• Journal of Gastric Cancer
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• 제11권1호
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• pp.46-54
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• 2011

Purpose: There are few studies that have focused on the predictors of recurrence after gastrectomy for gastric carcinoma. This study analyzed the patients who died of recurrent gastric carcinoma and we attempted to clarify the clinicopathologic factors that are associated with the timing of recurrence. Materials and Methods: From June 1992 to March 2009, 1,795 patients underwent curative gastric resection at the Department of Surgery, Hanyang University College of Medicine. Among them, 428 patients died and 311 of these patients who died of recurrent gastric carcinoma were enrolled in this study. The clinicopathologic findings were compared between the 72 patients who died within one year after curative gastrectomy (the early recurrence group) and the 92 patients who died 3 years after curative gastrectomy (the late recurrence group). Results: Compared with the late recurrence group, the early recurrence group showed an older age, a more advanced stage, a poorly differentiated type of cancer and a significantly higher tendency to have lymphatic invasion, vascular invasion and perineural invasion.Especially in the gastric cancer patients with a more advanced stage (stage III and IV), the early recurrence group was characterized by a significantly higher preoperative serum carcino embryonic antigen level, perineural invasion and a relatively small number of dissected lymph nodes. Conclusions: The clinicopathologic characteristics of recurrent gastric cancer are significantly different according to the stage of disease, and even in the same stage. For the early detection of recurrence after curative surgery, it is important to recognize the clinicopathological factors that foretell a high risk of recurrence. It is mandatory to make an individualized surveillance schedule according to the clinicopathologic factors.

• Asian Pacific Journal of Cancer Prevention
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• 제15권7호
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• pp.3319-3322
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• 2014

Breast cancer is the most common cancer in Jamaican women. This study assessed the clinicopathologic features of cases in a hospital-based specialist clinic in Kingston, Jamaica. A retrospective chart review was performed for the 2-year study period and relevant clinical and surgico-pathologic data were recorded and analyzed. Median age of the 121 breast cancer patients was 52 years (range 22-84, IQR 20) and there was 1 case of male breast cancer. Most patients (65%) were referred from the surgical service after definitive breast cancer surgery, 20% were referred for pre-operative systemic therapy, and 15% had a diagnosis of metastatic disease. The surgico-pathologic group comprised 78 women who were referred for adjuvant therapy. The majority had presented with a palpable breast lump (91%), with median tumour size 3.5cm (range 0.4-13, IQR 4). Most tumours were node positive (56%). Approximately one-third of patients had stage III disease (33%). Most women presented with large palpable tumours and had lymph node involvement confirmed on surgicopathological evaluation, indicative of limited early breast cancer detection. A national screening mammography programme is recommended for detection of earlier lesions. Pre-operative systemic therapy should be considered as an option for eligible patients.

• Journal of Gastric Cancer
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• 제7권1호
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• pp.23-30
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• 2007

목적: 위암 환자 수술 후 재발의 임상병리학적 특성에 대한 이해는 재발의 조기 발견과 이에 따른 보다 나은 치료 성적을 얻기 위하여 필수적인 정보이다. 즉 종양의 특성에 따른 재발의 유형, 재발시기, 재발 이후의 경과 등을 이해하고자 본 연구를 시행하였다. 대상 및 방법: 1992년 6월부터 2005년 12월까지 본원 외과에서 위암으로 근치적수술을 시행 받은 1,338명의 환자 가운데 재발 유형을 모르는 경우(n=60), 사고사 및 타 질환으로 사망한 경우(n=55)를 제외한 1,223명을 연구 대상자로 하였다. 재발예(n=241)와 비재발예(n=982) 사이의 임상병리학적 특성 및 재발예 가운데 재발의 유형에 따른 임상병리학적 특성을 비교 분석하였다. 결과: 재발예는 비재발예에 비하여 위전절제술, 진행된 병기, 림프관이나 혈관 침윤예, 위전벽암, 크기가 큰 암, 미분화암, 미만형, Borrmann 4형이 의미 있게 많았다. 복막파종은 여성, stage III, 위상부 및 위전벽암, 미분화암, 미만형, Borrmann 4형이 의미 있게 많았고, 혈행성전이는 조기위암, stage I, 국소전이는 Borrmann 1, 2, 3형이 의미 있게 많았다. 복막파종의 경우 혈행성전이나 국소전이에 비하여 재발 후 생존기간이 짧았다(7.0개월, 9.5개월, 12.5개월). 조기재발군은 병기3, 4기, N3, 림프관침윤율이 높았고, 후기재발군은 병기3기, N1이 조기재발군에 비해 의미 있게 많았다. 결론: 위암의 임상병리학적 특성에 대한 이해가 위암수술 후 재발을 조기에 발견하는 데 중요할 것으로 판단된다.

