• Journal of Pharmaceutical Investigation
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• v.25 no.4
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• pp.353-363
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• 1995

The purpose of this study was to investigate the intestinal and nasal absorption enhancement of cefotaxime (CTX) by ion-pairing with counterions and to design an effective oral and intranasal drug delivery system for antibiotics. Counterions for absorption promotion were cationic surfactants [cetylpyridinium chloride (CP), cetrimide (CT) and benzalkonium chloride (BA)]. In the presence of counterions, the apparent partition coefficient of cefotaxime was increased depending on the molar concentration of the counterions. Anion interference was observed for ion-pairing of cefotaxime with counterions because of the counterbalance between an anion and counterions. The present study employed the in situ simultaneous nasal and intestinal perfusion technique in rats. The apparent permeabilities $(P_{app})$ of cefotaxime were $1.43{\pm}0.04{\times}10^{-5}\;cm/sec(mean{\pm}S.E)$ in the nasal cavity and 0 in the jejunum, respectively, which indicated that the intrinsic absorptivity of cefotaxime was greater in the nasal cavity than in the jejunum. When ionupairing formers were used, the decreasing order of apparent cefotaxime permeability $(P_{app},\;10^{-5}\;cm/sec)$, corrected for surface area of absorption, was as followings: $BA\;(7.50{\pm}0.36)\;>\;CT\;(4.92{\pm}0.24)\;>\;CP\;(3.01{\pm}0.17)$ in the jejunum and $BA\;(22.31{\pm}1.36)\;>\;CP\;(18.24{\pm}0.81)\;>\;CT \;(16.22{\pm}1.87)$ in the nasal cavity. The increase in permeability of cefotaxime was about 13-fold in the rat nasal cavity and was marked in the rat jejunum for ion-pairing with counterions as compared to those without ion-pairing. The damages of jejunal and nasal mucosal membrane by counterions were observed within approximately 2hrs after removal of ion-pair of cefotaxime with counterions from the nasal cavity and jejunum. These results suggest that CP can be used as an ion-pairing former in the jejunum and CP and CT can be used as ion-pairing formers in the nasal cavity for cefotaxime, as well as for poorly absorbed drugs with a negative charge due to ionization.

• Bulletin of the Korean Chemical Society
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• v.30 no.2
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• pp.445-448
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• 2009

This study examined the effect of the uptake of one and two electrons on the atomic structure of three isomers of $C_{20}$ clusters, namely the ring, bowl (corannulene like), and cage (the smallest fullerene). Geometry optimizations were performed using the hybrid density functional (B3LYP) methods for neutral, singly and doubly charged $C_{20},\;{C_{20}}^-,and\;{C_{20}}^{2-}$. These results show that the symmetry of the lowest energies for ring and bowl isomers were not changed, whereas the increasing order of energy for the cage (the smallest fullerene) isomers was changed from $D_{2h}\;<\;C_{2h}\;{\leq}\;C_2\;of\;C_{20}\;through\;Ci\;<\;C_{2h}\;<\;C_2\;<\;D_{2h}\;of\;{C_{20}}^-\;to\;Ci\;<\;C_2\;<\;D_{2h}\;<\;C_{2h}\;of\;{C_{20}}^{2-}$. The reduced symmetry isomers of the cage have comparative energy and the ground state symmetry of the neutral and single and double charged $C_{20}$ decreased with increasing number of electrons taken up in the point of energetics. Interestingly, the difference in energy between the ground state and the next higher energy state of ${C_{20}}^{2-}$ was 3.5kcal/mol, which is the largest energy gap of the neutral, single anion and double anion of the cage isomers examined.

• Journal of Environmental Science International
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• v.12 no.12
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• pp.1277-1284
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• 2003

The photocatalytic oxidation of Rhodamine B (RhB) was studied using immobilized TiO$_2$ and fluidized bed reactor. Immobilized TiO$_2$ onto GF/C was employed as the photocatalyst and a 30 W germicidal lamp was used as the light source and the reactor volume was 4.8 L. The effects of parameters such as the amounts of photocatalyst, initial concentration, initial pH, air flow rate and anion additives (NO$_3$$\^$-/, SO$_4$$\^$2-/, Cl$\^$-/, CO$_3$$\^$2-/) competing for reaction. The results showed that the optimum dosage of the immobilized TiO$_2$ was 40.0 g/L. Initial removal rate of immobilized TiO$_2$ was expressed Langmuir - Hinshelwood equation.

• Journal of the Korean Society of Food Science and Nutrition
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• v.27 no.6
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• pp.1183-1188
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• 1998

This study was carried out to elucidate the immunomodulating activity of protein bound polysac charide extracted from Ganoderma lucidum(PSG). Macrophage drived reactive radicals were known as an effector for antimicrobial and anticancer functions. The promising immune response molecule, reactive oxygen intermediates(ROIs), was determined in TIB 71 cells with PSG at various experimental conditions. Treatment with 0.5mg PSG significantly increased the production of ROIs, superoxide anion as well as hydrogen peroxide, from TIB 71 cells(p<0.001). Under the same concentration, con siderable results were obtained from 24 hour cultivation with 106 cells at 5% CO2 incubator. The cells were trigged with PMA(5.3 M) after primed BCG(100 M) or IFN (100U) alone could not induce the production of ROIs, but it had a significant potentiating effect on ROIs secretion when the cells were treated with PSG.

