• Korean Journal of Acupuncture
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• 제26권3호
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• pp.111-120
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• 2009

Objectives : Although Hwe Yang Gu Chim Hyul is important for acupuncture treatment in emergency and has been widely used, but there is few study about that, except some comments in ancient literatures. So in this study, the author reviewed the Hwe Yang Gu Chim Hyul, investigating the composition and the function, and found the meaning with analysis based on meridian. Methods : 1. The author reviewed several ancient literatures related with the Hwe Yang Gu Chim Hyul. 2. The author investigated the composition of Hwe Yang Gu Chim Hyul, and the location, acupuncture treatment, specificity, disease of each acupoint. 3. Following the investigation, the author found the meaning, the mechanism of function, and the clinical usefulness, based on analysis with meridian. Results : 1. Hwe Yang Gu Chim Hyul had been referred in "Chim Gu Chwei Young" for the first time. 2. Hwe Yang Gu Chim Hyul is composed of 9 acupoints, i.e. 1 acupoint of Governor Vessel, 1 acupoint of Conception Vessel, 2 acupoints of Yang Myoung meridian, 1 acupoint of So Yang meridian, 1 acupoint of Tae Eum meridian, 2 acupoints of So Eum meridian, 1 acupoint of Gwel Eum meridian. 3. It has not been controversial since the comment of "Chim Gu Chwei Young", and it became the origin. Conclusions : 1. Hwe Yang Gu Chim Hyul can be used for an emergency resulted from chronic disease based on heart failure and accumulation of food.

• 한국임상수의학회지
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• 제27권4호
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• pp.402-406
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• 2010

Bovine leukemia virus (BLV) is a delta-retrovirus which causes chronic lymphocytosis in cattle. BLV infections have been divided into two groups such as enzootic bovine leukosis (EBL) and sporadic bovine leukosis (SBL) according to the clinical symptoms in infected cattle. The conventional detection method of BLV was hematological procedure which is determining lymphocytosis in the suspected animals. Recently several sensitive methods were developed to detect antibody to BLV and nucleic acid of the BLV from infected cattle. In this study we have compared the difference of positive rates between agar gel immunodiffusion (AGID) and enzyme linked immunosorbent assay (ELISA) which are using for BLV antibody detection methods. The positive detection rate of ELISA test was 7.4% greater than the positive rate of AGID. The discrepancy of the positive rate between ELISA and AGID were showed in the group of age over one year old to under three year old group. The result from each test agreed very well in the group of over 5 year old cattles. The serological test is very useful method to select the infected cattle for the eradication or control of the disease in the infected herd. But it has a limit by interference of the maternal antibody from the cow of under 6 month old. This study shows that 16.2% of these ages group showed BLV gene positive by polymerase chain reaction (PCR) method. The result suggests that ELISA test need to be used with PCR to clarify misinterpretation of positive animals by antibody response due to the natural infection from maternally derived antibody in calves of under 6 months old.

• 대한의용생체공학회:의공학회지
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• 제32권2호
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• pp.127-133
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• 2011

Arteria radialis is a branch of the brachial artery extending down the forearm around the wrist where it closes to skin surface. In the oriental medicine, the skin above arteria radialis has an important role because oriental medicine practitioners put their finger tips on the area, and diagnose patient's health conditions by feeling the pulsation of the arterial contraction. The finger tip diagnostic method relies on subjective decision of the practitioner; and there is a need to develop an objective diagnostic modality. The pulsation of the arterial contraction appears not only a movement on the site but also as temperature fluctuation due to pulsatile feeding of warmer blood. The goal of this study is to demonstrate a feasibility of using an infrared camera quantitatively to detect the temperature fluctuation on the skin. Clinical important three different areas, called chon, gwan, chuk, near a wrist where the arteria radialis reaches close to skin surface are marked with small pieces of surgical tape. A high-speed and high-resolution infrared camera with a 3 cm of field of view measures these areas for 10 second at 200 frames per second with a 320*240 pixel size. The pulsatile temperature fluctuation is calculated after passing a band pass filter to remove any stationary temperature over 10 second. The temperature fluctuation of a healthy male volunteer is measured at a room temperature as a control, and is compared with another measurement performed after 20 minutes staying in a room at a 40 degree Celsius. This comparison is repeated for three times, and indicates that the fluctuation increases after staying 20 minutes in the warm room. This increase becomes smaller when the person stays in the warm room with an acupuncture treatment that decreases body temperature. So that an objective diagnostics on the site may become feasible.