• 대한종양외과학회지
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• 제14권2호
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• pp.83-88
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• 2018

Purpose: Double primary colorectal cancer (CRC) and gastric cancer (GC) represent the most common multiple primary malignant tumors (MPMT) in Korea. The recognition and screening of hidden malignancies other than the primary cancer are critical. This study aimed to investigate the clinicopathologic characteristics and survival rates in patients with synchronous or metachronous double primary CRC and GC. Methods: Between January 1994 and May 2018, 11,050 patients were diagnosed with CRC (n=5,454) or GC (n=5,596) at Gil Medical Center. MPMT and metastatic malignant tumors were excluded from this study. A total of 103 patients with double primary CRC and GC were divided into two groups: the synchronous group (n=40) and the metachronous group (n=63). The incidence, clinicopathologic characteristics, and survival rate of the two groups were analyzed. Results: The incidence of synchronous and metachronous double primary CRC and GC was 0.93%. Double primary CRC and GC commonly occurred in male patients aged over 60 years with low comorbidities and minimal previous cancer history. There were significant differences between the synchronous and metachronous groups in terms of age, morbidity, and overall survival. Metachronous group patients were 6 years younger on average (P=0.009), had low comorbidities (P=0.008), and showed a higher 5-year overall survival rate (94.8% and 61.3%, P<0.001) in contrast to synchronous group. Conclusion: When primary cancer (CRC or GC) is detected, it is important to be aware of the possibility of the second primary cancer (GC or CRC) development at that time or during follow-up to achieve early detection and better prognosis.

• 대한두경부종양학회지
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• 제20권2호
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• pp.123-127
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• 2004

Objectives: The tall cell variant is an uncommon variant and has been known as more aggressive form of papillary thyroid carcinoma (PTC). Owing to the rarity of these thyroid cancers, their clinical behavior remains incompletely understood. To elucidate the clinicopathologic characteristics of tall cell variant, we retrospectively reviewed our surgical experience of patients with tall cell variant. Methods: Between August 1993 and July 2004, a total of 11 consecutive patients who were pathologically diagnosed with tall cell variant of papillary thyroid carcinoma were enrolled in this study. All patients underwent total (8 cases) or subtotal thyroidectomy (3 cases) with central compartment node dissections. The lateral neck dissection was added in 6 patients. After the operation, neck ultrasound and serum thyroglobulin were checked regularly during the follow-up period. Results: The mean age of the patients was 56.6years (range, 30-74years) at the time of diagnosis. 3 patients were men, and 8 were women. The mean diameter of tumor was 3.7cm(range, 1.5-6.0cm), and 6 patients had lateral neck node metastasis. Extrathyroidal extension was seen in 5 patients (45%). Loco-regional recurrence was found in 2 patients (18%), and distant metastasis in 1 patient (9%). The 5-year disease free survival rate was 68%. Conclusion: The tall cell variant of papillary thyroid carcinoma is an uncommon disease. Clinicopathologic feature and prognosis of this disease show more aggressive behaviors than ordinary papillary thyroid carcinoma. More aggressive treatment and close follow-up should be undertaken in the tall cell variant of papillary thyroid carcinoma.

• 대한두경부종양학회:학술대회논문집
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• 대한두경부종양학회 2005년도 제22차 추계학술대회
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• pp.236-236
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• 2005

• Asian Pacific Journal of Cancer Prevention
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• 제15권19호
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• pp.8469-8474
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• 2014

Introduction: Recent studies have indicated that down-regulation of the suppressor of cytokine signaling-1 (SOCS-1) gene results in tumor formation and that SOCS-1 acts as a tumor suppressor gene. SOCS-1 has been also suggested to function as a tumor suppressor with colorectal cancer. Objectives: In the present study, we aimed to determine the association of SOCS-1 expression in colorectal cancer tissues with clinicopathologic characteristics immunohistochemically and also to identify its prognostic significance. Materials and Methods: SOCS-1 expression was studied immunohistochemically in 67 patients diagnosed with resected colorectal carcinomas and 30 control subjects. Results: SOCS-1 expression was found in 46.3% of tumor tissues and 46.7% of the control group. Statistical analyses did not establish any significant association between SOCS-1 expression and clinicopathologic characteristics. Also, no significant association with SOCS-1 expression was found using progression-free survival and overall survival analyses (p=0.326 and p=0.360, respectively). Conclusions: Our results show that SOCS-1 has no prognostic significance in colorectal cancer.

