• Clinical and Experimental Pediatrics
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• v.51 no.10
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• pp.1031-1037
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• 2008

Macrolide antimicrobial agents including erythromycin, roxithromycin, clarithromycin, and azithromycin are commonly used in the treatment of respiratory tract infections in children. Newer macrolides that have structural modifications of older drug erythromycin show improved change in the spectrum of activity, dosing, and administration. However, recent studies reported that increasing use of macrolide antibiotics is the main force driving the development of macrolide resistance in streptococci. In particular, azithromycin use is more likely to select for macrolide resistance with Streptococcus pneumoniae than is clarithromycin use, a possible reflection of its much longer half life. Recently, erythromycin resistance rates of S. pneumoniae and Streptococcus pyogenes are rapidly increasing in Korea. Two main mechanisms of acquired macrolide resistance have been described, altered binding site on the bacterial ribosome encoded by the ermB gene and active macrolide efflux pump encoded by the mef gene. Relationship between the susceptibility of S. pneumoniae and the response to macrolides has been shown in studies of acute otitis media, but less clear in cases of pneumonia. This article reviews the spectrum of activity, pharmacokinetic properties, mechanisms of action and resistance, and clinical implication of resistance on the treatment of respiratory tract infections in children.

• Korean Journal of Biological Psychiatry
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• v.19 no.1
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• pp.9-16
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• 2012

This article aimed to describe typical event-related potentials (ERP) components of emotional processing in patients with anxiety disorder and highly anxious individuals. ERP components associated with emotional processing could be broadly divided into three components with short, middle and long, respectively. Many studies show that patients with anxiety disorders are characterized by different emotional bias to specific stimuli and more sensitive to emotional stimuli than normal individuals. In addition, these emotional biases were stronger and quicker in patients with anxiety disorder than normal individuals. Some studies reported that anxious people show abnormality at the initial stage (e.g. P1) of emotional processing. However, other studies reported the abnormality at the late stage (e.g. LPP) or wholeness of emotional processing in anxious individuals. We summarized the updated finding of possible ERP components of emotional processing in patients with anxiety disorder and highly anxious individuals. The significance and clinical implication were discussed.

• The Korean Journal of Pain
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• v.8 no.2
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• pp.319-323
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• 1995

The implication of cervical pain associated with an elongated styloid process is credited to W.W.Eagle. Even though there were earlier reports of ossification of the stylohyoid ligament, findings in more than 200 cases in 1980s and 1940s resulted in the naming of a clinical syndrome that continues to bear his name, Eagle's syndrome. It is also sometimes called styloid process neuralgia or elongated styloid process syndrome is more common than generally recognized. The clinical symptoms range from a dull nagging pain with occasional radiation to ear, or to a foreign body sensation. Dysphagia and odynophagia may also occur. We successfully treated one case by removal of the elongated styloid process under the general anesthesia and C2 ganglion block. We then reported the clinical feature of one case of the Eagle's syndrome and further researched with the foreign literature.

• Journal of the Society of Disaster Information
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• v.17 no.4
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• pp.778-785
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• 2021

Purpose: The study is to analyze the current status of international clinical trial information services related to COVID-19 and to find out the impact of disclosing activities of clinical trial registration on the medical and pharmaceutical industry. Method: To achieve the purpose of the study, this study analyzed the current status of 780 registered clinical trials for COVID-19 during March of 2020 by using regression analysis. Result: The analysis of clinical trial research registration information showed and proved its usefulness for the development of related new drugs, treatments, vaccines, predictive and prognostic diagnostic kits and treatments related to the COVID-19 (Corona 19) in the world. Conclusion: The study concludes and urges all medical and pharmaceutical companies to register their trials on CRIS and recommends utilizing this registered data to develop advanced drug to benefits all patients related to COVID-19.

• Neonatal Medicine
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• v.25 no.1
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• pp.23-28
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• 2018

Purpose: Abdominoperineal solid tumors presenting in neonates often require surgical intervention during the neonatal period. Although we report our single-center experience, this study would be meaningful to understand the clinical implications of these neoplasms. Methods: We retrospectively reviewed and analyzed the clinical data and characteristics of 22 patients (${\leq}28$ days old) diagnosed with histopathologically confirmed abdominoperineal solid neoplasms (benign or malignant) after surgical resection. Results: The mean gestational age and postnatal age at the time of operation were $38.3{\pm}1.8weeks$ and $13.5{\pm}8.3days$, respectively. Most patients (18/22, 81.8%) were diagnosed during antenatal care visits; however, 4 (18.2%) were identified after birth. The mean tumor size was $6.4{\times}5.3cm$ (3.5-17.0 cm), and tumors occurred most frequently within the sacrococcygeal region (8/22, 36.4%). Histopathologically, 14 patients (63.6%) demonstrated benign tumors and 8 (36.4%) demonstrated malignant tumors. Germ cell tumors and hepatoblastomas were the most commonly observed tumors. Fortunately, all patients showed a localized pattern of tumor involvement without distant metastasis. No recurrence or mortality was observed during the follow-up period (mean $66.4{\pm}44.2months$). Conclusion: Abdominoperineal solid tumors occurring in neonates show variable clinical patterns during the antenatal and postnatal monitoring/screening periods. We conclude that aggressive and multidisciplinary approaches could achieve good clinical results in these patients.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.5
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• pp.1125-1131
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• 2008