• Proceedings of the Materials Research Society of Korea Conference
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• 2003.03a
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• pp.248-248
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• 2003

층상이중수화물(Layered Double Hydroxides, LDH)은 층 사이에 무기물 음이온이 있는 2차원 충상구조물로서 이들 층 사이의 공간에 이동 가능한 수화된 음이온의 존재로 전하균형을 이룬다. 층 사이의 음이온은 교환이 가능하며, 나머지의 공간은 물분자로 채워져 있다. 이러한 특성을 응용하여 LDH는 촉매, 음이온 교환제, 흡착제, 담체로 사용가능하며, 특히 음이온 교환능이 있는 소재로 고분자에 적용되고 있으며, 층간에 염료를 삽입한 복합체의 제조 둥에 관한 연구가 활발히 이루어지고 있다. 이의 적용에서 LDH의 입도는 결정적인 한계 요인으로 작용하기도 한다. 본 실험에서는 Mg-Al-NO$_3$ 층상이중수산화물(Mg-Al-NO$_3$-LDH)을 공침전법으로 합성하고, 양이온의 농도와 공침시 pH 및 교반조건의 변화가 생성된 LDH의 결정상, 형상, 입도, 및 양이온교환능에 미치는 영향을 알아보았다. 특히 초음파 분산법을 적용하는 경우 생성되는 LDH 입자크기의 미세화에 효과적인 것을 확인 할 수 있었다.

• Proceedings of the Korea Concrete Institute Conference
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• 2009.05a
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• pp.221-222
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• 2009

The results showed that the addition of VAE polymer strongly reduces the $Ca(OH)_2$ formation, being this result attributed to reduce degree of cement hydration caused by different ion elution amount of polymer modified cement pastes and interaction between acetate anion from the partial hydrolysis of co-polymer and Ca$^{2+}$ion from OPC hydration.

• Journal of the Korean Chemical Society
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• v.9 no.2
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• pp.96-100
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• 1965

Possibility on carrier-free Fe-59 preparation by Korean TRIGA Mark Ⅱ reactor was investigated, namely average cross section on $Co^{59}$(n,p) $Fe^{59}$ reaction, separation by anion exchange resin and radiochemical purity. Radiochemical purity of Fe-59 separated was checked by the method of ${\gamma}$-ray spectrometry with 256-multichannel pulse height analyzer and of half life determination. This method permits Fe-59 preparation with radiochemical purity of > 99.9%.

• Bulletin of the Korean Chemical Society
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• v.23 no.10
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• pp.1409-1412
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• 2002

Polymeric membrane electrodes for acetate anion based on meso-(${\alpha}$,${\alpha}$,${\alpha}$,${\alpha}$)-5,10,15,20-tetrakis[2-(penta-fluorophenylurea) phenyl]porphyrin I and similar urea-functionalized porphyrins Ⅱ-Ⅳ as neutral ionophores were prepared. The membrane based on porphyrin I exhibits the best potentiometric properties in pH 6.0 rather than pH 7.0: linear stable response over a wide concentration range (6.0 ${\times}$$10^{-5}$-1.0 ${\times}$$10^{-2}$) with a slope of -59.6 mV/decade and a detection limit of log[CH3CO$O^-$] = -5.32. Selectivity coefficients obtained from the matched potential method (MPM) in pH 6.0 indicate that interferences of hydrophobic anions are very small for the membranes of porphyrins I and II having the strong withdrawing group. The electronic effect of urea-functionalized porphyrins and pH effect of buffer solutions are discussed on the potentiometric response.

• Bulletin of the Korean Chemical Society
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• v.27 no.11
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• pp.1832-1838
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• 2006

The present paper is focused on sorption concentration of silver (I) on some complex-forming ion exchangers in the initial thiocyanate form and subsequent determination of Ag(I) in the phase of anion exchanger AN-25 by diffuse reflectance spectroscopy. The sorption and kinetic characteristics of the sorbents were investigated. The apparent stability constants of thiocyanate silver complexes in the ion exchanger phase were calculated. The sorption-spectroscopic method is proposed for Ag(I) determination in aqueous solutions. The calibration curve is linear in the concentration range of 10-200 mg/L (sample volume is 10.0 mL) and the detection limit is 2 $\mu$g/mL. The presence of $Na^+,\;K^+,\;Mg^{2+}$ (macrocomponents) as well as of Ni (II), Co (II), Cu (II) do not hinder the determination of silver (I).

• Proceedings of the Membrane Society of Korea Conference
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• 1997.04b
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• pp.21-22
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• 1997

최근의 이온교환막은 종래의 양이온교환막의 표면에 polycation 등의 얇은 층을 덧붙인 다층막(multi-layer membrane)의 형태가 많이 이용되고 있으며, 정전기적 반발력의 차 등을 이용하여 원자가가 다른 이온들간의 투과성에 차를 부여하기 위하여 이용되고 있다. 이 때문에 polycation막을 통한 1가 이온과 2가 이온의 투과성을 연구하는 것은 우수한 이온교환막을 제작하는것 이상으로 중요하다. 본 연구에서는 고정전하농도(fixed charge density, $\Phi$ X)가 낮은 다공성 저전하음이온교환막을 제작하여, 양측에 대이온(counterion)은 같고 복이온(co-ion)이 다른 전해질용액을 두었을 경우에 관찰되는 막전위를 측정하였다. 이를 토대로 음이온교환막을 통한 막전위의 농도의존성에 관하여 검토하였으며, 비평형열역학(non-equilibrium thermodynamies)에 기초한 이론적 모델을 도입하여 실험치와 비교, 해석하였다.