• Journal of Gastric Cancer
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• 제9권4호
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• pp.262-268
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• 2009

목적: 위 유암종의 임상병리학적 특성과 치료방법 및 예후 등을 분석하였다. 대상 및 방법: 1996년부터 2006년까지 본원에서 치료받았던 18명을 대상으로, 의무기록을 이용한 후향적 연구를 통해 Rindi 분류에 의해 구분하여, 기존의 보고와 임상병리학적 특성 및 치료, 생존율을 비교 분석하였다. 결과: Type I은 8명, type III가 10명이었으며 type II는 없었다. 평균발생 연령은 type I이 47.75세, type III는 57.90세였고, type I은 남자 4명, 여자 4명으로 성비가 1：1이었으나 type III는 남자 7명, 여자 3 명으로 남자에서 많았다. Type I에서도 단발성인 경우가 4예가 있었으며, 1예를 제외하고는 점막 또는 점막하층에 국한되어 있고, 림프절 전이나 원격전이는 없었다. Type III는 병변의 침습성에 관계없이 모두 국소림프절 전이 또는 원격 전이가 있었다. 진단 시 원격전이가 없었던 13명 중 5예에서 내시경적 절제술, 8예에선 수술이 시행되었으며 5년 생존율은 92.3%였다. 원격 전이가 있었던 5예는 평균 생존 기간이 22개월로 이 중 고식적 수술을 시행 받은 3예의 중위 생존 기간은 24개월이었다(95%, ${\pm}6.52$). 결론: 기존의 Rindi 분류법과 비교하여 보았을 때, 본 연구 결과 빈도에 있어서 type III가 type I보다 흔하였다. 또한 type I 유암종에 있어서 평균연령이 낮고, 단발성 종양이 절반 정도를 차지하며, 악성빈혈이 동반되지 않았던 점 등에서 서구와는 다른 특징이 관찰되었다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권2호
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• pp.471-474
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• 2015

Background: Male and female breast cancers were investigated for variation in the clinicopathologic characteristics and expression of steroid hormone receptors in the northeast of Iran. Materials and Methods: Tumor specimens of 17 males and 338 females with breast cancer were collected at the hospitals of Mashhad University of Medical Sciences. Immunohistochemical expression of hormone receptors and clinicopathologic features of breast cancer were compared between two groups. Results: The mean age in men was 15 years higher than women (p=0.000). Males and females were mainly in stage II and III respectively (p=0.007). Although more than 60% of male and female patients were grade II, the respective figures for grade I and III were 25% and 12.5% in men but 7.1% and 27.2% in women respectively (p=0.025). ER was significantly more positive in men against women; 82.3% versus 53.4% (p=0.016). The related measures for PR was 58.8% and 50.3%, respectively (p=0.424). Males also showed significantly more ER expression than postmenopausal females; 82.3% versus 48.9% (p=0.010). Conclusions: Breast cancer in males and females contrasted in age at diagnosis, histological type, stage, grade and ER expression which emphasize they are separate diseases with different behaviors.

• Asian Pacific Journal of Cancer Prevention
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• 제15권7호
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• pp.3099-3103
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• 2014

TMPRSS2:ERG gene fusions in prostate cancer have a dominant prevalence of approximately 50.0%, but infomration is limited on differences among ethnic and geographical groups. Some studies focusing on Japanese and Korean patients reported a lower incidence. Investigations concerning Chinese revealed controversial results. We evaluated TMPRSS2:ERG, TMPRSS2:ETV1 and TMPRSS2:ETV4 fusions in more than 100 Eastern Chinese prostate cancer patients. Paraffin blocks of needle biopsy and radical prostatectomy were collected from 91 and 18 patients respectively. All patients' clinicopathologic factors were gathered. TMPRSS2:ERG, TMPRSS2:ETV1 and TMPRSS2:ETV4 fusions were tested by multi-probe fluorescence in situ hybridization (FISH) assay. TMPRSS2:ERG fusions was present in 14.3% biopsy specimens and 11.1% radical prostatectomy patients. Neither TMPRSS2:ETV1 nor TMPRSS2:ETV4 fusion was found in any case. Altogether, 13 (86.7%) TMPRSS2:ERG fusion positive cases possessed deletion pattern and 7 (46.6%) and insertion pattern. Some 5 cases had both deletion and insertion patterns. While 38.5% (5/13) patients with deletion pattern had distant metastasis, except for one metastatic case harboring both deletion and insertion, there were no patients with insertion pattern accompanied with metastasis. There were no differences between fusion positive and negative cases in the distribution of age, PSA, Gleason score and TNM stage. Eastern Chinese prostate cancer patients have a significantly low incidence of TMPRSS2:ERG fusion. They also lack TMPRSS2:ETV1 and TMPRSS2:ETV4 fusion. There are more deletion pattern than insertion pattern in TMPRSS2:ERG positive cases. Fusion positive and negative patients have no clinicopathologic factor differences.