• 공업화학
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• 제31권1호
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• pp.49-56
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• 2020

본 연구에서는 실란 커플링제 프로필트리메톡시실란(propyltrimethoxysilane, PTMS)을 사용하여 CaCO₃ 나노입자의 표면을 개질하였으며, 개질된 CaCO₃ 나노입자를 에멀젼 유화제 및 기포 안정화제로의 적용 가능성을 시험하고자 나노입자 표면의 소수성 변화가 기포와 에멀젼의 안정성에 미치는 영향에 관하여 살펴보았다. PTMS에 의한 CaCO₃ 나노입자의 표면 개질은 FT-IR, TGA, DSC 분석을 통하여 확인하였으며, XRD 및 XPS 분석을 통하여 나노입자 표면의 원소 분석을 실행하였다. 또한 부상 시험과 접촉각 측정을 통하여 PTMS 농도가 CaCO₃ 나노입자의 표면 개질에 미치는 영향에 관하여 살펴보았다.

• Journal of Microbiology and Biotechnology
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• 제15권3호
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• pp.510-518
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• 2005

In this study, we investigated whether PLGA microspheres in combination with hyaluronic acid (HA) gel have appropriate properties as a bulking agent for urologic injection therapies and whether the implantation of PLGA microspheres and HA gel induces angiogenesis in the newly formed tissues. In order to investigate whether this bulking agent is injectable, this material was injected through 24-gauge needles into the subcutaneous dorsum of the mouse. The bulking agent was easily injected without needle obstruction. Histological analyses of the hybrid tissues at 2 weeks showed that host cells at the surrounding tissues migrated into the spaces between the implanted PLGA microspheres and formed tissue-like structures. An inflammatory response to the implants was mild at 2 weeks and diminished at 8 weeks. Importantly, extensive ingrowth of blood vessels was observed in the hybrid tissues formed by the injection of PLGA microspheres and HA, whereas blood vessels rarely formed in the hybrid tissues formed by the injection of PLGA microspheres only. The implant volume was conserved for almost the entire implantation period. Histological analyses of the distant organs of the bulking agent-implanted animals, such as the lungs, liver, heart, brain, kidney, and spleen, showed no evidence of the injected microsphere migration. These results show that PLGA microspheres in combination with HA possess the appropriate characteristics for a bulking agent for urologic injection therapies and induce extensive blood vessel formation in the hybrid tissues.

• 대한약학회:학술대회논문집
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• 대한약학회 2005년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.63-64
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• 2005

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2002년도 창립10주년기념 및 국립독성연구원 의약품동등성평가부서 신설기념 국재학술대회:생물학적 동등성과 의약품 개발 전략을 위한 국제심포지움
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• pp.136-142
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• 2002

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.233.3-234
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• 2002

SB31, an extract of Pulsatilla koreana, has been tried as an antitumor agent by traditional medicine pratitioner in Korea for the past 30 years, SB31 was evaluated for cytotoxic and antitumor activity against a variety of cancer cell lines. The SB31 exhibited 5-6 fold less cytotoxic activity against normal mononuclear cells (ED$\sub$50/. 1.1 mg/$m\ell$) than against cancer cell lines (ED$\sub$50/ 0.14-0.19mg/$m\ell$). (omitted)

• 대한약학회:학술대회논문집
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• 대한약학회 2001년도 Proceedings of the Pharmaceutical Society of Korea
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• pp.132.2-133
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• 2001

• 공업화학
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• 제5권2호
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• pp.345-356
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• 1994

