• 제목/요약/키워드: co-validation

검색결과 436건 처리시간 0.025초

건강기능식품 원료로서 길초근 주정 추출물의 지표성분 분석법 검증 (HPLC Validation of Valerian Ethanol Extract as a Functional Food)

  • 조경애;한성희;배송환;신중철;서형주
    • 한국식품영양학회지
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    • 제31권1호
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    • pp.104-108
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    • 2018
  • The purpose of this study was to establish valerenic acid as a marker compound for the standardization of ethanol extract of Valerinan officinalis (valerian) root as a functional health food. We established valerenic acid as a marker compound using HPLC. HPLC was used to quantify the marker compound in the valerian extract after validation of methods with linearity, accuracy, and precision. The specificity for retention time was met by comparative analysis of the valerian extract and standard compound using HPLC. The method showed high linearity of the calibration curve with a coefficient of correlation ($R^2$) of 0.9999. The limit of quantification (LOQ) was $10{\mu}g/mL$. The accuracy of measurement was 99.88~00.68% and the relative standard deviation (RSD) value was 0.59%. In addition, our analytical method yielded a 29% mean content of valerenic acid in the valerian ethanol extract. These results indicate that the established HPLC method facilitated the determination of marker compounds in the valerian extract for the standardization of health functional foods.

공간예측모형에 기반한 산사태 취약성 지도 작성과 품질 평가 (Mapping Landslide Susceptibility Based on Spatial Prediction Modeling Approach and Quality Assessment)

  • 알-마문;박현수;장동호
    • 한국지형학회지
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    • 제26권3호
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    • pp.53-67
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    • 2019
  • The purpose of this study is to identify the quality of landslide susceptibility in a landslide-prone area (Jinbu-myeon, Gangwon-do, South Korea) by spatial prediction modeling approach and compare the results obtained. For this goal, a landslide inventory map was prepared mainly based on past historical information and aerial photographs analysis (Daum Map, 2008), as well as some field observation. Altogether, 550 landslides were counted at the whole study area. Among them, 182 landslides are debris flow and each group of landslides was constructed in the inventory map separately. Then, the landslide inventory was randomly selected through Excel; 50% landslide was used for model analysis and the remaining 50% was used for validation purpose. Total 12 contributing factors, such as slope, aspect, curvature, topographic wetness index (TWI), elevation, forest type, forest timber diameter, forest crown density, geology, landuse, soil depth, and soil drainage were used in the analysis. Moreover, to find out the co-relation between landslide causative factors and incidents landslide, pixels were divided into several classes and frequency ratio for individual class was extracted. Eventually, six landslide susceptibility maps were constructed using the Bayesian Predictive Discriminant (BPD), Empirical Likelihood Ratio (ELR), and Linear Regression Method (LRM) models based on different category dada. Finally, in the cross validation process, landslide susceptibility map was plotted with a receiver operating characteristic (ROC) curve and calculated the area under the curve (AUC) and tried to extract success rate curve. The result showed that Bayesian, likelihood and linear models were of 85.52%, 85.23%, and 83.49% accuracy respectively for total data. Subsequently, in the category of debris flow landslide, results are little better compare with total data and its contained 86.33%, 85.53% and 84.17% accuracy. It means all three models were reasonable methods for landslide susceptibility analysis. The models have proved to produce reliable predictions for regional spatial planning or land-use planning.

MWR 관측치와 비교를 통한 GPS 가강수량 정밀도 검증 (Precision Validation of GPS Precipitable Water Vapor via Comparison with MWR Measurements)

  • 하지현;박관동;장기호;양하영
    • 대기
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    • 제17권3호
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    • pp.291-298
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    • 2007
  • The precipitable water vapors (PWVs) obtained from Global Positioning System (GPS) and Microwave Radiometer (MWR) measurements have been compared for validation of precision of the GPS PWV at Daegwallyoung station for 21 days from Sep. 30 to Oct. 20, 2006. The GPS PWV is estimated using the delay of GPS signals due to the water vapor in the atmosphere with a local mean temperature equation, called HP model, and the MWR PWV by the combinational radiance observation of two channels (23.8 and 31.4 GHz). During the co-observation period, the MWR and GPS PWV show a similar trend, and the bias between the PWVs is 1.7 mm on average. When the bias is removed, the PWV of GPS gives good agreement with that of MWR, having about 1 mm for both the standard deviation and RMS error between the GPS and MWR PWV.