• Journal of Korean Medical Science
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• 제33권44호
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• pp.273.1-273.15
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• 2018

Background: Sparganosis is a larval cestodiasis caused by the plerocercoid of Spirometra spp. Since the first description of human sparganosis in 1924, several hundred cases have been reported in Korea. However, systematic approaches for literature surveys of Korean sparganosis have seldom appeared. Methods: We searched publicly available databases such as PubMed, Research Information Sharing Service, and Korea Medical Citation Index with relevant Medical Subject Headings. Results: At least 438 Korean sparganosis cases have been described from 1924 to 2015. Preoperative diagnosis has been significantly increased since the 1980s due to popularization of serological and imaging diagnostics. Cases were largely detected from fifth decades in general, but cerebral sparganosis was detected in relatively young age groups (third and fourth decades). Sparganosis was prevalent in men (75.9%). Consumption of frog/snake and drinking unfiltered water were found in 63.4% and 16.9% of patients, respectively. Most frequently affected sites were subcutaneous tissues (49.9%), followed by the central nervous system (36.2%). Involvements of visceral organs (7.6%), ocular regions (3.6%), and muscles (2.7%) were noticed. In women, breast sparganosis constituted a large proportion (34.2%). Sparganosis associated with immunocompromised patients has recently been reported. Conclusion: Sparganosis has been continuously reported in Korea during the past 90 years, although its incidence has decreased during the last 20 years. The disease is mostly characterized by subcutaneous nodule, but infection of the worm in vital organs often results in serious illness. Continuous awareness is warranted to monitor sparganosis occurrence and associated clinical consequences.

• 대한한의학방제학회지
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• 제29권4호
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• pp.311-319
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• 2021

1. 만성염증 질환인 전신성 건선 환자를 대상으로 437일간 단독 한방 치료를 진행하였다. 2. 침구치료는 환부 및 환부주위와 ST36(족삼리(足三里)), LI11(곡지(曲池)), LI4(합곡(合谷)), LR3(태충(太衝))을 기본 혈위(穴位)로 선정하고, 한약치료는 가미소요산(加味逍遙散), 육미지황탕(六味地黃湯)(환(丸))을 주 처방으로 삼았으며, 환자의 상태에 따라 혈위(穴位)와 약재를 가감(加減)하여 치료를 시행하였다. 3. 그 결과 PASI score가 28.2에서 0으로 감소하였다.

• 대한예방한의학회지
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• 제22권3호
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• pp.61-72
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• 2018

Objectives : This study was conducted to review the research trends in Korean Medicine of pompholyx based on publications in Korea. Methods : Literature published after 2000 were collected using OASIS, NDSL, KISS, and key words searched were "한포진" "발한이상" "pompholyx" "dyshidrotic eczema". Results : 10 case reports and 4 patient studies were selected for study. Conclusions : Korean medicine treatments included acupuncture, pharmacopuncture, venesection therapy, herbal medicine, ointments and carbon arc lamp therapy. The most commonly used diagnostic method for pompholyx was inspection along with pulse diagnosis, abdominal diagnosis, tongue diagnosis, culture test, and KOH smear screening. The most frequently used treatment evaluation method was Likert scale while VAS(Visual Analog Scale) and Visual&Subjective symptoms were each used in 4 studies. Among 29 patients in 14 papers who showed clinical manifestations of pompholyx, there were 15 male patients (52%), 14 female patients (48%), and the male to female ratio showed 1.07:1. Symptoms were improved using Korean Medicine treatments including acupuncture and herbal medicine. Concurrent treatment using special treatments such as pharmacopuncture, jiyang-go, bojungikgi-tang(ex), external applications showed higher treatment effects. Korean medical treatment of pompholyx was effective in all studies, but the lack of numbers of research on Korean medicine of pompholyx was witnessed compared to other diseases such as psoriasis. Also considering the number of patients suffering from pompholyx, further studies should be conducted.

• 고신대학교 의과대학 학술지
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• 제33권3호
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• pp.307-317
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• 2018

Background: Detection of antibodies to extractable nuclear antigens (ENAs) is needed for the diagnosis in systemic autoimmune diseases. In this study, we compared three reagents using line immunoblot assay (LIA) or multiplex bead immunoassay for detecting the anti-ENAs. Methods: A total of 89 sera were tested by 3 different assays: EUROASSAY Anti-ENA Profile (Euroimmune, Germany), Polycheck Autoimmune Test (Biocheck GmbH, Germany), and $FIDIS^{TM}$ Connective Profile (Biomedical Diagnostics, France). The following individual ENAs were investigated: Sm, SS-A (Ro), SS-B (La), Scl-70, Jo-1 and RNP. We reviewed medical records to investigate the discrepant results among three methods. Results: Overall percent agreements were 96.1% between EUROASSAY Anti-ENA Profile and $FIDIS^{TM}$ Connective profile; 90.4% between EUROASSAY Anti-ENA Profile and Polycheck Autoimmune Test using the manufacturers' cutoff; 96.4% between EUROASSAY Anti-ENA Profile and Polycheck Autoimmune Test using a upward cutoff; 90.4% between $FIDIS^{TM}$ Connective profile and Polycheck Autoimmune Test the manufacturers' cutoff; and 96.4% between $FIDIS^{TM}$ Connective profile and Polycheck Autoimmune Test a upward cutoff. Conclusions: The three assays showed excellent agreement with each other. With appropriate cutoff, the all three assays for six of the anti-ENA tests investigated in this study can be used in clinical laboratories for detecting the anti-ENAs.

