability regarding the change of inclined incident waves. Therefore, the results of this study is estimated to be applied as an accurate numerical analysis referring to inclined incident waves in real sea.