내구유연발수제를 제조할 목적으로 전보에서 합성한 poly(OMA-co-DAMA)[PODC], poly(DMA-co-DAMA)[PDDC], poly(EMA-co-DAMA)[PEDC] 각각의 양이온화물, 본 실험에서 합성한 지방산 카르바미드의 양이온화물(ODTCC), 왁스류 및 유화제들을 블렌드시켜 발수제 PODCW, PDDCW, PEDCW를 각각 제조하였다. 발수제 PODCW, PDDCW, PEDCW 각각을 면직물에 단독 및 수지병용으로 처리하여 내세탁성, 인열강도, 방추도 및 접촉각 등을 측정해 본 결과, 물성의 향상을 가져왔다. 그러나 발수도는 PODCW의 경우 80 정도로 사용 가능하였으나, PDDCW와 PEDCW의 발수도는 현저히 저하되었다. 제조된 발수제의 적정 열경화온도는 $140^{\circ}C$, 적정 사용농도는 3wt%이었고, 사용된 발수제용 촉매 중 아세트산나트륨이 가장 좋았으며, 촉매의 사용농도는 0.6wt%가 적당하였다. 또한 발수제와 셀룰로오스 섬유화의 반응메카니즘을 규명하고 내세탁성 결과치를 검토한 결과, 제조된 발수제가 내구성 발수제임을 입증하였으며, SEM으로 발수처리된 면직물의 표면구조를 관찰하였다.

• 한국미생물생명공학회:학술대회논문집
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• 한국미생물생명공학회 2004년도 Annual Meeting BioExibition International Symposium
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• pp.337-341
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• 2004

• 대한약리학회지
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• 제30권2호
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• pp.227-242
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• 1994

The general pharmacological effects of a new anthracycline anticancer agent, DA-125 $[7-0-(2,\;6-dideoxy-2-fluoro-{\alpha}-L-talopyranosyl)-adriamycinone-14-{\beta}-alaninate{\cdot}HCI]$ were investigated in mice, rats, guinea pigs, rabbits and dogs. Intravenous administration of DA-125 presented no significant effects on the central and peripheral nervous systems of ICR mice except a decrease in the numbers of acetic acid-induced writhing response at a dose of 10 mg/kg. In anesthetized rats and dogs, DA-125 produced a transient depression of blood pressure and an increase in heart rate, but did not affect the peripheral blood flow in the isolated ear vessels of rabbits and the mechanical functions of the isolated hearts of guinea pigs. No significant effects were observed on the gastrointestinal functions and the contractilities of smooth muscle preparations obtained from guinea pig trachea, rabbit ileum, pregnant and non-pregnant uterus and vas deferens of rats. DA-125 Increased the contractility of the isolated ileum of guinea pigs in a dose range of $10^{-6}{\sim}10^{-9}g/ml$, and also increased, but weaker than adriamycin, the vascular permeability in rat skin. DA-125 had no effect on the kallikrein-induced increase in permeability and the permeability of the visceral organs. DA-125 did not adversely affect the liver function and the blood coagulation system, and did not induce hemolysis in vitro. It is concluded from the results that the general pharmachological effects of DA-125 are similar to or weaker than those of adriamycin, and that little adverse effects are anticipated with a therapeutic dose range.

• Biomolecules & Therapeutics
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• 제12권3호
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• pp.157-164
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• 2004

DA-3711 is a novel anti-wrinkle agent containing growth factors derived from culture medium of artificial human skin. Photoprotective effect by DA-3711 against chronic UVB (ultraviolet B)-induced skin damage was investigated in hairless mice model. Methods: After hairless mice were irradiated to induce photodamage for 8 weeks with UVB, grouped mice were treated topically once a day with lotion base, DA-3711 (30% or l5%), Cylasphere retinol$^{\circed{R}}$ (2500 I.U.), NouriCel$^{\circed{R}}$ along with concomitant exposure to UVB for further 8 weeks. Then mice were sacrificed to assess photodamage-protective effect by replica analysis, biochemistry and histology. DA-3711 of 30% lotion significantly reduced UVB radiation-induced wrinkling, histological alterations and increased collagen contents. Whereas DA-3711 of l5% lotion and NouriCel$^{\circed{R}}$ treatment showed a partial protective effect on skin wrinkle, epidermal and dermal thickness, and collagen content, Cylasphere retinol$^{\circed{R}}$ showed no protective effects. These results demonstrate that topical application of DA-3711 can alleviate UVB-induced photodamage and potentially be used for reduction of UVB-induced photodamage.