• Journal of Korean Medical Science
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• 제33권48호
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• pp.306.1-306.6
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• 2018

This study examined the add-on efficacy of eye movement desensitization and reprocessing (EMDR) therapy among adult civilians with post-traumatic stress disorder (PTSD) who continued to be symptomatic after more than 12 weeks of initial antidepressant treatment. Scores for the Clinician Administered PTSD Scale (CAPS) were rated pre- and post-EMDR and at a 6-month follow-up. After an average of six sessions of EMDR treatment, seven of 14 patients (50%) showed more than a 30% decrease in CAPS score and eight (57%) no longer met the criteria for PTSD. Our results indicate that EMDR could be successfully added after failure of initial pharmacotherapy for PTSD.

• 생물정신의학
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• 제28권1호
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• pp.1-6
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• 2021

Pharmacogenetics is opening a new era of precision medicine in psychiatry. Drug-metabolizing enzymes are characterized by genetic polymorphisms, which render a large portion of variability in individual drug metabolism. Dose adjustment based on pharmacogenetics knowledge is a first step to translate pharmacogenetics into clinical practice. However, diverse factors including cost-effectiveness should be addressed to provide clinical recommendation. To address current challenges in pharmacogenetics testing in psychiatry, this review provides an update regarding genotyping (SNP analysis, array, and next-generation sequencing), genotype-phenotype correlations, and cost-effectiveness. The current updates on pharmacogenetics in psychiatry will provide guidance for both clinician and researchers to have a consensus in harmonizing efforts to advance the pharmacogenetics field in a part of precision medicine in psychiatry.

• Journal of Korean Neurosurgical Society
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• 제64권3호
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• pp.414-417
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• 2021

During the last two decades, there have been remarkable advances in knowledge regarding secondary neurulation. An increased number of cases of occult spinal dysraphism and progress in basic embryology research have provoked the continuous discovery of new disease entities and the reclassification of occult spinal dysraphic lesions. Examples of such changes are described. The characteristics of secondary neurulation compared with those of primary neurulation are listed and discussed. Our fundamental questions include what the evolutionary significance of secondary neurulation is and what the advantages of having secondary neurulation are. However, our current data and speculations are insufficient to support scientific inference. The direction of future progress of research in this field is predicted. The role of clinicians in this progress is emphasized.

• 대한소화기학회지
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• 제72권6호
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• pp.281-285
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• 2018

Acute pancreatitis is a common gastrointestinal disease that is associated with significant morbidity and consumes enormous health care resources. As such, it requires up-to-date evidence-based diagnosis and standard treatment guidelines with broad support from the clinician. Korean Pancreatobiliary Association has developed clinical practice guidelines for the diagnosis and treatment of acute pancreatitis to provide a framework for clinicians to manage acute pancreatitis and to improve national health care. The guidelines were divided into four parts: the diagnosis of acute pancreatitis, the assessment of the severity, the initial management, and the treatment of necrotizing pancreatitis and local complications of acute pancreatitis. In this article, we summarize and present the diagnosis and treatment guidelines for acute pancreatitis established in Korea.

• Anatomy and Cell Biology
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• 제51권4호
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• pp.305-308
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• 2018

Anatomical variations of the sternocleidomastoid muscle (SCM) have been observed to occupy multiple origins and insertion points and have supernumerary heads, sometimes varying in thickness. During routine dissection, a SCM was observed to have six distinct insertions that interface with the course of the superior nuchal line, ending at the midline, bilaterally. This variation was also seen to receive innervation from the accessory nerve as well as the great auricular nerve. To our knowledge, this variant of supernumerary insertions and nerve innervations has not yet been reported. These variants may pose as problematic during surgical approaches to the upper neck and occiput, and should thus be appreciated by the clinician. Herein we discuss the case report, possible embryological origins, and the clinical significance of the observed variant SCM.

• 대한구강악안면병리학회지
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• 제42권6호
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• pp.199-204
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• 2018

Differential diagnosis of the malignant lesion and the benign lesion is critically important for the precise treatment. A clinician should diagnose in a comprehensive manner considering clinical, radiological, and histopathological perspectives. The lesion in the oral cavity in this study was clinically and radiologically malignant. However, the lesion was histopathologically benign. Surgical intervention was not performed except biopsy. The lesion improved after about one month of supportive medication after the biopsy. The importance of decision making process was emphasized in this report.

• 대한치과의사협회지
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• 제57권7호
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• pp.403-411
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• 2019

A cracked tooth is defined as an incomplete fracture initiated from the crown and extending subgingivally and usually directed mesiodistally. Cracked teeth were most frequently involved in mandibular and maxillary molars at the age of 50s. Cracks occurred mainly in nonbonded restorations such as gold and amalgam, and majority of cracks were found in intact teeth. A pulpal and periapical diagnosis is dependent on the extent of the crack and duration of the symptom. The pulp of a cracked tooth might become inflamed because of microleakage, which induces thermal sensitivity. Once the crack has extended and exposed the pulp, severe pulp and periapical pathosis will likely be present. In addition, the extended crack can cause a bony dehiscence with a resulting narrow and deep periodontal pocket. Therefore, early diagnosis of the cracked tooth and proper treatment planning are important for clinician.

• Journal of Dental Anesthesia and Pain Medicine
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• 제22권1호
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• pp.71-74
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• 2022

Posterior superior alveolar nerve block (PSANB) is one of the most common and safe injection techniques in the field of dentistry. As with any other procedure, it also has inherent complications, of which ophthalmic complications are relatively rare. Transient diplopia following the administration of PSANB is rare and daunting for both the patient and the clinician. We present a case of transient diplopia in a 26-year-old female patient following administration of PSANB and review its probable pathophysiology and management and prevention.

• 시스템엔지니어링학술지
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• 제17권2호
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• pp.91-97
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• 2021

User interface for cancer classification system is a software application with clinician's friendly tools and functions to diagnose cancer from pathology images. Pathology evolved from manual diagnosis to computer-aided diagnosis with the help of Artificial Intelligence tools and algorithms. In this paper, we explained each block of the project life cycle for the implementation of automated breast cancer classification software using AI and machine learning algorithms to classify normal and invasive breast histology images. The system was designed to help the pathologists in an automatic and efficient diagnosis of breast cancer. To design the classification model, Hematoxylin and Eosin (H&E) stained breast histology images were obtained from the ICIAR Breast Cancer challenge. These images are stain normalized to minimize the error that can occur during model training due to pathological stains. The normalized dataset was fed into the ResNet-34 for the classification of normal and invasive breast cancer images. ResNet-34 gave 94% accuracy, 93% F Score, 95% of model Recall, and 91% precision.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2009년도 춘계학술발표대회
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• pp.155-156
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• 2009

In this paper we present 3D image analysis of liver and blood vessels using MDCT. The purpose is to enhance the performance of clinician in assessing anatomical information of liver and blood vessels. The system consists of two parts: 3D image reconstruction and analysis of the 3D liver and blood vessel image. The central vein of the liver is the most important blood vessel for the liver transplantation. We will find the central vein's location and characteristic, and will scheme out a computer assistant liver transplantation planning. It will be an effective tool for interventional radiology, surgical planning, and quantitative diagnosis.