비이식형 요실금 치료용 신경근 전기자극 의료기기 개발 (The Development of Neuromuscular Electrical Stimulation Medical Devices for The Treatment of Non-implantable Urinary Incontinence)

  • 이재용;이창두;권기진
    • 전기학회논문지P
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    • 제64권3호
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    • pp.175-181
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    • 2015
  • In this paper, the neuromuscular electrical stimulation medical devices for non-implantable incontinence treatment other than vaginal insertion type was developed and commercialized. The structure of medical devices for electrical stimulation based on the anatomy of the pelvic floor muscle designed. Then, the optimum parameters that may be effective in pelvic floor muscle electrical stimulation was set. The circuit system based on the optimum parameters were designed and manufactured. The frequency of the pulse voltage for electrical stimulation is 75[Hz], the pulse width is 300[${\mu}s$], the development of medical devices was to have seven program functions to the various treatments. The circuit system of medical devices was composed of microcontroller, comparator and converter. The performance of the developed circuit system in KTC(Korea Testing Certification) were carried out medical equipment inspection test. Test results, test specifications were satisfied with the medical device, the performance was verified to be commercialized as a medical device. The development of medical devices were validated risk assessment and product performance through a software validation. Commercialization of medical equipment was acquired to enable the certification standards of the international standard IEC 60601-1.

피로수명해석에 의한 지게차용 후차축 주물빔 설계 (Steeraxle Casting Beam Design of Forklift Truck by Fatigue Life Analysis)

  • 박진홍;구재민;이오영;석창성
    • 한국정밀공학회지
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    • 제28권11호
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    • pp.1309-1315
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    • 2011
  • The design process for obtaining the reliable steeraxle casting beam of fork lift truck is studied in this paper, as the casting beam is major component of steeraxle which has a steering function at driving. In this study, the driving mode and damage pattern of casting beam which could be occurred from the customer site were analyzed and it established the design process to predict the fatigue life by FEA(Finite Element Analysis) so that the reliability of steeraxle casting beam could be verified at DVT(Design Validation Test) mode. This paper provides guidance on the process of designing the reliable steeraxle casting beam at the initial design stage and also, provides guidance on the process of solving the problem when the failure is occurred in the field.

한국형 보육교사 직무만족척도개발을 위한 타당화 예비연구 (Preliminary Study for Validation of Development of Korean Childcare Teacher's Job Satisfaction Scale)

  • 조성연;백은주;김혜금;권연희;정지나
    • 가정과삶의질연구
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    • 제28권5호
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    • pp.89-100
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    • 2010
  • The purpose of this study was to develop a "Korean Childcare Teacher's Job Satisfaction Scale"(KCTJSS) and to evaluate its reliability and validity. KCTJSS was 72 items and 6 point Likert scale. Participants consisted of 211 childcare teachers by purposive sampling. Results were as follows: First, Exploratory factor analysis resulted in 40 items composed of 6 factors : The principal's childcare center operation system, working environments and welfare, social recognition, amount of work and time management, relationships with co-workers, relationships with parents. Second, the confirmatory factor analysis supported a 6 factor structure. Third, Criterion-related validity was confirmed by significant correlations of the present scale with Early Childhood Job Satisfaction Survey(Jorde-Bloom, 1989). Fourth, the reliability of factors using Cronbach's ${\alpha}$ appeared high, ranging from .83 to .93.