• 한방안이비인후피부과학회지
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• 제34권4호
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• pp.198-209
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• 2021

Objectives : The purpose of this study is to report 3 cases of Korean medical treatment on adult atopic dermatitis. Methods : Three patients with adult atopic dermatitits were treated with herbal medicine (Soyo-san hap Samul-tang), acupuncture, and moxibustion. Psychosomatic symptoms were considered the main criteria for treatment. The effects of treatment were evaluated through photographs of the lesions, using EASI and DLQI scores. Results : After treatment, EASI and DLQI scores on three atopic dermatitis patients improved significantly. Conclusions : This clinical case study has demonstrated that Korean medicine may be an effective option for treating adult atopic dermatitis. In addition, considering psychosomatic symptoms when treating atopic dermatitis may also lead to effective treatment.

• 대한한의학원전학회지
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• 제34권4호
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• pp.65-78
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• 2021

Objectives : This study aims to provide a methodology for effectively searching similar applications of formulas by comparing applications of pre-existing prescriptions and those applied clinically based on the difference in weight ratio of each medicinal. Methods : The clinical application part was substituted by prescriptions from the Donguibogam. Samples of pre-existing prescriptions were taken from the Bangyakhappyeon. The component ratio of Donguibogam prescriptions(Y) and Bangyakhappyeon prescriptions(X1, X2) were calculated and expressed as Y = a×X1 +b×X2 + α. (a,b: numbers, α: the rest) Results : 1. In order to express the component ratio based on arbitrary prescriptions as standard prescription, a system that incorporates a storage sector for pre-existing prescription data, an input sector for arbitrary prescription data, an analysis sector that compares the two, and an output sector that generates analysis results is required. 2. The current study shows that the suggested analysis method allows for two standard prescriptions to an arbitrary prescription. Therefore, it is possible to analyze prescriptions that are combinations of two standard prescriptions. 3. Based on arbitrary prescription(Y) and pre-existing prescription(X1, X2), the combinations could be expressed as Y= a×X1 + b×X2 + α. Through finding the most simple combination, it is possible to search the most similar application to each arbitrary prescription.

• Journal of Oral Medicine and Pain
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• 제45권4호
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• pp.97-109
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• 2020

Purpose: Cervicogenic headache (CGH) is pain referred to the head/ face from the structures in vicinity of upper cervical spinal nerves via trigeminocervical pathway. Ponticulus Posticus (PP) and Elongated Styloid Process (ESP) are anatomical structures that cause compression of vasculature present around upper cervical nerve plexus. Recently, computational fluid dynamics (CFD) has shown to play an essential role in identification of these high-pressure zones in the brain. The aim of this research is to study the association of ESP and PP in patients with CGH and to develop a hypothesis by CFD to analyse vertebrobasilar insufficiency as a contributing factor in occurrence of CGH. Methods: Retrospective analysis of 4500 full skull CBCT scans was done for the presence of partial or complete PP and length of Styloid Process (SP). Research was divided into two phases; In first Preliminary Phase, 150 scans that showed the presence of PP and ESP were analysed, and only 134 patients gave consent to fill the questionnaire containing 96 question items pertaining to symptoms associated with CGH. In the second phase, simulation of Vertebral and Carotid Artery was done using Fluent 14.5 Software and by CFD, pressure distribution on arteries was obtained that helped to identify high pressure regions. Results: Both PP and ESP showed a statistically significant association with CGH (p<0.001). By CFD analysis, both steady and transient phases of simulation showed drop in pressure due to constriction of internal carotid and vertebral artery by ESP and PP respectively and were found to decrease the volume of blood reaching the brain, 0.12 /0.13 mL and 0.06 mL respectively. Conclusions: Our analysis proves ESP and PP as contributing factors towards CGH. Hence for proper diagnosis and management of headache disorders, clinicians should have adequate knowledge about these anatomical structures and their resulting clinical symptoms.