The purpose of this study is to evaluate the clinical implication of Eight Principle Pattern Identification, EPPI in Sasang Typology. Although EPPI is considered as the most basic differential diagnosis in Oriental Medical Science, it has not been used actively enough in clinical practice owing to the presumption that EPPI is not sufficient for the analysis of complex clinical symptoms. In Zhang Jiebin's Jingyuequanshu, he separates Yin-Yang with Six-identification in EPPI when explaining them. This implies that it is difficult to talk about each of EPPI in same perspective. Thus, for the active clinical usage of EPPI it is necessary to study in hierarchical perspective. Lee Je-ma's Sasang typology could be a good example that uses the hierarchical perspective of EPPI. In the book Dongeuisoosebowon Lee Je-ma talks about differentiating Yin with Yang by constitution, Exterior with Interior and Cold with Heat accordingly, to apply in prescriptions. After differentiation, Yin and Yang are placed in higher level from the rest of EPPI, thus Yin and Yang can influence the rest of EPPI. This study showed the importance of EPPI in understanding the differential diagnosis system of Sasang typology in clinical perspectives.

• Korean Journal of Otorhinolaryngology-Head and Neck Surgery
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• v.61 no.11
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• pp.580-587
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• 2018

Background and Objectives We evaluated the clinical characteristics and vestibular function of patients with direction changing vibration induced nystagmus (DC VIN) and unilateral vestibular hypofunction and suggest clinical implication and a proposed mechanism of DC VIN. Subjects and Method The records of 315 patients who underwent the VIN test were reviewed retrospectively. Among these, 18 patients (5.7%) showed DC VIN, and out of whom, 15 patients (4.8%) were diagnosed as unilateral vestibular hypofunction by caloric, rotation chair (RCT), and video head impulse test (vHIT). We analyzed the relationship between DC VIN and the dizziness characteristics, duration of disease, and the outcome of the vestibular function test. Results The mean age of 15 patients was $67.4{\pm}10.7years$ and the mean duration of dizziness was $13.6{\pm}29.7months$. The caloric test revealed 25% of the patients to have significant canal paresis [Caloric vestibular neuritis (VN)], while 75% showed normal caloric response. However, unilateral vestibular hypofunction was observed by abnormal results in RCT or vHIT (Non-caloric VN). Seven patients showed ipsilateral DC VIN (nystagmus to vibrated side) and eight patients contralateral DC VIN (nystagmus to opposite side of vibration). Patients with ipsilateral DC VIN were shown to have a significant longer duration of dizziness than those with contralateral DC VIN. Conclusion Although rare, DC VIN can also be found in patients with unilateral vestibular hypofunction. Patients with DC VIN had a mild vestibular asymmetry with Non-caloric VN or Caloric VN in the process of compensation. The mechanism of ipsilateral DC VIN seems to be due to the small amount of vestibular asymmetry, which is smaller than the interaural attenuation of vibration.

• The Journal of Advanced Prosthodontics
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• v.3 no.1
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• pp.51-55
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• 2011

BACKGROUND. Mandibular displacement is a common complication of condylar fracture. In the mandibular displacement due to condylar fracture, it is difficult to restore both esthetics and function without using orthognathic surgery. CASE DESCRIPTION. This clinical report described a full mouth rehabilitation in the patient with bilateral condylar fractures and displaced mandible using bilateral sagittal split ramus osteotomy (BSSRO) and simultaneous dental implant surgery. Mandibular position was determined by model surgery through the diagnostic wax up and restoration of fractured teeth. The precise amount of the mandibular shift can be obtained from the ideal intercuspation of remaining teeth. CLINICAL IMPLICATION. Mandibular displacement by both condylar fractures can be successfully treated by orthognathic surgery. Determination of occlusal plane and visualization from diagnostic wax up are mandatory for mandibular repositioning of model surgery. Stable occlusion and regular recall check up are needed for long-term outcome.

• Journal of Korean Academy of Nursing
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• v.36 no.2
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• pp.244-254
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• 2006

Purpose: This study was performed to analyze effects of the power and empowerment on job satisfaction and organizational commitment. This study was based on the Kanter's theory of organizational empowerment. Method: A predictive, non-experimental design was used to test the model in a sample of 688 nurses working in 7 university hospitals that have over 500 beds in Seoul, Kyunggi and Kangwon provinces. The data were collected from December, 2003 to January, 2004. It was analyzed with descriptive statistics and Pearson correlation of SPSS and with path analysis of LISREL. Result: The formal and informal power had direct effects on empowerment. Formal power also had direct effects on informal power. Empowerment had direct effects on job satisfaction and organizational commitment. Organizational commitment had direct effects on job satisfaction. There was positive effects in all of the variables. Conclusion: The positive changes show on personal behaviors and attitudes when the nurses who have formal and informal power are empowered. These findings would be important resource to nurse administrators for clinical implication.

• The Journal of Advanced Prosthodontics
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• v.2 no.4
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• pp.154-159
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• 2010

BACKGROUND. Generalized aggressive periodontitis (GAP) is a destructive periodontal disease that can develop in young age. Only a few cases of full mouth rehabilitation, using dental implants, have been reported in a patient with aggressive periodontitis. CASE DESCRIPTION. This clinical report describes the treatment procedures and results of full mouth rehabilitation in a patient with aggressive periodontitis. After all teeth were extracted, 6 implants were placed in the maxilla and mandible, respectively. Fixed detachable implant prostheses were made. The patient was satisfied with the final results. She was followed for 10 months postloading. CLINICAL IMPLICATION. For a long-term success, continuous maintenance care is critical, as the contributing factors of the disease (such as immune factors or periodontal pathogens) may not be controlled adequately.