수두차를 이용한 수저퇴적물 제거장치 개발에 관한 연구 (Study on the Development of Removing System for Waterbed Sediment by the Difference of Water Head)

  • 이영길;손충렬;정우철;유진원;정광열;김강신;김방열
    • 대한조선학회논문집
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    • 제45권1호
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    • pp.101-107
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    • 2008
  • According to the existing research result on the seabed organic sediment, pollutants from the land and the sea contaminate the coastal water and sediment on the seabed. To tackle this problem, we need to dredge organic sediment. In the present paper, the development of removing system of seabed sediment by the difference of water head is researched by experimental method. For the validation of the decompression system, computations for validation are carried out for sediment removing equipment. The performance of inhalation equipment is analysed by some model tests.

부모역할행동검사의 개발 및 타당화 연구 (The Development and Validation of the Parenting Style Inventory(PSI))

  • 김은정;김영아;김유진;문수종
    • 아동학회지
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    • 제27권4호
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    • pp.219-232
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    • 2006
  • The purpose of this research is to develop and validate an instrument that can be used to measure critical aspects of a parent's attitude and behavior that influence child development and adaptation. This instrument is named Parenting Style Inventory and self-reporting assessment of parent for preschoolers. We reported findings from 578 preschooler's care-givers. Five factors were extracted from 55 items developed for preschooler version and finally 29 items were selected. Subscales were empathy, respect, parental authority, coerciveness, perfectionism. Internal consistency of these subscales were .77, .86, .70, .74, .68 relatively. Empathy, respect and authoritative scales were regarded as the basic dimensions of parent's behavior. For clinical validation, we divided the preschooler care-giver sample into 8 groups according to scores of the basic dimensions and compared the 8 groups with parenting stress and parenting self-efficacy scores. The results indicated that three basic factors would have different effects on parental experiences and satisfaction. We suggested the clinical implication and limitation of this instrument.

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모델 기반 내장형 소프트웨어의 효율적 신뢰성 시험 기법 (An Efficient Software Reliability Testing Method for the Model based Embedded Software)

  • 박장성;조성봉;박현룡;김도완;김성균
    • 한국시뮬레이션학회논문지
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    • 제27권1호
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    • pp.25-32
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    • 2018
  • 본 논문은 모델 기반 내장형 소프트웨어의 자동 생성 코드에 대한 효율적인 신뢰성 시험 절차와 구체화된 동적 시험 방안에 대해서 제시하고 있다. 모델 정적/동적 시험 각각을 코드 정적/동적 시험 전에 수행함으로서 코드 신뢰성 시험 수행의 이점이 있음을 기술하였다. 또한, 모델과 코드의 신뢰성 시험 상관관계를 모델의 경우 Model Advisor와 Verification and Validation tool, 코드의 경우 Polyspace와 LDRA를 이용하여 살펴보고 제시한 절차대로 수행한 신뢰성 시험의 결과를 보여주고 있다.

Copper neutron transport libraries validation by means of a 252Cf standard neutron source

  • Schulc, Martin;Kostal, Michal;Novak, Evzen;Simon, Jan
    • Nuclear Engineering and Technology
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    • 제53권10호
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    • pp.3151-3157
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    • 2021
  • Copper is an important structural material in various nuclear energy applications, therefore the correct knowledge of copper cross sections is crucial. The presented paper deals with a validation of different copper transport libraries by means of activation of selected samples. An intense 252Cf(sf) source with a reference neutron spectrum was used as a neutron source. After irradiation, the samples were measured using a high purity germanium detector and the dosimeter reaction rates were inferred. These experimental data were compared with MCNP6 calculations using CENDL-3.1, JENDL-4.0, ENDF/B-VII.1, ENDF/B-VIII.0, JEFF-3.2 and JEFF-3.3 evaluated Cu transport libraries. The experiment specifically focuses on 58Ni(n,p)58Co, 93Nb(n,2n)92mNb, 197Au(n,g)198Au and 55Mn(n,g)56Mn dosimetry reactions. Evaluated activation cross sections of these dosimetric reactions were taken from the IRDFF-II library. The best library performance depends on the energy region of interest.